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The Ability Of Streptomycin-loaded Chitosan-coated Magnetic Nanocomposites To Possess Antimicrobial And Antituberculosis Activities

M. E. El Zowalaty, Samer Hassan Hussein Al Ali, M. Husseiny, B. Geilich, T. Webster, M. Hussein
Published 2015 · Medicine, Materials Science
Referenced 2 times by Citationsy Users

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Magnetic nanoparticles (MNPs) were synthesized by the coprecipitation of Fe2+ and Fe3+ iron salts in alkali media. MNPs were coated by chitosan (CS) to produce CS-MNPs. Streptomycin (Strep) was loaded onto the surface of CS-MNPs to form a Strep-CS-MNP nanocomposite. MNPs, CS-MNPs, and the nanocomposites were subsequently characterized using X-ray diffraction and were evaluated for their antibacterial activity. The antimicrobial activity of the as-synthesized nanoparticles was evaluated using different Gram-positive and Gram-negative bacteria, as well as Mycobacterium tuberculosis. For the first time, it was found that the nanoparticles showed antimicrobial activities against the tested microorganisms (albeit with a more pronounced effect against Gram-negative than Gram-positive bacteria), and thus, should be further studied as a novel nano-antibiotic for numerous antimicrobial and antituberculosis applications. Moreover, since these nanoparticle bacteria fighters are magnetic, one can easily envision magnetic field direction of these nanoparticles to fight unwanted microorganism presence on demand. Due to the ability of magnetic nanoparticles to increase the sensitivity of imaging modalities (such as magnetic resonance imaging), these novel nanoparticles can also be used to diagnose the presence of such microorganisms. In summary, although requiring further investigation, this study introduces for the first time a new type of magnetic nanoparticle with microorganism theranostic properties as a potential tool to both diagnose and treat diverse microbial and tuberculosis infections.
This paper references
Waves of resistance: Staphylococcus aureus in the antibiotic era
H. Chambers (2009)
Synthesis, characterization, and antimicrobial properties of copper nanoparticles
M. Usman (2013)
Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
S. Hussein-Al-Ali (2014)
Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?
M. Falagas (2007)
The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America.
B. Spellberg (2008)
"Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era.
Ae Jung Huh (2011)
Testing of susceptibility of Mycobacterium tuberculosis to isoniazid and rifampin by mycobacterium growth indicator tube method.
S. Walters (1996)
The World Health Organization.
Carmen Dolea (1962)
Superparamagnetic agents in magnetic resonance imaging: physicochemical characteristics and clinical applications. A review.
B. Bonnemain (1998)
Multicenter Laboratory Validation of the BACTEC MGIT 960 Technique for Testing Susceptibilities of Mycobacterium tuberculosis to Classical Second-Line Drugs and Newer Antimicrobials
S. Rüsch-Gerdes (2006)
The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles.
R. Prucek (2011)
Nano-technology for targeted drug delivery to combat antibiotic resistance
A. Sharma (2012)
Antimicrobial resistance: global report on surveillance 2014. World Health Organization (WHO); 2014. Available from: http://www.who. int/drugresistance/documents/surveillancereport/en
Preparation and characterization of carboxyl-group functionalized superparamagnetic nanoparticles and t he potential for bio-applications
Zhi Shan (2007)
pH effect on the synthesis of magnetite nanoparticles by the chemical reduction-precipitation method
Â. Andrade (2010)
Nanomaterials : synthesis, properties, and applications
A. Edelstein (1996)
Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study.
Babes (1999)
Synthesis of Magnetite Nanoparticles by Precipitation with Forced Mixing
Yihua Zhu (1999)
Infectious Diseases Society of America. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America
B Spellberg (2008)
Antibacterial resistance worldwide: causes, challenges and responses
S. Levy (2004)
Synthesis and characterization of ultra-small superparamagnetic iron oxide nanoparticles thinly coated with silica.
A. Bumb (2008)

This paper is referenced by
Improving the pharmacokinetics and tissue distribution of pyrinezolid by self-assembled polymeric micelles.
H. Long (2017)
Green synthesis of gold and silver nanoparticles from Cannabis sativa (industrial hemp) and their capacity for biofilm inhibition
Priyanka Singh (2018)
Antibiofilm effect of chlorhexidine-carrier nanosystem based on iron oxide magnetic nanoparticles and chitosan.
Ana Paula Miranda Vieira (2019)
Current applications of nanoparticles in infectious diseases.
H. Zazo (2016)
Nanoparticles for Signaling in Biodiagnosis and Treatment of Infectious Diseases
C. I. Colino (2018)
Nanoantimicrobials: Activity, Benefits, and Weaknesses
J. Jampílek (2017)
Recent Developments in Food Packaging Based on Nanomaterials
Yukun Huang (2018)
Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans”
P. Baptista (2018)
From Nano to Micro: using nanotechnology to combat microorganisms and their multidrug resistance.
M. Natan (2017)
Nanotechnology Based Therapeutics, Drug Delivery Mechanisms and Vaccination approaches for Countering Mycobacterium avium subspecies paratuberculosis (MAP) Associated Diseases
Stephen Bj (2015)
Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics
H. C. Janßen (2020)
Utilization of Chemically Synthesized Super Paramagnetic Iron Oxide Nanoparticles in Drug Delivery, Imaging and Heavy Metal Removal
P. D. Sruthi (2018)
Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
Alan J Hibbitts (2018)
Biomedical Potentialities of Silver Nanoparticles for Clinical Multiple Drug-Resistant Acinetobacter baumannii
Minghui Chen (2019)
Alternative strategies for the application of aminoglycoside antibiotics against the biofilm-forming human pathogenic bacteria
Fazlurrahman Khan (2020)
How can nanoparticles contribute to antituberculosis therapy?
J. Costa-Gouveia (2017)
Superparamagnetic Iron Oxide Nanoparticles and Essential Oils: A New Tool for Biological Applications
M. Miguel (2020)
Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity
L. S. Arias (2018)
Antimicrobial Applications of Superparamagnetic Iron Oxide Nanoparticles
A. B. Seabra (2017)
Chitosan nanoparticles in drug therapy of infectious and inflammatory diseases
P. Rajitha (2016)
Functional nanomaterials for the detection and control of bacterial infections.
Huiqiong Jia (2019)
Magnetic Nanoconjugated Teicoplanin: A Novel Tool for Bacterial Infection Site Targeting
Ilaria Armenia (2018)
Synthesis of magnetic iron oxide nanoparticles using pulp and seed aqueous extract of Citrullus colocynth and evaluation of their antimicrobial activity
Faten Farouk (2019)
Nanoparticles as New Emerging Antibacterials: Potentials and Limitations
Fohad Mabood Husain (2019)
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