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Tramadol Reduces Testicular Damage Of Ischemia-reperfusion Rats

A. Asghari, G. Akbari, Abbas Mohammad Beigi, P. Mortazavi
Published 2016 · Medicine

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The main purpose of this study was to determine effect of tramadol administration on testis histology and oxidative stress experimental on testicular ischemia-reperfusion injury in male Wistar rats. Twenty-four male Wistar rats were randomly divided into four experimental groups. The Sham group (A): no medication was employed; abdominal cavity was opened but no ischemia-reperfusion-induced. The ischemia-reperfusion group (B): abdominal cavity was opened, testicular ischemia-reperfusion-induced without pre-medication. Ischemia-reperfusion +20 mg/kg tramadol group (C), animal orally administrated with Tramadol (20 mg/kg) for 1 week prior testicular ischemia-reperfusion. Ischemia-reperfusion +40 mg/kg tramadol group (D) was similar to group C, but the animals received 40 mg/kg tramadol instead of 20 mg/kg. In all experimental groups, animals were exposed to midline laparotomy with occlusion of the infrarenal aortic for 1 h ischemia by 24 h of reperfusion in the left testis. After 24 h, the abdomen was opened, the left testis extracted for histopathological studies. Semen samples from caudal epididymis were collected to determine malondialdehyde, superoxide dismutase, glutathione peroxidase and total antioxidant status. According to the data, testicular ischemia-reperfusion degenerated seminiferous tubules and spermatogenesis in animals (P < 0.05). Administration of 40 mg/kg of tramadol protect testicular against ischemia-reperfusion injury (P < 0.05). Administration of 40mg/kg tramadol increased superoxide dismutase and glutathione peroxidase while diminished malondialdehyde levels in testicular ischemia-reperfusion injury (P < 0.05). These results suggest tramadol might be a potent agent in preventing testicular IR injury.
This paper references
10.1016/j.jpedsurg.2008.01.065
Effects of melatonin on spermatogenesis and testicular ischemia-reperfusion injury after unilateral testicular torsion-detorsion.
Müslim Yurtçu (2008)
10.1007/s11255-015-1101-2
The protective role of curcumin on testicular tissue after hindlimb ischemia reperfusion in rats
M. Takhtfooladi (2015)
Protective effects of garlic aquous extract (Allium sativum), vitamin E, and N-acetylcysteine on reproductive quality of male rats exposed to lead
R. Asadpour (2013)
10.1016/j.jpedsurg.2008.11.043
Efficacy of antioxidant treatment in the prevention of testicular atrophy in experimental testicular torsion.
Müslim Yurtçu (2009)
[Myocardial ischemia-reperfusion injury and melatonin].
E. Sahna (2006)
10.1093/HUMUPD/7.1.78
The study of varicocele through the use of animal models.
T. Turner (2001)
10.5935/abc.20150059
Tramadol Alleviates Myocardial Injury Induced by Acute Hindlimb Ischemia Reperfusion in Rats
H. Takhtfooladi (2015)
Cypermethrin induced reproductive toxicity in male Wistar rats: protective role of Tribulus terrestris.
Poonam Sharma (2013)
10.1042/CS0840407
A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates.
N. J. Miller (1993)
10.1093/humrep/den060
Protective effect of antioxidant supplementation in sperm-preparation medium against oxidative stress in human spermatozoa.
H. Chi (2008)
tramadol) treatment on testicular functions in adult male rats: The role of nitric oxide and oxidative stress
R Asadpour (2013)
10.1016/0003-2697(66)90167-9
Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems.
Z. Placer (1966)
10.12816/EJHM.2006.17946
Biochemical Toxicity Induced By Tramadol Administration In Male Rats
Inass El-Gaafarawi (2006)
10.1080/14017430701227747
Effects of tramadol on myocardial ischemia-reperfusion injury
A. Bilir (2007)
Improved method for the determination of blood glutathione.
E. Beutler (1963)
exposed to chromium chloride
J Ghiasi Ghalehkandi (2015)
10.1111/1440-1681.12213
Effects of opioid (tramadol) treatment on testicular functions in adult male rats: The role of nitric oxide and oxidative stress
M. Ahmed (2014)
10.1016/j.ijsu.2012.12.003
The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats.
A. Tüfek (2013)
10.1186/1477-7827-12-1
Study of the effects of oral zinc supplementation on peroxynitrite levels, arginase activity and NO synthase activity in seminal plasma of Iraqi asthenospermic patients
M. H. Hadwan (2014)
10.3109/15376516.2012.716092
Effect of tramadol on behavioral alterations and lipid peroxidation after transient forebrain ischemia in rats
Pandian Nagakannan (2012)
10.1016/j.jpedsurg.2010.09.044
Protective effect of rutin on testicular ischemia-reperfusion injury.
S. Wei (2011)
rutin on testicular ischemia-reperfusion injury
JA Woolliams (1983)
10.2307/2527799
Multiple range tests for correlated heteroscedastic means
David B. Duncan (1957)
10.1016/J.FERTNSTERT.2004.09.006
Effect of experimental varicocele on the expressions of Notch 1, 2, and 3 in rat testes: an immunohistochemical study.
Z. Şahin (2005)
Assessment of the effects of red onion (Allium cepa Linn) juice on semen oxidative status compared to Zn sulfate in rats
J. G. Ghalehkandi (2015)
10.1016/0304-3959(83)90201-4
Ethical guidelines for investigations of experimental pain in conscious animals
M. Zimmermann (1983)
10.5555/URI:PII:0022214367900765
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.
D. Paglia (1967)
10.1590/S1677-5538.IBJU.2014.01.16
The effects of carvedilol on ischemia-reperfusion injury in the rat testis.
B. S. Parlaktas (2014)
dexmedetomidine on testicular ischemia-reperfusion injury
SM (2001)
10.1095/biolreprod.105.040741
Evidence for a Role of Mitogen-Activated Protein Kinase 3/Mitogen-Activated Protein Kinase in the Development of Testicular Ischemia-Reperfusion Injury
L. Minutoli (2005)
10.1590/S0102-865020150060000007
The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury.
D. Tuğlu (2015)
10.7150/IJBS.2.23
Seminal malondialdehyde concentration but not glutathione peroxidase activity is negatively correlated with seminal concentration and motility
Y. Hsieh (2006)
Garlic ( Allium sativum ) juice protects from semen oxidative stress in male rats exposed to chromium chloride
J. G. Ghalehkandi (2014)
10.1097/ALN.0b013e3182503964
Dexmedetomidine Administration before, but Not after, Ischemia Attenuates Intestinal Injury Induced by Intestinal Ischemia-Reperfusion in Rats
Xu-Yu Zhang (2012)
10.1159/000178170
Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males.
S. Johnsen (1970)
Effects of melatonin on testis histology, oxidative stress and spermatogenesis after experimental testis ischemia-reperfusion in rats.
Murat Koksal (2012)
10.1016/j.urology.2008.07.053
Role of oxidative stress in pathogenesis of varicocele and infertility.
A. Agarwal (2009)



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