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Delay Phenomenon By Botulinum Toxin A In Transverse Rectus Abdominis Myocutaneous (TRAM) Flap Of Rat

Joo Chul Lee, E. S. Park, Yong Bae Kim
Published 2013 · Medicine

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Currently, delay procedures remain a reliable method of maximizing flap survival but the necessity of additional procedures is a persistent disadvantage. Botulinum toxin A (BTXA) is considered to exert the most powerful neuromuscular blockade. In this study, BTXA is used to demonstrate the usefulness of a chemical delay technique. Thirty rats were subdivided into three groups of 10. In the group 1(control), no procedure was performed before the transverse rectus abdominis musculocutaneous (TRAM) flap elevation. In the group 2 (surgical delay), TRAM flaps were delayed surgically one week before formal elevation. And, in the group 3 (BTXA delay) rats, 4U BTXA was injected into the under surface of TRAM flaps two weeks before surgical elevation. The TRAM flaps were designed in rectangular shape, on the rat abdomen. On the seventh day after operation, the results were evaluated and compared in terms of flap survival area, vessel counts and vascular endothelial growth factor (VEGF) expression. The mean percentages of the flap survival area in group 2 (71.76 ±.86%) and group 3 (73.92±.70%) were significantly higher than those in group 1 (34.60±.14%) (p<0.05). The vessel counts of group 2 (13.90±.18) and group 3 (15.40±.88%) were significantly higher than those of group 1 (5.10±.20) (p<0.05). The VEGF expression is increased in two experimental groups than in the control group. In conclusion, the injection of BTXA could increase flap survival area in rat TRAM flap model, as likely as surgical delay. These results are thought to be made due to the effect of chemodenervation and secondary inflammation. (Archives of Aesthetic Plastic Surgery 19: 64, 2013)
This paper references
Botulinum-induced changes in monkey eyelid muscle. Comparison with changes seen in extraocular muscle.
J. Porter (1991)
Study of the Delay Phenomenon in the Rat TRAM Flap Model
H. E. Özgentaş (1994)
Delay Phenomenon by Lipo-PGE1 in Single Perforator-based Abdominal Skin Flap of Rat
W. I. Son (2004)
Histopathologic Changes after Injection of Botulinum Toxin A in the Rat.
S. Y. Kim (2000)
Pharmacology and immunology of botulinum toxin serotypes
K. Aoki (2001)
The Effect of Botulinum Toxin-A on the Survival of Random-Pattern Cutaneous Flap in Rat
Young-Seok Kim (2008)
Prefabrication of a secondary TRAM flap.
H. E. Ozgentaş (1995)
Chemical Delay: An Alternative to Surgical Delay Experimental Study
E. Karacaoğlu (2002)
Development of a TRAM Flap Model in the Rat and Study of Vascular Dominance
H. E. Özgentaş (1994)
The effects of botulinum toxin A on the survival of a random cutaneous flap.
T. K. Kim (2009)
Improvement of Skin Paddle Survival by Application of Vascular Endothelial Growth Factor in a Rat TRAM Flap Model
F. Zhang (2001)
Versatility of Botulinum Toxin: A Use in Stabilization of Pedicled Muscle Flaps
Esra Celik (2006)
Repeated stimuli for axonal growth causes motoneuron death in adult rats: the effect of botulinum toxin followed by partial denervation
C. M. White (1999)

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