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Lignin-graft-PLGA Drug-delivery System Improves Efficacy Of MEK1/2 Inhibitor In Triple-negative Breast Cancer Cell Line.
C. Byrne, C. Astete, Manibarathi Vaithiyanathan, A. Melvin, Mahsa Moradipour, S. Rankin, B. L. Knutson, C. Sabliov, E. C. Martin
Published 2020 · Chemistry, Medicine
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Aim: Few targeted therapies are available for triple-negative breast cancer (TNBC) patients. Here, we propose a novel alkaline-lignin-conjugated-poly(lactic-co-glycolic acid) (L-PLGA) nanoparticle drug delivery system to improve the efficacy of targeted therapies. Materials & methods: L-PLGA nanoparticles (NPs) loaded with the MEK1/2 inhibitor GDC-0623 were characterized, tested in vitro on MDA-MB-231 TNBC cell line and compared with loaded PLGA NPs. Results: Loaded L-PLGA NPs were less than half the size of PLGA NPs, had slower drug release and improved the efficacy of GDC-0623 when tested in vitro. We demonstrated that GDC-0623 reversed epithelial-to-mesenchymal transition in TNBC. Conclusion: Our findings indicate that L-PLGA NPs are superior to PLGA NPs in delivering GDC-0623 to cancer cells for improved efficacy in vitro.
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