Online citations, reference lists, and bibliographies.
← Back to Search

Cigarette Smoking, Preinvasive Bronchial Lesions, And Autofluorescence Bronchoscopy.

D. Moro-Sibilot, M. Jeanmart, S. Lantuéjoul, F. Arbib, M. H. Laverriere, E. Brambilla, C. Brambilla
Published 2002 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
STUDY OBJECTIVES Autofluorescence bronchoscopy (AFB), when used as an adjunct to standard white light bronchoscopy (WLB), enhances the bronchoscopist's ability to localize small neoplastic lesions, especially intraepithelial lesions. The current study was undertaken in order to define the population in which the rate of detection is higher using AFB. DESIGN AND PATIENTS Two hundred forty-four consecutive patients, who were symptomatic smokers or patients who previously had been treated for lung cancer or head and neck cancers, underwent WLB and AFB. All patients with endoscopic abnormalities underwent biopsies. Data concerning smoking history were prospectively registered. RESULTS We report the prevalence of high-grade or invasive lesions at the time of examination. On a lesion-by-lesion analysis, 92 low-grade lesions, 42 high-grade lesions (ie, moderate dysplasia, severe dysplasia, and carcinoma in situ), and 39 invasive carcinomas were diagnosed. There was no effect of age, gender, and age at smoking initiation on the prevalence of preinvasive or invasive lesions. The 10 patients who previously had undergone surgery for lung cancer and exhibited high-grade preinvasive lesions had a history of carcinoma of the epidermoid histologic type (p = 0.01). These 10 patients displayed multiple lesions in the bronchial tree (mean No. of lesions, 1.8 per patient). In current smokers, the prevalence of high-grade or invasive lesions were both related to the number of pack-years smoking had occurred (p = 0.01) and to the duration of smoking (p = 0.01). In contrast, the prevalence of preinvasive lesions in former smokers was related to a history of epidermoid carcinoma. CONCLUSIONS AFB should be recommended in patients with a history of epidermoid carcinomas of the lung. Current smokers with a prolonged smoking history appear to comprise a population in which the rate of detection of preneoplastic lesions is high with AFB.
This paper references
Fluorescence versus white-light bronchoscopy for detection of preneoplastic lesions: a randomized study.
F. Hirsch (2001)
Early age at smoking initiation and tobacco carcinogen DNA damage in the lung.
J. Wiencke (1999)
Tolerance and acceptability of autofluorescence endoscopy performed under local anesthesia [abstract
L Thiberville (1996)
Bronchial Intraepithelial Neoplastic Lesions in Head and Neck Cancer Patients: Results of Autofluorescence Bronchoscopy
B. Venmans (2001)
Sex-related differences in bronchial epithelial changes associated with tobacco smoking.
S. Lam (1999)
Detection of dysplasia and carcinoma in situ with a lung imaging fluorescence endoscope device.
S. Lam (1993)
Tolerance and acceptability of autofluorescence endoscopy performed under local anesthesia
L Thiberville
A randomized study of fluorescence bronchoscopy vs white light bronchoscopy for early detection of lung cancer in high risk patients [ abstract ]
TC Kennedy (2000)
Follow-up of bronchial precancerous lesions and carcinoma in situ using fluorescence endoscopy.
S. Bota (2001)
Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977.
O. Auerbach (1979)
Clonal genetic alterations in the lungs of current and former smokers.
L. Mao (1997)
Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy.
S. Lam (1998)
The molecular and cellular basis of human lung cancer.
A. Gazdar (1994)
Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies
R. Peto (2000)
Lights flicker on fluorescence bronchoscopy in patients at risk for lung cancer.
K. M. O'Neil (1998)
The multistep nature of cancer.
B. Vogelstein (1993)
Squamous metaplasia of the bronchial mucosa and its relationship to smoking.
E. J. Peters (1993)
Molecular damage in the bronchial epithelium of current and former smokers.
I. Wistuba (1997)
The new World Health Organization classification of lung tumours
E. Brambilla (2001)
Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers.
R. Doll (1978)
Postoperative fluorescence bronchoscopic surveillance in non-small cell lung cancer patients.
T. Weigel (2001)
Autofluorescence bronchoscopy in the detection of squamous metaplasia and dysplasia in current and former smokers.
J. Kurie (1998)
Variable regression of experimental bronchial preneoplasia during carcinogenesis.
W. Hammond (1991)
A randomized study of fluorescence bronchoscopy versus white-light bronchoscopy for early detection of lung cancer in high risk patients
T. Kennedy (2000)
Dark tobacco and lung cancer in Cuba.
O. G. Joly (1983)
Regression of bronchial epithelial cancer in hamsters.
R. Sawyer (1993)
Cytokines and obstructive lung disease: introduction
M. Decramer (2001)
Determination of biomarkers for intermediate end points in chemoprevention trials.
J. S. Lee (1992)
Early Detection of Preinvasive Lesions in High-Risk Patients: A Comparison of Conventional Flexible and Fluorescence Bronchoscopy
B. Venmans (1998)

This paper is referenced by
Diagnostic bronchoscopy: state of the art
C. Dooms (2010)
A&E department: a missed opportunity for diagnosis of TB?
A. Smith (2006)
The Future of Bronchoscopy in Diagnosing, Staging and Treatment of Lung Cancer
F. Herth (2006)
Diagnostic value of autofluorescence bronchoscopy in lung cancer
B. Zaric (2013)
Autofluorescence videothoracoscopy in exudative pleural effusions: preliminary results
M. G. Chrysanthidis (2005)
Autofluorescence bronchoscopy and endobronchial ultrasound: a practical review.
D. Feller-Kopman (2005)
Principes d’application clinique de la photothérapie dynamique
H. Stepp (2008)
Traitements endoscopiques dans le cancer bronchique
Diane Leduc (2014)
Clinical prognostic indicators of high-grade pre-invasive bronchial lesions
D. Moro-Sibilot (2004)
[Bronchoscopy in the diagnosis of lung cancer: an evaluation of current practice].
F. Barlesi (2006)
Is there a relationship between the presence of lung mucosa preinvasive lesions and lung cancer incidence? Influence of tobacco consumption.
C. Clément-Duchêne (2014)
Role of inositol to improve surfactant functions and reduce IL-6 levels: A potential adjuvant strategy for SARS-CoV-2 pneumonia?
A. Laganà (2020)
Precursor and Preinvasive Lesions
A. Borczuk (2018)
Bronchoscopie par autofluorescence : contribution au diagnostic précoce du cancer bronchique
M. Taulelle (2005)
Autofluorescent Imaging in Patients With Peritoneal Carcinomatosis
Philipp von Breitenbuch (2014)
Early detection and screening of lung cancer
C. Mascaux (2010)
Comprehensive diagnostic bronchoscopy of central type early stage lung cancer.
N. Ikeda (2007)
Diagnosis and treatment of bronchial intraepithelial neoplasia and early lung cancer of the central airways: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
J. Wisnivesky (2013)
Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer.
A. Ali (2011)
Photodynamic therapy (PDT) in early central lung cancer: a treatment option for patients ineligible for surgical resection
K. Moghissi (2007)
Pathology and genetics of tumours of the lung , pleura, thymus and heart
W. D. Travis (2004)
Fluorescent bronchoscopy: contribution for lung cancer screening?
F. Stanzel (2004)
Abnormal Autofluorescence Bronchoscopy Pattern in a Bronchial Lipoma
F. Menivale (2004)
The Value of Autofluorescence Bronchoscopy Combined with White Light Bronchoscopy Compared with White Light Alone in the Diagnosis of Intraepithelial Neoplasia and Invasive Lung Cancer: A Meta-Analysis
J. Sun (2011)
Promoter methylation of genes in bronchial lavages: a marker for early diagnosis of primary and relapsing non-small cell lung cancer?
F. de Fraipont (2005)
Per lesion analysis is misleading.
K.-C. Chang (2006)
From Expert Review of Molecular Diagnostics
C. Mascaux (2010)
Bronchial intraepithelial neoplasia/early central airways lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition).
T. Kennedy (2007)
Current indications and future perspective of fluorescence bronchoscopy: a review study.
K. Moghissi (2008)
Effective detection of bronchial preinvasive lesions by a new autofluorescence imaging bronchovideoscope system.
M. Chiyo (2005)
Bimodality Lung Cancer Screening in High-Risk Patients
G. Loewen (2004)
Early proximal lung cancer diagnosis and treatment
A. McWilliams (2009)
See more
Semantic Scholar Logo Some data provided by SemanticScholar