Online citations, reference lists, and bibliographies.
← Back to Search

Asbestos In Extrapulmonary Sites: Omentum And Mesentery.

R. Dodson, M. O'sullivan, J. Huang, David B. Holiday, S. Hammar
Published 2000 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
STUDY OBJECTIVES Asbestos fibers have not been reported in tissues from the peritoneal cavity. Therefore, omentum, mesentery, and lung tissues from 20 individuals in whom mesothelioma was diagnosed were analyzed for asbestos bodies and asbestos fibers. DESIGN Tissue was digested and prepared filters were analyzed by light microscopy and analytical transmission electron microscopy. RESULTS Asbestos bodies were found in the lungs of 18 individuals, mesentery samples from 5, and omentum samples from 2. Uncoated asbestos fibers were found in lungs of 19 patients, 17 of whom had fibers in at least one extrapulmonary site. The most common asbestos in the omentum and mesentery was amosite. Several features of asbestos found in lung influenced the likelihood of amphibole fibers being found in the omentum or mesentery. Lung features included total amphibole fiber burden, length, aspect ratio, and ferruginous body burden. An increased total ferruginous body burden was strongly associated with increased likelihood of detecting amphiboles in the omentum (p < 0. 05). CONCLUSION Asbestos fibers reach areas in the peritoneal cavity where some mesotheliomas develop. This study suggests their presence can be predicted based on concentrations and characteristics of fiber burdens in lung tissue.
This paper references
10.1164/ARRD.1976.114.1.187
Asbestos-related diseases of the lung and other organs: their epidemiology and implications for clinical practice.
M. Becklake (1976)
10.1111/j.1749-6632.1991.tb24443.x
A Comparison of Asbestos Burden in Lung Parenchyma, Lymph Nodes, and Plaques
R. Dodson (1991)
10.1289/EHP.803555
Lymphatic removal of fluids and particles in the mammalian lung.
L. Leak (1980)
The pathogenesis of pleural plaques and pulmonary asbestosis: possibilities and impossibilities.
G. Hillerdal (1980)
10.1136/oem.51.3.205
Retention patterns of asbestos fibres in lung tissue among asbestos cement workers.
M. Albin (1994)
10.1289/EHP.9088311
Effects of fiber characteristics on lung deposition, retention, and disease.
M. Lippmann (1990)
10.1080/15287398209530282
A procedure for the isolation of amosite asbestos and ferruginous bodies from lung tissue and sputum.
M. G. Williams (1982)
10.1164/AJRCCM/142.4.843
Asbestos content of lung tissue, lymph nodes, and pleural plaques from former shipyard workers.
R. Dodson (1990)
10.1164/ARRD.1977.115.4.625
Alveolar clearance and the role of the pulmonary lymphatics.
J. M. Lauweryns (1977)
10.1016/0013-9351(70)90033-2
Asbestos and mesotheliomas
M. Godwin (1970)
10.3109/01913129709021930
Analysis of asbestos fiber burden in lung tissue from mesothelioma patients.
R. Dodson (1997)
Asbestos bodies in pulmonary hilar lymph nodes.
V. Roggli (1990)
10.1136/oem.37.4.337
Deposition, retention, and clearance of inhaled particles.
M. Lippmann (1980)
10.1164/AJRCCM/139.4.885
Rapid short-term clearance of chrysotile compared with amosite asbestos in the guinea pig.
A. Churg (1989)
10.1016/0013-9351(82)90166-9
Analysis of cores of ferruginous bodies from former asbestos workers.
R. Dodson (1982)



This paper is referenced by
10.1111/j.1749-6632.2002.tb04931.x
Asbestos Fibers Contributing to the Induction of Human Malignant Mesothelioma
Y. Suzuki (2002)
10.1080/10937404.2011.556045
Applying Definitions of “Asbestos” to Environmental and “Low-Dose” Exposure Levels and Health Effects, Particularly Malignant Mesothelioma
B. Case (2011)
10.1191/0748233701th101oa
Asbestos content of omentum and mesentery in nonoccupationally exposed individuals
R. Dodson (2001)
10.1016/j.yrtph.2012.05.015
Malignant pleural mesothelioma in US automotive mechanics: reported vs expected number of cases from 1975 to 2007.
B. Finley (2012)
10.1136/oem.2009.051466
Incidence of extrapleural malignant mesothelioma and asbestos exposure, from the Italian national register
A. Marinaccio (2010)
10.1002/JSO.20266
Malignant peritoneal mesothelioma
K. Bani-Hani (2005)
10.1002/ajim.20694
Asbestos fibers in para-aortic and mesenteric lymph nodes.
T. Uibu (2009)
10.1136/ijgc-00009577-200401000-00023
Malignant peritoneal mesothelioma in a 76-year-old woman with a history of asbestos fiber ingestion
P. V. van Kesteren (2003)
10.3109/01913123.2016.1170085
Asbestos content of lung tissue in patients with malignant peritoneal mesothelioma: A study of 42 cases
G. D. de Ridder (2016)
10.1002/AJIM.10263
Asbestos fiber length as related to potential pathogenicity: a critical review.
R. Dodson (2003)
10.1111/j.1440-1827.2009.02452.x
Malignant peritoneal mesothelioma: Quantitative analysis of asbestos burden
Ryota Kurimoto (2009)
10.1007/3-540-30903-9_8
Mineralogical Analysis of Lung Samples
P. Dumortier (2006)
10.1186/1476-069X-7-4
Translocation pathways for inhaled asbestos fibers
Giuseppe Miserocchi (2008)
[The role of asbestos fibre dimensions in the pathogenesis and prevention of mesothelioma].
L. Tomatis (2006)
10.1016/j.tranon.2014.12.002
Changing Pattern in Malignant Mesothelioma Survival
J. Faig (2015)
10.1080/10937404.2016.1195319
Tyler asbestos workers: A mortality update in a cohort exposed to amosite
J. Levin (2016)
Increased mesothelioma incidence in New Zealand: the asbestos-cancer epidemic has started.
T. Kjellstrom (2000)
10.1201/9781420038149.ch3
Analysis and Relevance of Asbestos Burden in Tissue
R. Dodson (2011)
10.1201/B10958-14
Malignant Diseases Attributed to Asbestos Exposure
Gary D. Friedman (2011)
10.21037/jgo.2017.08.01
Clinical presentation, diagnosis, classification and management of peritoneal mesothelioma: a review.
A. García-Fadrique (2017)
10.2486/INDHEALTH.39.150
Asbestos tissue burden study on human malignant mesothelioma.
Y. Suzuki (2001)
10.1007/s12199-016-0576-5
Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study
Y. Koga (2016)
10.1007/978-1-4471-2825-0_15
Malignant Mesothelioma: Asbestos Exposure
R. Attanoos (2014)
10.1201/9781420038149.CH4
Molecular and Cellular Responses to Asbestos Exposure
M. Atkinson (2005)
10.1007/978-3-642-02322-4_43
Tumoren und tumorartige Läsionen des Peritoneums
F. Offner (2013)
10.1007/978-3-030-30766-0_19
Malignant Mesothelioma: Mechanism of Carcinogenesis
A. Kane (2014)
10.1002/AJIM.20236
Re: Evaluation of the size and type of free particulates collected from unused asbestos-containing brake components as related to potential for respirability.
D. Paustenbach (2006)
III Italian Consensus Conference on Malignant Mesothelioma of the Pleura. Epidemiology, Public Health and Occupational Medicine related issues.
C. Magnani (2015)
10.1007/978-0-387-72114-9_12
Neoplasms of the Pleura
S. Hammar (2008)
10.1080/10937404.2016.1195326
Quantitative structure–mesothelioma potency model optimization for complex mixtures of elongated particles in rat pleura: A retrospective study
P. M. Cook (2016)
10.1016/j.canep.2019.04.001
Peritoneal mesothelioma mortality in Italy: Spatial analysis and search for asbestos exposure sources.
A. Zona (2019)
10.1002/jcp.22724
Malignant mesothelioma: Facts, Myths, and Hypotheses
M. Carbone (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar