Online citations, reference lists, and bibliographies.
← Back to Search

Stimulatory Effect Of Glucose On Macrophage Lipoprotein Lipase Expression And Production.

M. Sartippour, A. Lambert, M. Laframboise, P. St-Jacques, G. Renier
Published 1998 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Cardiovascular diseases are the leading cause of morbidity and mortality in diabetes. Lipoprotein lipase (LPL), a major secretory product of macrophages, has been suggested to play a key role in the development of atherosclerosis. In the present study, we evaluated the effect of high glucose on macrophage LPL mRNA expression and secretion. Exposure of murine J774 macrophages to high D-glucose concentrations (20-30 mmol/l) resulted in a dramatic upregulation of LPL mRNA expression and immunoreactive mass. This effect was not observed when these cells were incubated in the presence of L-glucose or mannitol. High glucose concentrations were also found to enhance LPL gene expression and immunoreactive mass in human monocyte-derived macrophages. J774 cells cultured in a high glucose environment expressed increased c-fos mRNA levels. Treatment of these cells with c-fos antisense DNA or protein kinase C inhibitor inhibited the stimulatory effect of glucose on LPL mRNA expression. In J774 cells exposed to high glucose concentrations, enhanced nuclear protein binding to the AP-1-responsive region of the murine LPL promoter was observed, while LPL mRNA stability remained unchanged. Overall, these results demonstrate that high glucose upregulates macrophage LPL gene expression and immunoreactive mass and that this effect involves transcriptional events.



This paper is referenced by
10.2337/DIABETES.51.4.1180
Homocysteine induces protein kinase C activation and stimulates c-Fos and lipoprotein lipase expression in macrophages.
M. Beauchamp (2002)
10.2337/DIACARE.24.8.1505
Serum nonesterified fatty acids are related with carotid atherosclerotic plaque in nonobese nonhypertensive Japanese type 2 diabetic patients.
A. Taniguchi (2001)
10.1152/ajpendo.90920.2008
Lipoprotein lipase: from gene to obesity.
H. Wang (2009)
10.2741/1300
Direct effects of long-chain non-esterified fatty acids on vascular cells and their relevance to macrovascular complications of diabetes.
J. Oram (2004)
10.1152/AJPENDO.00242.2005
Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway.
L. M. Grønning (2006)
10.4103/0975-3583.64436
Role of diabetes, hypertension, and cigarette smoking on atherosclerosis
R. K. Mathur (2010)
10.1007/s00125-003-1247-9
Oleate, not ligands of the receptor for advanced glycation end-products, promotes proliferation of human arterial smooth muscle cells
C. B. Renard (2003)
10.1194/jlr.M800024-JLR200
C-reactive protein enhances macrophage lipoprotein lipase expression Published, JLR Papers in Press, 14 May 2008. This study was supported by Diabète Québec.
F. Maingrette (2008)
10.2337/DIABETES.52.8.2121
Leptin increases lipoprotein lipase secretion by macrophages: involvement of oxidative stress and protein kinase C.
F. Maingrette (2003)
10.1194/JLR.M400169-JLR200
Advanced glycation end products potentiate the stimulatory effect of glucose on macrophage lipoprotein lipase expression Published, JLR Papers in Press, June 21, 2004. DOI 10.1194/jlr.M400169-JLR200
M. Beauchamp (2004)
10.1097/01.GIM.0000144012.18935.48
Lipoprotein lipase locus and progression of atherosclerosis in coronary-artery bypass grafts
K. Taylor (2004)
10.1097/00041433-200210000-00002
Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism
Karina Preiss-Landl (2002)
Glucose-Induced Macrophage Foam Cell Formation Glucose Enhances Human Macrophage LOX-1 Expression : Role for LOX-1 in
Tatsuya Sawamura (2004)
10.1194/jlr.M600236-JLR200
Placental triglyceride accumulation in maternal type 1 diabetes is associated with increased lipase gene expression Published, JLR Papers in Press, August 29, 2006.
Marie L S Lindegaard (2006)
10.1016/S0008-6363(02)00405-4
The pivotal role of lipoprotein lipase in atherosclerosis.
J. R. Mead (2002)
10.1097/00041433-200404000-00013
Zinc finger protein ZNF202 structure and function in transcriptional control of HDL metabolism
G. Schmitz (2004)
10.20381/RUOR-838
Effect of Glucose on Human Adipogenesis and its Regulation by Macrophages
Vian Peshdary (2016)
10.1111/j.1469-7793.2001.0261g.x
Thermogenesis induced by osmotic stimulation of the intestines in the rat
T. Osaka (2001)
10.1161/01.ATV.20.1.104
Differential regulation of macrophage peroxisome proliferator-activated receptor expression by glucose : role of peroxisome proliferator-activated receptors in lipoprotein lipase gene expression.
M. Sartippour (2000)
10.1016/j.jcjd.2016.02.012
Effect of High Glucose Concentration on Human Preadipocytes and Their Response to Macrophage-Conditioned Medium.
Vian Peshdary (2016)
10.2337/DIABETES.50.3.660
Direct regulatory effect of fatty acids on macrophage lipoprotein lipase: potential role of PPARs.
S. E. Michaud (2001)
10.1074/JBC.M205112200
Oleate and Linoleate Enhance the Growth-promoting Effects of Insulin-like Growth Factor-I through a Phospholipase D-dependent Pathway in Arterial Smooth Muscle Cells*
B. Askari (2002)
10.1159/000109344
Free Radicals, Antioxidants and Diabetes: Embryopathy, Retinopathy, Neuropathy, Nephropathy and Cardiovascular Complications
O. Aruoma (2006)
10.2337/DIABETES.49.4.597
Upregulation of macrophage lipoprotein lipase in patients with type 2 diabetes: role of peripheral factors.
M. Sartippour (2000)
10.2337/DIABETES.52.7.1843
Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium.
L. Li (2003)
10.1016/j.bbalip.2014.03.013
Physiological regulation of lipoprotein lipase.
S. Kersten (2014)
10.2337/DIACARE.24.8.1496
High prevalence of hypovitaminosis D in female type 2 diabetic population.
G. Isaia (2001)
10.1210/JC.2003-030911
Enhanced lipoprotein lipase secretion and foam cell formation by macrophages of patients with growth hormone deficiency: possible contribution to increased risk of atherogenesis?
O. Serri (2004)
10.1074/JBC.275.15.11404
Estrogen Suppresses Transcription of Lipoprotein Lipase Gene
Hideaki Homma (2000)
10.1074/jbc.275.23.17728
Molecular Mechanisms of Tumor Necrosis Factor α Gene Expression in Monocytic Cells via Hyperglycemia-induced Oxidant Stress-dependent and -independent Pathways*
M. Guha (2000)
Régulation de la lipoprotéine lipase macrophagique et de LOX-1 par des facteurs métaboliques. Implications dans l’athérosclérose associée au diabète de type 2.
Fritz Maingrette (2009)
10.1016/B978-0-12-802101-9.00002-8
Patient-Oriented Research
Ellen W. Seely (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar