Online citations, reference lists, and bibliographies.
← Back to Search

Fgf8 Drives Myogenic Progression Of A Novel Lateral Fast Muscle Fibre Population In Zebrafish

J. A. Groves, C. Hammond, S. Hughes
Published 2005 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Fibroblast growth factors (Fgfs) have long been implicated in regulating vertebrate skeletal muscle differentiation, but their precise role(s) in vivo remain unclear. Here, we show that Fgf8 signalling in the somite is required for myod expression and terminal differentiation of a subset of fast muscle cells in the zebrafish lateral somite. In the absence of Fgf8, lateral somite cells transiently express myf5 but fail to make muscle and remain in a dermomyotome-like state characterised by pax3 and meox expression. Slow muscle fibres form and commence normal migration in the absence of Fgf8, but fail to traverse the expanded undifferentiated lateral somite. The Fgf8-independent residual population of medial fast muscle fibres is not Hedgehog dependent. However, Fgf8-independent medial fast muscle precursors are lacking in floatinghead mutants, suggesting that they require another ventral midline-derived signal. We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite.
This paper references
10.1089/104454999315655
Fast skeletal muscle-specific expression of a zebrafish myosin light chain 2 gene and characterization of its promoter by direct injection into skeletal muscle.
Y. Xu (1999)
10.2741/KLINT
Signal transduction by fibroblast growth factor receptors.
P. Klint (1999)
Fgf 8 is required for pharyngeal arch and cardiovascular
R. Abu-Issa (2002)
Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle.
N. Itoh (1996)
10.1111/j.1525-142X.2006.05079.x
Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish
S. Devoto (2006)
10.1016/j.cub.2004.03.058
FGF8-like1 and FGF8-like2 Encode Putative Ligands of the FGF Receptor Htl and Are Required for Mesoderm Migration in the Drosophila Gastrula
Tanja Gryzik (2004)
A clockwork somite
K. J. Dale (2000)
10.1016/S0092-8674(01)00437-8
FGF Signaling Controls Somite Boundary Position and Regulates Segmentation Clock Control of Spatiotemporal Hox Gene Activation
J. Dubrulle (2001)
10.1002/(SICI)1521-1878(200001)22:1<72::AID-BIES12>3.0.CO;2-S
A clock-work somite.
K. J. Dale (2000)
An Fgf8 mutant
E. N. 403-406. Meyers (1998)
10.1007/s00429-002-0227-z
Spatial and temporal pattern of Fgf-8 expression during chicken development
D. Stolte (2002)
The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.
P. H. Crossley (1995)
The u-boot mutation
C. Wolff (2001)
10.1016/S0960-9822(01)00143-9
Zebrafish pea3 and erm are general targets of FGF8 signaling
H. Roehl (2001)
Zebrafish pea 3 and erm are general targets of FGF 8 signaling
S. Roy (2001)
10.1016/S0092-8674(00)80189-0
Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD
S. Tajbakhsh (1997)
Mutations affecting somite formation and patterning in the zebrafish, Danio rerio.
F. V. van Eeden (1996)
10.1016/J.YDBIO.2004.07.030
Hedgehog signaling is required for commitment but not initial induction of slow muscle precursors.
E. Hirsinger (2004)
Zebrafish fgf 24 functions with fgf 8 to promote posterior mesodermal
S. J. Du (1997)
Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells.
E. Bober (1994)
10.1126/SCIENCE.285.5426.403
Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH.
E. Meyers (1999)
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome.
D. Frank (2002)
10.1038/364532A0
Myogenin gene disruption results in perinatal lethality because of severe muscle defect
Y. Nabeshima (1993)
10.1002/(SICI)1520-6408(1998)22:3<212::AID-DVG4>3.0.CO;2-9
Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm.
A. Michelson (1998)
10.1101/GAD.195801
The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo.
S. Roy (2001)
eFGF is required for activation of XmyoD expression in the myogenic cell lineage of Xenopus laevis.
M. E. Fisher (2002)
Fgf/MAPK signalling is a crucial positional cue in somite boundary formation.
A. Sawada (2001)
Coordinate embryonic expression of three zebrafish engrailed genes.
M. Ekker (1992)
10.1016/S1534-5807(04)00026-7
Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis.
T. A. Moreno (2004)
10.1016/S0925-4773(02)00422-7
RETRACTED: Expression of the FGF receptor 2 gene (fgfr2) during embryogenesis in the zebrafish Daniorerio
N. Tonou-Fujimori (2002)
Distinct
C. Marcelle (1994)
10.1038/35040549
Evolutionary origins of vertebrate appendicular muscle
C. Neyt (2000)
10.1016/S0959-437X(00)00215-X
Skeletal muscle formation in vertebrates.
M. Buckingham (2001)
10.1101/GAD.13.23.3136
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch.
A. Trumpp (1999)
10.1006/DBIO.2001.0221
Misexpression of Fgf-4 in the chick limb inhibits myogenesis by down-regulating Frek expression.
F. Edom-Vovard (2001)
Murine Wnt-11 and Wnt
D. G. Wilkinson (1995)
10.1016/s0925-4773(03)00112-6
Expression of the FGF receptor 2 gene (fgfr2) during embryogenesis in the zebrafish Danio rerio.
N. Tonou-Fujimori (2002)
The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity.
M. J. Barresi (2000)
A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula.
M. Fürthauer (1997)
Murine Wnt11 and Wnt12 have temporally and spatially restricted expression patterns during embryonic development
J. H. Christiansen (1995)
Zebrafish pea 3 and erm are general targets of FGF 8 signaling
H. Roehl (2001)
10.1038/82601
Fgf8 is required for outgrowth and patterning of the limbs
A. Moon (2000)
10.1016/S0925-4773(97)00175-5
The zebrafish Pax3 and Pax7 homologues are highly conserved, encode multiple isoforms and show dynamic segment-like expression in the developing brain
Hee-Chan Seo (1998)
10.1002/1097-0177(2000)9999:9999<::AID-DVDY1065>3.0.CO;2-A
Somite development in zebrafish
H. Stickney (2000)
Myogenin gene disruption results in perinatal lethality owing to severe muscle defect
C. Neyt (2000)
10.1016/0092-8674(93)90621-V
MyoD or Myf-5 is required for the formation of skeletal muscle
M. Rudnicki (1993)
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis.
F. Reifers (1998)
10.1242/dev.00552
Analysis of a key regulatory region upstream of the Myf5 gene reveals multiple phases of myogenesis, orchestrated at each site by a combination of elements dispersed throughout the locus
J. Hadchouel (2003)
Fgf8 is required for outgrowth
A. M. Moon (2000)
expression of a new avian fibroblast growth factor receptor
I. Marics (2002)
The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)
M. Westerfield (1995)
10.1242/dev.01194
Hedgehog regulation of superficial slow muscle fibres in Xenopus and the evolution of tetrapod trunk myogenesis
A. Grimaldi (2004)
10.1016/S1097-2765(02)00481-1
Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression.
D. Bergstrom (2002)
10.1016/0168-9525(96)81431-4
Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants.
M. Halpern (1995)
Diversity of expression of engrailedlike antigens in zebrafish
K. Hatta (1991)
Zebrafish pea3 and erm
H. Roehl (2001)
10.1083/JCB.128.4.563
Myogenin is required for late but not early aspects of myogenesis during mouse development
J. Venuti (1995)
eFGF and its mode of action in the community effect during Xenopus myogenesis.
H. Standley (2001)
10.1242/dev.01275
FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression
A. E. Brent (2004)
10.1016/0012-1606(74)90152-3
Clonal analysis of vertebrate myogenesis. I. Early developmental events in the chick limb.
P. H. Bonner (1974)
10.1038/nature02876
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
L. Kassar-Duchossoy (2004)
10.1016/J.YDBIO.2004.03.032
fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos.
Y. Cao (2004)
10.1242/dev.00671
Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development
B. Draper (2003)
10.1002/dvdy.10481
Signals regulating tendon formation during chick embryonic development
Frédérique Edom-Vovard (2004)
and somitogenesis
F. Reifers
The zebrafish
M. J. Barresi (2000)
of slow muscle identity
D. A. Bergstrom (2002)
10.1038/364501A0
Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
P. Hasty (1993)
10.1016/S0925-4773(00)00475-5
Overlapping and distinct functions provided by fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs
F. Reifers (2000)
Diversity of expression of engrailed-like antigens in zebrafish.
K. Hatta (1991)
An Fgf 8 mutant allelic series generated by Creand Flpmediated recombination
E. N. Meyers (1998)
genes, Fgf8, Fgf17 and Fgf18, in the mouse
E. N. Meyers (1999)
Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar).
F. Reifers (2000)
Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse.
Radwan Abu-Issa (2002)
10.1006/DBIO.1999.9535
Loss of FGF receptor 1 signaling reduces skeletal muscle mass and disrupts myofiber organization in the developing limb.
H. Flanagan-Steet (2000)
10.1016/0168-9525(96)81475-2
Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb.
A. Vogel (1996)
10.1016/S0960-9822(03)00461-5
Multiple Muscle Cell Identities Induced by Distinct Levels and Timing of Hedgehog Activity in the Zebrafish Embryo
C. Wolff (2003)
Regulation of segmental patterning
A T. (2004)
The mouse Fgf8 gene
P. H. Crossley (1995)
10.1083/JCB.139.1.145
Positive and Negative Regulation of Muscle Cell Identity by Members of the hedgehog and TGF-β Gene Families
S. Du (1997)
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish.
H. Schauerte (1998)
FGFR4 signaling is a necessary step in limb muscle differentiation.
I. Marics (2002)
Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail.
Kevin J P Griffin (1995)
10.1101/GAD.11.17.2163
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog.
C. S. Blagden (1997)
A clockwork somite
S. H. Devoto (1996)
10.1002/AJA.1002030309
Novel FGF receptor (Z‐FGFR4) is dynamically expressed in mesoderm and neurectoderm during early zebrafish embryogenesis
B. Thisse (1995)
10.1002/1526-968X(200101)29:1<22::AID-GENE1002>3.0.CO;2-Z
Molecular structure, dynamic expression, and promoter analysis of zebrafish (Danio rerio) myf‐5 gene
Y. Chen (2001)
Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation.
S. Devoto (1996)
10.1038/378150A0
A homeobox gene essential for zebrafish notochord development
W. Talbot (1995)
10.1006/DBIO.2001.0193
Hedgehog signalling is required for maintenance of myf5 and myoD expression and timely terminal differentiation in zebrafish adaxial myogenesis.
O. Coutelle (2001)
Misexpression of Fgf4 in the chick limb inhibits myogenesis by downregulating Frek expression
F. Edom-Vovard (2001)
10.1016/S0092-8674(03)00268-X
A Somitic Compartment of Tendon Progenitors
A. E. Brent (2003)
10.1242/dev.00662
Tracing of her5 progeny in zebrafish transgenics reveals the dynamics of midbrain-hindbrain neurogenesis and maintenance
A. Tallafuss (2003)
10.1101/GAD.13.14.1834
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.
X. Sun (1999)
10.1006/DBIO.2002.0707
Fgf4 positively regulates scleraxis and tenascin expression in chick limb tendons.
F. Edom-Vovard (2002)
10.1038/NG0298-136
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
E. Meyers (1998)
Signal transduction by fibroblast
P. 466-471. Klint (1999)
10.1002/AJA.1001250406
Development of the lateral musculature in the teleost, Brachydanio rerio: a fine structural study.
R. Waterman (1969)
10.1038/21892
Mox2 is a component of the genetic hierarchy controlling limb muscle development
B. Mankoo (1999)
10.1016/0012-1606(88)90264-3
Clonal analysis of vertebrate myogenesis. VIII. Fibroblasts growth factor (FGF)-dependent and FGF-independent muscle colony types during chick wing development.
J. Seed (1988)
Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos.
E. Weinberg (1996)
An Fgf 8 mouse mutant phenocopies human 22 q 11 deletion syndrome
D. Frank (2002)
Distinct developmental expression of a new avian fibroblast growth factor receptor.
C. Marcelle (1994)
Myogenin gene disruption results in perinatal lethality owing to severe muscle defect
Y. Nabeshima (1993)
10.1016/0925-4773(95)00383-5
Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development
J. Christiansen (1995)
10.1016/S0925-4773(98)00061-6
Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo
Y. Maruoka (1998)



This paper is referenced by
10.4199/c00011ed1v01y201004deb002
FGF Signalling in Vertebrate Development
M. Pownall (2010)
10.1002/jmor.20095
The zebrafish myotome contains tonic muscle fibers: Morphological characterization and time course of formation
J. Marschallinger (2013)
Muscle growth and flesh quality of farmed Atlantic halibut (Hippoglossus hippoglossus) in relation to season of harvest
Ø. Hagen (2008)
10.1016/j.ydbio.2009.11.031
Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome.
C. Niro (2010)
10.1387/ijdb.150136pr
CILP1 is dynamically expressed in the developing musculoskeletal system of the trout.
C. Rallière (2015)
10.1016/j.diff.2019.02.007
Development of myofibres and associated connective tissues in fish axial muscle: Recent insights and future perspectives.
P. Rescan (2019)
10.1002/dvdy.22243
BMP regulation of myogenesis in zebrafish
S. Patterson (2010)
10.1016/J.BBADIS.2006.07.003
Modeling human muscle disease in zebrafish.
J. Guyon (2007)
10.1007/s00427-007-0148-1
A NLRR-1 gene is expressed in migrating slow muscle cells of the trout (Oncorhynchus mykiss) embryo
E. Dumont (2007)
10.1242/jeb.006981
Temperature influences the coordinated expression of myogenic regulatory factors during embryonic myogenesis in Atlantic salmon (Salmo salar L.)
D. Macqueen (2007)
10.1016/J.MODGEP.2007.06.003
Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle.
Y. Hinits (2007)
10.1038/s41467-018-06583-6
Myogenin promotes myocyte fusion to balance fibre number and size
Massimo Ganassi (2018)
10.1016/J.YDBIO.2006.08.056
Hedgehog acts directly on the zebrafish dermomyotome to promote myogenic differentiation.
Xuesong Feng (2006)
Molecular Biotechnology of Development and Growth in Fish Muscle
I. Johnston (2008)
10.1002/dvdy.22201
Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesis
F. Kok (2010)
10.1016/j.febslet.2006.08.016
A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization
D. Macqueen (2006)
10.1016/j.mod.2013.06.001
Control of muscle fibre-type diversity during embryonic development: The zebrafish paradigm
Harriet E. Jackson (2013)
10.1016/S0001-4079(19)31002-7
[New insights into adult muscle fiber-type diversity: involvement of Six homeoproteins].
Pascal Maire (2015)
10.1242/dev.061002
Ret signalling integrates a craniofacial muscle module during development
R. Knight (2011)
10.1242/dmm.022251
Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair
Tapan G Pipalia (2016)
10.1242/dev.003905
Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
L. Maves (2007)
Analysis of Sox10 target genes in zebrafish early development
Thomas R Chipperfield (2009)
10.1242/dev.028019
Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations
Y. Hinits (2009)
10.3390/jdb7020012
The Developmental Phases of Zebrafish Myogenesis
S. R. Keenan (2019)
10.1074/jbc.M708594200
Smarcd3 Regulates the Timing of Zebrafish Myogenesis Onset*
Haruki Ochi (2008)
10.12681/eadd/29857
Expression of skeletal myosin light chain 2 in gilthead sea bream (Sparus aurata, L): regulation and correlation to growth markers.
S. Georgiou (2013)
10.7554/eLife.07343
Logics and properties of a genetic regulatory program that drives embryonic muscle development in an echinoderm
Carmen Andrikou (2015)
10.1242/dev.02789
Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants
Valentina Svetic (2007)
10.1242/jeb.005751
In ovo temperature manipulation influences embryonic motility and growth of limb tissues in the chick (Gallus gallus)
C. Hammond (2007)
10.1242/dev.071555
Initiation of synapse formation by Wnt-induced MuSK endocytosis
Laura R. Gordon (2012)
10.1242/dev.113431
Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish
S. Windner (2015)
Développement et caractérisation de deux modèles murins présentant un phénotype hypermusclé
O. Monestier (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar