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Diabetes Mellitus Is A Predictive Factor For Radiation Pneumonitis After Thoracic Radiotherapy In Patients With Lung Cancer

Moonkyoo Kong, Yu Jin Lim, Youngkyong Kim, Mi Joo Chung, Soonki Min, Dong Oh Shin, Weonkuu Chung
Published 2019 · Medicine
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Purpose We evaluated the effects of diabetes mellitus (DM) and DM-related serologic factors (HbA1c and fasting glucose) on the development of radiation pneumonitis in patients with lung cancer. Methods We retrospectively analyzed the clinical data of 123 patients with lung cancer treated with radiotherapy. Radiation pneumonitis was scored according to the toxicity criteria of the Radiation Therapy Oncology Group. We used binary logistic regression analysis to find significant predictive factors for the development of grade ≥3 radiation pneumonitis. Results On univariable analysis, V20, mean lung dose, DM, HbA1c, and fasting glucose level were significantly associated with the development of grade ≥3 radiation pneumonitis. On multivariable analysis, V20, mean lung dose, DM, HbA1c, and fasting glucose level remained significant predictive factors for grade ≥3 radiation pneumonitis. The incidence of grade ≥3 radiation pneumonitis was 44.4% in patients with DM and 20.7% in patients without DM. The incidence of grade ≥3 radiation pneumonitis was 12.7% for HbA1c level ≤6.15% and 41.5% for HbA1c level >6.15%. The incidence of grade ≥3 radiation pneumonitis was 17.2% for fasting glucose level ≤121 mg/dL and 35.5% for fasting glucose level >121 mg/dL. Conclusion DM, HbA1c, and fasting glucose level are significant predictive factors for the development of grade ≥3 radiation pneumonitis in patients with lung cancer. Patients with DM, patients who have HbA1c >6.15%, and patients who have fasting glucose >121 mg/dL should be treated with greater caution.
This paper references
10.1016/s0899-5885(18)30335-6
Diabetes and wound healing.
J. S. Meyer (1996)
10.1016/j.ijrobp.2004.07.695
Rectal bleeding after hypofractionated radiotherapy for prostate cancer: correlation between clinical and dosimetric parameters and the incidence of grade 2 or worse rectal bleeding.
Tetsuo Akimoto (2004)
10.1097/01.coc.0000260950.44761.74
Can Serum Markers Be Used to Predict Acute and Late Toxicity in Patients With Lung Cancer?: Analysis of RTOG 91-03
William F. Hartsell (2007)
10.4143/crt.2013.45.4.295
Predictive Factors for Radiation Pneumonitis in Lung Cancer Treated with Helical Tomotherapy
Youngkyong Kim (2013)
10.3978/j.issn.2072-1439.2013.12.04
Molecular markers to predict clinical outcome and radiation induced toxicity in lung cancer.
Joshua D Palmer (2014)
10.1016/j.ijrobp.2008.10.065
Elevation of plasma TGF-beta1 during radiation therapy predicts radiation-induced lung toxicity in patients with non-small-cell lung cancer: a combined analysis from Beijing and Michigan.
Lujun Zhao (2009)
10.1016/j.jdiacomp.2015.12.018
Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications.
Caroline Pereira Domingueti (2016)
10.1016/S0169-5002(02)00532-9
Concurrent two-dimensional radiotherapy and weekly docetaxel in the treatment of stage III non-small cell lung cancer: a good local response but no good survival due to radiation pneumonitis.
Hiroshi Onishi (2003)
10.1016/S0360-3016(98)00460-X
Diabetes mellitus: a predictor for late radiation morbidity.
David M. Herold (1999)
10.1016/j.ijrobp.2012.04.043
Predicting radiation pneumonitis after chemoradiation therapy for lung cancer: an international individual patient data meta-analysis.
David A. Palma (2013)
10.1016/j.clgc.2016.08.020
Prostate Cancer Patients With Unmanaged Diabetes or Receiving Insulin Experience Inferior Outcomes and Toxicities After Treatment With Radiation Therapy
Nicholas G Zaorsky (2017)
10.1016/j.ijrobp.2003.09.045
Target cells in radiation pneumopathy.
Klaus Rüdiger Trott (2004)
10.1016/s0094-1298(20)30624-6
Wound healing in diabetes mellitus.
William D. Morain (1990)
10.3904/kjim.2016.253
Current status of managing diabetes mellitus in Korea
Kyoung Hwa Ha (2016)
Impact of diabetes mellitus on clinicopathological factors and relation with radiation pneumonitis in 332 patients with lung
H Zhou (2013)
10.1016/S1470-2045(15)70168-3
Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials.
Joe Y Chang (2015)
10.1016/j.ctro.2017.02.003
What is the impact of diabetes mellitus on radiation induced acute proctitis after radical radiotherapy for adenocarcinoma prostate? A prospective longitudinal study
Abduelmenem Alashkham (2019)
10.3390/cancers10070222
Radiation Pneumonitis: Old Problem, New Tricks
Varsha Jain (2018)
10.1200/JCO.2008.20.6763
Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy.
Xianglin Yuan (2009)
10.1200/JCO.2009.27.3011
Diabetes mellitus and breast cancer outcomes: a systematic review and meta-analysis.
Kimberly S. Peairs (2011)
10.1016/j.ijrobp.2018.04.012
Clinical and Dosimetric Factors Predicting Grade ≥2 Radiation Pneumonitis After Postoperative Radiotherapy for Patients With Non-Small Cell Lung Carcinoma.
Keeratikarn Boonyawan (2018)
10.1016/J.IJROBP.2015.07.1576
Effect of Diabetes Mellitus and Selected Medications on the Development of Radiation Pneumonitis in Patients With Locally Advanced Non-Small Cell Lung Cancer
Wei-fan Hsia (2015)
10.3857/roj.2017.00066
Predictive factors of symptomatic radiation pneumonitis in primary and metastatic lung tumors treated with stereotactic ablative body radiotherapy
Kangpyo Kim (2017)
10.1007/s10620-009-0944-8
Colorectal Cancer Outcomes, Recurrence, and Complications in Persons With and Without Diabetes Mellitus: A Systematic Review and Meta-Analysis
Kelly B. Stein (2009)
10.1016/j.radonc.2004.02.015
Prediction of radiation pneumonitis by dose - volume histogram parameters in lung cancer--a systematic review.
George B. Rodrigues (2004)
10.1007/s00432-012-1284-1
Prediction of radiation pneumonitis in lung cancer patients: a systematic review
Xiao-jing Zhang (2012)
[Effect of diabetes mellitus on the development of radiation pneumonitis in patients with non-small cell lung cancer].
Hao Song (2009)
10.3969/j.issn.1672-7347.2013.02.005
[Impact of diabetes mellitus on clinicopathological factors and relation with radiation pneumonitis in 332 patients with lung cancer].
Haizhi Zhou (2013)
10.1097/COC.0b013e3181d6b40f
Chemotherapy Significantly Increases the Risk of Radiation Pneumonitis in Radiation Therapy of Advanced Lung Cancer
B. S. Nagendra Parashar (2011)
10.1016/j.urology.2013.01.047
Toxicity after external beam radiotherapy for prostate cancer: an analysis of late morbidity in men with diabetes mellitus.
Kapila Kalakota (2013)
10.1016/J.IJROBP.2013.06.1359
Evaluation of Diabetes as a Risk Factor for the Development of Clinically Symptomatic Pneumonitis Following Stereotactic Body Radiation Therapy (SBRT)
Matthew D. Orton (2013)
10.1186/1748-717X-5-35
Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy
Anhui Shi (2010)



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