Online citations, reference lists, and bibliographies.
← Back to Search

Polymorphisms Of Xenobiotic-metabolizing Enzymes And Susceptibility To Cancer.

A. Hirvonen
Published 1999 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
The variation in individual responses to exogenous agents is exceptionally wide. It is because of this large diversity of responsiveness that risk factors to environmentally induced diseases have been difficult to pinpoint, particularly at low exposure levels. Opportunities now exist for studies of host factors in cancer or other diseases in which an environmental component can be presumed. Many of the studies have shown an elevated disease proneness for individuals carrying the potential at-risk alleles of metabolic genes, but a number of controversial results have also been reported. This article is an overview of the data published to date on metabolic genotypes related to individual susceptibility to cancer.
This paper references
Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.
F. Oesch (1973)
Multiple N-acetyltransferases and drug metabolism. Tissue distribution, characterization and significance of mammalian N-acetyltransferase.
D. Hearse (1973)
Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.
G. Kellermann (1973)
International agency for research on cancer.
J. Higginson (1974)
Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide
P. Sims (1974)
Environmental Health Perspectives
J. Harington (1976)
The apparent ubiquity of epoxide hydratase in rat organs.
F. Oesch (1977)
Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers.
G. Hunninghake (1983)
The association of the slow acetylator phenotype with bladder cancer.
D. Evans (1983)
The acetylator genes and drug response
W. Weber (1987)
A Taq I polymorphism in the human P450IIE1 gene on chromosome 10 (CYP2E).
O. Mcbride (1987)
A Taql polymorphism in the human P 45011 E 1 gene on chromosome 10 ( CYP 2 E )
OW McBride (1987)
Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion.
J. Seidegård (1988)
Proc NatI Acad Sci
The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects.
D. W. Nebert (1989)
Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.
K Ikeya (1989)
Human CYP 1 A 2 sequence , gene structure , comparison with the mouse and rat orthologous gene , and genetic differences in liver IA 2 mRNA concentrations
K lkeya (1989)
[Dietary factors and risk of colon cancer].
O. Skraastad (1990)
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1
R. Peter (1990)
Activation of promutagens by human cDNA-expressed cytochrome P450s.
F. Gonzalez (1990)
Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.
M. Blum (1990)
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1.
R. Peter (1990)
The role of glutathione and glutathione transferases in chemical carcinogenesis.
B. Coles (1990)
[30] DT-diaphorase : purification, properties, and function
C. Lind (1990)
DT-diaphorase: purification, properties, and function.
C. Lind (1990)
Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene
Kaname Kawajiri (1990)
In vitro metabolism of dinaline and acetyidinaline by human liver. Abstracts of 12th European Workshop on Drug Metabolism
Dm Grant (1990)
Myeloperoxidase in human lung lavage . I : A marker of local neutrophil activity
B Schmekel (1990)
In vitro metabolism of dinaline and acetyidinaline by human liver
DM Grant (1990)
Myeloperoxidase in human lung lavage . II : Intemalization of myeloperoxidase by alveolar macrophages
B Schmekel (1990)
Hydroxylation of chlor - zoxazone as a specific probe for human liver cytochrome P - 45011 E 1
R Peter (1990)
Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes.
D. Grant (1991)
DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family.
R. S. Marshall (1991)
Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population.
T. Tefre (1991)
Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes.
A. Daly (1991)
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.
F. Guengerich (1991)
Activation of (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to diolepoxides by human polymorphonuclear leukocytes or myeloperoxidase.
W. Mallet (1991)
Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer
F. Uematsu (1991)
Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population.
F. Broly (1991)
Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene.
S. Hayashi (1991)
Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene.
S. Hayashi (1991)
Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon.
R. Turesky (1991)
Two common RFLPs of the human CYP2E gene.
F. Uematsu (1991)
Rotation and interaction with epoxide hydrolase of P-450 in proteoliposomes
H Etter (1991)
Rotation and interaction with epoxide hydrolase of P - 450 in proteolipo - somes
H Etter (1991)
Mspl polymorphism of the human CYP 2 E 1 gene [ Abstract ]
F Uematsu (1991)
Two common RFLPs of the human CYP 2 E 1 gene
F Uematsu (1991)
Genetic and metabolic criteria for the assignment of debrisoquine 4 - hydroxylation ( cytochrome P 4502 D 6 ) phenotypes
AK Daly (1991)
Multistep carcinogenesis: a 1992 perspective.
T. Sugimura (1992)
Human cytochrome P450IIE1 gene: DraI polymorphism and susceptibility to cancer.
F. Uematsu (1992)
N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells.
R. Minchin (1992)
Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites.
M. Butler (1992)
Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 restriction fragment length polymorphism.
P. Shields (1992)
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.
R. Traver (1992)
Acetyltransferases and susceptibility to chemicals.
D. Hein (1992)
Dissociation of a new glutathione S-transferase activity in human erythrocytes.
K. R. Schroeder (1992)
Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
A. Hirvonen (1992)
Interindividual variability of coumarin 7-hydroxylation in healthy volunteers.
A. Rautio (1992)
Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis.
F. Kadlubar (1992)
Stereoselective metabolism of (-)-benzo[a]pyrene-7,8-diol by human lung microsomes and peripheral blood lymphocytes: effect of smoking.
M. Rojas (1992)
Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine.
S. Cholerton (1992)
N - Acetyltransferase
DA. Evans (1992)
Pharmacogenetics of Drug Metabolism (Kalow W
Da Evans (1992)
Arylamine N - acetyltransferase in cultured cell lines [ Abstract ]
E Coroneos (1992)
Detection of a new polymorphism of human arylamine N - acetyltransferase NAT 1 using p - aminosalicylic acid as an in vivo probe [ Abstract ]
DM Grant (1992)
Polycyclic aromatic hydrocarbons - DNA adducts and the CYPlAl restriction fragment length polymorphism
PG Shields (1992)
Point mutational Mspl and lle / Val polymorphism linked in the CYPlAl gene : lack of association with susceptibility to lung cancer in a Finnish population
A Hirvonen (1992)
The CYP1A1 gene and cancer susceptibility.
K. Kawajiri (1993)
Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung.
C. J. Omiecinski (1993)
Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification.
C. Furlong (1993)
The genetic toxicology of putative nongenotoxic carcinogens.
M. Jackson (1993)
The AH-receptor: genetics, structure and function.
H. Swanson (1993)
The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases.
C. Jin (1993)
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.
I. Johansson (1993)
Immunohistochemical localization of glutathione S-transferases in human lung.
S. Anttila (1993)
The molecular basis of the human serum paraoxonase activity polymorphism
R. Humbert (1993)
Glucuronidation of carcinogen metabolites by complementary DNA-expressed uridine 5'-diphosphate glucuronosyltransferases.
P. Mackenzie (1993)
Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population.
C. Masimirembwa (1993)
Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.
D. Hein (1993)
Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiology.
H. Lin (1993)
Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone.
V. Carrière (1993)
The multistep nature of cancer.
B. Vogelstein (1993)
Pharmacogenetics: Its biologic roots and the medical challenge
W. Kalow (1993)
The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population.
A. Hirvonen (1993)
Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus.
K. P. Vatsis (1993)
Correlation between N-acetyltransferase activity and NAT2 genotype in Chinese males.
N. Rothman (1993)
Critical Aspects of Initiation, Promotion, and Progression in Multistage Epidermal Carcinogenesis
H. Hennings (1993)
Acetylation phenotype and cytochrome P450IA2 phenotype are unlikely to be associated with peripheral arterial disease
K. Ilett (1993)
Both cytochromes P 45011 E 1 and lA 1 are involved in the metabolism of chlorzoxazone
V Carriere (1993)
Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5'-flanking region.
J. Watanabe (1994)
The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization.
C. Hassett (1994)
Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene.
H. Lin (1994)
Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties.
P. Zimniak (1994)
Role of oncogenes and tumor suppressor genes in multistage carcinogenesis.
S. Yuspa (1994)
Functional significance of different human CYP1A1 genotypes.
F. Crofts (1994)
Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity.
F. Guengerich (1994)
Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types.
A. K. Alexandrie (1994)
Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.
A. Daly (1994)
Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9.
A. Rettie (1994)
Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.
I. Johansson (1994)
Carcinogen activation by sulfate conjugate formation.
C. Michejda (1994)
Polymorphic arylamine N‐acetyltransferase (NAT2) genes in children with insulin‐dependent diabetes mellitus
P. M. Mrozikiewicz (1994)
Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxazone: a putative measure of CYP2E1 activity.
R. Kim (1994)
Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study.
J. Brockmöller (1994)
Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans.
M. Landi (1994)
Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Y. Yanagawa (1994)
Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism.
S. Pemble (1994)
Effect of fasting and obesity in humans on the 6‐hydroxylation of chlorzoxazone: A putative probe of CYP2E1 activity
D. O'Shea (1994)
Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: possible relevance to low smoking exposure.
F. Uematsu (1994)
Relationship between in vivo acetylator phenotypes and cytosolic N-acetyltransferase and O-acetyltransferase activities in human uroepithelial cells.
S. M. Frederickson (1994)
Pharmacogenetics: the slow, the rapid, and the ultrarapid.
U. Meyer (1994)
Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants.
C. Hassett (1994)
NAD(P)H:quinone oxidoreductase1 (DT-diaphorase): expression, regulation, and role in cancer.
P. Joseph (1994)
The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression.
R. Hines (1994)
Human liver glucuronidation of benzidine.
S. R. Babu (1994)
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
T. Shimada (1994)
A prospective study of cigarette smoking and risk of colorectal adenoma and colorectal cancer in U.S. men.
E. Giovannucci (1994)
Loss of heterozygosity at the NAD(P)H: quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line.
P. Eickelmann (1994)
Interindividual variations in CYP2C9
T Shimada (1994)
Inherited GSTM 1 and NAT 2 defects as concurrent risk modifiers for asbestos - associated human malignant mesothelioma
A Hirvonen (1994)
Glutathione S - transferase Ml and its variants A and B as host factors of bladder cancer susceptibility : a case - control study
J Brockmoller (1994)
Effect of fasting and obesity in humans on the 6 - hydroxylation of chlorzoxazone : a putative probe of CYP 2 E 1 activ
D O'Shea (1994)
Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California.
S. London (1995)
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.
P. Fernández-Salguero (1995)
Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking.
E. Rosvold (1995)
Polymorphic drug metabolism: studies with recombinant Chinese hamster cells and analyses in human populations.
Tsuyoshi Yokoi (1995)
Gene structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation.
I. Owens (1995)
Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.
M. L. Dahl (1995)
Glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk.
J. E. McWilliams (1995)
Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer.
J. Kolesar (1995)
Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A.
A. Inskip (1995)
Studies on interindividual variations of CYP2E1 using chlorzoxazone as an in vivo probe.
E. Vesell (1995)
Role of GSTT1and GSTM1genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes
H. Norppa (1995)
Model for the epigenetic mechanism of action of nongenotoxic carcinogens.
M. Costa (1995)
Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma.
A. Hirvonen (1995)
Genetic polymorphism and cancer susceptibility: fourteenth Sapporo Cancer Seminar.
F. Gonzalez (1995)
The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.
P. Fernández-Salguero (1995)
Pulmonary expression of glutathione S-transferase M3 in lung cancer patients: association with GSTM1 polymorphism, smoking, and asbestos exposure.
S. Anttila (1995)
Lung cancer and mutations at the polymorphic NAT2 gene locus.
C. Martı́nez (1995)
Mechanisms for species differences in receptor-mediated carcinogenesis.
J. Barrett (1995)
The molecular biology of the flavin-containing monooxygenases of man.
I. R. Phillips (1995)
Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.
D. Eaton (1995)
Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity.
I. Cascorbi (1995)
Metabolic polymorphisms and cancer susceptibility.
G. Smith (1995)
Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer.
A. Risch (1995)
Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium.
D. Wild (1995)
N-acetylbenzidine and N,N'-diacetylbenzidine formation by rat and human liver slices exposed to benzidine.
V. Lakshmi (1995)
Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder.
A. Badawi (1995)
Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis.
J. Wiencke (1995)
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
J. Hayes (1995)
Interindividual variability of chlorzoxazone 6‐hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms
R. Kim (1995)
Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans.
H. Bartsch (1995)
Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer.
D. Bell (1995)
Nomenclature for N-acetyltransferases.
K. P. Vatsis (1995)
Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.
K. McGlynn (1995)
Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population
J. Agúndez (1995)
Role of GSTM 1 and GSTT 1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes
H Norppa (1995)
Polymorphism in the NATI polyadenylation signal : association of NATl * 10 allele with higher N - acetylation activity in bladder and colon tissue samples
A Badawi (1995)
Polymorphism in the NATI polyadenylation signal: association of NATl*10 allele with higher N-acetylation activity in bladder and colon tissue samples
Da Bell (1995)
Role of cytochrome P 4501 A 2 in chemical carcinogenesis : implications for human variability in expression and enzyme activity
DA Eaton (1995)
Role of GSTM1 and GSTT1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes
H Norppa (1995)
Interindividual variability of 6 - hydroxylation of chlorzoxazone in men and women and its relationship to CYP 2 E 1 genetic polymorphisms
RB Kim (1995)
Nomenclature for N - acetyl - transferases
DA Bell (1995)
A prospective study of NAT 2 acetylation genotype , cigarette smoking , and risk of breast cancer
DJ Hunter (1995)
Glutathione S - transferase Ml ( GSTM 1 ) deficiency and lung cancer risk
JE McWilliams (1995)
Glutathione Stransferase Ml (GSTM1) deficiency and lung cancer risk
Je Mcwilliams (1995)
Interindividual variability of 6-hydroxylation of chlorzoxazone in men and women and its relationship to CYP2E1 genetic polymorphisms
Rb Kim (1995)
Polymorphism of glutathione S-transferase Ml and lung cancer risk among African-Americans and Caucasians in Los Angeles county
S J London (1995)
Metabolic activation of the potent carcinogen dibenzo[a,l]pyrene by human recombinant cytochromes P450, lung and liver microsomes.
M. Shou (1996)
Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer.
D. Nebert (1996)
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.
E. Aklillu (1996)
Human N-acetylation of benzidine: role of NAT1 and NAT2.
T. Zenser (1996)
Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disorders.
A. Hirvonen (1996)
Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk.
C. Ambrosone (1996)
Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers.
M. Deakin (1996)
Polymorphism at the glutathione S-transferase locus GSTM3: interactions with cytochrome P450 and glutathione S-transferase genotypes as risk factors for multiple cutaneous basal cell carcinoma.
L. Yengi (1996)
The effect of tobacco on lung cancer risk depends on CYP2D6 activity.
C. Bouchardy (1996)
Identification and prevalence study of 17 allelic variants of the human NAT2 gene in a white population.
J. Agúndez (1996)
Lack of association between the polyadenylation polymorphism in the NAT1 (acetyltransferase 1) gene and colorectal adenomas.
N. M. Probst-Hensch (1996)
Occupational history and genetic N-acetyltransferase polymorphism in urothelial cancer patients of Leverkusen, Germany.
K. Golka (1996)
Microsomal epoxide hydrolase polymorphism as a risk factor for ovarian cancer
J. Lancaster (1996)
Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx.
V. Jahnke (1996)
A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.
I. Cascorbi (1996)
Life (and death) in a malignant tumour
K. Kinzler (1996)
Homozygous rapid arylamine N-acetyltransferase (NAT2) genotype as a susceptibility factor for lung cancer.
I. Cascorbi (1996)
Glutathione S - transferase GSTT 1 genotypes and susceptibility to cancer : studies of interactions with GSTM 1 in lung , oral , gastric and colorectal cancers
M Deakin (1996)
A C 4887 A polymorphism in exon 7 of human CYPlAl : population frequency , mutation linkages , and impact on lung cancer susceptibility
I Cascorbi (1996)
Cytochrome P 450 CYPlA 1 Mspl polymorphism and lung cancer susceptibility
X Xu (1996)
de Waziers 1. Human cytochrome P450 IIE1 (CYP2E1): from genotype to phenotype
V Carriere (1996)
GST and NAT genotypes and asbestos - associated pulmonary disorders
A Hirvonen (1996)
Genetic polymorphisms and the risk of cancer : a review of the literature
A d'Errico (1996)
Human cytochrome P 450 IIE 1 ( CYP 2 E 1 ) : from genotype to phenotype
V Carriere (1996)
Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms and lung cancer risk among Northwestern Mediterraneans.
J. To-Figueras (1997)
Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies.
W. Schulz (1997)
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations.
J. Goldstein (1997)
Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.
D. Ryberg (1997)
In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility.
I. Persson (1997)
Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema
C. A. Smith (1997)
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.
C. Sachse (1997)
A restriction fragment length polymorphism assay that differentiates human N-acetyltransferase-1 (NAT1) alleles.
A. Deitz (1997)
Active Site Architecture of Polymorphic Forms of Human GlutathioneS-Transferase P1-1 Accounts for Their Enantioselectivity and Disparate Activity in the Glutathione Conjugation of 7β,8α-Dihydroxy-9α, 10α-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene
X. Hu (1997)
Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.
L. Harries (1997)
Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants
Francis Ali-Osman (1997)
Lung cancer risk in relation to the CYP2C9 genetic polymorphism among Caucasians in Los Angeles County.
S. London (1997)
Molecular epidemiology of the human glutathione S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility.
T. Rebbeck (1997)
CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan.
A. Hildesheim (1997)
CYP1A1 genetic polymorphisms, tobacco smoking and lung cancer risk in a French Caucasian population.
C. Bouchardy (1997)
Identification of a novel allele at the human NAT1 acetyltransferase locus.
M. Doll (1997)
The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics.
J. Seidegård (1997)
A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.
D. Hunter (1997)
Combinations of susceptible genotypes and individual responses to toxicants.
A. Hirvonen (1997)
Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility.
M. Esteller (1997)
Human acetyltransferase polymorphisms.
D. Grant (1997)
Myeloperoxidase genetic polymorphism and lung cancer risk.
S. London (1997)
Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians.
R. A. McLellan (1997)
Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7,8-dihydroxy-9
X Hu (1997)
A restriction fragment length polymorphism assay that differentiates human N - acetyltransferase - 1 ( NAT 1 ) alleles
MA Doll (1997)
Myelo - peroxidase genetic polymorphism and lung cancer risk
SJ London (1997)
Lung cancer risk in relation to the CYP 2 C 9 genetic polymorphism among Caucasians in Los Angeles County
SJ London (1997)
Johansson 1, lngelman-Sundberg M In vitro kinetics of two human CYPlA1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibility
CYP2C9 and GSTP1 genetic polymorphisms in patients with smoking-related lung cancer [Abstract]
S Ozawa (1997)
CYP 2 C 9 and GSTP 1 genetic polymorphisms in patients with smoking - related lung cancer [ Abstract ]
S Ozawa (1997)
Lung cancer risk in relation to the CYP2C9genetic polymorphism among Caucasians in Los Angeles County
Sj London (1997)
Polymorphism of the Pi class glutathione S-transferase in normal populations and cancer patients.
M. Harris (1998)
Glutathione S transferase M1 andT1 genotypes and susceptibility to smoking related larynx cancer.
R. Jaskula‐Sztul (1998)
A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer.
J. Chen (1998)
Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers.
C. Matthias (1998)
Association of Ile462Val (Exon 7) polymorphism of cytochrome P450 IA1 with lung cancer in the Asian population: further evidence from a case-control study in Okinawa.
H. Sugimura (1998)
Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms.
S. Raaka (1998)
Nicotine metabolism defect reduces smoking
M. Pianezza (1998)
The glutathione S-transferase GSTP1 polymorphism: effects on susceptibility to oral/pharyngeal and laryngeal carcinomas.
C. Matthias (1998)
Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease.
A. Rostami-Hodjegan (1998)
Larynx cancer risk in relation to glutathione S-transferase M1 and T1 genotypes and tobacco smoking.
N. Jourenkova (1998)
N-acetyltranferase NAT1 and NAT2 genotypes and lung cancer risk
C. Bouchardy (1998)
Role of glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes in modulating susceptibility to smoking-related lung cancer.
N. Jourenkova-Mironova (1998)
Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk.
R. Millikan (1998)
Combined effect of polymorphic GST genes on individual susceptibility to lung cancer
S. Saarikoski (1998)
Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
N. Ishibe (1998)
N-acetyltransferase NAT1 and NAT2 genotypes and lung cancer risk.
C. Bouchardy (1998)
A new deleted allele in the human cytochrome P450 2A6 (CYP2A6) gene found in individuals showing poor metabolic capacity to coumarin and (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502).
K. Nunoya (1998)
The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene-gene-exposure three-way interaction.
J. Taylor (1998)
Cancer Epidemiol Biomarker Prev
Polymorphic NATs and cancer proneness
A Hirvonen (1998)
Lung cancer and mutations at the polymorphic NAT 2 gene locus
C Martinez (1998)
Cancer Res
Meta - Analysis of studies of the CYP 2 D 6 polymorphism in relation to lung cancer and Parkinson ' s disease
A Rostami-Hodjegan (1998)
N - Acetyltransferase NAT 1 and NAT 2 genotypes and lung cancer risk
WW Weber (1998)
Nicotine metabolism defect reduces smoking [ Letter to the Editor ]
ML Pianezza (1998)
Multiple N-acetyltransferases and and drug metabolism
Dj Hearse
CYP2C9 and GSTP1 genetic polymorphisms in patients with smoking-related lung cancer
S Ozawa
Acetylator pharmacogenetics and aromatic amine - induced cancer
WW Weber
Mspl polymorphism of the human CYP2E1 gene
F Uematsu
Arylamine N-acetyltransferase in cultured cell lines
E Coroneos
Role of NAT2 deficiency in 46 Environmental Health Perspectives Supplement * February 1999 METABOUC GENOTYPES AND CANCER susceptibility to lung cancer among asbestosexposed individuals
St Saarikoski
Detection of a new polymorphism of human arylamine Nacetyltransferase NAT1 using p-aminosalicylic acid as an in vivo probe
D M Grant
Role of NAT2 deficiency in exposed individuals
S T Saarikoski
Human liver polymorphic (NAT2) and monomorphic (NAT1 ) N acetyltransferase isozymes catalyze metabolic activation of N-hydroxyarylamine and N-hydroxy-N-acetylarylamine proximate carcinogens
D W Hein

This paper is referenced by
The connection between microsomal epoxide hydrolase enzyme and cancer risk
Zehra Okat (2018)
United States Patent US 007054758 B 2 ( 12 ) ( 10 ) Patent No . : US 7 , 054 , 758 B 2
Kay (2017)
Etude des facteurs de risque génétiques et des interactions gène-environnement dans les cancers différenciés de la thyroïde
Catherine Ines Tcheandjieu Gueliatcha (2017)
Role for human arylamine N‐acetyltransferase 1 in the methionine salvage pathway
Katey L. Witham (2017)
Xenobiotics Metabolizing Enzymes Gene Polymorphism and susceptibility of Hepatocellular Carcinoma in Egyptian Patients with Hepatitis C Virus-induced Cirrhosis
Manar Obada (2016)
Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults
A. Topić (2016)
The effects of endocrine disrupting chemicals and genetic susceptibility on male infertility
Merve Arıcı Gül Özhan (2016)
The role of oxidative DNA damage and GSTM1, GSTT1, and hOGG1 gene polymorphisms in coronary artery disease risk
E. Kadioglu (2016)
E. F. Al-Jumaily (2015)
Oxaliplatin-induced neuropathy in colorectal cancer: many questions with few answers.
A. Zedan (2014)
By (2014)
Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis.
H. Ding (2014)
GSTM3 A/B Polymorphism and Risk for Head and Neck Cancer: A Meta-Analysis
Y. Xu (2014)
Xenobiotic Metabolising Enzymes (CYP1A1, CYP2E1 and NAT2) Gene Polymorphism in Malaysian Students
M. Alshagga (2014)
Investigation of the Association between Genetic Polymorphism of Microsomal Epoxide Hydrolase and Primary Brain Tumor Incidence
A. Aydın (2013)
Long-term biomonitoring of breast cancer patients under adjuvant chemotherapy: the comet assay as a possible predictive factor.
E. Uriol (2013)
Recherche d’une éventuelle association entre les polymorphismes génétiques cytochrome P4501A1*2C, glutathion-S-transférase M1 null et le cancer du poumon chez une population Tunisienne
Slim Slama (2013)
Health Risks to Children and Adults Residing in Riverine Environments where Surficial Sediments Contain Metals Generated by Active Gold Mining in Ghana
F. Armah (2013)
Génotoxicité et exposition professionnelle ou environnementale
Micheline Kirsch-Volders (2013)
Artigo Original Original Article
Letícia Santos (2013)
Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility
Yufeng Qin (2013)
RETRACTED ARTICLE: Glutathione S-transferase P1 gene Ile105Val polymorphism might be associated with lung cancer risk in the Chinese Han population
Xiaogang Chen (2012)
Study of the Association of CYP2D6*4 Polymorphism with the Susceptibility of HCV- Related Liver Cirrhosis and Liver Cancer.
S. Sayed (2012)
Study of the Association of CYP 2 D 6 * 4 Polymorphism with the Susceptibility of HCV-Related Liver Cirrhosis and Liver Cancer
S. Sayed (2012)
Investigation of a possible relationship between EPHX1 gene polymorphisms and colorectal cancer in Turkish society.
O. Sahin (2012)
Genetic variants in epoxide hydrolases modify the risk of oligozoospermia and asthenospermia in Han-Chinese population.
Yufeng Qin (2012)
Assessment of individual susceptibility to baseline DNA and cytogenetic damage in a healthy Turkish population: evaluation with lifestyle factors.
E. Kadioglu (2012)
GSTM1 and GSTT1 allele frequencies among various Indian and non-Indian ethnic groups.
K. Senthilkumar (2012)
Association of CYP1A1, GSTM1, and GSTT1 gene polymorphism with risk of oral submucous fibrosis in a section of North Indian population
T. Ghosh (2012)
Genetic polymorphism of GSTM 1 and GSTP 1 in lung cancer in Egypt
M. Ramzy (2011)
Glutathione-S-transferase M1 and T1 genes and gastric cancer: a case control study in North Indian population.
Deepmala J. Yadav (2011)
Association of Functionally Important Polymorphism of Microsomal Epoxide Hydrolase Gene (EPHX1) With Lung Cancer Susceptibility
A. Tilak (2011)
See more
Semantic Scholar Logo Some data provided by SemanticScholar