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Age-related Changes In Motor Cortical Properties And Voluntary Activation Of Skeletal Muscle.
B. Clark, J. Taylor
Published 2011 · Medicine
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Aging is associated with dramatic reductions in muscle strength and motor control, and many of these agerelated changes in muscle function result from adaptations in the central nervous system. Aging is associated with widespread qualitative and quantitative changes of the motor cortex. For example, advancing age has been suggested to result in cortical atrophy, reduced cortical excitability, reduced cortical plasticity, as well as neurochemical abnormalities.The associated functional effects of these changes likely influence numerous aspects of muscle performance such as muscle strength and motor control. For example, there is evidence to suggest that the muscle weakness associated with aging is partially due to impairments in the nervous system's ability to fully activate motor neurons- particularly in the larger proximal muscle groups. In this review article we discuss age-related changes in the motor cortex, as well as the abilityor lack thereof- of older adults to voluntarily activate skeletal muscle. We also provide perspectives on scientific and clinical questions that need to be addressed in the near future.
This paper references
Older adults can maximally activate the biceps brachii muscle by voluntary command.
S. J. De Serres (1998)
The effect of ageing and immobilization on structure and function of human skeletal muscle fibres.
G. D'Antona (2003)
Human skeletal sarcoplasmic reticulum Ca2+ uptake and muscle function with aging and strength training.
S. Hunter (1999)
Dopamine transporters decrease with age.
N. Volkow (1996)
Treatment of Parkinson's with L-DOPA. The early discovery phase, and a comment on current problems
A. Carlsson (2002)
Spinal and supraspinal factors in human muscle fatigue.
S. Gandevia (2001)
Compensatory mechanisms in the aging motor system
N. Ward (2006)
Intermuscle differences in activation
David G. Behm (2002)
Longitudinal study of muscle strength, quality, and adipose tissue infiltration.
M. Delmonico (2009)
Point: the interpolated twitch does/does not provide a valid measure of the voluntary activation of muscle.
J. Taylor (2009)
Age-related enhancement of fatigue resistance is evident in men during both isometric and dynamic tasks.
I. Lanza (2004)
Age-related decline in rate of torque development is accompanied by lower maximal motor unit discharge frequency during fast contractions.
M. Klass (2008)
Effects of aging on actin sliding speed on myosin from single skeletal muscle cells of mice, rats, and humans.
P. Höök (2001)
Dynamic and static sensitivities of muscle spindle primary endings in aged rats to ramp stretch
T. Miwa (1995)
Knee extensor strength, activation, and size in very elderly people following strength training
S. Harridge (1999)
Force and the motor cortex
J. Ashe (1997)
Marked loss of myelinated nerve fibers in the human brain with age
L. Marner (2003)
Are voluntary muscle activation deficits in older adults meaningful?
J. Stevens (2003)
Conventionally assessed voluntary activation does not represent relative voluntary torque production
R. Kooistra (2007)
Doublet discharges in motoneurons of young and older adults.
A. Christie (2006)
Motor unit number estimates in the tibialis anterior muscle of young, old, and very old men
C. McNeil (2005)
Measurement of voluntary activation of fresh and fatigued human muscles using transcranial magnetic stimulation
G. Todd (2003)
Is a Fall Just a Fall: Correlates of Falling in Healthy Older Persons. The Health, Aging and Body Composition Study
N. de Rekeneire (2003)
Role of Ca2+, membrane excitability, and Ca2+ stores in failing muscle contraction with aging
A. M. Payne (2009)
Extrapolation of the interpolated twitch-voluntary torque relationship is misleading.
R. Herbert (2009)
Change in muscle mass and muscle strength after a hip fracture: relationship to mobility recovery.
M. Visser (2000)
Comparison of interpolation and central activation ratios as measures of muscle inactivation
David G. Behm (2001)
Age‐related muscle fatigue after a low‐force fatiguing contraction is explained by central fatigue
Tejin Yoon (2008)
Knee Extension Strength Cutpoints for Maintaining Mobility
T. Manini (2007)
Adaptability of elderly human muscles and tendons to increased loading
M. Narici (2006)
Ageing and human muscle: observations from Sweden.
J. Lexell (1993)
Voluntary muscle activation varies with age and muscle group.
J. Jakobi (2002)
Age-related differences in corticospinal control during functional isometric contractions in left and right hands.
M. V. Sale (2005)
Recovery from supraspinal fatigue is slowed in old adults after fatiguing maximal isometric contractions.
S. Hunter (2008)
Functional MRI in human motor control studies and clinical applications.
K. Toma (2002)
Aging is associated with contrasting changes in local and distant cortical connectivity in the human motor system
J. Rowe (2006)
Functionally relevant thresholds of quadriceps femoris strength.
L. Ploutz-Snyder (2002)
Synaptic control of motoneuronal excitability.
J. Rekling (2000)
Does healthy aging affect the hemispheric activation balance during paced index-to-thumb opposition task? An fMRI study
M. Naccarato (2006)
Specific strength and voluntary muscle activation in young and elderly women and men.
J. Kent-braun (1999)
Mechanisms that contribute to differences in motor performance between young and old adults.
R. Enoka (2003)
A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women.
W. Frontera (1991)
Evaluation of neuronal loss, astrocytosis and abnormalities of cytoskeletal components of large motor neurons in the human anterior horn in aging
F. cruz-Sánchez (1998)
Aging does not affect voluntary activation of the ankle dorsiflexors during isometric, concentric, and eccentric contractions.
M. Klass (2005)
Relation between isometric force and stimulus rate in cat's hindlimb motor units of different twitch contraction time
Dr. D. Kernell (2004)
Increased intracortical inhibition in middle-aged humans; a study using paired-pulse transcranial magnetic stimulation
A. Kossev (2002)
Aging of the Somatosensory System: A Translational Perspective
S. Shaffer (2007)
Transcranial magnetic stimulation in neurology
M. Kobayashi (2003)
Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time
D. Madden (2004)
Glutamatergic neurotransmission in aging: a critical perspective
G. Segovia (2001)
Adaptations in muscular activation of the knee extensor muscles with strength training in young and older adults.
C. Knight (2001)
Comparison of skeletal muscle motor unit discharge characteristics in young and aged humans.
R. Nelson (1983)
Effects of aging on the human motor cortical plasticity studied by paired associative stimulation
D. Fathi (2010)
Quadriceps muscle strength, contractile properties, and motor unit firing rates in young and old men
M. R. Roos (1999)
Comparative effects of resistance training on peak isometric torque, muscle hypertrophy, voluntary activation and surface EMG between young and elderly women
J. Cannon (2007)
Ageing of human muscles and tendons
M. Narici (2008)
Contractile changes in opposing muscles of the human ankle joint with aging.
A. Vandervoort (1986)
Loss of D2 receptors during aging is partially due to decreased levels of mRNA
E. Mesco (1991)
Functional Decline in Cognitive Impairment – The Relationship between Physical and Cognitive Function
T. Auyeung (2008)
Age-related resistance to skeletal muscle fatigue is preserved during ischemia
L. H. Chung (2007)
Spinal excitation and inhibition decrease as humans age.
A. Kido (2004)
Neural Basis of Aging: The Penetration of Cognition into Action Control
S. Heuninckx (2005)
Normalized force, activation, and coactivation in the arm muscles of young and old men.
C. Klein (2001)
Fatigue of elbow flexor muscles in younger and older adults
M. Bilodeau (2001)
Voluntary activation during maximal contraction with advancing age: a brief review
M. Klass (2006)
Muscular performances at the ankle joint in young and elderly men.
E. Simoneau (2005)
Age-related changes in the nigrostriatum: a behavioral and biochemical analysis.
J. Joseph (1978)
Age-related Differences In Cortical Excitability: 629
B. C. Clark (2010)
Effects of aging on Type II muscle fibers: a systematic review of the literature.
F. Brunner (2007)
The numbers of limb motor neurons in the human lumbosacral cord throughout life
B. Tomlinson (1977)
Age changes in signal transduction and gene expression
G. Roth (1997)
Older adults exhibit more intracortical inhibition and less intracortical facilitation than young adults
Marisa McGinley (2010)
Older adults exhibit a reduced ability to fully activate their biceps brachii muscle.
G. Yue (1999)
Age‐related changes in motor unit function
M. R. Roos (1997)
Erratum to “Force and the motor cortex”: [Behavioural Brain Research 86 (1997) 1–15]
J. Ashe (1997)
Midlife hand grip strength as a predictor of old age disability.
T. Rantanen (1999)
Morphometry of the human cortex cerebri and corpus striatum during aging
H. Haug (1991)
Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort.
A. Newman (2006)
Reexamining the Sarcopenia Hypothesis: Muscle Mass versus Muscle Strength
M. Visser (2000)
Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNAs during aging
M. Hayashi (1997)
Motor unit firing rates and contractile properties in tibialis anterior of young and old men.
D. Connelly (1999)
Adrenergic and serotonergic receptors in aged monkey neocortex
Matthew H. Bigham (1995)
Plantar flexor activation capacity and H reflex in older adults: adaptations to strength training.
G. Scaglioni (2002)
Skeletal Muscle Mass and Muscle Strength in Relation to Lower‐Extremity Performance in Older Men and Women
M. Visser (2000)
Age‐dependent changes in the ability to encode a novel elementary motor memory
L. Sawaki (2003)
An evaluation of the length-tension relationship in elderly human plantarflexor muscles.
K. Winegard (1997)
Cellular and Molecular Mechanisms of Impaired Dopaminergic Function during Aging
G. Roth (1994)
The cholinergic hypothesis of geriatric memory dysfunction.
R. Bartus (1982)
Effect of age on muscle activation and twitch properties during static and dynamic actions
Melissa R Wilder (2009)
Thinning of the cerebral cortex in aging.
D. Salat (2004)
Assessing Voluntary Muscle Activation with the Twitch Interpolation Technique
A. Shield (2004)
Age‐related fatigue resistance in the knee extensor muscles is specific to contraction mode
Damien M. Callahan (2009)
Dopamine and Serotonin Systems in Human and Rodent Brain: Effects of Age and Neurodegenerative Disease
D. G. Morgan (1987)
Age-related changes in short-latency motor cortex inhibition
A. Smith (2009)
Age-dependent changes in the neural correlates of force modulation: An fMRI study
N. Ward (2008)
Voluntary strength and fatigue
P. Merton (1954)
Glutamate–dopamine–GABA interactions in the aging basal ganglia
F. Mora (2008)
Motor unit discharge behavior in older adults during maximal-effort contractions.
G. Kamen (1995)
Cortical projections to spinal motoneurons
A. Eisen (1996)
The estimated numbers and relative sizes of thenar motor units as selected by multiple point stimulation in young and older adults
T. Doherty (1993)
External Ca2+‐dependent excitation–contraction coupling in a population of ageing mouse skeletal muscle fibres
A. M. Payne (2004)
This paper is referenced by
Impact of Aging on Endurance and Neuromuscular Physical Performance: The Role of Vascular Senescence
G. Mendonca (2016)
Tongue Force Training Induces Plasticity of the Lingual Motor Cortex in Young Adult and Aged Rats
Miranda J Cullins (2019)
Age-related changes in neuromuscular function of the quadriceps muscle in physically active adults.
A. Mau-Moeller (2013)
Functional Implications of Dynamic DNA Methylation for the Developing, Aging and Diseased Brain
Geraldine Zimmer-Bensch (2019)
Innovative training programs for frail elderly in the skilling up stage
S. Rogan (2016)
Neuromuscular function in different stages of sarcopenia
Tobias Morat (2016)
Interrelationship between muscle strength, motor units, and aging
Ryan D. Kaya (2013)
Eccentric Torque-Producing Capacity is Influenced by Muscle Length in Older Healthy Adults
Ruth C. Melo (2016)
Changes in leg cycling muscle synergies after training augmented by functional electrical stimulation in subacute stroke survivors: a pilot study
E. Ambrosini (2020)
A pilot study assessing reliability and age‐related differences in corticomuscular and intramuscular coherence in ankle dorsiflexors during walking
F. Gennaro (2020)
Vastus Lateralis Motor Unit Recruitment Thresholds are Compressed Towards Lower Forces in Older Men
R. Girts (2020)
Transcranial direct current stimulation (tDCS) in behavioral and food addiction: a systematic review of efficacy, technical, and methodological issues
A. Sauvaget (2015)
Progressive resistance training before and after total hip and knee arthroplasty: a systematic review
Birgit Skoffer (2015)
Prediction of age at onset in Parkinson’s disease using objective specific neuroimaging genetics based on a sparse canonical correlation analysis
J. Won (2020)
The Contributions of Fiber Atrophy, Fiber Loss, In Situ Specific Force, and Voluntary Activation to Weakness in Sarcopenia
J. McPhee (2018)
A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation
A. Bhandari (2016)
Muscle power and nutrition
D. Eglseer (2015)
Discharge properties of human diaphragm motor units with ageing
D. Nguyen (2019)
DNA methyltransferase 1 (DNMT1) function is implicated in the age-related loss of cortical interneurons
A. Hahn (2020)
What is dynapenia?
B. C. Clark (2012)
Contraction Phase and Force Differentially Change Motor Evoked Potential Recruitment Slope and Interhemispheric Inhibition in Young Versus Old
Elsa Ermer (2020)
Dynapenia: Term, causes and consequences
Bojan Međedović (2018)
Can a High-Intensity Contraction Be Enhanced by a Conditioning Contraction? Insight from the Relationship Between Shortening Velocity of Muscle Fibers and Postactivation Potentiation
Atsuki Fukutani (2015)
Cognitive challenges, aging, and neuromuscular fatigue
Ashley E. Shortz (2017)
Evolving concepts on the age-related changes in “muscle quality”
D. Russ (2012)
The Click Test: A Novel Tool to Quantify the Age-Related Decline of Fast Motor Sequencing of the Thumb.
F. Bodranghien (2017)
Age and gender, two key factors in the associations between physical activity and strength during the ageing process.
A. Gómez-Cabello (2014)
Effects of age and sex on fatigability and recovery from a sustained maximal isometric voluntary contraction.
Rima Solianik (2017)
The effects of testosterone and insulin-like growth factor 1 on motor system form and function
Kentaro Oki (2015)
Dynapenia and aging: an update.
T. Manini (2012)
Corticospinal Control of Human Locomotion as a New Determinant of Age-Related Sarcopenia: An Exploratory Study
F. Gennaro (2020)
Mechanisms for the age-related increase in fatigability of the knee extensors in old and very old adults.
Christopher W Sundberg (2018)See more