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The Cerebral Correlates Of Set-shifting: An FMRI Study Of The Trail Making Test.

Jorge Moll, Ricardo de Oliveira-Souza, Fernanda Tovar Moll, Ivanei E. Bramati, Pedro Angelo Andreiuolo
Published 2002 · Psychology, Medicine
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The trail making test (TMT) pertains to a family of tests that tap the ability to alternate between cognitive categories. However, the value of the TMT as a localizing instrument remains elusive. Here we report the results of a functional magnetic resonance imaging (fMRI) study of a verbal adaptation of the TMT (vTMT). The vTMT takes advantage of the set-shifting properties of the TMT and, at the same time, minimizes the visuospatial and visuomotor components of the written TMT. Whole brain BOLD fMRI was performed during the alternating execution of vTMTA and vTMTB in seven normal adults with more than 12 years of formal education. Brain activation related to the set-shifting component of vTMTB was investigated by comparing performance on vTMTB with vTMTA, a simple counting task. There was a marked asymmetry of activation in favor of the left hemisphere, most notably in dorsolateral prefrontal cortex (BA 6 lateral, 44 and 46) and supplementary motor area/cingulate sulcus (BA 6 medial and 32). The intraparietal sulcus (BA 7 and 39) was bilaterally activated. These findings are in line with clinico-anatomic and functional neuroimaging data that point to a critical role of the dorsolateral and medial prefrontal cortices as well as the intraparietal sulci in the regulation of cognitive flexibility, intention, and the covert execution of saccades/anti-saccades. Many commonly used neuropsychological paradigms, such as the Stroop, Wisconsin Card Sorting, and go - no go tasks, share some patterns of cerebral activation with the TMT.
This paper references
10.1192/bjp.112.482.27
Perseveration--the clinical symptoms--in chronic schizophrenia and organic dementia.
T Freeman (1966)
Neuropsychological assessment. 3
Md Lezak (1995)
10.1126/science.288.5472.1835
Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control.
Angus W. MacDonald (2000)
10.1152/jn.2000.84.3.1645
A comparison of frontoparietal fMRI activation during anti-saccades and anti-pointing.
Jason D. Connolly (2000)
Functional magnetic resonance imaging of pantomimes of tool use
J Moll (2000)
10.1002/(SICI)1097-4679(199808)54:5<585::AID-JCLP4>3.0.CO;2-K
The differential contribution of mental tracking, cognitive flexibility, visual search, and motor speed to performance on parts A and B of the Trail Making Test.
Simon F. Crowe (1998)
10.1093/brain/123.6.1142
The impact of deep brain stimulation on executive function in Parkinson's disease.
Marjan Jahanshahi (2000)
10.1093/cercor/9.7.745
Contribution of working memory to transient activation in human inferior prefrontal cortex during performance of the Wisconsin Card Sorting Test.
Seiki Konishi (1999)
10.5860/choice.29-2400
A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary
Otfried Spreen (1991)
10.1002/mrm.1910330508
Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold.
Steven D. Forman (1995)
10.1002/(SICI)1097-0193(1998)6:1<14::AID-HBM2>3.0.CO;2-O
Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI.
Andreas Belger (1998)
10.1093/arclin/11.8.697
Application of the oral trail making test to a mixed clinical sample
Elizabeth Abraham (1996)
10.1097/00001756-200012180-00011
Cortical activation evoked by visual mental imagery as measured by fMRI
Matthias Knauff (2000)
10.1002/ana.410180518
Reversible go-no go deficits in a case of frontal lobe tumor.
M E Leimkuhler (1985)
Intentional motor disorders.
K. M. Heilman (1991)
10.1002/ana.410420414
Functional magnetic resonance imaging of single motor events reveals human presupplementary motor area.
Mike Humberstone (1997)
Neuropsychological assessment of mental state Principles of behavioral and cognitive neurology. 2.Ed
S Weintraub (2000)
10.1073/pnas.91.22.10507
Cognitive processes and cerebral cortical fundi: findings from positron-emission tomography studies.
Hans Joachim Markowitsch (1994)
10.1136/jnnp.46.2.152
Motor neglect.
Dominique Laplane (1983)
10.1097/00005053-195909000-00006
DIFFERENTIAL EFFECTS OF LATERALIZED BRAIN LESIONS ON THE TRAIL MAKING TEST
Ralph M. Reitan (1959)
10.1017/S0033291700009934
Clinical applications of visual analogue scales: a critical review.
H M McCormack (1988)
10.1001/archneur.1991.00530240106031
Frontal lobe dysfunction following infarction of the left-sided medial thalamus.
Thomas A. Sandson (1991)
Neuropsychological assessment of mental state
S Weintraub (2000)
10.1016/0028-3932(71)90067-4
The assessment and analysis of handedness: the Edinburgh inventory.
Richard Charles Oldfield (1971)
Neuropsychological assessment of mental state. In Mesulan MM (Ed.) Principles of behavioral and cognitive neurology. 2.Ed
S. Weintraub (2000)
10.1097/00001756-199705260-00042
Functional heterogeneity of left inferior frontal cortex as revealed by fMRI
Eraldo Paulesu (1997)
10.1016/S0926-6410(99)00029-4
Prefrontal cortex activation in task switching: an event-related fMRI study.
Anja Dove (2000)
10.1016/S0028-3932(99)00068-8
The calculating brain: an fMRI study
Timothy C. Rickard (2000)
Intentional motor disorders Frontal lobe function and dysfunction
Km Heilman (1991)
10.1006/nimg.2000.0665
Color-Word Matching Stroop Task: Separating Interference and Response Conflict
Stefan Zysset (2001)
Abulia minor vs agitated behavior
CM Fisher (1984)
10.1037/0735-7028.22.6.510
Neuropsychological test usage.
Michelle Butler (1991)
10.1016/0006-8993(96)00389-7
Functional anatomy of GO/NO-GO discrimination and response selection — a PET study in man
Ryuta Kawashima (1996)
10.1073/pnas.96.14.8301
Right hemispheric dominance of inhibitory control: an event-related functional MRI study.
Hugh Garavan (1999)
10.2466/pms.1958.8.3.271
Validity of the Trail Making Test as an Indicator of Organic Brain Damage
Ralph M. Reitan (1958)
10.1016/S0028-3932(99)00093-7
Wisconsin Card Sorting Test performance in patients with focal frontal and posterior brain damage: effects of lesion location and test structure on separable cognitive processes
Donald T. Stuss (2000)
10.1590/S0004-282X2000000500006
Trail making and cognitive set-shifting.
R D Olivera-Souza (2000)
Neuropsychological assessment, 3rd ed.
Muriel Deutsch Lezak (1995)
10.2307/1317431
Statistical Analysis: An Interdisciplinary Introduction to Univariate and Multivariate Methods
Sam Kash Kachigan (1986)



This paper is referenced by
10.1080/02699050601149088
Validation of the Behavioral Dyscontrol Scale-Electronic Version: Sensitivity to subtle sequelae of mild traumatic brain injury
Yana Suchy (2007)
10.1007/s40708-015-0025-z
Quantitative electroencephalographic and neuropsychological investigation of an alternative measure of frontal lobe executive functions: the Figure Trail Making Test
Paul S. Foster (2015)
10.1037/neu0000231
Abnormal frontal theta oscillations underlie the cognitive flexibility deficits in children with high-functioning autism spectrum disorders.
Michael K Yeung (2016)
10.1002/da.22658
Cognitive enhancing effects of rTMS administered to the prefrontal cortex in patients with depression: A systematic review and meta‐analysis of individual task effects
Donel M. Martin (2017)
The Apathy Evaluation Scale : An ineffective tool for measuring affective , behavioural , and cognitive dimensions of apathy
Marcelle Dianne Boshoff (2018)
10.1016/j.gaitpost.2019.12.007
How accuracy of foot-placement is affected by the size of the base of support and crutch support in stroke survivors and healthy adults.
Susanne M van der Veen (2019)
10.1007/s00221-007-0906-3
Cognitive inhibition in patients with medial orbitofrontal damage
Iwona Szatkowska (2007)
The Impact of Lifetime ADHD on Neuropsychological Functioning in Young Adults with Bipolar Disorder: A Comparison of Bipolar Disorder with and without Childhood ADHD, ADHD, and Control Groups.
Jason Brown (2012)
10.1080/13854046.2017.1324045
Clinimetric validity of the Trail Making Test Czech version in Parkinson’s disease and normative data for older adults
Ondrej Bezdicek (2017)
10.1007/s11065-016-9325-1
Does Therapeutic Repetitive Transcranial Magnetic Stimulation Cause Cognitive Enhancing Effects in Patients with Neuropsychiatric Conditions? A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Donel M. Martin (2016)
10.3143/GERIATRICS.52.71
パフォーマンステストである認知機能評価法“Trail Making Peg test”の妥当性と信頼性の検討
巧 阿部 (2015)
10.1037/a0021053
Effects of alcohol on tests of executive functioning in men and women: a dose response examination.
Casey R. Guillot (2010)
10.1016/j.bbi.2012.06.004
Thinking through postoperative cognitive dysfunction: How to bridge the gap between clinical and pre-clinical perspectives
Iris B Hovens (2012)
10.1176/appi.neuropsych.12070176
Systematic review of neuroimaging correlates of executive functioning: converging evidence from different clinical populations.
Milap Anil Nowrangi (2014)
10.1016/j.bandc.2011.06.001
An fMRI investigation of a novel analogue to the Trail-Making Test
Sarah C. Jacobson (2011)
A Principal Components Analysis of Executive Processes: Exploring the Structure of Executive Functions using Neuropsychological Tests Examination Number: B006603 MSc Human Cognitive Neuropsychology
Jennifer Foley (2011)
Demencia frontotemporal por mutaciones en el gen de la progranulina. Aspectos clínicos y moleculares
Fermín Moreno Izco (2016)
Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study.
Jirí Horácek (2006)
10.1007/s11695-017-2894-0
Neuropsychological Functioning in Mid-life Treatment-Seeking Adults with Obesity: a Cross-sectional Study
Christina Prickett (2017)
10.1007/s00406-012-0296-9
Depressive symptoms and apathy are associated with psychomotor slowness and frontal activation
Masayo Sawa (2012)
10.1016/j.clinph.2011.10.006
Clinically-oriented monitoring of acute effects of methylphenidate on cerebral hemodynamics in ADHD children using fNIRS
Yukifumi Monden (2012)
10.1016/j.acn.2004.10.003
Anxious-depression in boys: an evaluation of executive functioning.
Carol S. Emerson (2005)
Original article An analysis of performance in the Trail Making Test by subjects after a stroke with different lesion locations
Anna Rajtar-Zembaty (2015)
10.1590/S0100-879X2009000500010
Acute exercise performed close to the anaerobic threshold improves cognitive performance in elderly females.
Claudio Córdova (2009)
10.1007/s11682-007-9000-5
The Relationship Between Gray Matter Morphometry and Neuropsychological Performance in a Large Sample of Cognitively Healthy Adults
Lisa M. Newman (2007)
10.1590/1980-57642015DN93000008
Use of a modified version of the switching verbal fluency test for the assessment of cognitive flexibility
Jonas J de Paula (2015)
10.1016/j.jpsychires.2012.11.011
1H MRSI of middle frontal gyrus in pediatric ADHD.
Sharwin Tafazoli (2013)
10.1017/S1355617710000408
Gray matter correlates of set-shifting among neurodegenerative disease, mild cognitive impairment, and healthy older adults.
Judy Pa (2010)
10.3389/fped.2016.00062
Influence of Yoga-Based Personality Development Program on Psychomotor Performance and Self-efficacy in School Children
Madhusudan Das (2016)
10.1371/journal.pone.0089078
Alternative Type of the Trail Making Test in Nonnative English-Speakers: The Trail Making Test-Black & White
Hyun Jung Kim (2014)
10.1016/j.pscychresns.2013.03.006
Trail Making Test B and brain perfusion imaging in mild cognitive impairment and mild Alzheimer's disease
Seishi Terada (2013)
10.3233/jad-191063
Circulating Progenitor Cells and Cognitive Impairment in Men and Women with Coronary Artery Disease.
Kasra Moazzami (2020)
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