Online citations, reference lists, and bibliographies.
← Back to Search

Anatomical Evidence Of Multimodal Integration In Primate Striate Cortex

A. Falchier, S. Clavagnier, P. Barone, H. Kennedy
Published 2002 · Psychology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The primary visual cortex (area 17 or V1) is not thought to receive input from nonvisual extrastriate cortical areas. However, this has yet to be shown to be the case using sensitive tracers in the part of area 17 subserving the peripheral visual field. Here we show using retrograde tracers that peripheral area 17 subserving the visual field at an eccentricity of 10–20° receives projections from the core and parabelt areas of the auditory cortex as well as from the polysensory area of the temporal lobe (STP). The relative strength of these projections was calculated for each injection by computing the proportions of retrogradely labeled neurons located in the auditory and STP areas with respect to number of labeled neurons constituting the established projection from the superior temporal sulci (STS) motion complex (middle temporal area, medial superior temporal, fundus of the superior temporal area). In peripheral area V1 the projection from auditory cortex corresponds to 9.5% of that of the STS motion complex and STP to 35% of that from the STS motion complex. Compared to peripheral area 17, central and paracentral area 17 showed considerably weaker inputs from auditory cortex (0.2–0.8%) but slightly more from STP cortex (3.5–6.1%). The present results show that the connectivity of area 17 is eccentricity dependent. Direct projections from auditory and STP cortex to peripheral area 17 have important consequences for higher visual functions of area 17, including multimodal integration at early stages of the visual cortical pathway.
This paper references
10.1038/22106
Improved auditory spatial tuning in blind humans
B. Roeder (1999)
10.1038/38278
Functional relevance of cross-modal plasticity in blind humans
L. Cohen (1997)
10.1523/JNEUROSCI.07-02-00330.1987
Functional subdivisions of the temporal lobe neocortex
G. Baylis (1987)
10.1152/JN.1997.78.3.1263
Sensory modality specificity of neural activity related to memory in visual cortex.
J. Gibson (1997)
10.1126/SCIENCE.7792596
How the brain creates imagery: projection to primary visual cortex.
Y. Miyashita (1995)
10.1093/CERCOR/1.1.1
Distributed hierarchical processing in the primate cerebral cortex.
D. Felleman (1991)
10.1523/JNEUROSCI.03-12-02563.1983
The connections of the middle temporal visual area (MT) and their relationship to a cortical hierarchy in the macaque monkey
J. Maunsell (1983)
10.1162/089892999563544
Auditory-Visual Integration during Multimodal Object Recognition in Humans: A Behavioral and Electrophysiological Study
M. H. Giard (1999)
10.1002/(SICI)1096-9861(19961202)376:1<112::AID-CNE7>3.0.CO;2-6
Neurofilament protein is differentially distributed in subpopulations of corticocortical projection neurons in the macaque monkey visual pathways
P. Hof (1996)
10.1093/BRAIN/121.3.409
Different activation patterns in the visual cortex of late and congenitally blind subjects.
C. Büchel (1998)
10.1002/1531-8249(199904)45:4<451::AID-ANA6>3.0.CO;2-B
Period of susceptibility for cross‐modal plasticity in the blind
L. Cohen (1999)
10.1073/PNAS.97.22.11800
Mechanisms and streams for processing of "what" and "where" in auditory cortex.
J. Rauschecker (2000)
10.1038/85170
Two distinct modes of sensory processing observed in monkey primary visual cortex (V1)
H. Supèr (2001)
10.1007/978-1-4757-9625-4_10
The Superior Temporal Polysensory Region in Monkeys
C. Cusick (1997)
10.1002/CNE.902260204
Direct connections of rat visual cortex with sensory, motor, and association cortices
M. Miller (1984)
10.1002/CNE.903080411
Topographic organization of cortical input to striate cortex in the Cebus monkey: A fluorescent tracer study
A. B. Sousa (1991)
10.5860/choice.31-4365
The Merging of the Senses
B. Stein (1993)
10.1002/CNE.903600312
Chemoarchitectonics and corticocortical terminations within the superior temporal sulcus of the rhesus monkey: Evidence for subdivisions of superior temporal polysensory cortex
C. Cusick (1995)
10.1152/JN.1999.82.1.343
Responses to auditory stimuli in macaque lateral intraparietal area. II. Behavioral modulation.
J. F. Linden (1999)
@BULLET Primary Visual Cortex and Multisensory Integration J. Neurosci
Falchier (2002)
10.1073/PNAS.97.17.9777
Visuo-tactile cross-modal associations in cortical somatosensory cells.
Y. Zhou (2000)
10.1016/0042-6989(84)90041-5
The visual field representation in striate cortex of the macaque monkey: Asymmetries, anisotropies, and individual variability
D. Essen (1984)
10.1007/978-1-4612-2838-7_5
Physiology of Thalamus and Cortex
J. Clarey (1992)
10.1007/BF00229410
Prosencephalic connections of striate and extrastriate areas of rat visual cortex
K. J. Sanderson (2004)
10.1007/s002210050553
Neural mechanisms for synthesizing sensory information and producing adaptive behaviors
B. Stein (1998)
Physiology of thalamus and cortex. In: The mammalian auditory pathways: neurophysiology (Fay R, Popper A, eds), pp 232–334
JC Clarey (1992)
10.1016/0028-3932(86)90091-6
Impairments in orienting to visual stimuli in monkeys following unilateral lesions of the superior sulcal polysensory cortex
Karen E. Luh (1986)
10.1002/CNE.902960311
Pathways for motion analysis: Cortical connections of the medial superior temporal and fundus of the superior temporal visual areas in the macaque
D. Boussaoud (1990)
10.1073/PNAS.97.22.11793
Subdivisions of auditory cortex and processing streams in primates.
J. Kaas (2000)
10.1093/BRAIN/93.4.793
An anatomical study of converging sensory pathways within the cerebral cortex of the monkey.
E. Jones (1970)
10.1046/j.0953-816x.2001.01538.x
The cortical connections of area V6: an occipito‐parietal network processing visual information
C. Galletti (2001)
10.1152/JN.1999.82.1.330
Responses to auditory stimuli in macaque lateral intraparietal area. I. Effects of training.
A. Grunewald (1999)
10.1002/(SICI)1096-9861(19980713)396:4<493::AID-CNE6>3.0.CO;2-X
Area‐specific laminar distribution of cortical feedback neurons projecting to cat area 17: Quantitative analysis in the adult and during ontogeny
A. Batardière (1998)
10.1001/ARCHNEUR.1994.00540220060015
Posterior neocortical systems subserving awareness and neglect. Neglect associated with superior temporal sulcus but not area 7 lesions.
R. T. Watson (1994)
10.1523/JNEUROSCI.20-09-03263.2000
Laminar Distribution of Neurons in Extrastriate Areas Projecting to Visual Areas V1 and V4 Correlates with the Hierarchical Rank and Indicates the Operation of a Distance Rule
P. Barone (2000)
10.1002/CNE.902290103
Corticocortical connections among visual areas in the cat
L. Symonds (1984)
10.1152/JN.1988.60.5.1615
Polysensory properties of neurons in the anterior bank of the caudal superior temporal sulcus of the macaque monkey.
K. Hikosaka (1988)
10.1523/JNEUROSCI.21-21-08594.2001
Motion Processing in the Macaque: Revisited with Functional Magnetic Resonance Imaging
A. Tolias (2001)
10.1162/089892900564037
Transient Activity in the Human Calcarine Cortex During Visual-Mental Imagery: An Event-Related fMRI Study
I. Klein (2000)
10.1126/SCIENCE.1060698
Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors
J. Rutter (2001)
10.1126/SCIENCE.276.5312.593
Activation of auditory cortex during silent lipreading.
G. Calvert (1997)
10.1111/j.1460-9568.1989.tb00799.x
The Organization of Connections between Areas V5 and V2 in Macaque Monkey Visual Cortex
S. Shipp (1989)
10.1038/16056
Dual streams of auditory afferents target multiple domains in the primate prefrontal cortex
L. Romanski (1999)
10.1016/S0896-6273(02)00580-9
Evidence for a Modified V3 with Dorsal and Ventral Halves in Macaque Monkeys
D. C. Lyon (2002)
10.1017/S0952523800000080
Antibody labeling of functional subdivisions in visual cortex: Cat-301 immunoreactivity in striate and extrastriate cortex of the macaque monkey.
E. DeYoe (1990)
10.1002/CNE.903170302
Visual factors in sound localization in mammals
R. Heffner (1992)
10.1002/CNE.902720106
Characterization of transient cortical projections from auditory, somatosensory, and motor cortices to visual areas 17, 18, and 19 in the kitten
C. Dehay (1988)
10.1016/0006-8993(75)90833-1
Cortico-cortical projections from striate cortex of the squirrel monkey (Saimiri sciureus). A radioautographic study
Luis Martinez-Milla´n (1975)
10.1113/jphysiol.1961.sp006803
The representation of the visual field on the cerebral cortex in monkeys
P. Daniel (1961)
10.1016/S0042-6989(97)00464-1
The role of the primary visual cortex in higher level vision
T. Lee (1998)
10.1152/JN.2000.83.4.2315
Frequency and intensity response properties of single neurons in the auditory cortex of the behaving macaque monkey.
G. Recanzone (2000)
Involuntary orienting to sound improves visual perception
M. Keeling (2000)
10.1002/CNE.902720207
Development of projections from auditory to visual areas in the cat
G. Innocenti (1988)
10.1002/(SICI)1096-9861(19970922)386:2<304::AID-CNE10>3.0.CO;2-K
Tonotopic organization of auditory cortical fields delineated by parvalbumin immunoreactivity in macaque monkeys
H. Kosaki (1997)
10.1006/nimg.2001.0812
Detection of Audio-Visual Integration Sites in Humans by Application of Electrophysiological Criteria to the BOLD Effect
G. Calvert (2001)
10.1152/JN.1981.46.2.369
Visual properties of neurons in a polysensory area in superior temporal sulcus of the macaque.
C. Bruce (1981)
10.1038/380526A0
Activation of the primary visual cortex by Braille reading in blind subjects
N. Sadato (1996)
10.1007/BF00230466
Retinotopy of cortical connections between the striate cortex and extrastriate visual areas in the rat
V. Montero (2004)
10.1152/JN.1994.72.5.2383
Functional organization of sound direction and sound pressure level in primary auditory cortex of the cat.
J. Clarey (1994)
10.1016/S0896-6273(01)00318-X
Cross-Modal Plasticity Underpins Language Recovery after Cochlear Implantation
A. Giraud (2001)
10.1126/SCIENCE.1058911
Functional Specialization in Rhesus Monkey Auditory Cortex
B. Tian (2001)
10.1126/SCIENCE.1057099
Fast Backprojections from the Motion to the Primary Visual Area Necessary for Visual Awareness
A. Pascual-Leone (2001)
10.1002/CNE.902010405
Visual topography of V2 in the macaque
R. Gattass (1981)
10.1002/(SICI)1096-9861(19960715)371:1<129::AID-CNE8>3.0.CO;2-5
Topographic patterns of V2 cortical connections in macaque monkeys
I. Stepniewska (1996)
Physiology of thalamus and cortex. In: The mammalian auditory pathways: neurophysiology
Jc Clarey (1992)
10.1212/WNL.52.7.1413
Neural pathways in tactile object recognition
E. Deibert (1999)
10.1002/CNE.903340111
Cortical connections of inferior temporal area TEO in macaque monkeys
C. Distler (1993)
10.1017/S0952523800006064
Cortical afferents of visual area MT in the Cebus monkey: possible homologies between New and Old World monkeys.
M. G. Rosa (1993)
10.1126/SCIENCE.289.5482.1206
Modulation of human visual cortex by crossmodal spatial attention.
E. Macaluso (2000)
10.1002/CNE.903350312
Tonotopic organization, architectonic fields, and connections of auditory cortex in macaque monkeys
A. Morel (1993)
10.1523/JNEUROSCI.20-07-02664.2000
A Positron Emission Tomographic Study of Auditory Localization in the Congenitally Blind
R. Weeks (2000)
10.1073/PNAS.94.14.7617
Functional impact of cerebral connections.
W. Vanduffel (1997)
10.1002/(SICI)1096-9861(19980518)394:4<475::AID-CNE6>3.0.CO;2-Z
Subdivisions of auditory cortex and ipsilateral cortical connections of the parabelt auditory cortex in macaque monkeys
T. Hackett (1998)
10.1152/JN.2000.83.5.2723
Correlation between the activity of single auditory cortical neurons and sound-localization behavior in the macaque monkey.
G. Recanzone (2000)
10.1007/BF00229557
Combined eye-head gaze shifts to visual and auditory targets in humans
J. Goldring (2004)
10.1016/S0960-9822(00)00513-3
Evidence from functional magnetic resonance imaging of crossmodal binding in the human heteromodal cortex
G. Calvert (2000)
10.1152/JN.1996.75.3.1206
Cortical synthesis of azimuth-sensitive single-unit responses with nonmonotonic level tuning: a thalamocortical comparison in the cat.
P. Barone (1996)
10.1017/S0952523800002480
Divergent feedback connections from areas V4 and TEO in the macaque.
K. Rockland (1994)
10.1002/cne.1407
Architectonic identification of the core region in auditory cortex of macaques, chimpanzees, and humans
T. Hackett (2001)
10.1523/JNEUROSCI.05-10-02815.1985
A double-labeling investigation of the afferent connectivity to cortical areas V1 and V2 of the macaque monkey
H. Kennedy (1985)
10.1523/JNEUROSCI.11-01-00168.1991
Organization of visual inputs to the inferior temporal and posterior parietal cortex in macaques
J. Baizer (1991)
10.1002/(SICI)1096-9861(19981026)400:3<417::AID-CNE10>3.0.CO;2-O
Brainstem inputs to the ferret medial geniculate nucleus and the effect of early deafferentation on novel retinal projections to the auditory thalamus
A. Angelucci (1998)
10.1038/380479a0
Novel sensations in the congenitally blind
Tim Rons (1996)
TOPOGRAPHY OF COGNITION: Parallel Distributed Networks in Primate Association Cortex
P. Goldman (1988)



This paper is referenced by
10.1371/journal.pone.0122862
A Synchrony-Dependent Influence of Sounds on Activity in Visual Cortex Measured Using Functional Near-Infrared Spectroscopy (fNIRS)
I. M. Wiggins (2015)
10.1016/B978-0-444-53860-4.00016-7
Self-organization and interareal networks in the primate cortex.
H. Kennedy (2012)
10.3389/fpsyg.2013.00664
Sensitive and critical periods in visual sensory deprivation
P. Voss (2013)
10.1016/j.neubiorev.2012.01.008
The role of visual experience for the neural basis of spatial cognition
A. Pasqualotto (2012)
10.6084/M9.FIGSHARE.C.4658321.V1
Supplementary material from "Synaesthesia: a distinct entity that is an emergent feature of adaptive neurocognitive differences"
J. Ward (2019)
L'intégration audiovisuelle en fonction du type de stimuli, de la maturation, de l'intégrité neurologique et de l'expérience
C. Tremblay (2009)
10.1007/s10339-004-0012-4
Neuroimaging of multisensory processing in vision, audition, touch, and olfaction
T. Thesen (2004)
10.1371/journal.pbio.1000445
Auditory Cortex Tracks Both Auditory and Visual Stimulus Dynamics Using Low-Frequency Neuronal Phase Modulation
H. Luo (2010)
10.1038/nrn2331
Multisensory integration: current issues from the perspective of the single neuron.
B. Stein (2008)
10.1016/j.neulet.2006.01.069
Cortical oscillations related to processing congruent and incongruent grapheme–phoneme pairs
A. T. Herdman (2006)
10.1093/cercor/bhu127
Electrocorticography Reveals Enhanced Visual Cortex Responses to Visual Speech.
I. Schepers (2015)
10.1007/s00221-009-1759-8
Sound enhances touch perception
T. Ro (2009)
Adaptation in multisensory neurons
Xutao Kuang (2008)
10.1152/jn.00828.2007
Early stages of melody processing: stimulus-sequence and task-dependent neuronal activity in monkey auditory cortical fields A1 and R.
Pingbo Yin (2008)
Functional imaging of peripheral vision and dorsal visual stream in the human cerebral cortex
Linda Stenbacka (2010)
10.1073/pnas.1730169100
A morphometric analysis of auditory brain regions in congenitally deaf adults
K. Emmorey (2003)
10.1016/j.pneurobio.2019.01.004
The circuit architecture of cortical multisensory processing: Distinct functions jointly operating within a common anatomical network
Guido T. Meijer (2019)
eview ultisensory perceptual learning and sensory substitution
ichael J. Proulxa (2014)
10.1016/j.heares.2010.06.003
Evidence for modality-specific but not frequency-specific modulation of human primary auditory cortex by attention
P. E. Gander (2010)
10.1016/j.neuroimage.2013.04.047
Parietal connectivity mediates multisensory facilitation
D. Brang (2013)
10.1007/s00221-014-4001-2
The prediction of visual stimuli influences auditory loudness discrimination
Andrea Desantis (2014)
10.1093/cercor/bhr150
Interhemispheric differences in auditory processing revealed by fMRI in awake rhesus monkeys.
O. Joly (2012)
10.1007/s10548-012-0220-7
Inverse Effectiveness and Multisensory Interactions in Visual Event-Related Potentials with Audiovisual Speech
Ryan A. Stevenson (2012)
LipreadingandCovertSpeechProductionSimilarly ModulateHumanAuditory-CortexResponsestoPureTones
IiroP . Jaaskelainen (2010)
10.1152/jn.00226.2012
Sound-driven enhancement of vision: disentangling detection-level from decision-level contributions.
Alexis Pérez-Bellido (2013)
Intégration sensorielle chez les individus ayant un trouble du spectre de l’autisme
Geneviève Charbonneau (2019)
10.1016/j.neuron.2007.12.013
Multisensory Interplay Reveals Crossmodal Influences on ‘Sensory-Specific’ Brain Regions, Neural Responses, and Judgments
J. Driver (2008)
10.1016/J.COGDEV.2017.02.007
What is the function of auditory cortex when it develops in the absence of acoustic input
S. Lomber (2017)
10.1038/s41598-018-31319-3
Effect of acceleration of auditory inputs on the primary somatosensory cortex in humans
S. Sugiyama (2018)
10.7554/eLife.44006
Context-dependent signaling of coincident auditory and visual events in primary visual cortex
Thomas Deneux (2019)
10.1016/j.neuron.2012.02.001
Suppressive Competition: How Sounds May Cheat Sight
C. Kayser (2012)
10.1007/3-540-36723-3_3
Microtubules in the Cerebral Cortex: Role in Memory and Consciousness
N. Woolf (2006)
See more
Semantic Scholar Logo Some data provided by SemanticScholar