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Prevention Or Promotion Of Dryness And Eczema By Moisturizers

M. Lodén
Published 2008 · Medicine

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The use of moisturizers is almost instinctive and is also routinely recommended to reduce the likelihood of developing dryness and eczema. However, recent findings demonstrate that treatment with creams may increase the risks for eczema. Symptoms of dryness may appear in normal skin and the skin susceptibility to outside stressors may increase. Moisturizing creams contain a great variety of ingredients, some of which are found in the stratum corneum. However, knowledge regarding the mechanisms of the impact of different ingredients on the skin is still lacking and, currently, it is a matter of trial and error to find the most suitable moisturizer for an individual. The cosmetic properties and the simplicity to use the products are important parameters for adherence, but even more important are the effects on the skin barrier function. A defect in skin barrier function has been suggested as the major cause for atopic eczema. Increased rate of transepidermal water loss (TEWL) induces signals that stimulate ...
This paper references
10.5107/SCCJ.27.348
Solid-State 13C-NMR Studies on Elastic Property of the Stratum Corneum
Y. Jokura (1993)
10.1046/j.1365-2133.1999.03200.x
Improved topical treatment of lamellar ichthyosis: a double‐blind study of four different cream formulations
A. Gånemo (1999)
10.1111/j.1600-0625.2007.00596.x
Lipophilic and hydrophilic moisturizers show different actions on human skin as revealed by cryo scanning electron microscopy
J. Caussin (2007)
10.1001/ARCHDERM.1994.01690040056007
Abnormality of water barrier function in psoriasis. Role of ceramide fractions.
S. Motta (1994)
10.1034/j.1600-0625.2001.110308.x
Basis for the permeability barrier abnormality in lamellar ichthyosis
P. Elias (2002)
Instrumental and sensory evaluation of the frictional response of the skin following a single application of five moisturizing creams
M. Lodén (1992)
The increase in skin hydration after application of emollients with different amounts of lipids.
M. Lodén (1992)
10.1111/j.1365-2230.1995.tb01280.x
Sleep difficulties and their management in preschoolers with atopic eczema
P. Reid (1995)
10.1111/1523-1747.EP12474562
Stratum corneum lipids serve as a bound-water modulator.
G. Imokawa (1991)
10.1080/09546630600552216
Evaluation of a new moisturizer (Exomega milk®) in children with atopic dermatitis
F. Giordano-Labadie (2006)
10.1111/j.1365-2133.1989.tb08190.x
Stratum corneum hydration and amino acid content in xerotic skin
I. Horii (1989)
10.1111/j.1365-2133.1989.tb01335.x
Topical eicosapentaenoic acid (EPA) in the treatment of psoriasis
Catherine E.Dewsbury (1989)
Prevention of stratum corneum lipid phase transitions in vitro by glyceroI--An alternative mechanism for skin moisturization
C. Froebe (1990)
Relationship between skin permeability and corneocyte size according to anatomic site, age, and sex in man
A. Rougier (1988)
10.1111/j.1365-2230.1992.tb00194.x
Topical fish oil in psoriasis—a controlled and blind study
S. Escobar (1992)
10.1111/J.0022-202X.2004.22317.X
Relationship between NMF (lactate and potassium) content and the physical properties of the stratum corneum in healthy subjects.
N. Nakagawa (2004)
10.1007/BF02505052
Urea-containing moisturizers influence barrier properties of normal skin
M. Lodén (2006)
10.1136/bmj.326.7403.1367
Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study
J. Berth-Jones (2003)
10.1080/000155599750009825
Glycerol accelerates recovery of barrier function in vivo.
J. Fluhr (1999)
10.1016/0190-9622(92)70060-S
Effects of petrolatum on stratum corneum structure and function.
R. Ghadially (1992)
10.1111/1523-1747.EP12323752
Reduced skin barrier function parallels abnormal stratum corneum lipid organization in patients with lamellar ichthyosis.
A. P. Lavrijsen (1995)
10.1159/000086159
Nickel Susceptibility and Skin Barrier Function to Water after Treatment with a Urea-Containing Moisturizer
M. Lodén (2004)
10.1016/S0190-9622(96)90009-2
The occurrence of atopic dermatitis in north Europe: an international questionnaire study.
F. Schultz Larsen (1996)
10.1111/j.1600-0536.1993.tb03563.x
The efficacy of a moisturizer (Locobase) among cleaners and kitchen assistants during everyday exposure to water and detergents
Lars Halkier-Søsensen (1993)
10.1046/j.1467-2494.2001.00060.x
The influence of a cream containing 20% glycerin and its vehicle on skin barrier properties
M. Lodén (2001)
The effect of ceramide-containing skin care products on eczema resolution duration.
Z. Draelos (2008)
Prevention of model stratum corneum lipid phase transitions in vitro by cosmetic additives : differential scanning calorimetry, optical microscopy, and water evaporation studies
J. Mattai (1993)
10.1038/ng1767
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
C. Palmer (2006)
10.1111/j.1365-2133.2008.08478.x
Noninvasive biophysical assessments of the efficacy of a moisturizing cosmetic cream base for patients with atopic dermatitis during different seasons
K. Kikuchi (2008)
10.1016/J.JACI.2006.05.004
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.
S. Weidinger (2006)
10.1016/S0190-9622(97)70140-3
Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin.
E. Zettersten (1997)
10.1111/j.1399-3038.2007.00706.x
Emollients improve treatment results with topical corticosteroids in childhood atopic dermatitis: a randomized comparative study
Jolanta Szczepanowska (2008)
10.1016/0009-8981(73)90237-4
The concentration of pyroglutamic acid (2-pyrrolidone-5-carboxylic acid) in normal and psoriatic epidermis, determined on a microgram scale by gas chromatography.
S. Marstein (1973)
10.1046/j.1365-2133.1999.02696.x
Emotional dysfunction, child–family relationships and childhood atopic dermatitis
Howlett (1999)
10.1201/b14251
Dry skin and moisturizers :chemistry and function
M. Lodén (1999)
10.1046/j.1468-3083.2000.00103.x
Incorporation of ceramide 3B in dermatocosmetic emulsions: effect on the transepidermal water loss of sodium lauryl sulphate‐damaged skin
K. de Paepe (2000)
10.1111/1523-1747.EP12470197
The influence of stratum corneum morphology on water permeability.
R. Potts (1991)
Clinical and non-invasive evaluation of 12% ammonium lactate emulsion for the treatment of dry skin in atopic and non-atopic subjects.
J. Vilaplana (1992)
10.1007/BF02507107
Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function
A. V. Rawlings (2006)
10.1111/j.1365-2133.1996.tb07604.x
Effect of topically applied lipids on surfactant‐irritated skin
M. Lodén (1996)
10.1016/0009-8981(73)90478-6
Effect of stimulators and inhibitors of hydrochloric acid secretion on numbers of oxidoreductase-positive gastric parietal cells in rats.
F. Barbarino (1973)
10.1073/PNAS.97.8.4291
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases.
B. Chang (2000)
10.1034/j.1600-0846.2003.00363.x
Differences among moisturizers in affecting skin susceptibility to hexyl nicotinate, measured as time to increase skin blood flow
C. Duval (2003)
10.1111/j.1600-0846.2007.00220.x
Facial anti‐wrinkle cream: influence of product presentation on effectiveness: a randomized and controlled study
M. Lodén (2007)
Identification of a Natural Moisturizing Agent in Skin
K. Laden (1967)
10.1111/j.1600-0536.1999.tb06125.x
Hypothesis: from epidermal barrier dysfunction to atopic disorders
A. Taïeb (1999)
10.1111/j.1365-2133.2008.08703.x
Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo
J. Crowther (2008)
10.1111/j.1365-2133.1993.tb03322.x
Borage oil, an effective new treatment for infantile seborrhoeic dermatitis
A. Tollesson (1993)
10.1159/000081068
Treatment of Surfactant-Damaged Skin in Humans with Creams of Different pH Values
I. Buraczewska (2004)
10.1080/000155599750011705
Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants.
E. Held (1999)
Skin barrier responses to moisturizers
I. Buraczewska (2008)
10.1080/09546630260199442
Advised best practice for the use of emollients in eczema and other dry skin conditions
C. Holden (2002)
10.1046/J.1523-1747.1998.00296.X
Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development.
L. Kömüves (1998)
10.1111/1523-1747.EP12607005
Molecular analysis of elastic properties of the stratum corneum by solid-state 13C-nuclear magnetic resonance spectroscopy.
Y. Jokura (1995)
10.1038/SJ.JID.5700739
Filaggrin mutations in children with severe atopic dermatitis.
N. Morar (2007)
10.1007/BF00373429
The effect of glycerol and humidity on desmosome degradation in stratum corneum
A. Rawlings (2004)
Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis.
Y. Werner (1985)
10.3109/09546639609086881
10% urea cream (Laceran) for atopic dermatitis: A clinical and laboratory evaluation
P. Pigatto (1996)
10.1016/0012-1606(86)90230-7
Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment.
I. R. Scott (1986)
10.1034/j.1600-0536.2001.450505.x
Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study
E. Berardesca (2001)
10.1111/j.1398-9995.2008.01683.x
Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment
A. Wollenberg (2008)
10.1111/1523-1747.EP12340135
Optimization of physiological lipid mixtures for barrier repair.
M. Man MQ (1996)
10.1038/jid.2008.29
Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum.
S. Kezic (2008)
10.1111/j.1365-2133.2007.07965.x
Artificial reduction in transepidermal water loss improves skin barrier function
I. Buraczewska (2007)
Regulation of epidermal sphingolipid synthesis by permeability barrier function.
W. Holleran (1991)
10.1046/J.1523-1747.2003.12033.X
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.
Ashley J Fowler (2003)
10.1034/j.1600-0536.2002.470402.x
Implementation of fatty acid carriers to skin irritation and the epidermal barrier
N. Schürer (2002)
10.1124/jpet.107.131565
Ceramide: a Key Signaling Molecule in a Guinea Pig Model of Allergic Asthmatic Response and Airway Inflammation
E. Masini (2008)
10.1046/j.1365-4362.2002.01436.x
Atopic dermatitis is associated with a decrement in health‐related quality of life
G. Kiebert (2002)
10.1080/000155500300012774
Skin-identical lipids versus petrolatum in the treatment of tape-stripped and detergent-perturbed human skin.
M. Lodén (2000)
10.1111/1523-1747.EP12515911
Dietary supplementation with ethyl ester concentrates of fish oil (n-3) and borage oil (n-6) polyunsaturated fatty acids induces epidermal generation of local putative anti-inflammatory metabolites.
C. C. Miller (1991)
10.1001/ARCHDERM.1995.01690190063012
Exogenous nonphysiologic vs physiologic lipids. Divergent mechanisms for correction of permeability barrier dysfunction.
M. Mao-qiang (1995)
10.1007/S11882-001-0041-3
Effects of allergic dermatosis on health-related quality of life
R. Anderson (2001)
10.3109/09546639909056023
The effect of two urea-containing creams on dry, eczematous skin in atopic patients. I. Expert, patient and instrumental evaluation
A. Andersson (1999)
Handbook of Pharmaceutical Excipients
A. H. Kibbe (2003)
10.1080/00015550310007418
Effect of a moisturizer on skin susceptibility to NiCl2.
C. Zachariae (2003)
Emollients for managing dry skin conditions.
S. Burr (1999)
10.1111/1523-1747.EP12665893
Cutaneous permeability barrier disruption increases fatty acid synthetic enzyme activity in the epidermis of hairless mice.
K. Ottey (1995)
10.1046/J.1523-1747.2003.12134.X
Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice.
J. Fluhr (2003)
10.1080/09546630050517171
Objective bioengineering methods to assess the effects of moisturizers on xerotic leg skin of elderly people
L. Kolbe (2000)
10.1046/j.1365-2133.1999.02660.x
Improvement in skin barrier function in patients with atopic dermatitis after treatment with a moisturizing cream (Canoderm®)
Lodén (1999)
10.3310/HTA4370
Systematic review of treatments for atopic eczema.
C. Hoare (2000)
10.1111/j.1365-2133.1993.tb00482.x
Barrier function parameters in various keratinization disorders: transepidermal water loss and vascular response to hexyl nicotinate
A. Lavrijsen (1993)
10.1111/j.1365-2133.2006.07185.x
A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases
P. Beattie (2006)
10.1046/J.0022-202X.2001.01626.X
Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.
M. Sheu (2002)
10.2340/0001555576353356
Topical treatment by urea reduces epidermal hyperproliferation and induces differentiation in psoriasis.
I. Hagemann (1996)
10.1111/j.1467-2494.1984.tb00363.x
Effect of 2‐hydroxyacids on guinea‐pig footpad stratum corneum: mechanical properties and binding studies
S. G. Alderson (1984)
10.1016/S0378-5173(99)00388-9
Unexpected skin barrier influence from nonionic emulsifiers.
E. Bárány (2000)
10.1111/1523-1747.EP12340962
Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis.
I. R. Harris (1997)
10.1159/000083462
The Influence of Urea Treatment on Skin Susceptibility to Surfactant-Induced Irritation: A Placebo-Controlled and Randomized Study
M. Lodén (2004)
10.1034/j.1398-9995.2000.00665.x
Atopic dermatitis in 5–6‐year‐old Swedish children: cumulative incidence, point prevalence, and severity scoring
A. Broberg (2000)
10.2340/00015555731820
Transepidermal water loss and water content in the stratum corneum in infantile seborrhoeic dermatitis.
A. Tollesson (1993)
10.1111/j.1525-1470.1997.tb00968.x
Use of an Emollient As a Steroid‐Sparing Agent in the Treatment of Mild to Moderate Atopic Dermatitis in Children
A. Lucky (1997)
10.1111/j.1396-0296.2004.04S1005.x
Moisturization and skin barrier function
A. V. Rawlings (2004)
10.1177/154411130201300603
P21Waf1 control of epithelial cell cycle and cell fate.
W. Weinberg (2002)
10.1159/000065863
Pimecrolimus Cream in the Long-Term Management of Atopic Dermatitis in Adults: A Six-Month Study
M. Meurer (2002)
10.1007/BF00372018
Quantitative evaluation of urea in stratum corneum of human skin
K. Wellner (2004)
Urea and retinoic acid in ichthyosis and their effect on transepidermal water loss and water holding capacity of stratum corneum.
K. Grice (1973)
10.1016/S1046-199X(99)90054-4
Epidermal pathogenesis of inflammatory dermatoses.
P. Elias (1999)
10.1067/MJD.2002.124617
Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity.
S. Chamlin (2002)
10.1111/1523-1747.EP12475679
Cell shedding from human plantar skin in vitro: evidence of its dependence on endogenous proteolysis.
A. Lundström (1988)
10.1111/j.1600-0846.2007.00271.x
Human skin buffering capacity: an overview
J. Levin (2008)
10.1007/s00403-008-0906-6
Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation
I. Buraczewska (2008)
10.1136/adc.76.2.159
Atopic eczema: its impact on the family and financial cost
J. C. Su (1997)
10.1067/MAI.2003.174
Actigraphy assessment of sleep disturbance in patients with atopic dermatitis: An objective life quality measure
B. Bender (2003)
10.1111/j.1365-2133.1975.tb03058.x
An explanation for the ‘placebo’ effect of bland ointment bases *
S. Tree (1975)
10.1111/1523-1747.EP12582813
Stratum corneum structure and function correlates with phenotype in psoriasis.
R. Ghadially (1996)
10.1016/0923-1811(90)90007-Z
Metabolism of topically applied fatty acid methyl esters in BALB/C mouse epidermis.
P. W. Wertz (1990)
10.1136/BMJ.39405.503773.AD
Management of atopic eczema in children aged up to 12 years: summary of NICE guidance
S. Lewis-Jones (2007)
10.1172/JCI114514
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in murine epidermis. Modulation of enzyme content and activation state by barrier requirements.
E. Proksch (1990)
10.1038/nrm1619
The cornified envelope: a model of cell death in the skin
E. Candi (2005)
10.1111/j.2042-7158.1988.tb05183.x
The in‐vitro percutaneous absorption of glycerol trioleate through hairless mouse skin
S. J. Moloney (1988)
10.1111/J.1523-1747.2005.23726.X
Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle.
A. V. Rawlings (2005)
10.1111/1523-1747.EP12264813
Ichthyosis vulgaris: identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules.
V. Sybert (1985)
10.18553/JMCP.2002.8.5.333
The effect of atopic dermatitis on total burden of illness and quality of life on adults and children in a large managed care organization.
D. Fivenson (2002)
10.1111/j.1365-2133.2008.08484.x
Pimecrolimus cream 1% in the long‐term management of adult atopic dermatitis: prevention of flare progression. A randomized controlled trial
H. Gollnick (2008)
10.1111/j.1365-2133.2000.03705.x
Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier
O. Tanno (2000)
10.1111/j.1365-2133.2006.07685.x
Changes in skin barrier function following long‐term treatment with moisturizers, a randomized controlled trial
I. Buraczewska (2007)
10.1111/j.1365-2133.1992.tb07810.x
Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin
M. Lodén (1992)
10.1111/j.1600-0536.1997.tb00213.x
Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream
M. Lodén (1997)
The influence of hydroxy acids on the rheological properties of stratum corneum
Motoji Takahashi (1985)
The skin plasticisation effect of 2-hydroxyoctanoic acid.
K. J. Hall (1986)
10.1159/000078462
Long-Term Efficacy and Safety of Pimecrolimus Cream 1% in Adults with Moderate Atopic Dermatitis
M. Meurer (2004)
Development of a skin cream designed to reduce dry and flaky skin
J. Middleton (1974)
10.1021/JP0632440
How small polar molecules protect membrane systems against osmotic stress: the urea-water-phospholipid system.
Fátima O. Costa-Balogh (2006)
10.1002/BMS.1200060504
Determination of free glycerol on human skin surface.
T. Yoneya (1979)



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