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Translocation Frequency In Patients With Repeated CT Exposure: Comparison With CT-Naive Patients.

J. Lee, M. S. Lee, M. Moon, Hyunsik Woo, Y. J. Hong, Seongjae Jang, S. Oh
Published 2019 · Medicine, Biology

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Epidemiologic studies using clinical indicators are limited in the assessment of the biological effects of low-dose ionizing radiation for medical purposes. We evaluated the biological effect of low-dose radiation by comparing translocation frequencies in patients with repeated computed tomography (CT) exposure and CT-naïve patients. The goal of this prospective case-control study was to determine whether repeated CT exposure is associated with increased frequency in chromosomal translocations. Two cohorts, comprised of case patients with a history of repeated CT exposure and age- and sex-matched CT-naïve control patients (n = 48 per cohort), were consecutively enrolled in this single-institution study. CT-radiation exposure was estimated using dose-length products, and translocation frequencies of peripheral blood lymphocytes were assessed using whole chromosome paints by fluorescence in situ hybridization (FISH). Comparison of translocation frequencies between cases and controls was performed using the Wilcoxon rank sum test (paired samples), and the relationship between cumulative radiation exposure and translocation frequency was assessed using a partial correlation analysis. Translocation frequencies were significantly different between cases and controls (P = 0.0003). The median translocation frequency was 7 [95% confidence interval (CI): 6, 8] for cases and 4 (95% CI: 3, 6) for controls. By using cumulative radiation exposure as the effect variable and translocation frequency as the response variable, we found a significant correlation between cumulative radiation exposure and translocation frequency (r = 0.6579, P < 0.0001). Chromosomal translocations were more frequent with repeated CT-exposed patients than in CT-naïve patients, and a positive dose-response relationship was present between cumulative radiation exposure and translocation frequency.
This paper references
10.2307/3577031
Radiation carcinogenesis: time-dose relationships.
R. Ullrich (1987)
10.1148/RADIOL.2421060171
Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure.
K. Rothkamm (2007)
10.1097/01.HP.0000326333.42287.a2
MEDICAL RADIATION EXPOSURE IN THE U.S. IN 2006: PRELIMINARY RESULTS
F. Mettler (2008)
10.1016/S0140-6736(04)15433-0
Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries
A. González (2004)
10.1148/radiol.13130567
Policy statement of the International Organization for Medical Physics.
W. Hendee (2013)
10.1073/pnas.2235592100
Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know
D. Brenner (2003)
10.1186/gb-2011-12-6-r61
Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy
Michal Ozery-Flato (2011)
10.1093/jrr/rrv090
Analysis of chromosome translocation frequency after a single CT scan in adults
Yu Abe (2016)
10.1016/j.mrgentox.2008.01.005
International study of factors affecting human chromosome translocations.
A. Sigurdson (2008)
10.1038/leu.2015.32
Role of chromosomal aberrations in clonal diversity and progression of acute myeloid leukemia
T. Bochtler (2015)
10.1016/j.canlet.2014.12.038
DNA damage response--a double-edged sword in cancer prevention and cancer therapy.
H. Tian (2015)
10.1111/bjh.13507
Mechanisms and clinical applications of chromosomal instability in lymphoid malignancy
M. Krem (2015)
10.1667/RR2629.1
Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950–2003: An Overview of Cancer and Noncancer Diseases
K. Ozasa (2012)
10.1016/S2352-3026(15)00094-0
Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study
K. Leuraud (2015)
10.1093/aje/kwj367
Re: "Chromosomal aberrations and cancer risk: results of a cohort study from central Europe".
G. Chodick (2007)
The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103.
J. Valentin (2007)
10.1259/BJR/24766640
Reconstruction of doses from ionizing radiation using fluorescence in situ hybridization techniques.
A. Edwards (2007)
10.1080/09553000701283816
Enhanced yield of chromosome aberrations after CT examinations in paediatric patients
G. Stephan (2007)
10.1016/j.cll.2011.07.007
Solid tumor cytogenetics: current perspectives.
Gouri J. Nanjangud (2011)
10.1148/RADIOL.2312030767
Diagnostic CT scans: assessment of patient, physician, and radiologist awareness of radiation dose and possible risks.
C. Lee (2004)
10.1093/OXFORDJOURNALS.RPD.A033013
Use of FISH-translocations Analyses for Retrospective Biological Dosimetry: How Stable are Stable Chromosome Aberrations?
F. Darroudi (2000)
10.1158/0008-5472.CAN-08-1691
Routine diagnostic X-ray examinations and increased frequency of chromosome translocations among U.S. radiologic technologists.
A. Sigurdson (2008)
10.1016/j.mrrev.2008.04.001
Low-dose ionizing radiation and chromosome translocations: a review of the major considerations for human biological dosimetry.
J. Tucker (2008)
10.1056/NEJMRA072149
Computed tomography--an increasing source of radiation exposure.
D. Brenner (2007)
10.1056/NEJMoa0901249
Exposure to low-dose ionizing radiation from medical imaging procedures.
R. Fazel (2009)
10.1007/s00330-012-2426-1
DNA double-strand breaks as potential indicators for the biological effects of ionising radiation exposure from cardiac CT and conventional coronary angiography: a randomised, controlled study
D. Geisel (2012)
10.1148/radiol.2532082010
Radiologic and nuclear medicine studies in the United States and worldwide: frequency, radiation dose, and comparison with other radiation sources--1950-2007.
Fred A. Mettler (2009)
10.1016/0921-8734(95)00015-X
The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting.
M. Ramsey (1995)
10.1148/radiol.2015142859
Informed Consent for Radiation Risk from CT Is Unjustified Based on the Current Scientific Evidence.
H. Harvey (2015)
10.1007/S004110050073
No evidence for increased tumor rates below 200 mSv in the atomic bomb survivors data
W. Heidenreich (1997)
10.1259/BJR/88081058
Radiation protection in humans: extending the concept of as low as reasonably achievable (ALARA) from dose to biological damage.
K. Prasad (2004)
10.1093/jrr/rrv028
Retrospective biodosimetry using translocation frequency in a stable cell of occupationally exposed to ionizing radiation
Min Su Cho (2015)
10.1038/nrc2091
The impact of translocations and gene fusions on cancer causation
F. Mitelman (2007)
10.1093/RPD/NCH452
Review of translocations detected by FISH for retrospective biological dosimetry applications.
A. Edwards (2005)



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