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Compatibility Study Between Naproxen And Tablet Excipients Using Differential Scanning Calorimetry

S. Botha, A. P. Lötter
Published 1990 · Chemistry

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AbstractDifferential scanning calorimetry (DSC) was used to investigate the physico-chemical compatibility between naproxen and a number of commonly used tablet excipients.Interactions of naproxen with PVP, cross-linked PVP, Emcompress and the lubricants stearic acid, magnesium stearate and Precirol Ato 5 were found. Naproxen was found to be compatible with starch, Sta-Rx 1500, Primojel, Explotab, Avicel PH 101, Elcema G250, Ac-Di-Sol and Sterotex.
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