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Vitamin E Succinate-grafted-chitosan/chitosan Oligosaccharide Mixed Micelles Loaded With C-DMSA For Hg2+ Detection And Detoxification In Rat Liver

B. Wei, Muye He, Xiaoran Cai, Xinyu Hou, Yujie Wang, J. Chen, M. Lan, Yan-Zuo Chen, Kaiyan Lou, Feng Gao
Published 2019 · Chemistry, Medicine

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Aim To determine whether the use of a mixed polymeric micelle delivery system based on vitamin E succinate (VES)-grafted-chitosan oligosaccharide (CSO)/VES-grafted-chitosan (CS) mixed micelles (VES-g-CSO/VES-g-CS MM) enhances the delivery of C-DMSA, a theranostic fluorescent probe, for Hg2+ detection and detoxification in vitro and in vivo. Methods Mixed micelles self-assembled from two polymers, VES-g-CSO and VES-g-CS, were used to load C-DMSA and afforded C-DMSA@VES-g-CSO/VES-g-CS MM for cell and in vivo applications. Fluorescence microscopy was used to assess C-DMSA cellular uptake and Hg2+ detection in L929 cells. C-DMSA@VES-g-CSO/VES-g-CS MM was then administered intravenously. Hg2+ detection was assessed by fluorescence microscopy in terms of bio-distribution while detoxification efficacy in Hg2+-poisoned rat models was evaluated in terms of mercury contents in blood and in liver. Results The C-DMSA loaded mixed micelles, C-DMSA@VES-g-CSO/VES-g-CS MM, significantly enhanced cellular uptake and detoxification efficacy of C-DMSA in Hg2+ pretreated human L929 cells. Evidence from the reduction of liver coefficient, mercury contents in liver and blood, alanine transaminase and aspartate transaminase activities in Hg2+ poisoned SD rats treated with the mixed micelles strongly supported that the micelles were effective for Hg2+ detoxification in vivo. Furthermore, ex vivo fluorescence imaging experiments also supported enhanced Hg2+ detection in rat liver. Conclusion The mixed polymeric micelle delivery system could significantly enhance cell uptake and efficacy of a theranostic probe for Hg2+ detection and detoxification treatment in vitro and in vivo. Moreover, this nanoparticle drug delivery system could achieve targeted detection and detoxification in liver.
This paper references
10.1039/B007577I
Excellent mercury(II) ion selectivefluoroionophore based on a 3,6,12,15-tetrathia-9-azaheptadecane derivativebearing a nitrobenzoxadiazolyl moiety
Hidefumi Sakamoto (2000)
10.1016/j.mam.2012.02.003
The disturbed blood-brain barrier in human glioblastoma.
H. Wolburg (2012)
10.1016/j.jtemb.2014.04.010
Chelation therapy in intoxications with mercury, lead and copper.
Y. Cao (2015)
10.1016/j.neuro.2008.06.004
Docosahexaenoic acid may act as a neuroprotector for methylmercury-induced neurotoxicity in primary neural cell cultures.
P. Kaur (2008)
10.1016/j.placenta.2009.06.005
Effect of DMPS and DMSA on the placental and fetal disposition of methylmercury.
C. Bridges (2009)
10.1016/j.ajps.2017.04.002
Preparation of 5-fluorouracil-loaded chitosan nanoparticles and study of the sustained release in vitro and in vivo
L. Sun (2017)
10.1016/j.jconrel.2012.02.011
Drug targeting to the diseased liver.
K. Poelstra (2012)
10.1016/J.PROGPOLYMSCI.2011.10.001
PEGylated chitosan derivatives: synthesis, characterizations and pharmaceutical applications
L. Casettari (2012)
The efficacy of nimodipine drug delivery usingmPEG-PLAmicelles andmPEG-PLA/TPGSmixedmicelles.Eur
S Huang (2014)
10.1088/1361-6528/aaaf4a
Simple and green synthesis of piperazine-grafted reduced graphene oxide and its application for the detection of Hg(II).
Yinxiu Zuo (2018)
10.1016/j.jhazmat.2015.11.031
A review on the distribution of Hg in the environment and its human health impacts.
K. Kim (2016)
10.3109/10717544.2010.520355
In vivo evaluation of novel chitosan graft polymeric micelles for delivery of paclitaxel
J. Liu (2011)
10.1016/j.ejpb.2016.12.019
Polymeric mixed micelles as nanomedicines: Achievements and perspectives.
Maximiliano Cagel (2017)
EFFECT OF TAURINE AND GLUTATHIONE ON MERCURY TOXICITY IN LIVER TISSUE OF RATS
S. sankar Samipillai (2009)
10.1021/JA992630A
A Selective and Sensitive Fluoroionophore for HgII, AgI, and CuII with Virtually Decoupled Fluorophore and Receptor Units
K. Rurack (2000)
10.1016/j.fct.2009.09.016
Total mercury determination in different tissues of broiler chicken by using cloud point extraction and cold vapor atomic absorption spectrometry.
A. Shah (2010)
10.2147/IJN.S26305
Supramolecular micellar nanoaggregates based on a novel chitosan/vitamin E succinate copolymer for paclitaxel selective delivery
H. Lian (2011)
10.4314/OVJ.V2I1
Levels of heavy metals in liver and kidney of dogs from urban environment
F.P. Serpe (2012)
10.1016/J.MICROC.2012.02.001
Determination and speciation of mercury in environmental and biological samples by analytical atomic spectrometry
Y. Gao (2012)
10.1016/J.NANTOD.2010.06.007
Polymer- and lipid-based nanoparticle therapeutics for the treatment of liver diseases
L. Li (2010)
10.1021/acs.molpharmaceut.6b01068
Vitamin E Succinate-Grafted-Chitosan Oligosaccharide/RGD-Conjugated TPGS Mixed Micelles Loaded with Paclitaxel for U87MG Tumor Therapy.
Yanzuo Chen (2017)
10.1016/S0021-9797(02)00082-6
On the determination of the critical micelle concentration by the pyrene 1:3 ratio method
J. Aguiar (2003)
10.1016/J.SNB.2014.04.077
A highly selective turn-on fluorescence chemosensor for Hg(II) and its application in living cell imaging
Shiang-Yi Yu (2014)
10.1016/j.jtemb.2018.03.015
In vivo bio-distribution, clearance and toxicity assessment of biogenic silver and gold nanoparticles synthesized from Abutilon indicum in Wistar rats.
R. Mata (2018)
10.1039/c5cc00295h
Fluorescent theranostic agents for Hg(2+) detection and detoxification treatment.
C. Song (2015)
10.1016/j.etap.2009.10.003
Role of vitamin E in preventing acute mercury toxicity in rat.
R. Agarwal (2010)
10.1016/j.talanta.2009.06.053
Determination of organic and inorganic mercury species in water and sediment samples by HPLC on-line coupled with ICP-MS.
José Soares dos Santos (2009)
The ef fi cacy of nimodipine drug delivery usingmPEG - PLAmicelles andmPEG - PLA / TPGSmixedmicelles
S Huang (2014)
10.1016/j.ijpharm.2011.12.004
α-Tocopherol succinate-modified chitosan as a micellar delivery system for paclitaxel: preparation, characterization and in vitro/in vivo evaluations.
N. Liang (2012)
10.1016/J.NANTOD.2015.06.006
Nanoparticle Uptake: The Phagocyte Problem.
Heather Herd Gustafson (2015)
10.1016/j.nano.2016.11.005
Phototheranostic nanoplatform based on a single cyanine dye for image-guided combinatorial phototherapy.
Tony Duong (2017)
10.1021/ac1021503
Highly sensitive, colorimetric detection of mercury(II) in aqueous media by quaternary ammonium group-capped gold nanoparticles at room temperature.
Dingbin Liu (2010)
10.1016/j.aca.2013.11.042
A new fluorescent turn-on chemodosimeter for mercury ions in solution and its application in cells and organisms.
Y. Xu (2014)
VES-g-CSO/VES-g-CS (w/w=8:2) were determined on a Lumina fluorescence spectrometer
Preparation and characteristics of stearic acid grafted chitosan oligosaccharide polymeric micelle containing 10-hydroxycamptothecin
X Li (2008)
10.3390/ijms19123790
Construction of a Glutathione-Responsive and Silica-Based Nanocomposite for Controlled Release of Chelator Dimercaptosuccinic Acid
Hongqiang Zhai (2018)
10.1007/s10967-014-3163-5
Sample pretreatment for the determination of gamma emitting nuclides in dry radioactive waste using a dry ashing and high-performance microwave digestion system
Kwang-Soon Choi (2014)
10.1016/j.talanta.2007.02.012
Determination of mercury in biological samples by cold vapor atomic absorption spectrometry following cloud point extraction with salt-induced phase separation.
I. M. Dittert (2007)
10.1016/J.SNB.2016.02.037
A sensitive Hg(II) colorimetric sensor based on synergistic catalytic effect of gold nanoparticles and Hg
Lulu Tan (2016)
10.17179/excli2015-709
Effects of zinc against mercury toxicity in female rats 12 and 48 hours after HgCl2 exposure
M. Mesquita (2016)
10.1021/jf503207s
Grafting of gallic acid onto chitosan enhances antioxidant activities and alters rheological properties of the copolymer.
Minhao Xie (2014)
10.1371/journal.pone.0055806
Apocynin Prevents Vascular Effects Caused by Chronic Exposure to Low Concentrations of Mercury
D. A. Rizzetti (2013)
10.1081/CLT-120022000
Vitamin C, Glutathione, Or Lipoic Acid Did Not Decrease Brain Or Kidney Mercury In Rats Exposed To Mercury Vapor
H. Vasken Aposhian (2003)
Simple and green synthesis of piperazinegrafted reduced graphene oxide and its application for the detection of Hg(II). Nanotechnology
Y Zuo (2018)



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