Online citations, reference lists, and bibliographies.
← Back to Search

Associations Of Cardiorespiratory Fitness And Muscular Strength With Arterial Stiffness In Older Adults: 907 Board #141 May 29 2:00 PM - 3:30 PM

Emma E Albin, Angelique G Brellenthin, D. Lee
Published 2019 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Purpose: To evaluate the independent and combined associations of cardiorespiratory fitness (CRF) and muscular strength (MS) with arterial stiffness (AS) in older adults. Methods: This cross-sectional study included 427 older adults aged ≥65 years (mean age 72). CRF was assessed by time (seconds) to complete a 400-m walk test and MS by overall grip strength (maximum out of 3 trials on each hand, averaged; Jamar Plus+ 12064). Carotid-femoral pulse wave velocity (PWV) was used to assess AS (AtCor, Sphygmocor Xcel). High AS was defined as a PWV of 10 m/s or greater, as it has been established as a threshold for increased cardiovascular risk. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) of having high AS across sex-specific tertiles of CRF and MS. Linear and logistic regression were used to investigate the independent associations between CRF or MS with AS. Further, CRF and MS were dichotomized into either weak or unfit (lower one-third for each), or strong or fit (upper two-thirds for each) to investigate the combined associations of CRF and MS with high AS. Results: Sixty-three (17 %) adults were identified as having high AS. In logistic regression, compared to lower CRF (lowest 33%), ORs (95% CIs) of having high AS were 0.44 (0.23-0.85) and 0.46 (0.25-0.94) for middle and upper CRF, respectively, after controlling for age and sex. After further adjustment for mean arterial pressure (MAP) and lifestyle factors, only middle CRF remained significant (OR, 0.48 [95% CI 0.250.94]). Compared to lower MS (lowest 33%), ORs (95% CIs) of having high AS were 0.40 (0.20-0.80), 0.32 (0.15-0.70), and 0.34 (0.15-0.77) for upper MS, after adjustment
This paper references
Large Artery Stiffness Assessment Using SphygmoCor Technology
M. Butlin (2016)
Relationships between central arterial stiffness, lean body mass, and absolute and relative strength in young and older men and women
C. Fahs (2018)
Validity and reliability of aortic pulse wave velocity and augmentation index determined by the new cuff-based SphygmoCor Xcel
M-H Hwang (2014)
Comparison of Handgrip and Leg Extension Strength in Predicting Slow Gait Speed in Older Adults
M. Fragala (2016)
Age-related vascular stiffening: causes and consequences
J. C. Kohn (2015)
Effects of Exercise Modalities on Arterial Stiffness and Wave Reflection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
A. Ashor (2014)
Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association.
M. Nelson (2007)
2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
G. Mancia (2013)
The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: the Amsterdam Growth and Health Longitudinal Study.
I. Ferreira (2005)
Association between handgrip strength and vascular function in patients with hypertension
D. Lima-Júnior (2018)
Influence of lifestyle modification on arterial stiffness and wave reflections.
H. Tanaka (2005)
Prospective association between handgrip strength and cardiac structure and function in UK adults
S. E. Beyer (2018)
Exercise Capacity, Heart Failure Risk, and Mortality in Older Adults: The Health ABC Study.
V. Georgiopoulou (2017)
The Importance of Cardiorespiratory Fitness in the United States: The Need for a National Registry A Policy Statement From the American Heart Association
L. Kaminsky (2013)
Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects.
Y. Ben-Shlomo (2014)
The underappreciated role of muscle in health and disease.
R. Wolfe (2006)
Grip strength and healthy aging
R. Kozakai (2017)
Long-Term Effects of Changes in Cardiorespiratory Fitness and Body Mass Index on All-Cause and Cardiovascular Disease Mortality in Men: The Aerobics Center Longitudinal Study
D. Lee (2011)
Mechanisms, pathophysiology, and therapy of arterial stiffness.
S. Zieman (2005)
Arterial Stiffness and Cardiovascular Events: The Framingham Heart Study
G. Mitchell (2010)
Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability.
A. Newman (2006)
Maximal isometric muscle strength and functional ability in daily activities among 75‐year‐old men and women
K. Avlund (1994)
Test-retest reliability and validity of the 400-meter walk test in healthy, middle-aged women.
Kelley K Pettee Gabriel (2010)
Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms
T. V. Sloten (2016)
Walking performance and cardiovascular response: associations with age and morbidity--the Health, Aging and Body Composition Study.
A. Newman (2003)
Cardiorespiratory Fitness and Incidence of Major Adverse Cardiovascular Events in US Veterans: A Cohort Study
P. Kokkinos (2017)
The effect of lifelong exercise frequency on arterial stiffness
S. Shibata (2018)
Relative Contributions of Arterial Stiffness and Hypertension to Cardiovascular Disease: The Framingham Heart Study
T. Niiranen (2016)
Comparison of Rolyan and Jamar dynamometers for measuring grip strength.
V. Mathiowetz (2002)
The Combined Association of Skeletal Muscle Strength and Physical Activity on Mortality in Older Women: The HUNT2 Study
T. Karlsen (2017)
Determinants of arterial stiffness in an apparently healthy population over 60 years
C. Alecu (2006)
Estimated Functional Capacity Predicts Mortality in Older Adults
X. Sui (2007)
Impact of Aging on the Strength of Cardiovascular Risk Factors: A Longitudinal Study Over 40 Years
L. Lind (2018)
Influence of Cardiovascular Fitness and Muscle Strength in Early Adulthood on Long-Term Risk of Stroke in Swedish Men
N. Åberg (2015)
Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis.
S. Kodama (2009)
Mortality trends in the general population: the importance of cardiorespiratory fitness
D. Lee (2010)
Association of body size and muscle strength with incidence of coronary heart disease and cerebrovascular diseases: a population-based cohort study of one million Swedish men.
K. Silventoinen (2009)
Muscle strength in adolescent men and risk of cardiovascular disease events and mortality in middle age: a prospective cohort study
S. Timpka (2014)
Grip strength changes over 27 yr in Japanese-American men.
T. Rantanen (1998)
Clinical appraisal of arterial stiffness: the Argonauts in front of the Golden Fleece
C. Vlachopoulos (2006)
Heart disease and Stroke Statistics2015 Update. Circulation, 131
D Mozaffarian (2015)
Arterial stiffness: a brief review
Najeeb A. Shirwany (2010)
Strength fitness and body weight status on markers of cardiometabolic health.
Christian K. Roberts (2015)
Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women
Jun-Il Yoo (2018)
Muscular strength and incident hypertension in normotensive and prehypertensive men.
Andréa L. Maslow (2010)
Aortic stiffness: pathophysiology, clinical implications, and approach to treatment
S. Sethi (2014)
Muscular strength is inversely associated with aortic stiffness in young men.
C. Fahs (2010)
How many steps/day are enough? for adults
C. Tudor-Locke (2011)
Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity.
L. V. Van Bortel (2012)
The benefits of exercise for arterial stiffness.
I. Ferreira (2006)
Elevated Aortic Pulse Wave Velocity, a Marker of Arterial Stiffness, Predicts Cardiovascular Events in Well-Functioning Older Adults
K. Sutton-Tyrrell (2005)
Prognostic Value of Aortic Pulse Wave Velocity as Index of Arterial Stiffness in the General Population
T. Hansen (2006)
Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis.
C. Vlachopoulos (2010)
Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling
Y. Gando (2010)
Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study.
S. Endes (2016)
The role of habitual physical activity on arterial stiffness in elderly Individuals: a systematic review and meta-analysis
W. Park (2017)
Sarcopenia: European consensus on definition and diagnosis
A. Cruz-Jentoft (2010)
Physical fitness, activity and hand-grip strength are not associated with arterial stiffness in older individuals
S. C. Dijk (2015)
Absence of age-related increase in central arterial stiffness in physically active women.
H. Tanaka (1998)
Physical activity and cardiovascular aging: Physiological and molecular insights
D. Jakovljevic (2017)
Cardiorespiratory fitness and risk of nonfatal cardiovascular disease in women and men with hypertension.
X. Sui (2007)
Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men.
M. Ochi (2010)
Association between muscular strength and mortality in men: prospective cohort study
J. Ruiz (2008)
Estimating Cardiorespiratory Fitness in Well‐Functioning Older Adults: Treadmill Validation of the Long Distance Corridor Walk
E. Simonsick (2006)
Rigidez Arterial : Aspectos Fisiopatológicos e Genéticos Arterial Stiffness : Pathophysiological and Genetic Aspects
R. Alvim (2017)
Fitness and fatness as mortality predictors in healthy older men: the veterans exercise testing study.
Paul A. McAuley (2009)
Does obesity attenuate the beneficial cardiovascular effects of cardiorespiratory fitness?
K. Königstein (2018)
Grip strength predicts cause-specific mortality in middle-aged and elderly persons.
H. Sasaki (2007)
Resistance exercise training attenuates exercise-induced lipid peroxidation in the elderly
K. R. Vincent (2002)
Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign A Scientific Statement From the American Heart Association
R. Ross (2016)
Resistance exercise training decreases oxidative damage to DNA and increases cytochrome oxidase activity in older adults
G. Parise (2005)
Pulse wave velocity is associated with muscle mass decline: Health ABC study
A. Abbatecola (2011)
Effects of resistance training on arterial stiffness: a meta-analysis
M. Miyachi (2012)
Changes in fitness and fatness on the development of cardiovascular disease risk factors hypertension, metabolic syndrome, and hypercholesterolemia.
D. Lee (2012)
Measurement of grip strength: validity and reliability of the sphygmomanometer and jamar grip dynamometer.
G. F. Hamilton (1992)
Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study
D. Leong (2015)
Arterial Stiffness
A. Avolio (2013)
Association between cardiorespiratory fitness and arterial stiffness in men with the metabolic syndrome.
S. Y. Jae (2010)
Arterial Stiffness and Cardiovascular Events in Hypertensives
S. Laurent (2013)
The relationship between arterial stiffness and maximal oxygen consumption in healthy young adults
H. Namgoong (2018)
Handgrip strength and mortality in the oldest old population: the Leiden 85-plus study
C. Ling (2010)
Determinants of cardiorespiratory fitness in men aged 42 to 60 years with and without cardiovascular disease.
J. Laukkanen (2009)
Relative Handgrip Strength Is a Simple Indicator of Cardiometabolic Risk among Middle-Aged and Older People: A Nationwide Population-Based Study in Taiwan
W. Lee (2016)
Aging and arterial stiffness.
H. Lee (2010)
Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease
C. Stehouwer (2007)
Characteristics of 400-meter walk test performance and subsequent mortality in older adults.
S. Vestergaard (2009)
Associations of Grip Strength and Change in Grip Strength With All-Cause and Cardiovascular Mortality in a European Older Population
O. Prasitsiriphon (2018)
Cardiorespiratory Fitness, Physical Activity, and Arterial Stiffness: The Northern Ireland Young Hearts Project
C. Boreham (2004)
Resistance exercise in individuals with and without cardiovascular disease: 2007 update: a scientific statement from the American Heart Association Council on Clinical Cardiology and Council on Nutrition, Physical Activity, and Metabolism.
M. Williams (2007)
Daily activity energy expenditure and mortality among older adults.
T. Manini (2006)
Arterial stiffness is associated with low skeletal muscle mass in Japanese community‐dwelling older adults
R. Sampaio (2014)
Effects of Age and Aerobic Capacit on Arterial Stiffness in Healthy Adults
P. Vaitkevicius (1993)
Arterial Stiffness as a Predictor of Clinical Hypertension
Xiaoming Zheng (2015)
Resistance exercise training: its role in the prevention of cardiovascular disease.
R. Braith (2006)
Assessment of physical activity by self-report: status, limitations, and future directions.
J. Sallis (2000)
Associations of maximal strength and muscular endurance with cardiovascular risk factors.
J. Vaara (2014)
Arterial Elasticity, Strength, Fatigue, and Endurance in Older Women
G. Hunter (2014)
Influence on aerobic fitness on aortic stiffness in apparently healthy Caucasian and African-American subjects.
R. Arena (2007)
Differences in handgrip strength protocols to identify sarcopenia and frailty - a systematic review
A. R. Sousa-Santos (2017)
Association between handgrip strength, balance, and knee flexion/extension strength in older adults
A. Alonso (2018)
Sedentary Time, Cardiorespiratory Fitness, and Cardiovascular Risk Factor Clustering in Older Adults--the Generation 100 Study.
S. B. Sandbakk (2016)
Associations of cardiorespiratory fitness with cardiovascular disease risk factors in middle-aged Chinese women: a cross-sectional study
W. Zhu (2014)
Cardiorespiratory Fitness Suppresses Age‐Related Arterial Stiffening in Healthy Adults: A 2‐Year Longitudinal Observational Study
Y. Gando (2016)
A prospective study of muscular strength and all-cause mortality in men with hypertension.
E. G. Artero (2011)
Effects of Muscular Strength on Cardiovascular Risk Factors and Prognosis
E. G. Artero (2012)
Lifetime risks for cardiovascular disease mortality by cardiorespiratory fitness levels measured at ages 45, 55, and 65 years in men. The Cooper Center Longitudinal Study.
J. Berry (2011)

Semantic Scholar Logo Some data provided by SemanticScholar