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The Influence Of Estrogen On Skeletal Muscle

D. Enns, P. Tiidus
Published 2010 · Medicine

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As women enter menopause, the concentration of estrogen and other female hormones declines. This hormonal decrease has been associated with a number of negative outcomes, including a greater incidence of injury as well as a delay in recovery from these injuries. Over the past two decades, our understanding of the protective effects of estrogen against various types of injury and disease states has grown immensely. In skeletal muscle, studies with animals have demonstrated that sex and estrogen may potentially influence muscle contractile properties and attenuate indices of post-exercise muscle damage, including the release of creatine kinase into the bloodstream and activity of the intramuscular lysosomal acid hydrolase, β-glucuronidase. Furthermore, numerous studies have revealed an estrogen-mediated attenuation of infiltration of inflammatory cells such as neutrophils and macrophages into the skeletal muscles of rats following exercise or injury. Estrogen has also been shown to play a significant role in stimulating muscle repair and regenerative processes, including the activation and proliferation of satellite cells. Although the mechanisms by which estrogen exerts its influence upon indices of skeletal muscle damage, inflammation and repair have not been fully elucidated, it is thought that estrogen may potentially exert its protective effects by: (i) acting as an antioxidant, thus limiting oxidative damage; (ii) acting as a membrane stabilizer by intercalating within membrane phospholipids; and (iii) binding to estrogen receptors, thus governing the regulation of a number of downstream genes and molecular targets. In contrast to animal studies, studies with humans have not as clearly delineated an effect of estrogen on muscle contractile function or on indices of post-exercise muscle damage and inflammation. These inconsistencies have been attributed to a number of factors, including age and fitness level of subjects, the type and intensity of exercise protocols, and a focus on sex differences that typically involve factors and hormones in addition to estrogen. In recent years, hormone replacement therapy (HRT) or estrogen combined with exercise have been proposed as potentially therapeutic agents for postmenopausal women, as these agents may potentially limit muscle damage and inflammation and stimulate repair in this population. While the benefits and potential health risks of long-term HRT use have been widely debated, controlled studies using short-term HRT or other estrogen agonists may provide future new and valuable insights into understanding the effects of estrogen on skeletal muscle, and greatly benefit the aging female population. Recent studies with older females have begun to demonstrate their benefits.
This paper references
10.1152/japplphysiol.91573.2008
Effects of ovarian sex hormones and downhill running on fiber-type-specific HSP70 expression in rat soleus.
E. Bombardier (2009)
10.1152/JAPPL.1993.74.5.2140
No evidence of oxidant stress during high-intensity rowing training.
A. Dernbach (1993)
10.1007/s004240050587
Striated muscle calcium-stimulated cysteine protease (calpain-like) activity promotes myeloperoxidase activity with exercise
D. A. Raj (1998)
10.1152/PHYSREV.00026.2006
Estrogen receptors: how do they signal and what are their targets.
N. Heldring (2007)
10.1006/BBRC.1997.6223
Effects of estrogen on skeletal myoblast growth.
S. Kahlert (1997)
10.1113/jphysiol.1996.sp021381
Changes in muscle strength, relaxation rate and fatiguability during the human menstrual cycle.
R. Sarwar (1996)
10.1042/CS0960357
Hormone replacement therapy increases isometric muscle strength of adductor pollicis in post-menopausal women.
D. Skelton (1999)
10.1063/1.1383983
Anomalous colossal magnetoresistance effect in the Zn-doped Fe1−xZnxCr2S4 polycrystals with the spinel structure
S. X. Wang (2001)
10.1249/MSS.0b013e31817d1cce
Gender-related differences in muscle injury, oxidative stress, and apoptosis.
C. Kerksick (2008)
10.1249/mss.0b013e31815aedda
Sex differences in response to maximal eccentric exercise.
Kimberly A Sewright (2008)
10.1002/jcp.20000
IGF‐I mRNA levels in bovine satellite cell cultures: Effects of fusion and anabolic steroid treatment
E. Kamanga-Sollo (2004)
10.1046/J.1365-201X.1998.0303F.X
Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance.
M. Reid (1998)
10.1016/S0002-9440(10)65217-0
Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response.
G. Ashcroft (1999)
10.1007/s004210050579
Estrogen attenuates HSP 72 expression in acutely exercised male rodents
Z. Paroo (1999)
10.2170/PHYSIOLSCI.RP006906
Estrogen administration attenuates immobilization-induced skeletal muscle atrophy in male rats.
T. Sugiura (2006)
10.1097/00005768-199807000-00006
Creatine kinase release and clearance using MM variants following repeated bouts of eccentric exercise.
J. Hyatt (1998)
10.1152/ajpheart.1999.277.2.H467
Differential effects of ovariectomy on calcium activation of cardiac and soleus myofilaments.
J. Wattanapermpool (1999)
10.1080/026404100364965
Response of males and females to high-force eccentric exercise
J. Rinard (2000)
10.1152/JAPPL.1998.85.4.1316
Effects of ovariectomy and hindlimb unloading on skeletal muscle.
J. Fisher (1998)
10.1001/ARCHINTE.155.3.293
Is postmenopausal estrogen therapy associated with neuromuscular function or falling in elderly women? Study of Osteoporotic Fractures Research Group.
D. Seeley (1995)
10.1007/s00421-005-0078-4
Power output, isometric strength and steadiness in the leg muscles of pre- and postmenopausal women; the effects of hormone replacement therapy
S. Carville (2005)
10.1152/JAPPLPHYSIOL.00128.2007
Estrogen influences satellite cell activation and proliferation following downhill running in rats.
D. Enns (2008)
10.1113/jphysiol.1986.sp016126
Experimental human muscle damage: morphological changes in relation to other indices of damage.
D. Jones (1986)
10.1021/JM000170M
Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists.
S. Stauffer (2000)
10.1046/J.1365-201X.1999.00481.X
Gender differences in skeletal muscle fibre damage after eccentrically biased downhill running in rats.
J. Komulainen (1999)
10.1091/MBC.E02-01-0062
Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric oxide.
R. Tatsumi (2002)
10.1016/0022-510X(83)90058-8
Ultrastructural changes after concentric and eccentric contractions of human muscle
D. Newham (1983)
10.1249/00005768-199507000-00011
Inflammatory cell response to acute muscle injury.
J. Tidball (1995)
10.1016/S0378-5122(02)00079-8
Six months of hormone replacement therapy does not influence muscle strength in postmenopausal women.
E. Ribom (2002)
10.1016/0960-0760(95)00084-D
Antiestrogens: Mechanisms and actions in target cells
B. Katzenellenbogen (1995)
10.1006/JMCC.1997.0476
Myocardial protection of contractile function after global ischemia by physiologic estrogen replacement in the ovariectomized rat.
F. Kolodgie (1997)
10.1056/NEJMRA050776
Estrogen carcinogenesis in breast cancer.
J. Yager (2006)
10.1139/H08-108
Progesterone and estrogen influence postexercise leukocyte infiltration in overiectomized female rats.
S. Iqbal (2008)
10.1016/0014-4886(85)90219-5
Long-term effects of estrogen on rat skeletal muscle
S. Suzuki (1985)
10.1093/GERONA/56.6.B240
Skeletal muscle satellite cell characteristics in young and older men and women after heavy resistance strength training.
S. Roth (2001)
10.1152/JAPPL.1996.80.5.1660
Estradiol effect on anterior crural muscles-tibial bone relationship and susceptibility to injury
G. Warren (1996)
10.1006/BBRC.1997.6823
ED2+ macrophages increase selectively myoblast proliferation in muscle cultures.
M. L. Massimino (1997)
10.1152/JAPPLPHYSIOL.01583.2005
Estrogen status and skeletal muscle recovery from disuse atrophy.
J. McClung (2006)
10.1097/00003677-200301000-00008
Influence of Estrogen on Skeletal Muscle Damage, Inflammation, and Repair
P. Tiidus (2003)
10.1046/J.1365-201X.1999.00613.X
Slower fatigue and faster recovery of the adductor pollicis muscle in women matched for strength with men.
C. Fulco (1999)
10.1091/MBC.11.5.1859
A role for nitric oxide in muscle repair: nitric oxide-mediated activation of muscle satellite cells.
J. Anderson (2000)
10.1016/S0271-5317(99)00039-1
Vitamin C and vitamin E status in guinea pig tissues following estrogen administration
P. Tiidus (1999)
10.1042/CS20000264
Follow-up study of the benefits of hormone replacement therapy on isometric muscle strength of adductor pollicis in postmenopausal women.
N. Onambele (2001)
10.1152/AJPHEART.00957.2001
Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase.
Alyson Prorock (2003)
10.1152/JAPPL.2001.91.2.534
Myogenic satellite cells: physiology to molecular biology.
Thomas J. Hawke (2001)
10.1079/PNS2004354
Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation.
Shuichi Machida (2004)
10.1159/000071236
The Effects of Growth Hormone and Sex Steroid on Lean Body Mass, Fat Mass, Muscle Strength, Cardiovascular Endurance and Adverse Events in Healthy Elderly Women and Men
S. Harman (2003)
10.3181/00379727-209-43885C
Superoxide Radical: Controversies, Contradictions, and Paradoxes
J. McCord (1995)
10.1042/CS0970079
Changes in muscle strength in women following the menopause: a longitudinal assessment of the efficacy of hormone replacement therapy.
J. Greeves (1999)
10.1006/cbir.2000.0499
SATELLITE CELL REGULATION FOLLOWING MYOTRAUMA CAUSED BY RESISTANCE EXERCISE
J. Vierck (2000)
10.1016/S0015-0282(97)00428-7
Exercised-induced increase in lipid peroxidation parameters in amenorrheic female athletes.
S. Ayres (1998)
10.1007/s00418-006-0224-z
Evidence for estrogen receptor α and β expression in skeletal muscle of pigs
C. Kalbe (2006)
10.1113/jphysiol.1997.sp022016
Effects of acute changes in oestrogen on muscle function of the first dorsal interosseus muscle in humans.
J. Greeves (1997)
10.1016/0024-3205(96)00122-1
Sex steroid hormones and macrophage function.
L. Miller (1996)
10.1001/ARCHINTE.1995.00430030087010
Is Postmenopausal Estrogen Therapy Associated With Neuromuscular Function or Falling in Elderly Women
Dana G. Seeley (1995)
10.1046/J.0001-6772.2003.01186.X
Oestrogen receptor beta is expressed in adult human skeletal muscle both at the mRNA and protein level.
A. Wiik (2003)
10.2165/00007256-200232020-00003
Exercise-Induced Muscle Damage and the Potential Protective Role of Estrogen
Becky Kendall (2002)
10.1002/(SICI)1098-240X(199906)22:3<243::AID-NUR6>3.0.CO;2-X
Sex differences in leukocyte invasion in injured murine skeletal muscle.
B. St Pierre Schneider (1999)
10.1016/S0378-5122(02)00033-6
Relationship between estrogen use and musculoskeletal function in postmenopausal women.
D. Bemben (2002)
10.1152/JAPPL.1996.80.4.1331
Heart, liver, and skeletal muscle myeloperoxidase activity during exercise.
A. Belcastro (1996)
10.1152/JAPPLPHYSIOL.00926.2002
Gender differences in skeletal muscle fatigability are related to contraction type and EMG spectral compression.
B. C. Clark (2003)
10.1152/AJPCELL.00336.2001
Estrogen attenuates postexercise HSP70 expression in skeletal muscle.
Z. Paroo (2002)
10.1249/01.MSS.0000181678.28092.31
Estrogen replacement, muscle composition, and physical function: The Health ABC Study.
D. Taaffe (2005)
10.1113/jphysiol.2006.118265
Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo
J. Tidball (2007)
10.2165/00007256-199112030-00004
Mechanisms of Exercise-Induced Muscle Fibre Injury
R. Armstrong (1991)
10.1097/00075197-200111000-00008
Oestrogen and sex influence on muscle damage and inflammation: evidence from animal models
P. Tiidus (2001)
10.1139/Y01-011
Estrogen effect on post-exercise skeletal muscle neutrophil infiltration and calpain activity.
P. Tiidus (2001)
10.1016/0140-6736(93)92733-A
Oestrogen and protection against myocardial ischaemia
E. Versi (1993)
10.1111/J.1748-1716.1990.TB08823.X
Sex-linked variation in creatine kinase release, and its dependence on oestradiol, can be demonstrated in an in-vitro rat skeletal muscle preparation.
G. J. Amelink (1990)
10.1097/00075197-200111000-00011
Are women less susceptible to exercise-induced muscle damage?
P. Clarkson (2001)
10.1023/B:JURE.0000021398.78327.39
Effects of ovariectomy and estrogen on skeletal muscle function in growing rats
K. M. McCormick (2004)
10.7150/IJBS.4.126
Sex Hormones' Regulation of Rodent Physical Activity: A Review
J. Lightfoot (2008)
10.1097/01.GME.0000113847.74835.FE
The association between hormone therapy use and changes in strength and body composition in early postmenopausal women
G. Maddalozzo (2004)
10.1152/japplphysiol.91518.2008
Postmenopausal hormone replacement therapy modifies skeletal muscle composition and function: a study with monozygotic twin pairs.
P. Ronkainen (2009)
10.1002/mus.20594
CK‐MM autoantibodies: Prevalence, immune complexes, and effect on CK clearance
G. Warren (2006)
10.1083/JCB.9.2.493
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
A. Mauro (1961)
10.1111/J.1525-1373.2000.22308.X
Protective effect of estrogens against oxidative damage to heart and skeletal muscle in vivo and in vitro.
A. Persky (2000)
10.1177/1099800403262258
The Effects of Estradiol and Progesterone on Plantarflexor Muscle Fatigue in Ovariectomized Mice
B. A. Schneider (2004)
10.1016/S1062-1458(02)00920-0
Noncardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/progestin Replacement Study follow-up (HERS II).
S. Hulley (2002)
10.1249/00005768-199202000-00007
Activation of myogenic precursor cells after muscle injury.
T. Hurme (1992)
10.1046/J.1365-201X.2002.00943.X
Effect of endurance training on oestrogen receptor alpha transcripts in rat skeletal muscle.
S. Lemoine (2002)
10.1034/j.1600-0838.2003.20210.x
Muscle performance, sex hormones and training in peri‐menopausal and post‐menopausal women
S. Sipilä (2003)
10.1007/BF01986165
A morphological study of delayed muscle soreness
J. Fridén (2005)
10.1152/japplphysiol.00404.2009
Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women.
C. Dieli-Conwright (2009)
10.1161/01.RES.0000144126.57786.89
17&bgr;-Estradiol Reduces Cardiomyocyte Apoptosis In Vivo and In Vitro via Activation of Phospho-Inositide-3 Kinase/Akt Signaling
R. Patten (2004)
10.1249/00005768-199205000-00004
Muscle function after exercise-induced muscle damage and rapid adaptation.
P. Clarkson (1992)
A potent specific pure antiestrogen with clinical potential.
A. Wakeling (1991)
10.1007/BF00422739
Endurance capacity of untrained males and females in isometric and dynamic muscular contractions
R. Maughan (2004)
10.1249/MSS.0b013e3181621311
Response of the myocardium to exercise: sex-specific regulation of hsp70.
Kevin J. Milne (2008)
10.1023/A:1012395831685
Influence of Estrogen on Markers of Muscle Tissue Damage Following Eccentric Exercise
A. Carter (2004)
10.1111/j.1475-097X.2005.00628.x
The effect of hormone replacement therapy and/or exercise on skeletal muscle attenuation in postmenopausal women: a yearlong intervention
D. Taaffe (2005)
10.4049/jimmunol.180.12.7980
Chronic Estradiol Administration In Vivo Promotes the Proinflammatory Response of Macrophages to TLR4 Activation: Involvement of the Phosphatidylinositol 3-Kinase Pathway1
B. Calippe (2008)
10.1152/JAPPL.2001.91.4.1828
Effects of ovariectomy and estrogen on ischemia-reperfusion injury in hindlimbs of female rats.
N. Stupka (2001)
10.1016/S0378-5122(00)00132-8
Evaluation of the applicability of HRT as a preservative of muscle strength in women.
I. Meeuwsen (2000)
10.1113/expphysiol.2006.035071
Ovarian hormone status and skeletal muscle inflammation during recovery from disuse in rats
J. McClung (2007)
10.1080/GYE.13.S4.41.45
Progesterone and neurology.
D. Gruber (1999)
10.1152/JAPPL.1993.74.3.1381
Skeletal muscle calcium-activated neutral protease (calpain) with exercise.
A. Belcastro (1993)
10.1152/AJPHEART.2000.278.4.H1030
Effect of 6-wk estrogen withdrawal or replacement on myocardial ischemic tolerance in rats.
P. Mcnulty (2000)
10.2170/JJPHYSIOL.51.753
Effects of 17beta-estradiol on tension responses and fatigue in the skeletal twitch muscle fibers of frog.
J. Hatae (2001)
10.1111/j.1748-1716.2009.02033.x
Oestrogen receptor‐alpha activation augments post‐exercise myoblast proliferation
A. Thomas (2010)
10.1139/H06-008
Soleus muscle force following downhill running in ovariectomized rats treated with estrogen.
S. Sotiriadou (2006)
10.1023/A:1022071114344
The effects of physical activity and estrogen treatment on rat fast and slow skeletal muscles following ovariectomy
F. Kadi (2004)
Estrogen and gender do not affect fatigue resistance of extensor digitorum longus muscle in rats.
P. Tiidus (1999)
Effects of estrogen on gastrocnemius muscle strain injury and regeneration in female rats.
X. Feng (2004)
10.1152/JAPPLPHYSIOL.01305.2006
Estradiol replacement reverses ovariectomy-induced muscle contractile and myosin dysfunction in mature female mice.
Amy L. Moran (2007)
10.1139/y98-111
Estrogen administration, postexercise tissue oxidative stress and vitamin C status in male rats.
P. Tiidus (1998)
10.1152/JAPPLPHYSIOL.00869.2005
Ovariectomy prevents the recovery of atrophied gastrocnemius skeletal muscle mass.
Mitchell Sitnick (2006)
10.1016/0022-510X(86)90142-5
Exercise-induced muscle protein leakage in the rat: Effects of hormonal manipulation
G. J. Amelink (1986)
10.1161/01.RES.81.5.885
17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization.
T. Caulin-Glaser (1997)
10.1002/(SICI)1097-4598(199906)22:6<724::AID-MUS9>3.0.CO;2-O
Macrophages enhance muscle satellite cell proliferation and delay their differentiation
F. Merly (1999)
10.1152/jappl.2001.90.4.1407
Exercise-enhanced satellite cell proliferation and new myonuclear accretion in rat skeletal muscle.
H. Smith (2001)
10.1152/JAPPLPHYSIOL.00275.2004
Effects of eccentric exercise training on cortical bone and muscle strength in the estrogen-deficient mouse.
Monica Jeanne Hubal (2005)
10.1152/JAPPL.2001.91.6.2816
Selected contribution: Effects of gender on reduced-size liver ischemia and reperfusion injury.
H. Harada (2001)
10.1046/J.1365-201X.2001.00854.X
Differential effects of diminished oestrogen and androgen levels on development of skeletal muscle fibres in hypogonadal mice.
J. Sciote (2001)
Estradiol in females may negate skeletal muscle myostatin mRNA expression and serum myostatin propeptide levels after eccentric muscle contractions.
D. Willoughby (2006)
10.1161/01.CIR.96.6.1953
Amelioration of ischemia- and reperfusion-induced myocardial injury by 17beta-estradiol: role of nitric oxide and calcium-activated potassium channels.
K. Node (1997)
10.1016/0024-3205(88)90243-3
Prevention of exercise-induced muscle membrane damage by oestradiol.
P. Bär (1988)
10.1016/J.YJMCC.2004.05.021
Regulation of myocardial heat shock protein 70 gene expression following exercise.
C. Melling (2004)
10.1006/DBIO.1997.8803
HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cells.
R. Tatsumi (1998)
10.1139/H99-020
Etiology of exercise-induced muscle damage.
P. Clarkson (1999)
10.1113/jphysiol.1996.sp021706
Changes in maximal voluntary force of human adductor pollicis muscle during the menstrual cycle.
S. Phillips (1996)
10.1152/japplphysiol.90848.2008
Point:Counterpoint: Estrogen and sex do/do not influence post-exercise indexes of muscle damage, inflammation, and repair.
P. Tiidus (2009)
10.1016/S8756-3282(03)00098-X
Associations of hormone replacement therapy with bone structure and physical performance among postmenopausal women.
K. Uusi-Rasi (2003)
10.1016/S0039-128X(02)00040-5
Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system: Interaction of estrogen receptor α with phosphatidylinositol 3-OH kinase
T. Simoncini (2002)
10.1016/0378-5122(94)00857-4
Forearm bone density and grip strength in women after menopause, with and without estrogen replacement therapy.
E. Preisinger (1995)
10.1001/jama.288.1.58
Noncardiovascular disease outcomes during 6.8 years of hormone therapy : Heart and Estrogen/Progestin Study fellow-up (HERS II)
S. Hulley (2002)
10.1063/1.354743
Optical limitation and bistability in fullerene
F. Lin (1993)
10.1042/CS0840095
Muscle weakness in women occurs at an earlier age than in men, but strength is preserved by hormone replacement therapy.
S. Phillips (1993)
10.1006/JMCC.1996.0093
Protection from myocardial reperfusion injury by acute administration of 17 beta-estradiol.
J. Delyani (1996)
10.1519/JSC.0b013e31817392ec
Muscle Function in Men and Women During Maximal Eccentric Exercise
M. Hubal (2008)
10.1007/s00424-005-1406-6
The behaviour of satellite cells in response to exercise: what have we learned from human studies?
F. Kadi (2005)
10.1038/OBY.2001.81
Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy.
M. Sørensen (2001)
10.1093/AGEING/24.4.329
Maximal muscle strength of elderly women is not influenced by oestrogen status.
D. Taaffe (1995)
10.1007/PL00013796
Different effects of strenuous eccentric exercise on the accumulation of neutrophils in muscle in women and men
Donna L. Macintyre (2000)
10.1097/FJC.0b013e3181824d59
Estrogen Protects the Heart From Ischemia-Reperfusion Injury via COX-2-Derived PGI2
E. Booth (2008)
10.1249/01.MSS.0000058437.17262.11
Resistance training in postmenopausal women with and without hormone therapy.
P. Teixeira (2003)
10.1152/JAPPL.1999.87.1.22
Specific strength and voluntary muscle activation in young and elderly women and men.
J. Kent-braun (1999)
10.1111/j.1365-3083.1990.tb02820.x
Oestrogen Receptors in Macrophages
S. Gulshan (1990)
10.1152/JAPPL.2000.89.6.2325
Gender differences in muscle inflammation after eccentric exercise.
N. Stupka (2000)
10.1152/JAPPL.1975.38.5.863
Comparison of physiological responses of women and men to isometric exercise.
J. Petrofsky (1975)
10.1007/s00418-004-0707-8
Gender dimorphism influences extracellular matrix expression and regeneration of muscular tissue in mdx dystrophic mice
Maria Cristina Salimena (2004)
10.1093/GERONA/52A.3.B166
Hormone replacement therapy does not augment gains in muscle strength or fat-free mass in response to weight-bearing exercise.
M. Brown (1997)
10.1139/H95-002
Can estrogens diminish exercise induced muscle damage?
P. Tiidus (1995)
Estrogen modulation of JE/monocyte chemoattractant protein-1 mRNA expression in murine macrophages.
M. Frazier-Jessen (1995)
10.1016/S1534-5807(01)00049-1
The potential of muscle stem cells.
P. Seale (2001)
10.1161/01.CIR.0000105700.95607.49
Estradiol and Progestins Differentially Modulate Leukocyte Infiltration After Vascular Injury
D. Xing (2004)
10.1111/J.1365-201X.2005.01427.X
Oestrogen influence on myogenic satellite cells following downhill running in male rats: a preliminary study.
P. Tiidus (2005)
10.1161/01.RES.0000082334.17947.11
Modulation of Antioxidant Enzyme Expression and Function by Estrogen
K. Strehlow (2003)
10.1152/japplphysiol.00448.2009
HRT affects skeletal muscle contractile characteristics: a definitive answer?
G. Onambele-Pearson (2009)
10.1042/CS0910685
Effects of hormone replacement therapy on muscle performance and balance in post-menopausal women.
A. Armstrong (1996)
10.1152/JAPPLPHYSIOL.01029.2005
Removal of ovarian hormones from mature mice detrimentally affects muscle contractile function and myosin structural distribution.
Amy L. Moran (2006)
10.1016/S0024-3205(00)00669-X
Steroid hormone-induced effects on membrane fluidity and their potential roles in non-genomic mechanisms.
K. Whiting (2000)
10.1016/0014-5793(87)81293-0
Estrogens as natural antioxidants of membrane phospholipid peroxidation
K. Sugioka (1987)
10.1111/j.1748-1716.2008.01861.x
Oestrogen receptors mediate oestrogen‐induced increases in post‐exercise rat skeletal muscle satellite cells
D. Enns (2008)
10.1152/japplphysiol.00590.2009
Influence of hormone replacement therapy on eccentric exercise induced myogenic gene expression in postmenopausal women.
C. Dieli-Conwright (2009)
10.1210/JCEM.77.4.8408459
Antioxidant potential of specific estrogens on lipid peroxidation
M. Subbiah (1993)
10.1210/endo.142.3.8033
Minireview: Neuroprotective Effects of Estrogen-New Insights into Mechanisms of Action.
P. Wise (2001)
10.1007/BF02425503
Lack of variation in muscle strength with menstrual status in healthy women aged 45–54 years: data from a national survey
E. J. Bassey (2006)
10.1097/00005768-199903000-00009
Effect of exercise during the follicular and luteal phases on indices of oxidative stress in healthy women.
S. Chung (1999)
10.1007/s11064-004-6874-0
Estrogen as a Multi-Active Neuroprotective Agent in Traumatic Injuries
E. A. Sribnick (2004)
10.1152/JAPPLPHYSIOL.01342.2003
Men are more fatigable than strength-matched women when performing intermittent submaximal contractions.
S. Hunter (2004)
10.1042/CS20020360
Effect of menstrual cycle phase on the concentration of bioavailable 17-beta oestradiol and testosterone and muscle strength.
K. J. Elliott (2003)
10.1023/A:1006816123601
Exercise-induced muscle injury: A calpain hypothesis
A. Belcastro (2004)
10.1046/J.1365-201X.1999.00550.X
Oestrogen attenuates post-exercise myeloperoxidase activity in skeletal muscle of male rats.
P. Tiidus (1999)
10.1007/BF02007685
The susceptibility to exercise-induced muscle damage increases as rats grow larger
G. J. Kasperek (2005)



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M. Ravelojaona (2014)
10.3109/10582452.2010.502620
Skeletal Muscle Damage and Repair: Classic Paradigms and Recent Developments
Peter M Tiidus (2010)
10.1093/pm/pnv117
Does Pain in the Neonatal Period Influence Motor and Sensory Functions in a Similar Way for Males and Females During Post-Natal Development in Rats?
E. C. D. Carmo (2016)
10.1007/978-3-319-44558-8_14
Sex Hormones, Menstrual Cycle and Resistance Exercise
Yuki Nakamura (2017)
10.1152/physiol.00024.2014
Sex-based differences in skeletal muscle kinetics and fiber-type composition.
K. M. Haizlip (2015)
The Role of Oxytocin in Bovine Satellite Cell Proliferation and Differentiation
Zhenhe Zhang (2017)
10.1139/CJPP-2013-0037
The role of estrogen receptor-α in estrogen-mediated regulation of basal and exercise-induced Hsp70 and Hsp27 expression in rat soleus.
BombardierEric (2013)
10.1038/s41467-018-07057-5
Tamoxifen therapy in a murine model of myotubular myopathy
N. Maani (2018)
10.1210/jc.2014-1124
Longitudinal relationships of circulating reproductive hormone with functional disability, muscle mass, and strength in community-dwelling older men: the Concord Health and Ageing in Men project.
B. Hsu (2014)
10.1016/j.foodchem.2013.07.029
Oxytocin precursor gene expression in bovine skeletal muscle is regulated by 17β-oestradiol and dexamethasone.
S. Divari (2013)
10.1016/j.arr.2014.02.007
Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels
J. Ilich (2014)
10.1093/jhered/esaa008
The estrogen-responsive transcriptome of female secondary sexual traits in the Gulf pipefish.
A. P. Anderson (2020)
10.1016/j.bone.2015.04.015
Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease.
J. Carson (2015)
10.5152/eajm.2011.24
Benefits of estrogen replacement for skeletal muscle mass and function in post-menopausal females: evidence from human and animal studies.
P. Tiidus (2011)
10.1093/gerona/glv104
Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice.
C. M. Fearing (2016)
10.1249/MSS.0b013e3181e93316
Effect of high-protein feeding on performance and nitrogen balance in female cyclists.
David Stephen Rowlands (2011)
10.1016/j.bone.2015.07.013
Lean mass and fat mass have differing associations with bone microarchitecture assessed by high resolution peripheral quantitative computed tomography in men and women from the Hertfordshire Cohort Study.
M. Edwards (2015)
10.1007/s00421-013-2686-8
Acute effects of sex-specific sex hormones on heat shock proteins in fast muscle of male and female rats
W. Romani (2013)
T2 Relaxation Time in Men and Women Following Eccentric Elbow Flexor Exercise
Patrick A Moull (2015)
Endogenous and Exogenous Estrogens on Biochemical and Performance Indicators of Exercise Induced Muscle Damage in Users and non-Users of Oral Contraceptives
Emily K W Flanagan (2019)
Clinical effects of cross-sex hormone therapy in adult trans persons
K. Wierckx (2014)
10.1590/S0103-64402011000600010
Influence of female hormonal fluctuation on maximum occlusal force.
Thais Marques Simek Vega Gonçalves (2011)
10.1016/j.jphys.2018.05.002
Pelvic floor muscle training increases pelvic floor muscle strength more in post-menopausal women who are not using hormone therapy than in women who are using hormone therapy: a randomised trial.
Flávia Ignácio Antônio (2018)
10.1002/cbin.11057
Sex influences diaphragm muscle response in exercised mdx mice
T. A. Hermes (2018)
10.4000/BOOKS.INSEP.1865
Topic 3. Nutritional aspects of post-exercise recovery: a gender difference
Christophe Hausswirth (2015)
10.1007/s11332-017-0366-5
Effects of low-intensity pulsed ultrasound on muscle thickness and echo intensity of the elbow flexors following exercise-induced muscle damage
D. M. Medeiros (2017)
Skeletal Muscle Estrogen Receptor Activation in Response to Eccentric Exercise Up-Regulates Myogenic-Related Gene Expression Independent of Differing Serum Estradiol Levels Occurring during the Human Menstrual Cycle.
M Haines (2018)
10.3390/ijerph17051618
Influence of the Menstrual Cycle on Blood Markers of Muscle Damage and Inflammation Following Eccentric Exercise
Nuria Romero-Parra (2020)
10.1152/ajpregu.00427.2011
Increased fat deposition in injured skeletal muscle is regulated by sex-specific hormones.
Matthew Mchale (2012)
10.1007/s40279-013-0081-6
How Sex Hormones Promote Skeletal Muscle Regeneration
M. Velders (2013)
10.1152/physiolgenomics.00226.2010
Chronic exposure to anabolic steroids induces the muscle expression of oxytocin and a more than fiftyfold increase in circulating oxytocin in cattle.
N. De Jager (2011)
10.1016/j.afos.2016.06.002
The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia
Y. Kim (2016)
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