Online citations, reference lists, and bibliographies.
← Back to Search

Mitochondrial DNA Damage And Diseases

Gyanesh Singh, U C Pachouri, Devika Chanu Khaidem, Aman Kundu, Chirag Chopra, Pushplata Singh

Cite This
Download PDF
Analyze on Scholarcy
Share
Various endogenous and environmental factors can cause mitochondrial DNA (mtDNA) damage.  One of the reasons for enhanced mtDNA damage could be its proximity to the source of oxidants, and lack of histone-like protective proteins. Moreover, mitochondria contain inadequate DNA repair pathways, and, diminished DNA repair capacity may be one of the factors responsible for high mutation frequency of the mtDNA. mtDNA damage might cause impaired mitochondrial function, and, unrepaired mtDNA damage has been frequently linked with several diseases. Exploration of mitochondrial perspective of diseases might lead to a better understanding of several diseases, and will certainly open new avenues for detection, cure, and prevention of ailments.