Emerging Antineoplastic Biogenic Gold Nanomaterials For Breast Cancer Therapeutics: A Systematic Review
Muthupandian Saravanan, Hossein Vahidi, David Medina Cruz, Ada Vernet-Crua, Ebrahim Mostafavi, Ryan Stelmach, Thomas. J. Webster, Mohammad Ali Mahjoub, Masoumeh Rashedi, Hamed Barabadi
Published 2020 · Materials Science, Medicine
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Abstract Breast cancer remains as a concerning global health issue, being the second leading cause of cancer deaths among women in the United States (US) in 2019. Therefore, there is an urgent and substantial need to explore novel strategies to combat breast cancer. A potential solution may come from the use of cancer nanotechnology, an innovative field of study which investigates the potential of nanomaterials for cancer diagnosis, therapy, and theranostic applications. Consequently, the theranostic functionality of cancer nanotechnology has been gaining much attention between scientists during the past few years and is growing exponentially. The use of biosynthesized gold nanoparticles (AuNPs) has been explored as an efficient mechanism for the treatment of breast cancer. The present study supposed a global systematic review to evaluate the effectiveness of biogenic AuNPs for the treatment of breast cancer and their anticancer molecular mechanisms through in vitro studies. Online electronic databases, including Cochrane, PubMed, Scopus, Web of Science, Science Direct, ProQuest, and Embase, were searched for the articles published up to July 16, 2019. Our findings revealed that plant-mediated synthesis was the most common approach for the generation of AuNPs. Most of the studies reported spherical or nearly spherical-shaped AuNPs with a mean diameter less than 100 nm in size. A significantly larger cytotoxicity was observed when the biogenic AuNPs were tested towards breast cancer cells compared to healthy cells. Moreover, biogenic AuNPs demonstrated significant synergistic activity in combination with other anticancer drugs through in vitro studies. Although we provided strong and comprehensive preliminary in vitro data, further in vivo investigations are required to show the reliability and efficacy of these NPs in animal models.
This paper references
Biosynthesis and Characterization of Biogenic Tellurium Nanoparticles by Using Penicillium chrysogenum PTCC 5031: A Novel Approach in Gold Biotechnology
Hamed Barabadi (2018)
Nano-Medicine as a Newly Emerging Approach to Combat Human Immunodeficiency Virus (HIV).
Muthupandian Saravanan (2018)
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Ximei Qian (2008)
Epirubicin-loaded marine carrageenan oligosaccharide capped gold nanoparticle system for pH-triggered anticancer drug release
Xiangyan Chen (2019)
Green synthesis of Nerium oleander-conjugated gold nanoparticles and study of its in vitro anticancer activity on MCF-7 cell lines and catalytic activity
Abir Chandan Barai (2018)
In vitro antioxidant, antimicrobial, cytotoxic potential of gold and silver nanoparticles prepared using Embelia ribes
Manikandan Dhayalan (2017)
Green synthesis of biocompatible gold nanoparticles using Fagopyrum esculentum leaf extract
Punuri Jayasekhar Babu (2011)
Green synthesis of gold and silver nanoparticles using aqueous extract of Cibotium barometz root
Dandan Wang (2017)
Facile synthesis of biocompatible gold nanoparticles from Vites vinefera and its cellular internalization against HBL-100 cells
Kanchana Amarnath (2011)
Structural characterization, antioxidant and anticancer properties of gold nanoparticles synthesized from leaf extract(decoction)of Antigonon leptopus Hook. &Arn.
Govindasamy Balasubramani (2015)
Eco-friendly synthesis of gold nanoparticles using fruit extracts and in vitro anticancer studies
S. Vijayakumar (2019)
Protein Corona Formation on Colloidal Polymeric Nanoparticles and Polymeric Nanogels: Impact on Cellular Uptake, Toxicity, Immunogenicity, and Drug Release Properties.
Katja Obst (2017)
Neuroprotective, Neurogenic, and Amyloid Beta Reducing Effect of a Novel Alpha 2-Adrenoblocker, Mesedin, on Astroglia and Neuronal Progenitors upon Hypoxia and Glutamate Exposure
M. Melkonyan (2017)
BaiM,WangF.Green synthesis of gold nanoparticles using carrageenan oligosaccharide and their in vitro antitumor activity.Mar Drugs
Facile synthesis ofAu andAg nanoparticles using fruit extract of Lycium chinense and their anticancer activity
Genotoxicity of biosynthesized gold and silver nanoparticles on human cancer cell lines
A Parveen (2015)
Self-assembly of biogenic gold nanoparticles and their use to enhance drug delivery into cells.
Ji Min Seo (2015)
Synthesis of gold and silver nanoparticles using Mukia maderaspatna plant extract and its anticancer activity.
G. Karthiga Devi (2017)
Molecular aspects of cancer cell resistance to chemotherapy.
Magali Rebucci (2013)
Spontaneous ultra fast synthesis of gold nanoparticles using Punica granatum for cancer targeted drug delivery.
Moorthy Ganeshkumar (2013)
Green approach for synthesis of gold nanoparticles from Nigella arvensis leaf extract and evaluation of their antibacterial, antioxidant, cytotoxicity and catalytic activities
A. Chahardoli (2018)
Synthesis of Gold Nanoparticles Using Citrus macroptera Fruit Extract: Anti‐Biofilm and Anticancer Activity
Moumita Majumdar (2019)
The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene.
M. Gottesman (2015)
Biological synthesis of gold and silver chloride nanoparticles by Glycyrrhiza uralensis and in vitro applications
Yue Huo (2018)
Green synthesis of gold nanoparticles and their enhanced synergistic antitumor activity using HepG2 and MCF7 cells and its antibacterial effects
Thangavelu Muthukumar (2016)
Green synthesis of silver nanoparticles using Alysicarpus monilifer leaf extract and its antibacterial activity against MRSA and CoNS isolates in HIV patients
Muthupandi Kasithevar (2017)
Synthesis of gold nanoparticles using citrus macroptera fruit extract: anti-biofilm and anticancer activity. ChemistrySelect
M Majumdar (2019)
Protein corona: a new approach for nanomedicine design
Văn Hồng Nguyên (2017)
Pectin mediated gold nanoparticles induces apoptosis in mammary adenocarcinoma cell lines.
K. S. Uma Suganya (2016)
Cancer statistics, 2019.
Rebecca L Siegel (2019)
A green chemistry approach for synthesizing biocompatible gold nanoparticles
Sangiliyandi Gurunathan (2014)
Podophyllotoxin extraction from Linum usitatissimum plant and its anticancer activity against HT-29, A-549 and MDA-MB-231 cell lines with and without the presence of gold nanoparticles
Mohammad Safarpoor (2018)
The global breast cancer burden. Future Oncol
JR Benson (2012)
Cytotoxic and antibacterial activities of biologically synthesized gold nanoparticles assisted by Micrococcus yunnanensis strain J2
Mandana Jafari (2018)
Piper betle-mediated green synthesis of biocompatible gold nanoparticles
Jayasekhar Babu Punuri (2012)
Gold nanoparticles as potent anticancer agent: green synthesis, characterization, and in vitro study
Abolghasem Abbasi Kajani (2016)
Targeted Drug Delivery Systems Mediated by a Novel Peptide in Breast Cancer Therapy and Imaging
Ruei-Min Lu (2013)
Facile synthesis of Au and Ag nanoparticles using fruit extract of Lycium chinense and their anticancer activity
Mohan Chokkalingam (2019)
Green synthesis of anisotropic gold nanoparticles for photothermal therapy of cancer.
Sajid Fazal (2014)
Gold nanoparticles in delivery applications ?
byBrooke LaBranche (2018)
Biosynthesis of gold nanoparticles using marine Streptomyces griseus isolate (M8) and evaluating its antimicrobial and anticancer activity
Moaz M. Hamed (2019)
In-vitro Evaluation of Antioxidant and Antibacterial Potential of GreenSynthesized Silver Nanoparticles Using Prosopis farcta Fruit Extract
Sepideh Salari (2019)
Protein corona formed on silver nanoparticles in blood plasma is highly selective and resistant to physicochemical changes of the solution† †Electronic supplementary information (ESI) available: Supporting Information 1: Experimental details; figures and tables; protein abundance and corresponding s
Vladimir I. Gorshkov (2019)
Biosynthesis and characterization of gold nanoparticles: Kinetics, in vitro and in vivo study.
Nabeel Ahmad (2017)
Application of a Nanoporous Metal Organic Framework Based on Iron Carboxylate as Drug Delivery System
Bahare Miri (2018)
Preparation of Metal Nanoparticles and Their Application for Materials
Tetsu Yonezawa (2018)
Eco-friendly synthesis of gold nanoparticles (AuNPs) using Inonotus obliquus and their antibacterial, antioxidant and cytotoxic activities
Ko Eun Lee (2015)
Cancer cells biomineralize ionic gold into nanoparticles-microplates via secreting defense proteins with specific gold-binding peptides.
Ajay Vikram Singh (2018)
Nanomedicine applications in the treatment of breast cancer: current state of the art
Di Wu (2017)
Drug resistance and the solid tumor microenvironment.
Olivier Trédan (2007)
Synthesis and characterization of gold-conjugated Backhousia citriodora nanoparticles and their anticancer activity against MCF-7 breast and HepG2 liver cancer cell lines
Roshanak Khandanlou (2017)
Green Synthesis of Silver Nanoparticles using Bidens Frondosa Extract and their Tyrosinase Activity
Qamar Abbas (2017)
Starchmediated synthesis of mono- and bimetallic silver/gold nanoparticles as antimicrobial and anticancer agents
N Dubrawsky (1989)
ENHANCED APOPTOSIS IN MCF-7 HUMAN BREAST CANCER CELLS BY BIOGENIC GOLD NANOPARTICLES SYNTHESIZED FROM ARGEMONE MEXICANA LEAF EXTRACT
Selvaraj Varun (2014)
Does Biosynthetic Silver Nanoparticles Are More Stable With Lower Toxicity than Their Synthetic Counterparts?
Zohreh Rezvani Amin (2019)
Phytosynthesis of gold nanoparticles using Mappia foetida leaves extract and their conjugation with folic acid for delivery of doxorubicin to cancer cells
Suparna Madivalara Yallappa (2015)
Biofabrication of gold nanoparticles and its biocompatibility in human breast adenocarcinoma cells (MCF-7)
Muralidharan Murugan (2014)
Acalypha indica Linn: Biogenic synthesis of silver and gold nanoparticles and their cytotoxic effects against MDA-MB-231, human breast cancer cells
Chandran Krishnaraj (2014)
Highly biocompatible behaviour and slow degradation of a LDH (layered double hydroxide)-coating on implants in the middle ear of rabbits
Franziska Duda (2015)
Protein corona: Opportunities and challenges.
Saeid Zanganeh (2016)
High interstitial fluid pressure — an obstacle in cancer therapy
Carl-Henrik Heldin (2004)
Anti-proliferative effect of biogenic gold nanoparticles against breast cancer cell lines (MDA-MB-231 & MCF-7)
K. S. Uma Suganya (2016)
Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma.
James F. Hainfeld (2010)
Cytotoxicity of spherical gold nanoparticles synthesised using aqueous extracts of aerial roots of Rhaphidophora aurea (Linden ex Andre) intertwined over Lawsonia inermis and Areca catechu on MCF-7 cell line.
Mubarak Jannathul Firdhouse (2017)
Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology
Xue Xue (2012)
Biosynthesized gold and silver nanoparticles by aqueous fruit extract of Chaenomeles sinensis and screening of their biomedical activities
Keun Hyun Oh (2018)
Emerging Theranostic Biogenic Silver Nanomaterials for Breast Cancer: A Systematic Review
Hamed Barabadi (2019)
Optimization of myco-synthesized silver nanoparticles by response surface methodology employing Box-Behnken design
Hamed Barabadi (2019)
What is Cancer
Sonya Leff (1970)
Extraction of Sulfathiazole from Urine Using Biosynthesized Magnetic Nanoparticles
Mehdi Maham (2017)
Starch-mediated synthesis of mono- and bimetallic silver/gold nanoparticles as antimicrobial and anticancer agents
Diana Lomelí-Marroquín (2019)
Longan fruit juice mediated synthesis of uniformly dispersed spherical AuNPs: cytotoxicity against human breast cancer cell line MCF-7, antioxidant and fluorescent properties
Arif Ullah Khan (2016)
In-vitro antimicrobial and anticancer properties of green synthesized gold nanoparticles using Anacardium occidentale leaves extract
Veena Sunderam (2019)
Synthesis and characterization of biogenic selenium nanoparticles with antimicrobial properties made by Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Pseudomonas aeruginosa.
David Medina Cruz (2018)
Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection--synthesis, characterization and in vitro evaluation.
Sudeshna Basu Mukherjee (2015)
Anisotropic Gold Nanostructures: Optimization via in Silico Modeling for Hyperthermia
Ajay Vikram Singh (2018)
Enhanced Antimicrobial and Anticancer Activity of Silver and Gold Nanoparticles Synthesised Using Sargassum incisifolium Aqueous Extracts
Mokone Mmola (2016)
Synthesis of Titanium Dioxide Nanoparticles Using Echinacea purpurea Herba
Renata Dobrucka (2017)
Emerging Theranostic Silver and Gold Nanomaterials to Combat Prostate Cancer: A Systematic Review
Hamed Barabadi (2019)
Applications of Metal Nanoparticles in Medicine/Metal Nanoparticles as Anticancer Agents
Wenjie Mei (2017)
Cardamom fruits as a green resource for facile synthesis of gold and silver nanoparticles and their biological applications
Veronika Soshnikova (2018)
Biosynthesis of Au, Ag and Au–Ag bimetallic nanoparticles using protein extracts of Deinococcus radiodurans and evaluation of their cytotoxicity
Jiulong Li (2018)
Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity
Xiangyan Chen (2018)
Catalytic, antioxidant and anticancer activities of gold nanoparticles synthesized by kaempferol glucoside from Lotus leguminosae
M. Oueslati (2020)
Biofabrication of gold and silver nanoparticles for pharmaceutical applications
Hamed Barabadi (2016)
Green synthesis of gold nanoparticles from Dunaliella salina, its characterization and in vitro anticancer activity on breast cancer cell line
Ankit Kumar Singh (2019)
Dragon fruit extract capped gold nanoparticles: Synthesis and their differential cytotoxicity effect on breast cancer cells
Deepika Divakaran (2019)
The use of gold nanoparticles to enhance radiotherapy in mice.
James F. Hainfeld (2004)
Hybrid nanoparticles for combination therapy of cancer.
Chunbai He (2015)
Emerging Theranostic Silver Nanomaterials to Combat Lung Cancer: A Systematic Review
Hamed Barabadi (2020)
Pectinmediated gold nanoparticles induces apoptosis in mammary adenocarcinoma cell lines
KSU Suganya (2016)
Gold nanoparticles: A critical review of therapeutic applications and toxicological aspects
Maria Fernanda Hornos Carneiro (2016)
Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice.
Wolfgang A. Eck (2010)
Citric Juice-mediated Synthesis of Tellurium Nanoparticles with Antimicrobial and Anticancer Properties.
David Medina Cruz (2019)
MSP-4, an Antimicrobial Peptide, Induces Apoptosis via Activation of Extrinsic Fas/FasL- and Intrinsic Mitochondria-Mediated Pathways in One Osteosarcoma Cell Line
Hsiao-Mei Kuo (2018)
Seed-mediated synthesis of plasmonic gold nanoribbons using cancer cells for hyperthermia applications.
A. Singh (2018)
Highly stable gold nanoparticles green-synthesized by upcycling cartilage waste extract from yellow-nose skate (Dipturus chilensis) and evaluation of its cytotoxicity, haemocompatibility and antioxidant activity
Eun-Young Ahn (2018)
Antibacterial Activity of Polyaniline Coated Silver Nanoparticles Synthesized from Piper Betle Leaves Extract
Md. Mamun Or Rashida (2016)
Nanobiotechnology for Breast Cancer Treatment. In: Breast Cancer-From Biology to Medicine. IntechOpen; 2017
M Rocha (2019)
Genetic Epidemiology of Breast Cancer in Latin America
Valentina A Zavala (2019)
Green chemistry approach for the synthesis and stabilization of biocompatible gold nanoparticles and their potential applications in cancer therapy.
Sudip Mukherjee (2012)
Preparation and mechanistic aspect of natural xanthone functionalized gold nanoparticle.
Nabanita Patra (2018)
Green Nanotechnology from Tea: Phytochemicals in Tea as Building Blocks for Production of Biocompatible Gold Nanoparticles.
S. K. Nune (2009)
Phytosynthesized gold nanoparticles from C. roxburghii DC. leaf and their toxic effects on normal and cancer cell lines.
Pannerselvam Balashanmugam (2016)
Sensitization of Resistance Ovarian Cancer Cells to Cisplatin by Biogenic Synthesized Silver Nanoparticles through p53 Activation
Tayebe Ramezani (2019)
Biosynthesis, Characterization, Antimicrobial and Cytotoxic Effects of Silver Nanoparticles Using Nigella arvensis Seed Extract
A. Chahardoli (2017)
The global breast cancer burden.
J R Benson (2012)
Would Colloidal Gold Nanocarriers Present An Effective Diagnosis Or Treatment For Ischemic Stroke?
Hamed Amani (2019)
Successful Green Synthesis of Gold Nanoparticles using a Corchorus olitorius Extract and Their Antiproliferative Effect in Cancer Cells
Eman H Ismail (2018)
Histopathological Characteristics: Clinical Course of Breast Cancer Subtypes Depending on the ER(+) (−)/PR(+) (−) Receptor Status
Nilufer Bulut (2017)
Photo-bio-synthesis of irregular shaped functionalized gold nanoparticles using edible mushroom Pleurotus florida and its anticancer evaluation.
Ravishankar Bhat (2013)
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.
David Moher (2010)
Cytotoxicity and Genotoxicity of Biosynthesized Gold and Silver Nanoparticles on Human Cancer Cell Lines
Asra Parveen (2014)
Reema Zeineldin (2017)
Green synthesis of gold nanoparticles using Curcuma pseudomontana essential oil, its biological activity and cytotoxicity against human ductal breast carcinoma cells T47D
Nalluchamy Muniyappan (2014)
and the Elsevier Bibliographic databases. The manuscript management system is completely online and includes a very quick and fair peer-review system
GANODERMA LUCIDUM-ORIENTAL MUSHROOM MEDIATED SYNTHESIS OF GOLD NANOPARTICLES CONJUGATED WITH DOXORUBICIN AND EVALUATION OF ITS ANTICANCER POTENTIAL ON HUMAN BREAST CANCER MCF-7/DOX CELLS
Deivasigamani Ranjith Kumar (2017)
Current developments in green synthesis of metallic nanoparticles using plant extracts: a review
Morteza Yadi (2018)
Nanotechnology and picotechnology: a new arena for translational medicine
E Mostafavi (2019)
Ultrafast synthesis of stabilized gold nanoparticles using aqueous fruit extract of Limonia acidissima L. and conjugated epirubicin: targeted drug delivery for treatment of breast cancer
Chinnaiyan Senthil Kumar (2016)
Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
Ada Vernet Crua (2019)