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Natural Products Inhibitors Of The Enzyme Acetylcholinesterase

J. B. Filho, Karina C P Medeiros, M. Diniz, L. M. Batista, P. Athayde-Filho, M. E. Silva, E. V. Cunha, J. R. G. Almeida, L. Quintans-Júnior
Published 2006 · Biology

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Alzheimer's disease (AD) is a progressive, neurodegenerative pathology that primarily affects the elderly population, and is estimated to account for 50-60% of dementia cases in persons over 65 years of age. The main symptoms associated with AD involve cognitive dysfunction, primarily memory loss. Other features associated with the later stages of AD include language deficits, depression, behavioural problems including agitation, mood disturbances and psychosis. One of the most promising approaches for treating this disease is to enhance the acetylcholine level in the brain using acetylcholinesterase (AChE) inhibitors. The present work reviews the literature on plants and plant-derived compounds inhibitors of enzyme acetylcholinesterase. The review refers to 309 plant extracts and 260 compounds isolated from plants, which are classified in appropriate chemical groups and model tested, and cites their activity. For this purpose 175 references were consulted.
This paper references
Produtos naturais inibidores
HMM Cruz (2000)
10.1002/(SICI)1099-1573(199912)13:8<649::AID-PTR518>3.0.CO;2-9
Effect of active molluscicidal component of spices on different enzyme activities and biogenic amine levels in the nervous tissue of Lymnaea acuminata.
V. K. Singh (1999)
10.1080/1057563021000051086
New Steroidal Alkaloids From Sarcococca Saligna
Atta-ur-rahman (2003)
10.1590/S0100-40422004000400021
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer
Cláudio Viegas Junior (2004)
Cerebral function improvising drug containing a gomisin
K Itoh (1989)
Plant and plant-derived compounds employed in prevention of the osteoporosis
Joao Vianney Pereira (2002)
10.1021/jo00015a014
Synthesis of huperzine A and its analogues and their anticholinesterase activity
A. Kozikowski (1991)
10.1021/jm00116a010
Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.
A. Kozikowski (1991)
10.1016/S0040-4039(02)00465-3
Terreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity from Aspergillus terreus
Won-Gon Kim (2002)
10.1016/S0749-0690(05)70072-0
Treatment of Alzheimer's disease with cholinesterase inhibitors.
L. Schneider (2001)
10.1002/chin.199601277
Arisugacin, a Novel and Selective Inhibitor of Acetylcholinesterase from Penicillium sp. FO-4259.
S. O̅mura (1996)
10.1021/jo00054a013
Ulosantoin, a potent insecticide from the sponge Ulosa ruetzleri
B. C. Vanwagenen (1993)
10.1016/S0031-9422(01)00332-6
Acetyl and butyrylcholinesterase-inhibiting triterpenoid alkaloids from Buxus papillosa.
Atta-ur-rahman (2001)
10.1016/0031-9422(91)84255-Q
Crooksidine, an indole alkaloid from Haplophyton crooksii
M. A. Mroue (1991)
10.1002/CHIN.200229214
Pregnane-Type Steroidal Alkaloids of Sarcococca saligna: A New Class of Cholinesterase Inhibitors.
A. Atta‐ur‐Rahman (2002)
10.1073/PNAS.98.4.2089
Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning.
D. Woodruff-Pak (2001)
Inhibitory effects of huperzine B on cholinesterase activity in mice.
J. Liu (1999)
10.1021/jm00183a011
Evaluation of rotenone and related compounds as antagonists of slow-reacting substance of anaphylaxis.
R. Ashack (1980)
10.1016/0024-3205(93)90623-B
A paradoxical stimulatory effect of berberine on guinea-pig ileum contractility: possible involvement of acetylcholine release from the postganglionic parasympathetic nerve and cholinesterase inhibition.
D. Shin (1993)
10.1021/NP000441W
Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.
S. Kang (2001)
10.1021/np960070c
Indole Alkaloids of Haplophyton crooksii1
M. A. Mroue (1996)
10.1016/0163-7258(95)02002-0
The pharmacology of galanthamine and its analogues.
A. Harvey (1995)
Isolation, physicochemical properties and toxicities of of territrem A’ and B
KH Ling (1986)
10.1021/OL0167762
A new type of lycopodium alkaloid, lycoposerramine-A, from Lycopodium serratum Thunb.
H. Takayama (2001)
10.1016/S0021-9673(01)00624-0
Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining.
I. K. Rhee (2001)
10.1016/S0014-5793(99)01637-3
Structure of acetylcholinesterase complexed with (−)‐galanthamine at 2.3 Å resolution
H. Greenblatt (1999)
10.1055/S-2003-38489
α-Onocerin: An Acetylcholinesterase Inhibitor from Lycopodium clavatum
I. Orhan (2003)
10.1021/NP020446O
New triterpenoid alkaloid cholinesterase inhibitors from Buxus hyrcana.
M. Choudhary (2003)
In-vitro screening for anticholinesterase activity of plants used traditionally for memory improvement
MJR Howes (1999)
10.1016/S0367-326X(02)00314-3
Bioactive constituents of Leptadenia arborea.
A. El-Hassan (2003)
10.1016/S0079-6123(08)62429-2
Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease.
A. Enz (1993)
10.1021/jf960398b
Inhibition of Acetylcholinesterase Activity by Monoterpenoids with a p-Menthane Skeleton
M. Miyazawa (1997)
Isatin, an inhibitor of acetylcholinesterase activity in rat brain
R. Kumar (1993)
Huperzine A improves
Hsueh Pao (2000)
10.1016/0031-9422(93)85098-C
Endogenous pine wood nematicidal substances in pines, Pinus massoniana, P. strobus and P. palustris
T. Suga (1993)
10.1159/000138801
Effects of ginsenoside Rb1 on central cholinergic metabolism.
C. Benishin (1991)
Isolation of berbamine alkaloids from Stephania tetrandra as acetylcholinesterase inhibitors
T Ogino (1992)
10.1159/000138823
Effect of the steroidal alkaloid buxaminol-E on blood pressure, acetylcholinesterase activity and (3H)quinuclidinyl benzilate binding in cerebral cortex.
Z. Kvaltínová (1991)
10.1016/0014-5793(86)80606-8
Inhibition of acetylcholinesterase from electric eel by (−)‐ and (+)‐physostigmine and related compounds
A. Brossi (1986)
10.1021/JO015522R
Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast.
Y. Lin (2001)
10.1080/10575630108041281
Inhibition of Acetylcholinesterase Activity by Essential Oil from Citrus paradisi
M. Miyazawa (2001)
10.1021/np50034a023
Correlation of the anticholinesterase and molluscicidal activity of the latex of Euphorbia royleana on the snail Lymnaea acuminata.
D. Singh (1984)
10.1016/S0040-4039(00)97013-8
Synthesis and biological evaluation of (±)-Z-huperzine A
A. Kozikowski (1990)
An acetylcholinesterase inhibitor isolated from Corydalis tuber and its mode of action
SY Hwang (1996)
10.1080/02772249909358803
Effects of the ellagic acid on the N-acetyltransferase activity and acetylation of 2-aminofluorene in the rat
C. Ho (1999)
10.1016/0300-483X(82)90032-4
Pharmacological properties of melochinine, an alkaloid producing Central American cattle paralysis.
H. Breuer (1982)
10.1002/CHIN.200302187
New Steroidal Alkaloids from Fritillaria imperialis and Their Cholinesterase Inhibiting Activities.
Rahman-Atta-Ur Rahman-Atta-Ur (2003)
10.1016/J.BMCL.2003.12.055
1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative.
Y. Li (2004)
10.1016/S0955-2863(95)00186-7
Effect of dietary oils on brain enzymatic activities (2′-3′-cyclic nucleotide 3′-phosphodiesterase and acetylcholinesterase) and muscarinic receptor sites in growing rats
S. Salvati (1996)
10.1016/S0091-3057(03)00113-8
Ptychopetalum olacoides, a traditional Amazonian “nerve tonic”, possesses anticholinesterase activity
I. Siqueira (2003)
10.1016/0041-0101(94)00153-Y
Inhibition of acetylcholinesterase by a pseudozoanthoxanthin-like compound isolated from the zoanthid Parazoanthus axinellae (O. Schmidt).
T. Turk (1995)
Molecular mechanisms of the biological activity of quaternary benzophenanthridine and protoberberine alkaloids.
J. Ulrichová (1984)
Bioactive constituents
KP Zeller (2003)
10.1021/np50120a006
Acetylcholinesterase inhibition by territrem B derivatives.
F. Peng (1995)
10.1016/S0040-4020(00)00759-6
Turbotoxins A and B, novel diiodotyramine derivatives from the Japanese gastropod Turbo marmorata
H. Kigoshi (1999)
10.1055/s-2006-957926
Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa.
C. Park (1996)
10.1016/J.PHRS.2003.12.027
Acetylcholinesterase inhibitors: novel activities of old molecules.
M. Racchi (2004)
10.1016/J.JEP.2003.11.016
Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants.
I. Orhan (2004)
10.1002/CHIN.200201216
Synthesis and Acetylcholinesterase Inhibition of 5-Desamino Huperzine A Derivatives.
K. Hoegenauer (2002)
Anisodamine inhibits acetylcholine-induced endothelium-dependent relaxation of canine femoral artery.
Guo Hy (1992)
10.1016/0167-4889(94)90299-2
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells.
L. Korutla (1994)
10.1111/J.2042-7158.1998.TB02220.X
Galantamine. A novel treatment for Alzheimer's disease
D. Greenwood (1998)
Inhibition of acetylcholinesterase by barakol
C Permtermsin (2001)
Plants and Bioactive Compounds for the Treatment of Parkinson's Disease
L. C. S. Morais (2003)
10.1002/CHIN.200409183
Sieboldine A, a Novel Tetracyclic Alkaloid from Lycopodium sieboldii, Inhibiting Acetylcholinesterase.
Y. Hirasawa (2004)
10.1248/CPB.51.412
Cholinesterase inhibitory constituents from Onosma hispida.
I. Ahmad (2003)
10.1016/0008-6215(96)00017-1
Calystegin N1, a novel nortropane alkaloid with a bridgehead amino group from Hyoscyamus niger: structure determination and glycosidase inhibitory activities
N. Asano (1996)
Natural products reported as potential inhibitors of uterine cervical neoplasia
M. D. Moura (2002)
10.1021/JM000980Y
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
P. Camps (2000)
10.1515/znc-2001-5-611
Acetylcholinesterase and Insect Growth Inhibitory Activities of Gutierrezia microcephala on Fall Army worm Spodoptera frugiperda J. E. Smith
J. Calderón (2001)
10.1016/0024-3205(86)90470-4
Antihypertensive substance in seeds of Areca catechu L.
J. Inokuchi (1986)
10.1078/094471103321659988
Natural product inhibitors of ovarian neoplasia.
J. S. Silva (2003)
10.1016/S0378-8741(03)00080-1
Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat.
A. Sharifi (2003)
10.1016/S0031-9422(00)89606-5
The alkaloids huperzines C and D and huperzinine fromLycopodiastrum casuarinoides
Liu Jia-sen (1994)
10.1021/jm00120a008
Synthesis and anticholinesterase activity of (-)-N1-norphysostigmine, (-)-eseramine, and other N(1)-substituted analogues of (-)-physostigmine.
Q. Yu (1988)
10.11501/3129607
Arisugacins A and B,Novel and Selective Acetylcholinesterase Inhibitors from Penicillium sp.F0-4259(ペニシリウム属に属するF0-4259株由来の新規な選択的アセチルコリンエステラーゼ阻害物質arisugacinA及びBについて)
久野文義 (1996)
10.1002/PTR.1119
Pharmacological activities of stromata of Cordyceps scarabaecola.
K. Yu (2003)
10.1002/CHIN.200107188
Synthesis, Chiral Chromatographic Separation, and Biological Activities of the Enantiomers of 10,10-Dimethylhuperzine A.
V. Rajendran (2001)
10.1055/S-2002-19874
A new coumarin from Murraya paniculata.
M. Choudhary (2002)
10.1248/CPB.50.1423
New cholinesterase inhibiting steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.
S. Kalauni (2002)
Insecticidal activity of garlic oil
PLB Thomas (1974)
Pharmacologiacl study of Lawsonia inermis Linn
LC Lahon (1977)
10.1016/S0031-9422(03)00154-7
Antifungal isopimaranes from Hypoestes serpens.
L. Rasoamiaranjanahary (2003)
10.1515/znc-1985-3-401
Biochemisch-pharmakologische Untersuchung pflanzlicher Arzneistoffe. II . Hemmung der Acetylcholinesterase durch Monoterpenderivate in vitro / Molecular Pharmacological Investigation of Medicinal Plant Substances. II. Inhibition of Acetylcholinesterase by Monoterpene Derivatives in vitro
L. Gracza (1985)
10.1016/S0304-3940(01)02437-5
Stereoselectivities of enantiomers of huperzine A in protection against β-amyloid25–35-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice
H. Zhang (2002)
10.1016/S0968-0896(00)00234-0
Iantherans A and B, unique dimeric polybrominated benzofurans as Na,K-ATPase inhibitors from a marine sponge, Ianthella sp.
Y. Okamoto (2001)
Effect of oltipraz, alpha-tocopherol, beta-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidase.
E. M. V. Van Lieshout (1996)
10.1016/S0091-3057(97)00601-1
Comparative Studies of Huperzine A, E2020, and Tacrine on Behavior and Cholinesterase Activities
D. Cheng (1998)
The epidemic of Alzheimer's disease. How can we manage the costs?
N. Johnson (2000)
Excitory effect
SB (1992)
10.1016/S0031-9422(96)00545-6
Biochemical activities of berberine, palmatine and sanguinarine mediating chemical defence against microorganisms and herbivores.
T. Schmeller (1997)
New synthesis of rac-huperzine A and its Rac-7ethyl-derivative
P Camps (2000)
10.1111/j.1745-4514.1978.tb00621.x
INHIBITION OF RAT CHOLINESTERASE ISOENZYMES IN VITRO AND IN VIVO BY THE POTATO ALKALOID, α‐CHACONINE1,2
S. O. Alozie (1978)
10.1016/S0014-2999(00)00291-0
Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats.
L. Wang (2000)
10.1002/CHIN.199923258
Acetylcholinesterase Inhibiting Triterpenoidal Alkaloids from Buxus hyrcana
A. Atta‐Ur‐Rahman (1999)
10.1021/JM010894D
Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.
C. Brühlmann (2001)
10.1002/chin.199632239
Almazole D, a New Type of Antibacterial 2,5‐Disubstituted Oxazolic Dipeptide from a Red Alga of the Coast of Senegal.
I. Ndiaye (1996)
Screening of the acetylcholinesterase inhibitors from medicinal plants
B. H. Lee (1997)
10.1021/NP049863M
Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors.
C. L. Cardoso (2004)
10.1016/S0031-9422(00)90698-8
EFFECT OF HYDROXAMIC ACIDS FROM CEREALS ON APHID CHOLINESTERASES
L. Cuevas (1993)
10.1248/BPB.25.125
(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.
S. Sung (2002)
Mechanism of anthelmintic action of benzylisothiocyanate
D Kumar (2001)
10.1078/0944-7113-00050
Plants with central analgesic activity.
R. Almeida (2001)
10.1055/S-2004-832632
Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors.
A. Urbain (2004)
10.1136/bmj.1.4959.155-a
Biochemistry
F. G. Young (1955)
10.1016/0306-3623(79)90085-5
A biochemical study on the hypotensive effect of berberine in rats.
Y. Chun (1979)
Inhibitory effect of ursolic acid purified from Origanum majorana L on the acetylcholinesterase.
Y. Chung (2001)
10.1211/0022357001774598
In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes.
N. Perry (2000)
10.1002/(SICI)1099-1573(199608)10:5<383::AID-PTR855>3.0.CO;2-9
Enzyme Inhibition by Allicin, the Molluscicidal Agent of Allium sativum L. (Garlic)
V. Singh (1996)
10.1021/ja00012a056
A route to optically pure (-)-huperzine A : molecular modeling and in vitro pharmacology
F. Yamada (1991)
10.1016/0378-8741(94)01182-6
Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo.
X. Tang (1994)
Pharmacologiacl action of deoxynupharidine hydrochloride, a component of Nuphar japonicum
Y Shimosaka (1955)
The effect of vincristine on enzymatic activity in the brain.
M. Kozik (1983)
10.1016/S0031-9422(97)00393-2
A survey of plants for presence of cholinesterase activity
A. Gupta (1997)
STUDIES ON ANALOGUES OF HUPERZINE A III. SYNTHESIS OF N-METHYL PYRIDONE ANALOGUES OF HUPERZINE A
X. Zr (1996)
10.1002/PCA.623
A rapid TLC bioautographic method for the detection of acetylcholinesterase and butyrylcholinesterase inhibitors in plants.
A. Marston (2002)
10.1590/S0100-40422003000300002
Seleção de plantas com atividade anticolinasterase para tratamento da doença de Alzheimer
M. Trevisan (2003)
10.1111/j.1471-4159.1974.tb04381.x
Effect of bicuculline, leptazol and strychnine on the acetylcholinesterase activity of the frog spinal cord in vivo.
A. Nistri (1974)
10.1515/znc-1992-1-208
Modulation of the Activities of Membrane Enzymes by Cereal Grain Resorcinolic Lipids
A. Kozubek (1992)
10.1021/NP0103564
Huperzine R, a novel 15-carbon Lycopodium alkaloid from Huperzia serrata.
Chang-Heng Tan (2002)
10.1021/NP9905315
New norditerpenoid alkaloids from Aconitum falconeri.
Atta-ur-rahman (2000)
Crookshiine, a bisindole alkaloid from Haplophyton crooksii
M Mroue (1991)
Pharmacological studies on Bupleurum
Q Yu (1984)
10.1021/NP000466V
Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.
S. Kalauni (2001)
[The comparative clinico-experimental characteristics of aminostigmine and galanthamine used for treating poisonings by choline-blocking substances].
V. B. Prozorovskii (1996)
Anti-infl ammatory activity of alkaloids: A twentycentury review
JM Barbosa-Filho (2006)
Inhibitory effect of suberogorgin on acetylcholinesterase.
W. Peng (1996)
10.1016/0960-894X(96)00012-1
Synthesis of (±)-10,10-dimethylhuperzine A — a huperzine analogue possessing a slower enzyme off-rate
A. Kozikowski (1996)
10.1078/0944-7113-00082
Salvia lavandulaefolia essential oil inhibits cholinesterase in vivo.
N. Perry (2002)
Isoaltion, chemistry and biology of alkaloids from plants of the Papaveraceae
J Ulrichova (1983)
10.7164/antibiotics.46.1315
Cyclophostin, acetylcholinesterase inhibitor from Streptomyces lavendulae.
T. Kurokawa (1993)
10.3987/COM-97-7935
STUDIES ON INHIBITORY ACTIVITY AGAINST ACETYLCHOLINESTERASE OF NEW BISBENZYLISOQUINOLINE ALKALOID AND ITS RELATED COMPOUNDS
Tatsunori Ogino (1997)
10.1016/J.JEP.2003.08.008
Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies.
K. Ingkaninan (2003)
10.1021/JA017310H
Mechanism of acetylcholinesterase inhibition by fasciculin: a 5-ns molecular dynamics simulation.
K. Tai (2002)
10.1039/C39950000283
Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A
A. Kozikowski (1995)
[Studies on analogues of huperzine A for treatment of senile dementia. VI. Asymmetric total synthesis of 14-nor-huperzine A and its inhibitory activity of acetylcholinesterase].
Xu-chang He (2003)
Hepatoprotective effect of silymarin (carsil) on liver of D-galactosamine treated rats. Biochemical and morphological investigations.
N. Tyutyulkova (1981)
Molecular diversity in the alkaloids of Turkish Fumaria L
R Sener (2002)
Comparison of biological activity of some benzo (c)-phenanthridine alkaloids and their structural analogs.
J. Ulrichová (1986)
10.1021/JF9701547
Insecticidal Alkaloids against Drosophila melanogaster from Nuphar japonicum DC.
M. Miyazawa (1998)
10.1016/S0040-4039(00)00893-5
Huperzine P, a novel Lycopodium alkaloid from Huperzia serrata
Chang-Heng Tan (2000)
10.1002/CHIN.200024228
Arisugacins C and D, Novel Acetylcholinesterase Inhibitors and Their Related Novel Metabolites Produced by Penicillium sp. FO‐4259‐11
K. Otoguro (2000)
10.1016/0014-2999(91)90730-E
Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase.
M. Mckinney (1991)
Alkaloids of iraqi heliotropium ramosissimum phytochemistry and some biochemical aspects
M. J. Mahmoud (1987)
An acetylcholinesterase inhibitor from the leaves of Securinega suffruticosa
CH Jang (2003)
Natural products inhibitors of models of mammary neoplasia
MD Moura (2001)
EFFECTS OF TOOSENDANIN ON SEVERAL ENZYME SYSTEMS OF THE CABBAGE WORM FIERIS RAPAE L.
X. Zhang (1992)
10.1016/S0378-8741(00)00373-1
Neutralisation of lethality, myotoxicity and toxic enzymes of Naja kaouthia venom by Mimosa pudica root extracts.
M. Mahanta (2001)
10.1002/PTR.1280
Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders.
Melanie-Jayne R. Howes (2003)
10.1080/10575639808048281
Inhibition of Acetylcholinesterase Activity by Volatile α, β-Unsaturated Ketones
M. Miyazawa (1998)
10.1135/cccc19850978
Interaction of quaternary aromatic isoquinoline alkaloids with acetylcholinesterase from Electrophorus electricus
J. Ulrichová (1985)
10.1021/NP0302495
Heliotropamide, a novel oxopyrrolidine-3-carboxamide from Heliotropium ovalifolium.
A. Guntern (2003)
10.1016/0041-0101(74)90192-5
Sarcophine--a new toxin from the soft coral Sarcophyton glaucum (Alcyonaria).
I. Neeman (1974)
10.1590/S0102-695X2005000400021
Plants and their active constituents from South, Central, and North America with hypoglycemic activity
J. Barbosa-Filho (2005)
10.1016/0304-3835(92)90263-U
Antiproliferative effect of the garlic compound S-allyl cysteine on human neuroblastoma cells in vitro.
C. Welch (1992)
10.1016/J.PHYMED.2003.10.006
A review of natural products with antileishmanial activity.
L. G. Rocha (2005)
10.1016/0024-3205(94)00501-X
Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
J. Grunwald (1994)
Study of the reaction of galanthamine with tha acetylcholinesterase of the mouse brain in vivo
VD Tonkopii (1976)
10.1007/BF02282405
Alkaloids ofAnabasis aphylla and their cholinergic activities
Z. Tilyabaev (2005)



This paper is referenced by
ESTUDO FITOQUÍMICO E ATIVIDADES BIOLÓGICAS PRELIMINARES DE EXTRATOS DE POLYGONUM ACRE H.B.K. (POLYGONACEAE) E SYNADENIUM CARINATUM BOISS (EUPHORBIACEAE)
Mesquita Filho (2009)
Study of anticholinesterase activity of the plant Campomanesia lineatifolia ( myrtaceae )
G. OliveiraFilhoJ.W. (2012)
10.1186/1475-2859-13-24
A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds
Sony Pandey (2014)
10.2174/1570159X11311040004
Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy
A. Murray (2013)
10.1590/S0102-695X2006000500009
Antimicrobial activity of the essential oil of Bowdichia virgilioides Kunt.
J. R. G. Almeida (2006)
10.1002/cbdv.201200343
Acetylcholinesterase‐Inhibitory Activities of the Extracts from Sponges Collected in Mauritius Waters
Girish Beedessee (2013)
10.1590/S0102-695X2008000400023
Plantas medicinais e seus constituintes bioativos: uma revisão da bioatividade e potenciais benefícios nos distúrbios da ansiedade em modelos animais
F. C. Sousa (2008)
10.1177/1934578X1701200723
A New Stilbene from the Root of Cassia sieberiana D.C. (Fabaceae)
Saidu Jibril (2017)
10.1007/s00213-018-5105-3
Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-κB and IDO-1
P. Choubey (2018)
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