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A Consensus Statement For Safety Monitoring Guidelines Of Treatments For Major Depressive Disorder

Seetal Dodd, Gin S. Malhi, John Tiller, Isaac Schweitzer, Ian Hickie, Jon Paul Khoo, Darryl L. Bassett, Bill Lyndon, Philip B. Mitchell, Gordon Parker, Paul B. Fitzgerald, Marc Udina, Ajeet Singh, Steven Moylan, Francesco Giorlando, Carolyn Doughty, Christopher G. Davey, Michael Theodoros, Michael Berk

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Objective: This paper aims to present an overview of screening and safety considerations for the treatment of clinical depressive disorders and make recommendations for safety monitoring. Method: Data were sourced by a literature search using MEDLINE and a manual search of scientific journals to identify relevant articles. Draft guidelines were prepared and serially revised in an iterative manner until all co-authors gave final approval of content. Results: Screening and monitoring can detect medical causes of depression. Specific adverse effects associated with antidepressant treatments may be reduced or identified earlier by baseline screening and agent-specific monitoring after commencing treatment. Conclusion: The adoption of safety monitoring guidelines when treating clinical depression is likely to improve overall physical health status and treatment outcome. It is important to implement these guidelines in the routine management of clinical depression.