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Toxic Effects Of Crotocaudin Extracted From The Medicinal Plant Croton Tiglium

R. P. Yadav, A. Singh
Published 2010 · Medicine, Biology

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The compound crotocaudin extracted from the stem bark of the medicinal plant Croton tiglium Linn. was administered for 24 h or 96 h to the freshwater vector snail Lymnaea (Radix) acuminata Lamarck in order to test its toxicity. L. acuminata is the intermediate host of Fasciola hepatica and Fasciola gigantica which cause immense harm to man and his domestic animals. It was observed that the molluscicidal activity of crotocaudin against L. acuminata is time- as well as dose-dependent. There was a significant negative correlation among LC50 values and exposure periods, i.e. increasing the exposure time, the LC50 value of crotocaudin decreased from 5.37 μM (24 h) > 2.08 μM (48 h) > 1.36 μM (72 h) to 1.01 μM (96 h), respectively, against L. acuminata. The toxicological experiments to proof for environmental toxicity, if any, have also been carried out on the non-target freshwater fish Channa punctatus (Bloch) [Channidae (Ophicephalidae)], which shares the habitat with L. acuminata. The sublethal doses of crotocaudin (40% and 80% of LC50) administered over 24 h caused significant changes in the carbohydrate and nitrogenous metabolisms in nervous, hepatopancreas, and ovotestis tissues of Lymnaea acuminata. Channa punctatus was also exposed to sublethal doses of crotocaudin (40% and 80% of 24-h LC50 of L. acuminata) for 96 h which showed significant alterations in the metabolism in muscle, liver, and gonad tissues. After withdrawal of crotocaudin the snail tissues recovered in part after 7 days and the fish tissues completely.
This paper references
Two methods for the determination of glycogen in liver.
J. van der Vies (1954)
10.1201/9781003075363
Fundamentals of Aquatic Toxicology
S. R. Petrocelli (1985)
A modifi ed ninhydrine reagent for the photometric determination of amino acids and related compounds
Moore S Stein (1954)
Determination of nucleic acids in tissue by pentose analysis
P. ColowickS. (1957)
Antifungal , molluscicidal and cytotoxic compounds from plants used in traditional medicine
K. Hostettmann (1987)
Studies on some aspects of metabolic changes with emphasis on carbohydrate utility in the cell - free systems of the teleost T . mos - sambica ( Peters ) under methyl parathion exposure
K. SivaPrasadaRao (1980)
10.2105/AJPH.56.3.387
Standard methods for the examination of water and waste water.
F. W. Gilcreas (1966)
Effect of nuvan on some biochemical parameters of Indian catfi sh Mystus vittatus
T Arasta (1996)
10.1002/aheh.19880160202
Harmful gastropods and their control
R. A. Agarwal (1988)
10.1080/00401706.1996.10484493
Introduction to biostatistics
B. Armstrong (1998)
A microspectrophotometric method for the determination of cytochrome oxidase.
S. Cooperstein (1951)
10.1038/1931256a0
Limitations of the Phenazine Methosulphate Assay for Succinic and Related Dehydrogenases
O. Arrigoni (1962)
TM: Lactatic dehydrogenase (quantitative, colorimetric determination in serum, urine and cerebrospinal fl uid) at 400 -450 nm
Sigma Diagnostics (1984)
A new computer programme for probit log analysis
R M Russel (1977)
PYRUVIC ACID I. COLLECTION OF BLOOD FOR THE DETERMINATION OF PYRUVIC AND LACTIC ACIDS
T. Friedemann (1942)
Studies on some aspects of metabolic changes with emphasis on carbohydrate utility in the cell - free systems of the teleost T . mos - sambica ( Peters ) under methyl parathion exposure
K. SivaPrasadaRao (1980)
a (33) 3.622 ± 0.011 a (91) Liver
Determination of nucleic acids in tissue by pentose analysis
O. KaplanN. (1957)
10.1016/S0140-6736(85)90177-1
THREE-YEAR PROSPECTIVE STUDY OF THE EVOLUTION OF MANSON'S SCHISTOSOMIASIS IN NORTH-EAST BRAZIL
A. Sleigh (1985)
Studies of DNA-strand induced in human fibroblasts by chemical mutagens/carcinogens.
Magnus Nordenskjöld (1979)
A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.
S. Moore (1954)
(112) 98.30 ± 0.11 (151) 69.65 ± 0.21 a (107) Cytochrome oxidase Muscle
Colorimetric procedure for amino acids
R. SpiesJ. (1957)
10.1007/BF01057593
In vivo andIn vitro studies on synergism with anticholinesterase pesticides in the snailLymnaea acuminata
D. Singh (1983)
The colorimetric determination of lactic acid in biological material.
S. B. Barker (1941)
Protein measurement with the Folin phenol reagent.
O. H. Lowry (1951)
10.1093/jee/74.5.568
Toxicity of Certain Pesticides to Two Economic Species of Snails in Northern India
O. Singh (1981)
10.1016/0040-4020(77)80255-X
Crotocaudin; a rearranged labdane type norditerpene from Croton caudatus geisel
A. Chatterjee (1977)
Blood analysis , determination of lactic acid
L. OserB. (1961)
Effect of nu - van on some biochemical parameters of Indian cat - fi sh Mystus vittatus
O. Arrigoni (1996)
10.1016/0027-5107(79)90071-X
Studies of DNA-strand breaks induced in human fibroblasts by chemical mutagens/carcinogens
M. Nordenskjöld (1979)
Concept of Molecular Genetics, TMH Edition
D O M Woodward (1978)
Introduction to Biostatistics Colorimetric procedure for amino acids
R R Sokal (1957)
A modifi ed ninhydrine reagent for the photometric determination of amino acids and related compounds
M. Nordenskjold (1954)
Method of Enzymatic Analysis
U H Bergmeyer (1967)
LACTATE DEHYDROGENASE--STRUCTURE AND FUNCTION.
N. Kaplan (1964)
Blood analysis, determination of lactic acid In: Hawk's Physiological Chemistry
W E Huckabee (1961)
LACTATE DEHYDROGENASE--STRUCTURE AND FUNCTION.
Kaplan No (1964)
10.1042/bj0570410
Two methods for the determination of glycogen in liver.
J. V. D. Vies (1954)
10.1055/s-2007-971215
Plant molluscicides.
H. Kloos (1982)
A modifi ed ninhy - drine reagent for the photometric determination of amino acids and related compounds
M. Nordenskjold (1954)
10.1002/ps.2780130607
Changes induced by phorate in the carbohydrate metabolism of the snail Lymnaea acuminata
Vijay K. Mahendru (1982)
A new computer programme for probit log analysis
C. SchneiderW. (1977)
Effect of nuvan on some biochemical parameters of Indian catfi sh Mystus vittatus
O Arrigoni (1996)
Antifungal, molluscicidal and cytotoxic compounds from plants used in traditional medicine
A Marston (1987)
10.1038/184573b0
The Invertebrates
N. Eales (1959)
10.1097/00000542-197110000-00015
Effects of halothane, anoxia, and hemorrhage upon canine whole-body, skeletal muscle, and splanchnic excess lactate production.
R. A. Theye (1971)
Studies on some aspects of metabolic changes with emphasis on carbohydrate utility in the cell-free systems of the teleost T. mossambica (Peters) under methyl parathion exposure
Siva Prasada Rao (1980)
10.1007/BF01920243
Biochemical and environmental perspectives on nitrogen metabolism in fishes
T. Mommsen (2005)
Control of phosphorylase activity in a muscle glycogen particle. II. Activation by calcium.
L. Heilmeyer (1970)
10.1016/0006-2952(61)90145-9
A new and rapid colorimetric determination of acetylcholinesterase activity.
G. Ellman (1961)
10.1016/0048-9697(88)90058-7
Possibility of using latex of euphorbiales for snail control
A. Singh (1988)
In vivo and in vitro studies on synergism with anticholinesterase pesticides in the snail Lymnaea acuminata
K. SinghD. (1983)
Determination of nucleic acids in tissue by pentose analysis
W C Schneider (1957)
In vivo and in vitro studies on synergism with anticholinesterase pesticides in the snail Lymnaea acuminata. Arch. Environ
D K Singh (1983)
10.2307/1402925
Introduction to Biostatistics
R. Cormack (1975)
10.1021/ac60048a026
Folin colorimetric procedure for amino acids.
N. Furman (1950)



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