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Skin-controlled Release Lipid Nanosystems Of Pranoprofen For The Treatment Of Local Inflammation And Pain.
M. Rincón, A. Calpena, B. Clares, M. Espina, M. L. Garduño-Ramírez, M. J. Rodríguez-Lagunas, M. García, G. Abrego
Published 2018 · Medicine
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AIM The design and development of pranoprofen (PF) nanostructured lipid carriers (NLCs) for topical treatment of local inflammation and pain. MATERIALS & METHODS PF-NLCs were designed and optimized by central rotatable composite design. A physicochemical characterization was addressed. Release and skin permeation were performed in Franz diffusion cells. In vivo anti-inflammatory efficacy was assayed in mice and tolerance study in humans. RESULTS PF-NLCs F7 and F10 provided sustained release, good stability and optimal skin retention avoiding systemic undesired side effects. Anti-inflammatory activity was enhanced, suggesting an improved efficacy as compared with standard formulation. No skin irritancy was detected. CONCLUSION Topical PF-NLCs F7 and F10 could be effective and safe new therapeutic tools for the treatment of local inflammation and pain. [Formula: see text].
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