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Development Of Nanoparticles For Antimicrobial Drug Delivery.
L. Zhang, D. Pornpattananangku, C. Hu, C.-M. Huang
Published 2010 · Medicine
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This review focuses on the development of nanoparticle systems for antimicrobial drug delivery. Numerous antimicrobial drugs have been prescribed to kill or inhibit the growth of microbes such as bacteria, fungi and viruses. Even though the therapeutic efficacy of these drugs has been well established, inefficient delivery could result in inadequate therapeutic index and local and systemic side effects including cutaneous irritation, peeling, scaling and gut flora reduction. Nanostructured biomaterials, nanoparticles in particular, have unique physicochemical properties such as ultra small and controllable size, large surface area to mass ratio, high reactivity, and functionalizable structure. These properties can be applied to facilitate the administration of antimicrobial drugs, thereby overcoming some of the limitations in traditional antimicrobial therapeutics. In recent years, encapsulation of antimicrobial drugs in nanoparticle systems has emerged as an innovative and promising alternative that enhances therapeutic effectiveness and minimizes undesirable side effects of the drugs. Here the current progress and challenges in synthesizing nanoparticle platforms for delivering various antimicrobial drugs are reviewed. We also call attention to the need to unite the shared interest between nanoengineers and microbiologists in developing nanotechnology for the treatment of microbial diseases.
This paper references
Targeted delivery of arjunglucoside I using surface hydrophilic and hydrophobic nanocarriers to combat experimental leishmaniasis
R. Tyagi (2005)
Glyconanobiotics: Novel carbohydrated nanoparticle antibiotics for MRSA and Bacillus anthracis.
Sampath C Abeylath (2008)
Efficacy and Pharmacokinetics of Intravenous Nanocapsule Formulations of Halofantrine in Plasmodium berghei-Infected Mice
V. Mosqueira (2004)
Chemotherapeutic potential of free and liposome encapsulated streptomycin against experimental Mycobacterium avium complex infections in beige mice.
P. Gangadharam (1991)
′CASCADE′- AND ′NONSKID-CHAIN-LIKE′ SYNTHESES OF MOLECULAR CAVITY TOPOLOGIES
E. Buhleier (1978)
Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: an in vitro study.
Y. Cheng (2007)
Cytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles
R. Mueller (1996)
Liposomal amphotericin-B (AmBisome) for treatment of cutaneous widespread candidosis in an infant with methylmalonic acidaemia
S. Stöckler (2005)
Dendrimers: a versatile targeting platform☆
A. T. Florence (2005)
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
Preparation and Evaluation of Miconazole Nitrate-Loaded Solid Lipid Nanoparticles for Topical Delivery
M. Bhalekar (2009)
In vitro antileishmanial activity of amphotericin B loaded in poly(epsilon-caprolactone) nanospheres.
M. S. Espuelas (2002)
Preprints of the 1st SPSJ international polymer conference , society of polymer science
D A Tomalia (1984)
Alginate nanoparticles as antituberculosis drug carriers: formulation development, pharmacokinetics and therapeutic potential.
Zahoor Ahmad (2006)
Selected antimicrobial agents: mechanisms of action, side effects and drug interactions.
C. Walker (1996)
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
[Enhanced activity of rifampicin loaded with polybutyl cyanoacrylate nanoparticles in relation to intracellularly localized bacteria].
I. N. Skidan (2003)
Altered Tissue Distribution and Elimination of Amikacin Encapsulated in Unilamellar, Low-Clearance Liposomes (MiKasome®)
R. Fielding (2004)
Antibiotics for Emerging Pathogens
M. Fischbach (2009)
Single bilayer liposomes.
S. M. Johnson (1971)
Mechanism of Enhanced Activity of Liposome-Entrapped Aminoglycosides against Resistant Strains of Pseudomonas aeruginosa
Clement Mugabe (2006)
Diffusion of univalent ions across the lamellae of swollen phospholipids.
A. Bangham (1965)
Drug delivery strategies for improved azole antifungal action.
W. Yang (2008)
Enhanced killing of methicillin-resistantStaphylococcus aureus in human macrophages by liposome-entrapped vancomycin and teicoplanin
C. Onyeji (1994)
The future challenges facing the development of new antimicrobial drugs
A. Coates (2002)
Dendrimers and dendritic polymers in drug delivery.
E. Gillies (2005)
AmBisome : long circulating formulation of Amphotericin B
J. P. Adler-Moore (1998)
The antimicrobial activity of liposomal lauric acids against Propionibacterium acnes.
Darren Yang (2009)
The Delivery of Benzyl Penicillin to Staphylococcus aureus Biofilms by Use of Liposomes
H. Kim (2004)
The use of SLN and NLC as topical particulate carriers for imidazole antifungal agents.
E. Souto (2006)
Investigations on the occlusive properties of solid lipid nanoparticles (SLN).
S. Wissing (2001)
Solid lipid nanoparticles (SLN) as carriers for the topical delivery of econazole nitrate: in‐vitro characterization, ex‐vivo and in‐vivo studies
V. Sanna (2007)
Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes.
F. Olson (1979)
Pegylated lysine based copolymeric dendritic micelles for solubilization and delivery of artemether.
D. Bhadra (2005)
Liposome-entrapped ampicillin in the treatment of experimental murine listeriosis and salmonellosis.
E. Fattal (1991)
Safety, Tolerance, and Pharmacokinetics of a Small Unilamellar Liposomal Formulation of Amphotericin B (AmBisome) in Neutropenic Patients
T. Walsh (1998)
Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II--tissue distribution.
A. Bargoni (2001)
Cosmetic applications for solid lipid nanoparticles (SLN).
S. Wissing (2003)
SLN and NLC for topical delivery of ketoconazole
E. Souto (2005)
Continuous nanostructures for the controlled release of drugs.
J. Venugopal (2009)
Liposomal amphotericin (AmBisome) in the prophylaxis of fungal infections in neutropenic patients: a randomised, double-blind, placebo-controlled study
S. Kelsey (1999)
AmBisome®: Long Circulating Liposomal Formulation of Amphotericin B
J. Adler-Moore (1998)
Oral nanoparticle-based antituberculosis drug delivery to the brain in an experimental model.
R. Pandey (2006)
Liposome-incorporated ciprofloxacin in treatment of murine salmonellosis.
M. Magallanes (1993)
Optimization of Spray-Dried and -Congealed Lipid Micropellets and Characterization of Their Surface Morphology by Scanning Electron Microscopy
T. Eldem (2004)
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
Solid lipid particle-based inhalable sustained drug delivery system against experimental tuberculosis.
R. Pandey (2005)
Dendrimer−Silver Complexes and Nanocomposites as Antimicrobial Agents
L. Balogh (2001)
How to stabilize phospholipid liposomes (using nanoparticles).
L. Zhang (2006)
Preparation and characterization of liposomes as therapeutic delivery systems: a review.
S. Vemuri (1995)
AmBisome targeting to fungal infections.
J. Adler-Moore (1994)
Liposome-encapsulated ampicillin: physicochemical and antibacterial properties.
I. Schumacher (1997)
Inhibition of HIV-1 in Cell Culture by Oligonucleotide-Loaded Nanoparticles
M. Berton (2004)
Treatment of experimental salmonellosis in mice with ampicillin-bound nanoparticles.
E. Fattal (1989)
Delivery of antimicrobials to infected tissue macrophages
I. Bakker-Woudenberg (1995)
Safety, Tolerance, and Pharmacokinetics of High-Dose Liposomal Amphotericin B (AmBisome) in Patients Infected withAspergillus Species and Other Filamentous Fungi: Maximum Tolerated Dose Study
T. Walsh (2001)
Polymers for the sustained release of proteins and other macromolecules
R. Langer (1976)
Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.
E. Souto (2004)
In Vitro Antileishmanial Activity of Amphotericin B Loaded in Poly(ε-Caprolactone) Nanospheres
M. S. Espuelas (2002)
About Dendrimers: Structure, Physical Properties, and Applications.
A. W. Bosman (1999)
Enhanced activity of liposomal polymyxin B against Pseudomonas aeruginosa in a rat model of lung infection.
Abdelwahab Omri (2002)
Interactions between dendrimer biocides and bacterial membranes.
C. Chen (2002)
Microbiology of airway disease in patients with cystic fibrosis.
P. Gilligan (1991)
Comparative studies on the efficacy of AmBisome and Fungizone in a mouse model of disseminated aspergillosis.
K. Takemoto (2004)
Effect of nanoparticle-bound ampicillin on the survival of Listeria monocytogenes in mouse peritoneal macrophages.
F. Forestier (1992)
Liposome Letters, Academic Press London
A. D. Bangham (1983)
Update in Antifungal Therapy of Dermatophytosis
A. Gupta (2008)
Nanoparticle therapeutics: an emerging treatment modality for cancer
M. Davis (2008)
Bakker-Woudenberg, I. Liposomeencapsulated aminoglycosides in pre-clinical and clinical studies
R Schiffelers (2001)
Nanoparticles in Medicine: Therapeutic Applications and Developments
L. Zhang (2008)
AmBisome: long circulating formulation of Amphotericin B. Long Circulating Liposome: Old Drugs
J P Adler-Moore (1998)
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
R. Mueller (2002)
Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins.
B. Devarakonda (2005)
Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
F. Gu (2008)
Development, Characterization, Efficacy and Mode of Action of Ambisome, A Unilamellar Liposomal Formulation of Amphotericin B
J. Adler-Moore (1993)
Lymphatic targeting of zidovudine using surface-engineered liposomes.
C. D. Kaur (2008)
Macrophage Activation by Polymeric Nanoparticles of Polyalkylcyanoacrylates: Activity Against Intracellular Leishmania donovani Associated with Hydrogen Peroxide Production
R. Gaspar (2004)
Lymphatic Uptake of Pulmonary Delivered Radiolabelled Solid Lipid Nanoparticles
M. Videira (2002)
Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism.
A. Zur Mühlen (1998)
Treatment of Brucella canis and Brucella abortus in vitro and in vivo by stable plurilamellar vesicle-encapsulated aminoglycosides.
M. Fountain (1985)
Antibiotic-conjugated polyacrylate nanoparticles: new opportunities for development of anti-MRSA agents.
E. Turos (2007)
Intracellular Delivery of Saquinavir in Biodegradable Polymeric Nanoparticles for HIV/AIDS
Lipa K Shah (2006)
Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin.
R. Cavalli (2002)
The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis.
S. Gelperina (2005)
Comparison of ciprofloxacin hydrochloride-loaded protein, lipid, and chitosan nanoparticles for drug delivery.
D. Jain (2008)
Trends and developments in liposome drug delivery systems.
T. Lian (2001)
Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies.
R. Schiffelers (2001)
Dendrimers: a versatile targeting
A. T. Florence (2005)
The emerging nanomedicine landscape
Volker Wagner (2006)
Liposomal formulation of netilmicin
Isabel M. Mimoso (1997)
In In: Preprints of the 1st SPSJ international polymer conference, society of polymer
D. A. Tomalia (1984)
Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems.
C. Pouton (2000)
Lipid formulations of amphotericin B: recent progress and future directions.
J. Hiemenz (1996)
Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery.
J. Cheng (2007)
Preparation and characterization of liposomes as therapeutic delivery systems: a review. Pharma
S. Vemuri (1995)
Polymeric carriers for amphotericin B: in vitro activity, toxicity and therapeutic efficacy against systemic candidiasis in neutropenic mice.
M. S. Espuelas (2003)
AmBisome: liposomal formulation, structure, mechanism of action and pre-clinical experience.
J. Adler-Moore (2002)
Convergent Dendrons and Dendrimers: From Synthesis to Applications
S. Grayson (2002)
Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug.
Minglu Ma (2007)
Nanomedicine: developing smarter therapeutic and diagnostic modalities.
O. Farokhzad (2006)
Liposphere parenteral delivery system
A. J. Domb (1993)
Receptor Mediated Targeting of Lectin Conjugated Gliadin Nanoparticles in the Treatment of Helicobacter pylori
R. Umamaheshwari (2003)
Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains.
M. Alipour (2008)
Liposomal formulation of netilmicin Int. J. Pharm
I M Mimoso (1997)
This paper is referenced by
Invasin-functionalized liposome nanocarriers improve the intracellular delivery of anti-infective drugs
S. Menina (2016)
Drug-Free Cyclodextrin-Based Nanosponges for Antimicrobial Activity
D. Desai (2020)
Fungal endophytes of turmeric (Curcuma longa L.) and their biocontrol potential against pathogens Pythium aphanidermatum and Rhizoctonia solani
G. Vinayarani (2018)
Influence of hybrid inorganic/organic mesoporous and nanostructured materials on the cephalosporins' efficacy on different bacterial strains.
M. Carmen Chifiriuc (2012)
Nanoparticle based Drug Delivery Systems for Treatment of Infectious Diseases
M. Salouti (2014)
In vivo display: a selection and its derivatives for antimicrobial peptide lead identification
W. Colangelo (2012)
Silver salts of carboxylic acid terminated generation 1 poly (propyl ether imine) (PETIM) dendron and dendrimers as antimicrobial agents against S. aureus and MRSA
Nadia Suleman (2015)
Biocompatibility of transition metal-substituted cobalt ferrite nanoparticles
Noppakun Sanpo (2014)
Nanoencapsulation of Food Antimicrobial Agents and Essential Oils
Y. Zhang (2017)
Pulmonary drug delivery systems for tuberculosis treatment.
Dinh-Duy Pham (2015)
Chasing bacteria within the cells using levofloxacin-loaded hyaluronic acid nanohydrogels.
E. Montanari (2014)
Nanomedicine Approaches Against Parasitic Worm Infections
P. Li (2018)
Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics
L. Wang (2020)
Nanoparticles as 'smart' pharmaceutical delivery.
C. Chakraborty (2013)
Evaluation of antimicrobial activity of propolis and nanopropolis against Staphylococcus aureus and Candida albicans
H. Afrouzan (2012)
Synthesis and characterization of lipophilic bismuth dimercaptopropanol nanoparticles and their effects on oral microorganisms growth and biofilm formation
A. R. Badireddy (2014)
알루미늄 표면에 생물막의 형성인자 및 항균제에 의한 생물막 제거효과 분석
Sangjun Park (2015)
Advances in industrial biofilm control with micro-nanotechnology
Formulation development and characterization of curcumin loaded solid lipid nanoparticles for improved aqueous solubility and bioavailability
P. S. Kumar (2017)
Dendrimeric Biocides - A Tool for Effective Antimicrobial Therapy
R. Karthikeyan (2016)
Chapter 9 Pluronic Nanotechnology for Overcoming Drug Resistance
P. Chowdhury (2017)
Investigating of Antifungal Activity of Polylactic Acid Film Containing Iron Nanoparticles in a Food System
محمد جواد اکبریان میمند (2019)
Oral meropenem for superbugs: challenges and opportunities.
Aun Raza (2020)
Nanotechnology based anti‐infectives to fight microbial intrusions
M. Rai (2016)
pH-Controlled Cerium Oxide Nanoparticle Inhibition of Both Gram-Positive and Gram-Negative Bacteria Growth
Ece Alpaslan (2017)
Nanoparticle-Mediated Pulmonary Drug Delivery: A Review
M. Paranjpe (2014)
Advanced dextran based nanogels for fighting Staphylococcus aureus infections by sustained zinc release.
K. Malzahn (2014)
Potential of Kalopanax septemlobus Leaf Extract in Synthesis of Silver Nanoparticles for Selective Inhibition of Specific Bacterial Strain in Mixed Culture
B. K. Salunke (2014)
Identification et caractérisations physico-chimiques et pharmacologiques de nouvelles molécules bioactives isolées à partir de venins d’animaux : exemple des peptides antimicrobiens
Chloé Mollet (2017)
Nanoparticle Induced Suppression of Microbial Biofilm
Shatavari Kulshrestha (2016)
Antimicrobial Nanostructures for Neurodegenerative Infections
Arunachalam Muthuraman (2017)
Cure of tuberculosis using nanotechnology: An overview
Rout George Kerry (2018)See more