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(Diacetoxyiodo)Benzene Mediated Fused 1,2,4-Triazole Derivatives: Synthetic And Medicinal Perspective

Vinod Kumar, Mohit Kumar, Sunil Kumar

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Hypervalent iodine(III) reagents are well known for the mild and highly selective oxidative chemical transformations, specifically in synthesis of a variety of heterocycles, in a facile and environmentally friendly manner. In past decades, triazole derivatives have gained much attention of the scientific community as some of the products containing triazole moiety contribute towards the development of effective chemotherapeutics. (Diacetoxyiodo)benzene, a hypervalent iodine(III) reagent has proven its significant role in synthesis of 1,2,4-triazoles, in particular, fused derivatives. This review highlights the (Diacetoxyiodo)benzene mediated developments made for the synthesis of fused 1,2,4-triazole derivatives till date. In addition, medicinal perspective of these heterocycles has also been summarized.