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Regulation Of Early T Cell Activation By TNF Superfamily Members TNF And FASL: A Dissertation

B. Priyadharshini
Published 2010 · Biology

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The instructive signals received by T cells during the programming stages of activation will determine the fate of effector and memory populations generated during an immune response. Members of the tumor necrosis factor (TNF) superfamily play an essential role in influencing numerous aspects of T cell adaptive immune responses including cell activation, differentiation, proliferation, survival, and apoptosis. My thesis dissertation describes the involvement of two such members of the TNF superfamily, TNF and FasL, and their influence on the fate of T cells early during responses to viral infections and to the induction of transplantation tolerance. TNF is a pleiotropic pro-inflammatory cytokine that has an immunoregulatory role in limiting the magnitude of T cell responses during a viral infection. Our laboratory discovered that one hallmark of naïve T cells in secondary lymphoid organs is their unique ability to rapidly produce TNF after activation and prior to acquiring other effector functions. I hypothesized that T cell-derived TNF will limit the magnitude of T cell responses. The co-adoptive transfer of wild type (WT) P14 and TNF-deficient P14 TCR transgenic CD8 + T cells, that recognize the GP33 peptide of lymphocytic choriomeningitis virus (LCMV), into either WT or TNF-deficient hosts demonstrated that the donor TNF-deficient P14 TCR transgenic CD8 + T cells accumulate to higher frequencies after LCMV infection. Moreover, these co-adoptive transfer experiments suggested that the effect of T cell-derived TNF is localized in the microenvironment, since the TNF produced by WT P14 TCR transgenic CD8 + T cells did not prevent the
This paper references
10.1097/00007890-200102270-00009
FasL IS IMPORTANT IN COSTIMULATION BLOCKADE-RESISTANT SKIN GRAFT REJECTION
Joel Trambley (2001)
Expansion of mature thymocyte subsets before emigration to the periphery.
C. Pénit (1997)
10.1038/nm965
Homeostatic proliferation is a barrier to transplantation tolerance
Zihao Wu (2004)
10.1126/SCIENCE.8171323
A lymphotoxin-beta-specific receptor.
P. Crowe (1994)
10.1126/SCIENCE.7539157
Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity.
F. Rieux-Laucat (1995)
CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.
M. Jenkins (1991)
10.1038/nri1052
Cytokine control of memory T-cell development and survival
K. Schluns (2003)
10.1016/J.IMMUNI.2004.11.016
Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects.
S. Grivennikov (2005)
10.1038/ni804
Programmed contraction of CD8+ T cells after infection
V. Badovinac (2002)
10.1093/INTIMM/2.5.419
Analysis of recent thymic emigrants with subset- and maturity-related markers.
K. Kelly (1990)
10.1084/JEM.186.5.665
High Levels of a Major Histocompatibility Complex II–Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes
K. Inaba (1997)
10.1126/science.1139393
Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses
J. Chang (2007)
10.1172/JCI38482
Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans.
H. Bruns (2009)
10.1016/0092-8674(94)90334-4
Signal transduction by lymphocyte antigen receptors
A. Weiss (1994)
10.1038/416345a
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
X. Li (2002)
Adjuvant effect of IL-12: conversion of peptide antigen administration from tolerizing to immunizing for CD8+ T cells in vivo.
C. Schmidt (1999)
10.1172/JCI17573
Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection.
D. Goldstein (2003)
10.4049/jimmunol.0903548
Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3− Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells
Xin Chen (2010)
10.1016/S1074-7613(02)00343-6
Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin.
B. A. Sullivan (2002)
Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice.
P. Koni (1997)
10.1182/blood-2008-10-185223
The molecular signature of CD8+ T cells undergoing deletional tolerance.
I. Parish (2009)
10.1126/SCIENCE.283.5402.680
T lymphocyte costimulation mediated by reorganization of membrane microdomains.
A. Viola (1999)
10.1128/JVI.78.11.5535-5545.2004
Memory CD8 T-Cell Differentiation during Viral Infection
E. Wherry (2004)
10.1038/nri2091
Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development
L. Berg (2007)
10.1038/351150A0
Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells
W. Swat (1991)
10.1016/S0092-8674(02)00675-X
The Mechanism and Regulation of Chromosomal V(D)J Recombination
C. Bassing (2002)
10.1084/JEM.148.6.1560
The immunological basis of endotoxin-induced tumor regression. Requirement for a pre-existing state of concomitant anti-tumor immunity
M. Berendt (1978)
10.1038/nri2570
CD95, BIM and T cell homeostasis
P. Bouillet (2009)
10.1038/381434A0
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
C. Larsen (1996)
10.1128/JVI.00163-07
Indirect Regulation of CD4 T-Cell Responses by Tumor Necrosis Factor Receptors in an Acute Viral Infection
A. Singh (2007)
10.1016/S1074-7613(00)80461-6
The duration of antigenic stimulation determines the fate of naive and effector T cells.
G. Iezzi (1998)
10.4049/jimmunol.170.10.5018
IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells1
M. Bérard (2003)
10.1034/j.1600-065X.2002.18610.x
The immunological synapse: integrins take the stage
T. Sims (2002)
10.1073/pnas.0704397104
Allograft rejection mediated by memory T cells is resistant to regulation
J. Yang (2007)
10.1046/j.1600-065X.2003.00088.x
T‐cell costimulatory pathways in allograft rejection and tolerance
D. Rothstein (2003)
10.1126/SCIENCE.1604314
Human organ transplantation: background and consequences.
J. Murray (1992)
10.1038/ni.1817
Mechanisms maintaining peripheral tolerance
D. Mueller (2010)
10.4049/jimmunol.178.12.7503
The Innate Immune System in Allograft Rejection and Tolerance1
D. F. Larosa (2007)
10.1172/JCI18991
TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection.
A. Zganiacz (2004)
10.1084/JEM.166.3.678
On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes
T. Braciale (1987)
10.1038/87720
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells
S. Kaech (2001)
10.1038/85330
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Yvette Latchman (2001)
Role of tumor necrosis factor on toxicity and cytokine production after isolated hepatic perfusion.
T. Lans (2001)
10.1002/1521-4141(200002)30:2<683::AID-IMMU683>3.0.CO;2-5
TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide‐induced deletion under limited conditions
L. Nguyen (2000)
10.1016/S0952-7915(02)00376-X
Immunotherapy as a means to induce transplantation tolerance.
S. Adler (2002)
10.1038/nature02238
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
T. Mempel (2004)
10.1111/j.0105-2896.2006.00382.x
Signals required for programming effector and memory development by CD8+ T cells
M. Mescher (2006)
10.1016/S1074-7613(00)80490-2
Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity.
B. A. Schodin (1996)
10.4049/jimmunol.0803449
Modulation of T Lymphocyte Replicative Senescence via TNF-α Inhibition: Role of Caspase-31
Stanley T. Parish (2009)
Graft-versus-host disease.
S. Choi (2010)
10.1016/S0952-7915(00)00133-3
The role of T cell apoptosis in transplantation tolerance.
X. Li (2000)
10.1016/S0092-8674(01)00237-9
The TNF and TNF Receptor Superfamilies Integrating Mammalian Biology
R. Locksley (2001)
10.4049/jimmunol.170.8.4077
Direct Visualization of Cross-Reactive Effector and Memory Allo-Specific CD8 T Cells Generated in Response to Viral Infections1
M. Brehm (2003)
10.1038/87692
Immunological adjuvants promote activated T cell survival via induction of Bcl-3
Thomas C Mitchell (2001)
10.1016/S0959-437X(98)80062-2
Mechanism of activation and function of protein kinase B.
D. Alessi (1998)
10.1126/SCIENCE.1900951
Peripheral selection of the T cell repertoire.
B. Rocha (1991)
10.4049/jimmunol.0901203
A Default Pathway of Memory CD8 T Cell Differentiation after Dendritic Cell Immunization Is Deflected by Encounter with Inflammatory Cytokines during Antigen-Driven Proliferation1
N. Pham (2009)
10.1172/JCI23755
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages.
L. Schaefer (2005)
10.4049/jimmunol.166.4.2311
Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death1
T. Wekerle (2001)
10.1016/1074-7613(94)90067-1
The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice.
G. Singer (1994)
10.1111/j.1365-3083.2008.02181.x
Naive Human T‐Cells become Non‐Responsive towards Anti‐TNFα (Infliximab) Treatment In vitro if Co‐Stimulated through CD28
B. Gunnlaugsdottir (2008)
10.1016/S0041-1345(00)01913-8
ORAL ANTIGEN INDUCES ALLOGRAFT SURVIVAL BY LINKED SUPPRESSION VIA THE INDIRECT PATHWAY.: Abstract# 499 Poster Board #‐Session: P139‐II
M. Niimi (2000)
10.1083/JCB1785OIA10
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells
A. Intlekofer (2007)
10.1111/j.1600-6143.2010.03161.x
Allografts Stimulate Cross‐Reactive Virus‐Specific Memory CD8 T Cells with Private Specificity
M. Brehm (2010)
10.1038/87789
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
M. Jordan (2001)
10.1084/JEM.178.3.901
Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells
M. Bix (1993)
10.4049/jimmunol.174.11.6648
Analysis of the Role of Negative T Cell Costimulatory Pathways in CD4 and CD8 T Cell-Mediated Alloimmune Responses In Vivo1
T. Ito (2005)
10.1126/SCIENCE.1357752
Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells.
Y. Takahama (1992)
10.1084/jem.2008181120409c
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
R. Friedline (2009)
10.1016/0092-8674(91)90163-S
Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction
G. Schönrich (1991)
10.1084/JEM.188.12.2335
Type I Interferon-mediated Stimulation of T Cells by CpG DNA
S. Sun (1998)
10.1016/j.immuni.2007.12.017
Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity
P. Hughes (2008)
10.1126/SCIENCE.7688139
Differential T cell costimulatory requirements in CD28-deficient mice.
A. Shahinian (1993)
10.1126/SCIENCE.7509083
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
M. Iwashima (1994)
10.4049/jimmunol.172.10.6476
IFN-α Priming Results in a Gain of Proinflammatory Function by IL-10: Implications for Systemic Lupus Erythematosus Pathogenesis1
M. N. Sharif (2004)
10.1084/jem.20091175
One naive T cell, multiple fates in CD8+ T cell differentiation
C. Gerlach (2010)
10.4049/jimmunol.0903888
Anti-CD40L Immune Complexes Potently Activate Platelets In Vitro and Cause Thrombosis in FCGR2A Transgenic Mice
L. Robles-Carrillo (2010)
10.4049/jimmunol.181.3.1692
Mechanisms Underlying Blockade of Allograft Acceptance by TLR Ligands1
P. Porrett (2008)
10.1038/35006664
The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate
K. Yasutomo (2000)
10.1097/TP.0b013e3181806a60
Interferon-&ggr; Conditioning Ex Vivo Generates CD25+CD62L+Foxp3+ Regulatory T Cells That Prevent Allograft Rejection: Potential Avenues for Cellular Therapy
G. Feng (2008)
10.1097/00007890-199401001-00010
The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants.
W. Land (1994)
10.1016/J.PHARMTHERA.2007.10.001
Tumor necrosis factor antagonist mechanisms of action: a comprehensive review.
D. Tracey (2008)
10.1681/ASN.2008070778
IL-6 and TNF-alpha synergistically inhibit allograft acceptance.
H. Shen (2009)
Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice.
E. S. Razvi (1995)
10.4049/jimmunol.173.7.4500
Critical Role of TNF Receptor Type-2 (p75) as a Costimulator for IL-2 Induction and T Cell Survival: A Functional Link to CD281
E. Kim (2004)
10.1038/nri1184
Signalling pathways of the TNF superfamily: a double-edged sword
B. Aggarwal (2003)
The Late Stage of T Cell Development within Mouse Thymus
Weifengchen (2004)
10.1128/JVI.00855-06
Role of Bim in Regulating CD8+ T-Cell Responses during Chronic Viral Infection
J. M. Grayson (2006)
10.1016/S1074-7613(02)00322-9
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.
David A Hildeman (2002)
10.1007/s00417-007-0606-5
Prolongation of corneal allograft survival by CTLA4-FasL in a murine model
W. Shi (2007)
10.1016/0092-8674(94)90505-3
Evidence for a differential avidity model of T cell selection in the thymus
P. G. Ashton-Rickardt (1994)
10.1038/nri2580
New insights into the regulation of T cells by γc family cytokines
Yrina Rochman (2009)
10.1006/METH.2001.1261
An overview of real-time quantitative PCR: applications to quantify cytokine gene expression.
A. Giulietti (2001)
10.3899/jrheum.080219
Tumor Necrosis Factor-α Blockade Leads to Decreased Peripheral T Cell Reactivity and Increased Dendritic Cell Number in Peripheral Blood of Patients with Ankylosing Spondylitis
Li-ping Pang (2008)
10.4049/jimmunol.167.11.6092
Cutting Edge: Positive Selection Induced by a Self-Peptide with TCR Antagonist Activity1
F. R. Santori (2001)
Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets.
H. Hochrein (2001)
10.2210/pdb1hla/pdb
Structure of the human class I histocompatibility antigen, HLA-A2.
P. Bjorkman (2005)
10.1074/jbc.274.20.14229
Tyrosine 319 in the Interdomain B of ZAP-70 Is a Binding Site for the Src Homology 2 Domain of Lck*
M. Pelosi (1999)
10.1097/00007890-200203270-00005
Analysis of robust innate immune response after transplantation in the absence of adaptive immunity1
H. He (2002)
10.1172/jci17477
Heterologous immunity provides a potent barrier to transplantation tolerance.
A. Adams (2003)
10.1126/SCIENCE.1078231
Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells
C. Pasare (2003)
10.1097/00007890-199502270-00021
Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy.
P. Mottram (1995)
10.1084/jem.20070618
Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis
Sara Wojciechowski (2007)
10.1016/0167-5699(95)80069-7
Fas and Fas ligand: lpr and gld mutations.
S. Nagata (1995)
10.1097/01.TP.0000061601.26325.82
Induction of immunologic tolerance to cardiac allograft by simultaneous blockade of inducible co-stimulator and cytotoxic T-lymphocyte antigen 4 pathway1
H. Kosuge (2003)
10.4049/jimmunol.179.4.2074
Generation of CD8 T Cell Memory Is Regulated by IL-121
E. Pearce (2007)
10.1097/00007890-199612270-00039
Acute rejection of vascularized heart allografts in the absence of IFNgamma.
Sohail Saleem (1996)
10.1002/EJI.1830190221
Alternative molecular form of human T cell‐specific antigen CD27 expressed upon T cell activation
J. Borst (1989)
10.1038/2191076A0
Lymphocyte in vitro Cytotoxicity: Lymphotoxins of Several Mammalian Species
TERRY W. Williams (1968)
The TNF-TNF receptor system.
T. Hehlgans (2002)
10.1084/JEM.188.8.1465
Assembly of Productive T Cell Receptor δ Variable Region Genes Exhibits Allelic Inclusion
B. Sleckman (1998)
10.1016/S0898-6568(01)00262-5
TNF receptor subtype signalling: differences and cellular consequences.
D. MacEwan (2002)
10.4049/jimmunol.172.4.2163
Dependency of Direct Pathway CD4+ T Cells on CD40-CD154 Costimulation Is Determined by Nature and Microenvironment of Primary Contact with Alloantigen1
Andre van Maurik (2004)
10.1038/nri727
The B7–CD28 superfamily
A. Sharpe (2002)
10.1126/science.270.5238.985
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
P. Waterhouse (1995)
10.1016/S1470-2045(03)01141-0
Current uses of isolated limb perfusion in the clinic and a model system for new strategies.
A. Eggermont (2003)
Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells.
M. Brehm (2005)
10.1073/PNAS.0406168101
Activation of naïve CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling.
K. Sugie (2004)
10.1126/SCIENCE.7973657
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor.
V. Boussiotis (1994)
10.1007/s004670050359
Immunoregulatory drugs: mechanistic basis for use in organ transplantation
M. Suthanthiran (1997)
10.1097/00007890-199712270-00003
Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients.
M. Sayegh (1997)
10.1159/000099265
The role of Fas ligand and TNF-related apoptosis-inducing ligand (TRAIL) in the ocular immune response.
T. Ferguson (2007)
10.1038/nri1148
Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?
M. Croft (2003)
10.1038/ni.1833
Levees of immunological tolerance
D. Mathis (2010)
10.1038/nature01433
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
E. Treiner (2003)
Human tumor necrosis factor. Production, purification, and characterization.
B. Aggarwal (1985)
10.1038/87730
Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
M. V. Stipdonk (2001)
10.1080/01926230701320337
Apoptosis: A Review of Programmed Cell Death
S. Elmore (2007)
10.1126/science.1122927
Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes
O. Boyman (2006)
10.4049/jimmunol.181.2.1272
Biphasic Regulation of Il2 Transcription in CD4+ T Cells: Roles for TNF-α Receptor Signaling and Chromatin Structure1
S. McKarns (2008)
10.1172/JCI10467
CD4 T cell-mediated cardiac allograft rejection requires donor but not host MHC class II.
B. Pietra (2000)
10.1146/ANNUREV.IY.12.040194.005015
Tolerance, danger, and the extended family.
P. Matzinger (1994)
10.4049/jimmunol.173.9.5425
The Selective Increase in Caspase-3 Expression in Effector but Not Memory T Cells Allows Susceptibility to Apoptosis1
L. Sabbagh (2004)
10.1016/S0952-7915(02)00338-2
Homeostasis of naïve, effector and memory CD8 T cells.
R. A. Tuma (2002)
10.1038/nrd3030
TNF receptor 2 pathway: drug target for autoimmune diseases
D. Faustman (2010)
10.1038/icb.2010.12
TNFRI is a positive T‐cell costimulatory molecule important for the timing of cytokine responses
M. Evangelidou (2010)
10.4049/jimmunol.176.8.4553
Antigen Challenge Inhibits Thymic Emigration1
A. P. Uldrich (2006)
10.1067/MAI.2002.124259
T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse.
A. Nel (2002)
10.1016/S0092-8674(02)00699-2
NFAT Signaling Choreographing the Social Lives of Cells
G. Crabtree (2002)
10.1038/sj.cdd.4401189
Tumor necrosis factor signaling
H. Wajant (2003)
Role of lymphotoxin alpha in T-cell responses during an acute viral infection.
M. Suresh (2002)
Pillars Article: Immunological Surveillance against Altered Self Components by Sensitised T Lymphocytes in Lymphocytic Choriomeningitis. Nature, 1974, 251: 547–548.
R. Zinkernagel (2004)
10.1084/JEM.181.2.485
Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody
J. Ogasawara (1995)
10.1016/J.TRANSPROCEED.2005.01.071
Basiliximab (Simulect) reduces acute rejection among sensitized kidney allograft recipients.
J. Tan (2005)
10.1084/jem.20020394
Infectious Tolerance
H. Jonuleit (2002)
Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).
Yufang Zheng (2004)
10.1016/S1074-7613(00)80089-8
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
H. Nishimura (1999)
10.1084/jem.20040779
CD24 Expression on T Cells Is Required for Optimal T Cell Proliferation in Lymphopenic Host
O. Li (2004)
10.1038/NM0497-409
Essential roles of the Fas ligand in the development of hepatitis
T. Kondo (1997)
10.1038/9536
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
A. Kirk (1999)
10.1111/j.1600-6143.2004.00640.x
Mechanisms of Tolerance Induced by Donor‐Specific Transfusion and ICOS‐B7h Blockade in a Model of CD4+ T‐Cell‐Mediated Allograft Rejection
S. Sandner (2005)
The majority of CD4+8- thymocytes are functionally immature.
F. Ramsdell (1991)
10.1074/JBC.M208742200
Endotoxin Contamination in Recombinant Human Heat Shock Protein 70 (Hsp70) Preparation Is Responsible for the Induction of Tumor Necrosis Factor α Release by Murine Macrophages*
B. Gao (2003)
10.1038/324575A0
Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence
A. Townsend (1986)
10.1038/ni1487
Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
N. Huntington (2007)
10.1038/nri1391
Toll-like receptor signalling
S. Akira (2004)
10.1038/ni723
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
Jens Derbinski (2001)
10.1038/31002
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
S. Schoenberger (1998)
Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21).
M. Murphy (1992)
10.1073/pnas.0812354106
Postthymic maturation influences the CD8 T cell response to antigen
L. Makaroff (2009)
10.1038/415922a
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
P. Bouillet (2002)
Linked suppression of skin graft rejection can operate through indirect recognition.
M. Wise (1998)
10.1038/icb.1994.68
Twenty years into the saga of MHC‐restriction
G. Ada (1994)
10.1016/1074-7613(95)90161-2
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.
L. Boise (1995)
10.1098/RSTB.2001.0843
Involvement of the direct and indirect pathways of allorecognition in tolerance induction.
K. Womer (2001)
10.4049/jimmunol.169.10.5387
Cutting Edge: Persistent Viral Infection Prevents Tolerance Induction and Escapes Immune Control Following CD28/CD40 Blockade-Based Regimen1
M. Williams (2002)
10.1189/jlb.0803400
Expression of CD45RB functionally distinguishes intestinal T lymphocytes in inflammatory bowel disease
T. Hove (2004)
10.1126/scisignal.2000702
Regulation of Zap70 Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds
M. Saini (2010)
This information is current as Function Cells that Modulates Their Suppressive Regulatory T − Program in Human CD 45 RA Regulated Cellular − B κ TNF Activates a NF -
M. Nagar (2010)
10.4049/jimmunol.177.7.4495
Ligation of CD80 Is Critical for High-Level CD25 Expression on CD8+ T Lymphocytes1
Sharmila Pejawar-Gaddy (2006)
10.1016/j.immuni.2008.07.016
Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis.
Z. Hao (2008)
10.1126/SCIENCE.278.5335.124
Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1.
V. Boussiotis (1997)
10.1073/PNAS.0603086103
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage.
J. Cabarrocas (2006)
10.4049/jimmunol.165.12.6933
The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-κB Cascade by TCR and CD281
A. Khoshnan (2000)
10.1016/S0022-1759(97)00089-6
A simple method for evaluating the rejection of grafted spleen cells by flow cytometry and tracing adoptively transferred cells by light microscopy.
S. Oehen (1997)
10.1016/0167-5699(92)90198-G
The immune system evolved to discriminate infectious nonself from noninfectious self.
C. Janeway (1992)
10.1038/nri2251
Shaping and reshaping CD8+ T-cell memory
J. Harty (2008)
10.1099/VIR.0.80709-0
Mousepox conjunctivitis: the role of Fas/FasL-mediated apoptosis of epithelial cells in virus dissemination.
M. Krzyżowska (2005)
10.1046/j.1365-2567.2002.01441.x
Stimulation of naïve T‐cell adhesion and immunological synapse formation by chemokine‐dependent and ‐independent mechanisms
S. Bromley (2002)
10.1097/01.tp.0000179149.12979.13
Transplant Tolerance: Converging on a Moving Target
K. Newell (2006)
Recent insights into the signals that control alphabeta/gammadelta-lineage fate.
J. P. Lauritsen (2006)
10.1016/S1074-7613(00)00008-X
Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells.
E. Brugnera (2000)
10.1016/J.IMMUNI.2005.01.010
Peripheral tolerance of CD8 T lymphocytes.
William L. Redmond (2005)
10.1084/JEM.174.3.561
CTLA-4 is a second receptor for the B cell activation antigen B7
P. Linsley (1991)
Chronic rejection in experimental cardiac transplantation in a rat model.
M. Karnovsky (1994)
10.4049/jimmunol.179.10.6620
Type 1 IFN Mediates Cross-Talk between Innate and Adaptive Immunity That Abrogates Transplantation Tolerance12
T. Thornley (2007)
10.1016/0092-8674(94)90375-1
Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand
Tomohiro Takahashi (1994)
10.1038/30989
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
J. P. Ridge (1998)
Primary structure of human lymphotoxin derived from 1788 lymphoblastoid cell line.
B. Aggarwal (1985)
10.1111/j.1365-2249.2007.03499.x
Lipopolysaccharide and interferon‐γ enhance Fas‐mediated cell death in mouse vascular endothelial cells via augmentation of Fas expression
N. Koide (2007)
10.1073/PNAS.96.17.9787
A central role for thymic emigrants in peripheral T cell homeostasis.
S. Berzins (1999)
10.1038/356314A0
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
R. Watanabe-Fukunaga (1992)
10.1038/35103104
The role of Fas ligand in immune privilege
D. Green (2001)
10.4049/jimmunol.181.2.931
Induction of Tolerance to Cardiac Allografts Using Donor Splenocytes Engineered to Display on Their Surface an Exogenous Fas Ligand Protein1
E. Yolcu (2008)
10.1093/INTIMM/10.10.1563
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses.
H. Nishimura (1998)
10.1111/j.0105-2896.2006.00384.x
Programming, demarcating, and manipulating CD8+ T‐cell memory
V. Badovinac (2006)
10.1007/s12026-009-8113-x
The contribution of direct TLR signaling to T cell responses
A. Rahman (2009)
10.1155/1992/48713
Analysis by in Situ Hybridization of Cells Expressing mRNA for Tumor-Necrosis Factor in the Developing Thymus of Mice
J. Deman (1992)
10.1128/JVI.74.5.2210-2218.2000
Virus-Induced Abrogation of Transplantation Tolerance Induced by Donor-Specific Transfusion and Anti-CD154 Antibody
R. Welsh (2000)
10.1182/blood-2008-08-173658
Murine neonatal recent thymic emigrants are phenotypically and functionally distinct from adult recent thymic emigrants.
S. Opiela (2009)
10.1016/0092-8674(94)90169-4
T cell receptor antagonist peptides induce positive selection
K. Hogquist (1994)
TCR signal strength influences alphabeta/gammadelta lineage fate.
S. M. Hayes (2005)
10.1002/j.1460-2075.1995.tb06970.x
Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.
D. Watanabe (1995)
10.1016/S1074-7613(00)80210-1
ITAM multiplicity and thymocyte selection: how low can you go?
P. Love (2000)
10.1128/JVI.77.4.2469-2476.2003
Lack of Tumor Necrosis Factor Alpha Induces Impaired Proliferation of Hepatitis B Virus-Specific Cytotoxic T Lymphocytes
S. Kasahara (2003)
10.1002/1521-4141(200003)30:3<738::AID-IMMU738>3.0.CO;2-Y
Regulation and kinetics of premigrant thymocyte expansion
A. Le Campion (2000)
Down syndrome (DS) peripheral blood contains phenotypically mature CD3+TCR alpha, beta+ cells but abnormal proportions of TCR alpha, beta+, TCR gamma, delta+, and CD4+ CD45RA+ cells: evidence for an inefficient release of mature T cells by the DS thymus.
M. Murphy (1992)
10.1093/INTIMM/DXG013
IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells.
Y. M. Mueller (2003)
10.1038/nature08402
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
Lorraine A. O’ Reilly (2009)
10.4049/jimmunol.165.10.5621
TNF Regulates Thymocyte Production by Apoptosis and Proliferation of the Triple Negative (CD3−CD4−CD8−) Subset1
J. G. Baseta (2000)
10.1073/PNAS.94.17.9302
Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice.
M. Alimzhanov (1997)
10.1111/j.1600-6143.2006.01494.x
Direct versus Indirect Allorecognition: Visualization of Dendritic Cell Distribution and Interactions During Rejection and Tolerization
J. Ochando (2006)
10.1681/ASN.2007030295
Frontiers in nephrology: heterologous immunity, T cell cross-reactivity, and alloreactivity.
L. Selin (2007)
10.1038/ni814
Positive selection of MHC class Ib–restricted CD8+ T cells on hematopoietic cells
K. Urdahl (2002)
10.1038/ni1179
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
J. Fontenot (2005)
10.4049/jimmunol.165.12.6833
Early Programming of T Cell Populations Responding to Bacterial Infection1
R. Mercado (2000)
10.4049/jimmunol.174.2.718
T Cells Undergo Rapid ON/OFF but Not ON/OFF/ON Cycling of Cytokine Production in Response to Antigen1
G. A. Corbin (2005)
10.4049/jimmunol.165.8.4397
Reciprocal Expression of the TNF Family Receptor Herpes Virus Entry Mediator and Its Ligand LIGHT on Activated T Cells: LIGHT Down-Regulates Its Own Receptor1
Y. Morel (2000)
10.1126/SCIENCE.286.5445.1735
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.
P. Bouillet (1999)
10.4049/jimmunol.0803482
TNFR2-Deficient Memory CD8 T Cells Provide Superior Protection against Tumor Cell Growth1
E. Kim (2009)
10.1016/0092-8674(85)90103-5
Cytotoxic T cells recognize fragments of the influenza nucleoprotein
A. Townsend (1985)
10.1016/0092-8674(86)90019-X
The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
A. Townsend (1986)
10.1038/23287
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion
W. Yu (1999)
Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice.
Z. Dai (1998)
10.1038/ni.1794
Checkpoints in lymphocyte development and autoimmune disease
H. Boehmer (2010)
10.1016/S1074-7613(00)80371-4
Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells.
R. Mebius (1997)
Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage.
M. Haks (2005)
10.1111/j.1365-2567.2005.02143.x
The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games
Thomas Hehlgans (2005)
10.1126/SCIENCE.2113314
A cell culture model for T lymphocyte clonal anergy.
R. Schwartz (1990)
10.1016/0092-8674(91)90362-3
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
A. Strasser (1991)
10.1074/jbc.M203553200
Molecular Mechanisms of Pre-T Cell Receptor-induced Survival*
C. Murga (2002)
10.1002/EJI.1830220510
Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase
T. Mustelin (1992)
Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.
A. M. Michie (2002)
10.1084/JEM.172.5.1277
Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy
L. A. Jones (1990)
10.4049/jimmunol.165.3.1175
Anergic T Cells Inhibit the Antigen-Presenting Function of Dendritic Cells1
S. Vendetti (2000)
10.1097/01.tp.0000255592.09784.ba
Blockade of the Passive Cell Death Pathway Does Not Prevent Tolerance Induction to Islet Grafts
Anne M. Lehnert (2007)
10.1126/science.273.5271.109
Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice
H. Lau (1996)
10.1083/JCB1856OIA13
CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling
G. Strauss (2009)
10.1016/S1074-7613(00)80588-9
The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues.
A. Fütterer (1998)
10.4049/jimmunol.171.11.5727
IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion 1
Warren N. D’Souza (2003)
10.1136/ard.58.2008.i32
The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
G. Kollias (1999)
10.1126/scisignal.3114pe11
Two Receptors, Two Kinases, and T Cell Lineage Determination
B. Alarcón (2010)
10.1371/journal.pone.0011784
CD25 Appears Non Essential for Human Peripheral Treg Maintenance In Vivo
M. de Goër de Herve (2010)
10.1038/323338A0
Identity of differentiation inducing factor and tumour necrosis factor
K. Takeda (1986)
The developmental fate of T cells is critically influenced by TCRgammadelta expression.
J. Kang (1998)
10.1038/35105088
Transplantation tolerance from a historical perspective
T. Starzl (2001)
Intrathymic delta selection events in gammadelta cell development.
L. Passoni (1997)
10.1002/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O
Virus‐specific major MHC class II‐restricted TCR‐transgenic mice: effects on humoral and cellular immune responses after viral infection
A. Oxenius (1998)
10.1016/0167-5699(95)80179-0
Thymic emigration: conveyor belts or lucky dips?
R. Scollay (1995)
10.1146/ANNUREV.IMMUNOL.18.1.83
Population biology of lymphocytes: the flight for survival.
A. Freitas (2000)
10.1126/scisignal.3115re4
The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
P. Vandenabeele (2010)
Seventy-five years of immunology: the view from the MHC.
D. C. Shreffler (1988)
10.4049/jimmunol.177.2.1272
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR21
K. Scheibner (2006)
10.1073/pnas.2336198100
Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim
M. Pellegrini (2003)
10.4049/jimmunol.164.9.4706
DO11.10 and OT-II T Cells Recognize a C-Terminal Ovalbumin 323–339 Epitope1
J. Robertson (2000)
10.1093/JNCI/29.6.1169
Action of Bacterial Polysaccharide on Tumors. II. Damage of Sarcoma 37 by Serum of Mice Treated With Serratia Marcescens Polysaccharide, and Induced Tolerance
W. O'malley (1962)
10.1038/248701A0
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
R. Zinkernagel (1974)
10.4049/jimmunol.174.8.4465
Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation1
J. Curtsinger (2005)
10.1093/INTIMM/10.4.481
Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein.
S. Klasen (1998)
10.1016/1074-7613(95)90125-6
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.
E. Tivol (1995)
10.1017/S1462399499001179
Permanent survival of organ transplants without immunosuppression: Experimental approaches and possibilities for tolerance induction in clinical transplantation.
A. Bushell (1999)
10.1007/s00109-006-0098-5
Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications
L. Li (2006)
10.1084/JEM.184.4.1397
Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
M. Pasparakis (1996)
10.1038/nm0302-233
Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: An alternative mechanism of allorecognition
D. Kreisel (2002)
10.1073/pnas.211423598
TNF-α-dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection
J. Trevejo (2001)
10.4049/jimmunol.177.8.5307
Absence of Innate MyD88 Signaling Promotes Inducible Allograft Acceptance1
W. Walker (2006)
10.1038/nri1413
Helping the CD8+ T-cell response
M. Bevan (2004)
10.1038/318665A0
Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon
B. Aggarwal (1985)
10.4049/jimmunol.171.1.27
Cutting Edge: Rapid In Vivo Killing by Memory CD8 T Cells1
D. Barber (2003)
10.1073/pnas.0803429105
Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism
L. Ban (2008)
10.2337/DIABETES.48.7.1473
Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.
N. Kenyon (1999)
10.1126/SCIENCE.1075958
Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
M. Anderson (2002)
10.1084/JEM.181.5.1869
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
M. Sayegh (1995)
10.4049/jimmunol.167.6.3478
An Antagonist IL-15/Fc Protein Prevents Costimulation Blockade-Resistant Rejection1
S. Ferrari-Lacraz (2001)
10.1016/0092-8674(95)90013-6
Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
G. H. Fisher (1995)
10.4049/jimmunol.171.10.5165
CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine 1
J. Curtsinger (2003)
Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.
T. Banks (1995)
Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells.
J. Curtsinger (1999)
10.1016/S0952-7915(97)80043-X
The CD40 pathway in allograft rejection, acceptance, and tolerance.
C. Larsen (1997)
10.1073/PNAS.80.17.5397
Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon.
B. Williamson (1983)
10.1002/eji.200839191
Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus
D. Liepinsh (2009)
Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.
Fadi G Lakkis (1997)
10.1073/PNAS.95.6.3065
Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules.
M. Markiewicz (1998)
10.1146/ANNUREV.IMMUNOL.16.1.523
Ligand recognition by alpha beta T cell receptors.
M. Davis (1998)
Homeostatic T cell proliferation: how far can T cells be activated to self-ligands
C. D. Surh (2000)
10.1097/00007890-199305000-00032
Promotion of rat cardiac allograft survival by intrathymic inoculation of donor splenocytes.
J. Odorico (1993)
10.1016/J.IMMUNI.2007.08.007
Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection.
S. Kaech (2007)
10.1073/PNAS.72.9.3666
An endotoxin-induced serum factor that causes necrosis of tumors.
E. Carswell (1975)
10.1038/NM1097-1124
Interleukin-15 protects from lethal apoptosis in vivo
S. Bulfone-Paus (1997)
10.1038/icb.2008.63
Distinct functional capacities of mouse thymic and splenic dendritic cell populations
Anna I. Proietto (2008)
TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice.
T. Calzascia (2007)
10.1016/j.coi.2009.08.007
AIRE in the thymus and beyond.
J. Gard'ner (2009)
10.1084/jem.20070601
Thymic emigration revisited
Tom M. McCaughtry (2007)
10.4049/jimmunol.0900377
Control of Thymic T Cell Maturation, Deletion and Egress by the RNA-Binding Protein HuR1
O. Papadaki (2009)
10.1084/JEM.187.1.123
Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand
I. Suzuki (1998)
10.1111/j.1365-3083.2007.01976.x
CD4+CD25+Foxp3+ Indirect Alloreactive T cells from Renal Transplant Patients Suppress Both the Direct and Indirect Pathways of Allorecognition
M. Spadafora-Ferreira (2007)
Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells.
C. Ware (1992)
Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset.
J. Vernachio (1989)
10.1126/science.7824949
Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
J. Madrenas (1995)
10.1038/ni1049
Continued maturation of thymic emigrants in the periphery
T. Boursalian (2004)
10.1182/BLOOD-2006-03-008219
Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
M. Brehm (2007)
10.1038/nri1002
The complementary roles of deletion and regulation in transplantation tolerance
R. Lechler (2003)
10.4049/jimmunol.165.9.5017
Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation1
D. Jelley-Gibbs (2000)
10.1128/JVI.00840-08
Regulation of Cytokine Production by Virus-Specific CD8 T Cells in the Lungs
Ross B. Fulton (2008)
10.1084/jem.20050821
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
Ganesh A. Kolumam (2005)
10.1111/j.1600-065X.1978.tb00261.x
Intrathymic and Extrathymic T Cell Maturation
O. Stutman (1978)
10.1038/ni1304
T cells use two directionally distinct pathways for cytokine secretion
M. Huse (2006)
10.1073/PNAS.89.22.11102
T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.
L. A. Turka (1992)
10.1016/j.immuni.2007.12.014
Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction.
Ashley E Weant (2008)
10.1189/jlb.0303112
Regulation of TCR‐mediated T cell activation by TNF‐RII
R. Aspalter (2003)
10.1126/science.8094901
"Infectious" transplantation tolerance
S. Qin (1993)
10.1111/j.1600-6143.2007.01960.x
Role of IFNγ in Allograft Tolerance Mediated by CD4+CD25+ Regulatory T Cells by Induction of IDO in Endothelial Cells
P. Thébault (2007)
10.1038/nature03337
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
E. Janssen (2005)
Expansion of Premigrant Thymocytes Thymic T Cell Production by Clonal Quantitative and Qualitative Adjustment of
Armelle Le Campion (2002)
10.1084/JEM.180.4.1295
The role of B cells in lpr/lpr-induced autoimmunity
M. Shlomchik (1994)
10.1097/01.TP.0000089242.86443.40
Roles of tumor necrosis factor-related apoptosis-inducing ligand in corneal transplantation
L. Xie (2003)
10.4049/jimmunol.165.6.3506
Host CD40 Ligand Deficiency Induces Long-Term Allograft Survival and Donor-Specific Tolerance in Mouse Cardiac Transplantation But Does Not Prevent Graft Arteriosclerosis1
K. Shimizu (2000)
10.1038/384134A0
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
D. Garboczi (1996)
10.4049/jimmunol.167.9.5011
Lipopolysaccharide-Stimulated or Granulocyte-Macrophage Colony-Stimulating Factor-Stimulated Monocytes Rapidly Express Biologically Active IL-15 on Their Cell Surface Independent of New Protein Synthesis1 2
G. G. Neely (2001)
10.1084/JEM.173.1.79
Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway
M. Dallman (1991)
10.1016/J.BBI.2007.02.004
Thymus atrophy during Trypanosoma cruzi infection is caused by an immuno-endocrine imbalance
A. Pérez (2007)
10.1126/SCIENCE.288.5475.2351
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
F. K. Chan (2000)
10.1097/01.shk.0000097248.97298.ea
Regulation of Fas (APO-1, CD95) and Fas Ligand Expression in Leukocytes During Systemic Inflammation in Humans
C. Marsik (2003)
10.1016/S0966-3274(96)80043-8
Prolonged islet allograft acceptance in the absence of interleukin 4 expression.
P. Nickerson (1996)
10.1002/EJI.1830270827
Recent thymic emigrants are distinct from most medullary thymocytes
M. J. Gabor (1997)
10.1016/S0165-5728(02)00013-9
Peripheral LPS administrations up-regulate Fas and FasL on brain microglial cells: a brain protective or pathogenic event?
S. Terrazzino (2002)
10.4049/jimmunol.167.11.6623
Skin Allograft Maintenance in a New Synchimeric Model System of Tolerance1 2
N. Iwakoshi (2001)
10.1006/VIRO.1995.1314
CTL escape viral variants. I. Generation and molecular characterization.
H. Lewicki (1995)
10.1038/307168A0
Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts
S. Ildstad (1984)
10.1016/J.MOLCEL.2005.08.007
HuR as a negative posttranscriptional modulator in inflammation.
V. Katsanou (2005)
10.4049/jimmunol.176.3.1561
TLR Agonists Abrogate Costimulation Blockade-Induced Prolongation of Skin Allografts1
T. Thornley (2006)
10.1111/j.1432-2277.2005.00241.x
Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40‐CD40L costimulation blockade
P. Perco (2006)
Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand.
T. Kawai (2000)
10.1084/JEM.192.7.1027
Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
G. Freeman (2000)
10.1038/35005534
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
F. Sallusto (1999)
10.1073/pnas.092596999
Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs
G. Chalasani (2002)
10.4049/jimmunol.180.10.6467
Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells1
Xin Chen (2008)
10.1016/J.IMMUNI.2005.06.009
The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1.
M. Buxadé (2005)
10.1126/SCIENCE.7541554
Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation.
J. Zúñiga-Pflücker (1995)
10.1016/j.immuni.2007.12.015
Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity.
Jack Hutcheson (2008)
10.1084/JEM.193.11.1311
Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade
P. Taylor (2001)
10.1111/j.1600-065X.1984.tb01113.x
A Murine T Cell Receptor Gene Complex: Isolation, Structure and Rearrangement
M. Davis (1984)
10.1126/science.270.5236.630
T Cell Awareness of Paternal Alloantigens During Pregnancy
A. Tafuri (1995)
10.4049/jimmunol.176.8.4682
Direct Stimulation of T Cells by Type I IFN Enhances the CD8+ T Cell Response during Cross-Priming1
A. Le Bon (2006)
10.1016/S1359-6101(03)00021-2
The signaling adaptors and pathways activated by TNF superfamily.
P. W. Dempsey (2003)
10.1002/eji.200635897
Bim mediates apoptosis of CD127lo effector T cells and limits T cell memory
Sara Wojciechowski (2006)
10.4049/jimmunol.0802077
TLR Agonists Prevent the Establishment of Allogeneic Hematopoietic Chimerism in Mice Treated with Costimulation Blockade12
D. M. Miller (2009)
Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors.
R. D. de Jong (1991)
10.1038/nri798
T-cell development and the CD4–CD8 lineage decision
R. Germain (2002)
10.1084/JEM.188.11.1993
Stability and Diversity of  T Cell Receptor Repertoire Usage during Lymphocytic Choriomeningitis Virus Infection of Mice
Meei  Yun Lin (1998)
10.4049/jimmunol.181.8.5213
Cutting Edge: Contact with Secondary Lymphoid Organs Drives Postthymic T Cell Maturation12
E. Houston (2008)
10.1038/342559A0
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
H. Pircher (1989)
10.1038/30996
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Sally R. M. Bennett (1998)
10.1084/JEM.180.2.699
Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice
T. Ohteki (1994)
10.1182/BLOOD-2002-07-1957
IL-15 enhances survival and function of HIV-specific CD8+ T cells.
Y. M. Mueller (2003)
10.1182/BLOOD-2004-06-2364
Induction of tolerance using Fas ligand: a double-edged immunomodulator.
N. Askenasy (2005)
Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors.
K. Elkon (1997)
10.1038/nri778
Vaccines: Effector and memory T-cell differentiation: implications for vaccine development
S. Kaech (2002)
10.1016/j.semnephrol.2007.03.008
Transplantation tolerance.
K. Newell (2007)
10.1084/JEM.182.6.2091
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes
A. Bendelac (1995)
10.1038/329512A0
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
P. Bjorkman (1987)
10.1002/1521-4141(200201)32:1<223::AID-IMMU223>3.0.CO;2-4
Requirement of Fas expression in B cells for tolerance induction
H. Fukuyama (2002)
10.1097/00007890-199703270-00014
Immunosuppression by inhibition of cellular adhesion mediated by leukocyte function-associated antigen-1/intercellular adhesion molecule-1 in murine cardiac transplantation.
X. Xu (1997)
10.4049/jimmunol.167.3.1179
IL-15 Is Expressed by Dendritic Cells in Response to Type I IFN, Double-Stranded RNA, or Lipopolysaccharide and Promotes Dendritic Cell Activation1
F. Mattei (2001)
Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells.
A. Sadra (1999)
Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8alphabeta versus CD8alphaalpha expression.
A. G. Cawthon (2001)
10.4049/jimmunol.165.10.5537
Fas Ligand Costimulates the In Vivo Proliferation of CD8+ T Cells1
I. Suzuki (2000)
10.1073/PNAS.0308054101
Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets.
K. Huster (2004)
This information is current as CD 8 T Cell Responses Is Important for the Generation of Antiviral 4-1 BB Ligand , a Member of the TNF Family , Pearson and
J. T. Tan (1999)
10.1038/ni912
Dynamic programming of CD8+ T lymphocyte responses
M. V. Stipdonk (2003)
10.1016/S1471-4914(02)02415-2
Thymic regeneration: teaching an old immune system new tricks.
S. Berzins (2002)
10.1073/pnas.0910341107
Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity
N. Jain (2010)
10.1016/S1074-7613(01)00121-2
T cell death and transplantation tolerance.
X. Li (2001)
10.1016/S1074-7613(00)80566-X
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.
Y. Refaeli (1998)
10.4049/jimmunol.176.2.1026
TNF Receptor Type 2 (p75) Functions as a Costimulator for Antigen-Driven T Cell Responses In Vivo1
E. Kim (2006)
10.1111/j.1600-6143.2004.00544.x
TH1 Immune Responses to Fully MHC Mismatched Allografts are Diminished in the Absence of MyD88, a Toll‐Like Receptor Signal Adaptor Protein
B. M. Tesar (2004)
10.4049/jimmunol.165.5.2783
Proinflammatory Effects of IL-10 During Human Endotoxemia1
F. Lauw (2000)
10.4049/jimmunol.176.8.4525
Cutting Edge: CD8 T Cells Specific for Lymphocytic Choriomeningitis Virus Require Type I IFN Receptor for Clonal Expansion1
P. Aichele (2006)
10.1016/j.coi.2009.03.009
Mechanics of T cell receptor gene rearrangement.
M. Krangel (2009)
10.1016/S0149-7944(00)00341-X
Virus infection abrogates cd8(+) t cell deletion induced by donor-specific transfusion and anti-cd154 monoclonal antibody.
Turgeon (2000)
10.4049/jimmunol.166.10.5864
Cutting Edge: Antigen-Independent CD8 T Cell Proliferation
P. Wong (2001)
10.4049/jimmunol.167.9.4987
Characterization of Virus-Mediated Inhibition of Mixed Chimerism and Allospecific Tolerance1
M. Williams (2001)
10.1034/j.1600-065X.2003.00010.x
Thymic selection revisited: how essential is it?
H. von Boehmer (2003)
10.1046/j.1365-2567.2003.01641.x
Analysis of differential immune responses induced by innate and adaptive immunity following transplantation
H. He (2003)
10.1073/PNAS.94.16.8789
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.
A. Kirk (1997)
10.1038/15260
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
A. Wells (1999)
10.1038/79782
A cellular calculus for signal integration by T cells
A. Gett (2000)
Overexpression of LFA-1 and ICAM-1 in Down syndrome thymus. Implications for abnormal thymocyte maturation.
M. Murphy (1993)
10.4049/jimmunol.0902181
Bim-Mediated Apoptosis Is Not Necessary for Thymic Negative Selection to Ubiquitous Self-Antigens1
Q. Hu (2009)
10.1016/J.IMMUNI.2007.10.012
A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets.
C. Stemberger (2007)
10.1038/ni1009
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
S. Kaech (2003)
10.1073/PNAS.96.14.8132
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.
N. Kenyon (1999)
10.1128/JVI.79.1.202-213.2005
Role of Tumor Necrosis Factor Receptors in Regulating CD8 T-Cell Responses during Acute Lymphocytic Choriomeningitis Virus Infection
M. Suresh (2005)
10.1084/JEM.188.2.247
T Cell Receptor (TCR) Engagement Leads to Activation-induced Splicing of  Tumor Necrosis Factor (TNF) Nuclear Pre-mRNA
Y. Yang (1998)
10.1016/S0041-1345(02)04041-1
The effect of anti-CD25 monoclonal antibody (Simulect) to the lymphocytes in the peripheral blood of the recipients of kidney transplantation.
S. Bing-yi (2003)
10.1038/ni.1863
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
T. Kawai (2010)
10.1189/jlb.0407240
A role for TNF in limiting the duration of CTL effector phase and magnitude of CD8 T cell memory
A. Singh (2007)
10.1073/PNAS.87.7.2579
Kinetics of mature T-cell development in the thymus.
M. Egerton (1990)
Lymphocytic Choriomeningitis Virus as a Model for the Study of Cellular Immunology
R. M. Welsh (2000)
10.1084/JEM.181.3.993
Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance
B. Rocha (1995)
10.1073/PNAS.97.4.1707
The dual functions of fas ligand in the regulation of peripheral CD8+ and CD4+ T cells.
I. Suzuki (2000)
10.1084/JEM.189.3.521
Type I Interferons Keep Activated T Cells Alive
P. Marrack (1999)
10.1097/00007890-196907000-00021
CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
N. Ruddle (1968)
10.4049/jimmunol.174.10.5936
Cutting Edge: Re-evaluating the In Vivo Cytokine Responses of CD8+ T Cells during Primary and Secondary Viral Infections1
F. Liu (2005)
10.1111/j.1600-6143.2006.01489.x
TLR Engagement Prevents Transplantation Tolerance
L. Chen (2006)
10.4049/jimmunol.167.4.1945
Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1
S. Gregori (2001)
10.4049/jimmunol.165.4.1743
The NF-κB Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes1
A. Khoshnan (2000)
Exclusion and inclusion of alpha and beta T cell receptor alleles.
P. Borgulya (1992)
10.4049/jimmunol.167.1.140
CD28-independent Costimulation of T Cells in Alloimmune Responses1
A. Yamada (2001)
10.1016/J.JAUT.2005.04.008
IPEX and FOXP3: clinical and research perspectives.
R. Wildin (2005)
10.4049/jimmunol.178.9.5429
Cutting Edge: Lipopolysaccharide Induces IL-10-Producing Regulatory CD4+ T Cells That Suppress the CD8+ T Cell Response
J. D. den Haan (2007)
10.1093/INTIMM/10.11.1637
The induction of transplantation tolerance by intrathymic (i.t.) delivery of alloantigen: a critical relationship between i.t. deletion, thymic export of new T cells and the timing of transplantation.
N. D. Jones (1998)
10.1016/S1074-7613(04)00116-5
The roles of the new negative T cell costimulatory pathways in regulating autoimmunity.
S. Khoury (2004)
10.1084/jem.20072707
Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
C. Notley (2008)
10.1073/PNAS.93.24.13967
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.
W. Hancock (1996)
10.1016/j.immuni.2009.01.001
The many roles of FAS receptor signaling in the immune system.
A. Strasser (2009)
10.1084/JEM.128.6.1237
CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
N. Ruddle (1968)
10.1038/ni1319
CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium
Tracy L Staton (2006)
10.1016/S1074-7613(00)00011-X
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses.
A. Coyle (2000)
10.1126/SCIENCE.2119056
Induction of donor-specific unresponsiveness by intrathymic islet transplantation.
A. Posselt (1990)
10.1073/pnas.212515399
Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules
E. Schott (2002)
10.4049/jimmunol.178.3.1321
Environmental and Intrinsic Factors Lead to Antigen Unresponsiveness in CD4+ Recent Thymic Emigrants from Aged Mice1
K. Clise-Dwyer (2007)
10.4049/jimmunol.165.10.5387
Cutting Edge: OFF Cycling of TNF Production by Antigen-Specific CD8+ T Cells Is Antigen Independent1
V. Badovinac (2000)
10.1097/01.tp.0000226254.89987.ec
Proteomic Analysis of the Allograft Response
B. El Essawy (2006)
10.1097/00007890-200006150-00037
Alloantigen-driven T cell death mediated by Fas ligand and tumor necrosis factor-alpha is not essential for the induction of allograft acceptance.
M. Wagener (2000)
10.1002/1097-0029(20000801)50:3<196::AID-JEMT3>3.0.CO;2-9
Role of TNF in lymphocyte‐mediated cytotoxicity
M. Smyth (2000)
10.1038/76267
Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue
Fadi G Lakkis (2000)
A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.
D. Godfrey (1993)
10.1038/nature04790
Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
M. Williams (2006)
10.1016/J.IT.2005.01.004
IL-7: maintaining T-cell memory and achieving homeostasis.
L. Bradley (2005)
10.1016/0092-8674(94)90080-9
Partial T cell signaling: Altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy
J. Sloan-Lancaster (1994)
10.4049/jimmunol.166.2.973
Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question1
E. Suchin (2001)
Expression and functional significance of the J11d marker on mouse thymocytes.
I. N. Crispe (1987)
10.1016/J.IMMUNI.2007.07.010
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.
N. Joshi (2007)
Anti-Qa-2-induced T cell activation. The parameters of activation, the definition of mitogenic and nonmitogenic antibodies, and the differential effects on CD4+ vs CD8+ T cells.
A. Hahn (1989)
10.1084/JEM.178.5.1801
Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion
H. Lin (1993)
10.1128/MCB.22.24.8626-8634.2002
Redundancy in Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) Signaling In Vivo: Mice with Inactivation of the Entire TNF/LT Locus versus Single-Knockout Mice
D. Kuprash (2002)
10.1038/316552a0
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
B. Beutler (1985)



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