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MAP Kinases As Structural Adaptors And Enzymatic Activators In Transcription Complexes

J. W. Edmunds, L. Mahadevan
Published 2004 · Medicine, Biology

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Mitogen-activated protein kinase (MAPK) pathways regulate eukaryotic gene expression in response to extracellular stimuli. MAPKs and their downstream kinases phosphorylate transcription factors, co-regulators and chromatin proteins to initiate transcriptional changes. However, the spatial context in which the MAPKs operate in transcription complexes is poorly understood. Recent findings in budding yeast show that MAPKs can form integral components of transcription complexes and have novel structural functions in addition to phosphorylating local substrates. Hog1p MAPK is stably recruited to target promoters by specific transcription factors in response to osmotic stress, and acts as both a structural adaptor and enzymatic activator driving the assembly and activation of the transcription complex. We review the evidence that suggests a similar bifunctional role for MAPKs in mammalian transcription complexes.
This paper references
10.1074/JBC.275.18.13872
A Role for the p38 MAP Kinase Pathway in the Nuclear Shuttling of NFATp*
P. G. del Arco (2000)
10.1152/PHYSREV.1999.79.1.143
Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.
C. Widmann (1999)
10.1046/j.1365-2958.2001.02384.x
The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway‐dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage
M. Rep (2001)
10.1074/JBC.M107850200
Mitogen-activated Protein Kinase Phosphorylates and Negatively Regulates Basic Helix-Loop-Helix-PAS Transcription Factor BMAL1*
K. Sanada (2002)
10.1073/pnas.192264999
p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation
K. Ramsauer (2002)
10.1006/SCDB.1999.0302
MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction.
S. Thomson (1999)
10.1074/JBC.M100209200
The Absence of Activator Protein 1-dependent Gene Expression in THP-1 Macrophages Stimulated with Phorbol Esters Is Due to Lack of p38 Mitogen-activated Protein Kinase Activation*
A. B. Carter (2001)
Docking domains and
A. D. Sharrocks (2000)
10.1074/jbc.C901040199
Serine/Threonine Kinases 3pK and MAPK-activated Protein Kinase 2 Interact with the Basic Helix-Loop-Helix Transcription Factor E47 and Repress Its Transcriptional Activity*
B. Neufeld (2000)
10.1074/JBC.M007697200
Selective Targeting of MAPKs to the ETS Domain Transcription Factor SAP-1*
A. Galanis (2001)
10.1073/PNAS.89.12.5341
Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
V. Adler (1992)
10.1128/MCB.22.13.4522-4534.2002
Retinoic Acid Receptors Inhibit AP1 Activation by Regulating Extracellular Signal-Regulated Kinase and CBP Recruitment to an AP1-Responsive Promoter
M. Benkoussa (2002)
10.1128/MCB.20.12.4340-4349.2000
Aca1 and Aca2, ATF/CREB Activators in Saccharomyces cerevisiae, Are Important for Carbon Source Utilization but Not the Response to Stress
M. García-Gimeno (2000)
10.1101/GAD.7.11.2135
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
M. Hibi (1993)
Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction.
E. Cano (1995)
10.1093/emboj/cdg240
The mitogen‐activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB
Z. A. Felton-Edkins (2003)
10.1128/MCB.23.1.229-237.2003
Targeting the MEF2-Like Transcription Factor Smp1 by the Stress-Activated Hog1 Mitogen-Activated Protein Kinase
Eulàlia de Nadal (2003)
Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways
M. A. Read (1997)
Interaction of p 38 and Sp 1 in a mechanical forceinduced , beta 1 integrinmediated transcriptional circuit that regulates the actin - binding protein filaminA
M. D’Addario (2002)
Extracellular signalregulated kinase binds to TFIII and regulates its activation of the c - fos promoter
D. W. Kim (2000)
Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function.
T. Dai (1995)
10.1016/0092-8674(95)90402-6
MAP kinase pathways in yeast: For mating and more
I. Herskowitz (1995)
10.1038/sj.onc.1203892
The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades
C. Ducret (2000)
10.1093/emboj/17.19.5606
Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin β homologs NMD5 and XPO1
P. Ferrigno (1998)
10.1074/jbc.M910016199
The Transcriptional Response of Yeast to Saline Stress*
F. Posas (2000)
10.1128/MCB.19.1.537
Repressors and Upstream Repressing Sequences of the Stress-Regulated ENA1 Gene in Saccharomyces cerevisiae: bZIP Protein Sko1p Confers HOG-Dependent Osmotic Regulation
M. Proft (1999)
10.1093/emboj/cdg139
Transcriptional activation of the NF‐κB p65 subunit by mitogen‐ and stress‐activated protein kinase‐1 (MSK1)
L. Vermeulen (2003)
Van Damme A.
M. Haine (1986)
10.1016/S0014-5793(03)00451-4
MAP kinase‐mediated phosphoacetylation of histone H3 and inducible gene regulation
A. Clayton (2003)
pp 90 rsk 1 regulates estrogen receptor - mediated transcription through phosphorylation of Ser167
P. B. Joel (1998)
NH2-terminal kinases
V. Adler (1992)
10.1038/35065000
Mammalian MAP kinase signalling cascades
L. Chang (2001)
10.1002/j.1460-2075.1996.tb00576.x
The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE).
M. T. Martínez-Pastor (1996)
10.1016/S0898-6568(02)00112-2
Molecular recognitions in the MAP kinase cascades.
T. Tanoue (2003)
10.1002/jcp.10058
Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control
T. Oelgeschläger (2002)
elk-1 proteins interact with MAP kinases.
Rao Vn (1994)
10.1093/NAR/26.20.4771
Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.
C. Yang (1998)
10.1016/S1097-2765(01)00221-0
Stress-induced map kinase Hog1 is part of transcription activation complexes.
P. Alepuz (2001)
10.1128/MCB.20.14.5227-5234.2000
c-Jun NH2-Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1
C. W. Chow (2000)
Activation of the mitogen - activated protein kinase pathway in U 937 leukemic cells induces phosphorylation of the amino terminus of the TATAbinding protein
J. R. Biggs (1998)
10.1093/emboj/17.6.1740
Differential targeting of MAP kinases to the ETS‐domain transcription factor Elk‐1
S. Yang (1998)
10.1074/JBC.274.43.30858
The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP).
A. B. Carter (1999)
10.1016/S0092-8674(00)81999-6
c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions
T. Kallunki (1996)
10.1016/0092-8674(94)90380-8
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
B. Dérijard (1994)
10.1016/S0168-9525(02)02723-3
Yeast go the whole HOG for the hyperosmotic response.
S. O'Rourke (2002)
10.1128/MCB.18.2.710
The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif
S. Yang (1998)
10.1091/MBC.10.4.1147
Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae.
V. Reiser (1999)
Targeting the MEF 2like transcription factor Smp 1 by the stressactivated Hog 1 mitogen - activated protein kinase
E. de Nadal (2003)
c-Jun NH_2-terminal kinase の抑制はラット肺の虚血再灌流傷害を改善する
石井 誠 (2004)
10.1038/35085068
Transcriptional regulation by the phosphorylation-dependent factor CREB
B. Mayr (2001)
Nucleocytoplasmic traffic of MAP kinases.
V. Reiser (1999)
Mitogen - activated protein kinase phosphorylates and negatively regulates basic helixloophelixPAS transcription factor BMAL 1
K. Sanada (2002)
An
B. Derijard (1994)
10.1002/j.1460-2075.1995.tb07167.x
ATF‐2 contains a phosphorylation‐dependent transcriptional activation domain.
C. Livingstone (1995)
10.1126/SCIENCE.278.5343.1638
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway.
C. W. Chow (1997)
10.1093/emboj/18.6.1559
Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases
S. Wang (1999)
10.1016/S0960-9822(95)00151-5
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus
M. Karin (1995)
10.1016/S0378-1119(03)00816-3
Transcriptional regulation by the MAP kinase signaling cascades.
S. Yang (2003)
Nuclear accumulation of NFAT 4 opposed by the JNK signal transduction pathway
C. W. Chow (1997)
10.1128/MCB.19.3.2021
Jun Kinase Phosphorylates and Regulates the DNA Binding Activity of an Octamer Binding Protein, T-Cell Factor β1
S. Kasibhatla (1999)
10.1126/science.7824938
Transcription factor ATF2 regulation by the JNK signal transduction pathway
S. Gupta (1995)
10.1074/JBC.275.12.8290
The Transcriptional Response of Saccharomyces cerevisiae to Osmotic Shock
M. Rep (2000)
The p 38 mitogen - activated protein kinase is required for NFkappaBdependent gene expression . The role of TATAbinding protein ( TBP )
A. B. Carter (1999)
Targeting of p 38 mitogen - activated protein kinases to MEF 2 transcription factors
S. H. Yang (1999)
p 38 MAPK enhances STAT 1dependent transcription independently of Ser727 phosphorylation
K. Ramsauer (2002)
10.1091/MBC.E03-07-0521
Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.
S. O'Rourke (2004)
10.1074/JBC.M207681200
Interaction of p38 and Sp1 in a Mechanical Force-induced, β1 Integrin-mediated Transcriptional Circuit That Regulates the Actin-binding Protein Filamin-A*
M. D'Addario (2002)
Tumor necrosis factor alphainduced Eselectin expression is activated by the nuclear factorkappaB and c - JUN N - terminal kinase / p 38 mitogen - activated protein kinase pathways
M. A. Read (1997)
10.1093/embo-reports/kvf158
Dealing with osmostress through MAP kinase activation
E. de Nadal (2002)
10.1016/S1097-2765(02)00557-9
Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress.
M. Proft (2002)
10.1038/386296A0
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
J. Han (1997)
10.1074/jbc.M001020200
ERKs and p38 Kinase Phosphorylate p53 Protein at Serine 15 in Response to UV Radiation*
Q. She (2000)
10.1093/emboj/cdg590
Glucocorticoid receptor–JNK interaction mediates inhibition of the JNK pathway by glucocorticoids
A. Bruna (2003)
10.1074/JBC.M205501200
Regulation of the ETS Transcription Factor ER81 by the 90-kDa Ribosomal S6 Kinase 1 and Protein Kinase A*
Jianmin Wu (2002)
Activation of the mitogen-activated protein kinase pathway in U937 leukemic cells induces phosphorylation of the amino terminus of the TATA-binding protein.
Joseph R. Biggs (1998)
10.1074/JBC.M105399200
Nerve Growth Factor Uses Ras/ERK and Phosphatidylinositol 3-Kinase Cascades to Up-regulate theN-Methyl-d-aspartate Receptor 1 Promoter*
A. Liu (2001)
10.1074/jbc.M910024199
Human ERK1 Induces Filamentous Growth and Cell Wall Remodeling Pathways in Saccharomyces cerevisiae *
J. M. Atienza (2000)
10.1126/SCIENCE.8047888
An osmosensing signal transduction pathway in mammalian cells.
Z. Galcheva-Gargova (1994)
10.1074/JBC.M100236200
Intestinal Epithelial Cell Differentiation Involves Activation of p38 Mitogen-activated Protein Kinase That Regulates the Homeobox Transcription Factor CDX2*
M. Houde (2001)
10.1016/0014-5793(94)01052-8
MAP kinase binds to the NH2‐terminal activation domain of c‐Myc
S. Gupta (1994)
10.1016/S0955-0674(96)80067-6
Regulation of transcription by MAP kinase cascades.
R. Treisman (1996)
10.1074/JBC.M001573200
Big Mitogen-activated Kinase Regulates Multiple Members of the MEF2 Protein Family*
Y. Kato (2000)
10.1128/MCB.18.4.1978
pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167
P. Joel (1998)
10.1152/PHYSREV.2001.81.2.807
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.
J. Kyriakis (2001)
Transcriptional regulation by the phosphorylationdependent factor CREB
B. Mayr (2001)
10.1101/GAD.12.17.2658
JNK targets p53 ubiquitination and degradation in nonstressed cells.
S. Fuchs (1998)
10.1074/jbc.274.27.18932
Hyperphosphorylation of the Retinoid X Receptor α by Activated c-Jun NH2-terminal Kinases*
S. Adam-Stitah (1999)
10.1074/JBC.M000958200
c-Jun NH2-terminal Kinase Targeting and Phosphorylation of Heat Shock Factor-1 Suppress Its Transcriptional Activity*
R. Dai (2000)
10.1074/jbc.272.5.2753
Tumor Necrosis Factor α-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways*
M. Read (1997)
Transcription factor ATF 2 regulation by the JNK signal transduction pathway
S. Gupta (1995)
kinases that have arisen in mammalian cells
S. Adam-Stitah (1999)
Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter
D. W. Kim (2000)
Hyperphosphorylation of the retinoid X receptor alpha by activated c - Jun NH 2terminal kinases
S. Adam-Stitah (1999)
10.1128/MCB.16.7.3967
The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability.
T. Tanaka (1996)
10.1093/emboj/20.5.1123
Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress
M. Proft (2001)
10.1126/SCIENCE.1072682
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
G. Johnson (2002)
10.1093/emboj/cdg243
Osmostress‐induced transcription by Hot1 depends on a Hog1‐mediated recruitment of the RNA Pol II
P. Alepuz (2003)
10.1101/GAD.950902
An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.
Jeffrey J Seidel (2002)
10.1074/jbc.274.46.32580
Regulation of c-Myc through Phosphorylation at Ser-62 and Ser-71 by c-Jun N-Terminal Kinase*
K. Noguchi (1999)
Mitogen - activated protein kinase pathways mediated by ERK , JNK , and p 38 protein kinases
G. L. Johnson (2002)
c - Jun NH 2terminal kinase targeting and phosphorylation of heat shock factor - 1 suppress its transcriptional activity
R. Dai (2000)
10.1074/JBC.270.13.7420
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)
J. Raingeaud (1995)
10.1006/GENO.2000.6299
Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta.
K. Slentz-Kesler (2000)
10.1128/MCB.19.6.4028
Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors
S. Yang (1999)
10.1128/MCB.20.22.8382-8389.2000
ERK5 Is a Novel Type of Mitogen-Activated Protein Kinase Containing a Transcriptional Activation Domain
H. Kasler (2000)
10.1016/S1097-2765(04)00060-7
SUMO promotes HDAC-mediated transcriptional repression.
S. Yang (2004)
MAP kinasemediated signalling to nucleosomes and immediateearly gene induction
S. Thomson (1999)
SUMO promotes HDACmediated transcriptional repression
S. H. Yang (2004)
Transcriptional activation of the NFkappaB p 65 subunit by mitogenand stressactivated protein kinase1 ( MSK 1 )
L. Vermeulen (2003)
10.1002/j.1460-2075.1996.tb00636.x
Selective interaction of JNK protein kinase isoforms with transcription factors.
S. Gupta (1996)
10.1101/GAD.8.24.2996
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.
T. Kallunki (1994)
10.1074/jbc.M108145200
Specificity Determinants in MAPK Signaling to Transcription Factors*
D. Barsyte-Lovejoy (2002)
10.1128/MCB.19.8.5474
Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p
M. Rep (1999)
10.1016/S1097-2765(03)00036-4
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.
J. Zhao (2003)
10.1101/GAD.14.3.301
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.
M. Wu (2000)
10.1128/MCB.14.12.8376
Signal transduction by tumor necrosis factor mediated by JNK protein kinases.
H. K. Sluss (1994)
10.1038/nature02258
The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes
Eulàlia de Nadal (2004)
10.1016/S1369-5274(98)80008-8
Signal transduction by MAP kinase cascades in budding yeast.
F. Posas (1998)
elk-1 proteins interact with MAP kinases.
V. Rao (1994)
10.1016/S0968-0004(00)01627-3
Docking domains and substrate-specificity determination for MAP kinases.
A. Sharrocks (2000)
The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation
T. Tanaka (1996)



This paper is referenced by
10.1128/MCB.02276-06
Rev7/MAD2B Links c-Jun N-Terminal Protein Kinase Pathway Signaling to Activation of the Transcription Factor Elk-1
L. Zhang (2007)
10.1186/s13041-020-0560-2
Scopoletin ameliorates anxiety-like behaviors in complete Freund’s adjuvant-induced mouse model
Li Luo (2020)
10.1007/978-1-4614-8624-4
Fundamentals of Chromatin
J. Workman (2014)
10.1038/sj.emboj.7601756
The Sch9 kinase is a chromatin‐associated transcriptional activator of osmostress‐responsive genes
A. Pascual-Ahuir (2007)
10.1146/annurev-biochem-061809-175347
Signals and combinatorial functions of histone modifications.
T. Suganuma (2011)
Nouveaux modes de régulation des voies MAP kinase eucaryotes par phosphorylation
M. Arcand (2008)
REGULATION OF MEIOTIC RECOMBINATION BY A MULTIFUNCTIONAL ATF/CREB PROTEIN
J. Gao (2008)
10.1016/j.celrep.2019.03.060
Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK
Caterina Carbonell (2019)
10.1016/j.cell.2010.07.045
The ATAC Acetyltransferase Complex Coordinates MAP Kinases to Regulate JNK Target Genes
T. Suganuma (2010)
10.1038/s41598-017-04913-0
Phylogenomic analysis of MKKs and MAPKs from 16 legumes and detection of interacting pairs in chickpea divulge MAPK signalling modules
Savithri Purayannur (2017)
10.1111/J.1574-6968.2006.00295.X
Contrasting signal transduction mechanisms in bacterial and eukaryotic gene transcription.
Phillipa J. Cashin (2006)
10.1186/1476-9255-4-23
Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCε and JAK2 in RAW macrophages
E. Jones (2007)
10.1074/jbc.M110.165134
B-Raf Associates with and Activates the NHE1 Isoform of the Na+/H+ Exchanger*
P. Karki (2011)
10.1111/j.1476-5381.2009.00328.x
Cross‐regulation between β1‐ and β3‐adrenoceptors following chronic β‐adrenergic stimulation in neonatal rat cardiomyocytes
C. Ufer (2009)
10.1016/J.REPROTOX.2006.08.013
The hormonal herbicide, 2,4-dichlorophenoxyacetic acid, inhibits Xenopus oocyte maturation by targeting translational and post-translational mechanisms.
Alexis LaChapelle (2007)
10.1111/j.1471-4159.2005.03304.x
Integration of G protein signals by extracellular signal‐regulated protein kinases in SK‐N‐MC neuroepithelioma cells
A. S. Chan (2005)
10.1016/j.tcb.2009.03.002
Chromatin: the interface between extrinsic cues and the epigenetic regulation of muscle regeneration.
Valentina Guasconi (2009)
10.1101/sqb.2010.75.044
Cell signaling and transcriptional regulation via histone phosphorylation.
S. Berger (2010)
10.1016/j.biochi.2012.04.018
Histone H3 phosphorylation – A versatile chromatin modification for different occasions
Anna Sawicka (2012)
Study of the molecular effects of isoflavones on inflammatory gene expression.
Nathalie Dijsselbloem (2007)
Molecular Mechanisms Underlying The Regulation Of Gene Expression And Growth In Breast Cancer Cells
Miao Sun (2013)
The role of acetylation in the regulation of antimicrobial peptide gene expression in the human intestine
N. Fischer (2014)
10.1091/mbc.E13-10-0628
An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation
P. Sabbattini (2014)
10.1158/1541-7786.MCR-08-0309
10-Formyltetrahydrofolate Dehydrogenase–Induced c-Jun-NH2-Kinase Pathways Diverge at the c-Jun-NH2-Kinase Substrate Level in Cells with Different p53 Status
S. Ghose (2009)
10.1158/0008-5472.CAN-05-2957
Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappaB gene expression by soy isoflavones does not require estrogenic activity.
W. Vanden Berghe (2006)
10.1016/J.YMETH.2006.06.007
Genome-wide location analysis of the stress-activated MAP kinase Hog1 in yeast.
A. Pascual-Ahuir (2006)
10.1007/4735_2007_0244
Regulation of gene expression in response to osmostress by the yeast stress-activated protein kinase Hog1
Eulàlia de Nadal (2007)
10.1016/J.YDBIO.2006.10.014
A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo.
J. Lunn (2007)
10.1677/JOE-07-0570
Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway.
Parveen Abidi (2008)
10.1038/sj.emboj.7600737
The MAP kinase substrate MKS1 is a regulator of plant defense responses
E. Andréasson (2005)
10.1007/s00299-014-1629-0
MAPK cascades and major abiotic stresses
K. Moustafa (2014)
10.1007/978-1-4614-8624-4_14
Emerging Areas of Chromatin Research
T. Suganuma (2014)
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