Online citations, reference lists, and bibliographies.

Results Of R0 Resection For Colorectal Liver Metastases Associated With Extrahepatic Disease

D. Elias, L. Sidéris, M. Pocard, J. Ouellet, V. Boige, P. Lasser, J. Pignon, M. Ducreux
Published 2004 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Background: Extrahepatic malignant disease has always been considered an absolute contraindication to hepatectomy for colorectal liver metastases. This study reports the long-term outcome and prognostic factors of patients undergoing extrahepatic disease resection simultaneously with hepatectomy for liver metastases.Methods: From January 1987 to January 2001, 75 patients underwent a complete R0 resection of extrahepatic disease simultaneously with hepatectomy for colorectal liver metastases. They were inscribed in a registry and then prospectively followed up. They represented 25% of the 294 patients who underwent an R0 hepatectomy for colorectal liver metastases during the same period.Results: The mortality rate was 2.7%, and morbidity was 25%. After a median follow-up of 4.9 years (range, 1.7–13.4 years), the overall 3- and 5-year survival rates were 45% and 28%, respectively. By using a Cox model, there was a significant difference in survival between patients with single versus multiple sites of extrahepatic disease. Also, the presence of more than five liver metastases was a significant parameter.Conclusions: Extrahepatic disease in colorectal cancer patients with liver metastases should no longer be considered as a contraindication to hepatectomy. However, this intended R0 resection cannot be performed in 50% of laparotomized patients, and negative prognostic factors for surgery include the presence of multiple extrahepatic disease sites or more than five liver metastases.
This paper references
Chemotherapy of gynecologic cancers : Society of Gynecologic Oncologists handbook
S. Rubin (1996)
Resection of colorectal liver metastases
J. Scheele (2004)
Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis.
R. Bristow (2002)
Molecular detection of prostate epithelial cells from the surgical field and peripheral circulation during radical prostatectomy.
M. Oefelein (1996)
An attempt to clarify indications for hepatectomy for liver metastases from breast cancer.
D. Elias (2003)
The resection of hepatic metastases. Another view.
M. Adson (1989)
Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of indications for resection. Registry of Hepatic Metastases.
K. S. Hughes (1988)
Resection of liver metastases—When is it worthwhile?
M. Adson (2005)
Major Hepatic Resection for Metachronous Metastases from Colon Cancer
B. Cady (1985)
Seed and soil revisited: contribution of the organ microenvironment to cancer metastasis.
I. Fidler (2001)
Curative treatment of peritoneal carcinomatosis arising from colorectal cancer by complete resection and intraperitoneal chemotherapy
D. Elias (2001)
Cancer-induced immunosuppression: implications for therapy?
R. Pollock (1989)
Randomized trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
P Rougier (1998)
Intermittent vascular exclusion of the liver (without vena cava clamping) during major hepatectomy
D. Elias (1995)
Resection of hepatic metastases
P. Neuhaus (1986)
Résection chirurgicale des métastases hépatiques: enquête de l’Association Française de Chirurgie
B Norlinger (1992)
Intraperitoneal chemohyperthermia: rationale, technique, indications, and results.
D. Elias (2001)
Extrahepatic disease does not contraindicate hepatectomy for colorectal liver metastases
D. Elias (2003)
Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer: long-term results.
M. Minagawa (2000)
Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of patterns of recurrence.
K. Hughes (1986)
Detection of tumor cells in the portal and peripheral blood of patients with colorectal carcinoma using competitive reverse transcriptase‐polymerase chain reaction
S. Sadahiro (2001)
Survival after liver resection for secondary tumors.
J. Foster (1978)
Prognostic Features of 51 Colorectal and 130 Appendiceal Cancer Patients with Peritoneal Carcinomatosis Treated by Cytoreductive Surgery and Intraperitoneal Chemotherapy
P. Sugarbaker (1995)
Incidence, distribution, and significance of hilar lymph node metastases in hepatic colorectal metastases.
D. Elias (2003)
Hepatic resection for metastatic colorectal cancer results in cure for some patients.
R. L. Jamison (1997)
Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.
Y. Fong (1999)
Determinants of survival in liver resection for colorectal secondaries
H. Ekberg (1986)
Is simultaneous hepatectomy and intestinal anastomosis safe?
D. Elias (1995)
Immunologic dysfunction in cancer.
D. Kavanaugh (1996)
A note on quantifying follow-up in studies of failure time.
M. Schemper (1996)
Hepatic resection for metastatic colorectal adenocarcinoma: a proposal of a prognostic scoring system.
S. Iwatsuki (1999)
Chemotherapy of gynecologic cancer
M. Deppe (1984)
Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
P. Rougier (1998)
Detection and clinical significance of occult tumour cells in colorectal cancer . Review
G Tsavellas (2001)
Resection of colorectal metastases to liver
V. Panella (1986)
Detection and clinical significance of occult tumour cells in colorectal cancer
G. Tsavellas (2001)
Intraperitoneal chemotherapy and cytoreductive surgery for the prevention and treatment of peritoneal carcinomatosis and sarcomatosis.
P. Sugarbaker (1998)
Intraperitoneal chemotherapy for treatment and prevention of peritoneal carcinomatosis and sarcomatosis
P. Sugarbaker (1994)
Tumor cells in blood shed from the surgical field.
E. Hansen (1995)
Liver resection for colorectal metastases.
Y. Fong (1997)
Randomized comparison of ultrasonic vs clamp transection of the liver.
T. Takayama (2001)
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
J-Y. Douillard (2000)
Resection of liver metastases from colorectal cancer
I. K. Pedersen (1994)

This paper is referenced by
Increasing long-term survival in advanced colorectal cancer.
M. Verghese (2007)
Association between carcinoembryonic antigen levels and the applied value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in post-operative recurrent and metastatic colorectal cancer
Wenzhe Bu (2014)
The Role of Contrast Enhanced Computed Tomography in Integrated Positron Emission Tomography Computed Tomography Study
A. Nordin (2012)
Role of surgery in colorectal cancer liver metastases.
Ö. Akgül (2014)
Is hepatic resection justified after chemotherapy in patients with colorectal liver metastases and lymph node involvement?
R. Adam (2008)
Interval Period Tumor Progression: Does Delayed Hepatectomy Detect Occult Metastases in Synchronous Colorectal Liver Metastases?
H. Yoshidome (2008)
Designing Liver Resections and Pushing the Envelope with Resections for Hepatic Colorectal Metastases
Mary L Guye (2013)
Strategies to treat primary unresectable colorectal liver metastases.
E. Vibert (2005)
Simultaneous diaphragm and liver resection: a propensity-matched analysis of postoperative morbidity.
George Z Li (2013)
Peritoneal Carcinomatosis from Colorectal Cancer
Antonio Sommariva (2015)
Practical questions in liver metastases of colorectal cancer: general principles of treatment.
H. D. González (2007)
Metastasenchirurgie – anatomische und ethische Grenzen
Aristotelis Perrakis (2015)
Survival of patients operated for colorectal liver metastases and concomitant extra-hepatic disease: external validation of a prognostic model.
M. Mavros (2013)
Analysis of Response Evaluation Criteria in Solid Tumors reduction ratio of primary chemotherapy in unresectable advanced or recurrent colorectal cancer
Shiho Kawagoe (2019)
A Report of a Case Attained Long Term Disease Free Survival after Resection of Rectal Cancer with Ischial Metastasis
Hiroshi Iino (2010)
Patient selection for hepatic resection for metastatic colorectal cancer.
M. Weiss (2012)
Liver resection for colorectal cancer
Cindy Nhan (2013)
Surgical outcomes and prognostic factors in patients with synchronous colorectal liver metastases.
Rafael Mialski Fontana (2014)
Clinical Significance of Serum Carcinoembryonic Antigen (CEA) Level at Diagnosis of Liver Metastases in Patients with Colorectal Cancer
Jung-Su Nam (2008)
Influence of simultaneous liver and peritoneal resection on postoperative morbi-mortality and survival in patients with colon cancer treated with surgical cytoreduction and intraperitoneal hyperthermic chemotherapy.
Rafael Morales Soriano (2017)
Intraoperative magnetic resonance imaging for ablation of hepatic tumors
R. Martin (2005)
Local Recurrences After Intraoperative Radiofrequency Ablation of Liver Metastases: A Comparative Study with Anatomic and Wedge Resections
D. Élias (2004)
Treatment for liver metastases from breast cancer: results and prognostic factors.
X. Li (2005)
Selection for hepatic resection: expert consensus conference.
Myrddin Rees (2013)
Cytoreductive surgery and HIPEC for peritoneal metastases combined with curative treatment of colorectal liver metastases
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Peritoneal Carcinomatosis: Our Initial Experience.
Adrian Bartoș (2019)
Treatment of hepatic metastases from colorectal cancer: many doubts, some certainties.
G. Biasco (2006)
Which liver metastases are resectable
W. Bechstein (2007)
Hepatectomy for liver metastasis of colorectal cancer
Jianmin Xu (2008)
Colorectal Liver Metastases with Extrahepatic Disease—A New Criteria for Oncologic Resection?
T. Chua (2011)
Management of hepatic metastasis from colorectal cancers: an update.
S. Sharma (2008)
Neoadjuvant chemotherapy for patients with liver metastases from colorectal cancer
M. Mandala (2007)
See more
Semantic Scholar Logo Some data provided by SemanticScholar