Online citations, reference lists, and bibliographies.

Seaweed Polysaccharide-based Hydrogels Used For The Regeneration Of Articular Cartilage

Elena Geta Popa, Rui Luís Reis, Manuela E Gomes
Published 2015 · Medicine, Biology
Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract This manuscript provides an overview of the in vitro and in vivo studies reported in the literature focusing on seaweed polysaccharides based hydrogels that have been proposed for applications in regenerative medicine, particularly, in the field of cartilage tissue engineering. For a better understanding of the main requisites for these specific applications, the main aspects of the native cartilage structure, as well as recognized diseases that affect this tissue are briefly described. Current available treatments are also presented to emphasize the need for alternative techniques. The following part of this review is centered on the description of the general characteristics of algae polysaccharides, as well as relevant properties required for designing hydrogels for cartilage tissue engineering purposes. An in-depth overview of the most well known seaweed polysaccharide, namely agarose, alginate, carrageenan and ulvan biopolymeric gels, that have been proposed for engineering cartilage is also provided. Finally, this review describes and summarizes the translational aspect for the clinical application of alternative systems emphasizing the importance of cryopreservation and the commercial products currently available for cartilage treatment.
This paper references
10.3390/ma3031746
Injectable, Biodegradable Hydrogels for Tissue Engineering Applications
Huaping Tan (2010)
Alginates as biomaterials in tissue engineering
T Andersen (2012)
Antitumor and immunomo
P Jiang (2010)
10.1016/j.injury.2011.05.035
Chondrocytes or adult stem cells for cartilage repair: the indisputable role of growth factors.
A. M. Freyria (2012)
Animal models for cartilage
GG Reinholz (2004)
10.1016/S0168-3659(02)00373-5
Advances in drug delivery for articular cartilage.
Theresa A. Holland (2003)
10.1016/j.fct.2008.07.016
Anti-peroxidative and anti-hyperlipidemic nature of Ulva lactuca crude polysaccharide on D-galactosamine induced hepatitis in rats.
Arumugam Sathivel (2008)
10.1088/0957-4484/20/35/355602
Biofunctionalized magnetic hydrogel nanospheres of magnetite and kappa-carrageenan.
Ana Luísa Daniel-da-Silva (2009)
10.1016/0008-6215(95)00138-J
Cell-wall polysaccharides from the marine green alga Ulva “rigida” (ulvales, chlorophyta). Extraction and chemical composition☆
Bimalendu Ray (1995)
Critical Reviews in Biotechnology Downloaded from informahealthcare.com by Mrs Claire Summerfield on 04/08/14 For personal use only. chondrocytes in alginate bead culture
10.1002/ar.a.20010
Chondrogenesis of human bone marrow-derived mesenchymal stem cells in agarose culture.
C-Y Charles Huang (2004)
10.1098/rsta.2010.0009
Novel synthesis strategies for natural polymer and composite biomaterials as potential scaffolds for tissue engineering
Hsu-Feng Ko (2010)
10.1186/1472-6750-8-71
Molecular analysis of chondrocytes cultured in agarose in response to dynamic compression
Carole Bougault (2008)
10.3109/17453679509002314
Culture of chondrocytes in alginate and collagen carrier gels.
Job L. C. van Susante (1995)
10.1002/jbm.a.31841
Chondrocytes culture in three-dimensional porous alginate scaffolds enhanced cell proliferation, matrix synthesis and gene expression.
Yen Jen Lin (2009)
10.1016/S1060-1872(95)80033-6
Basic science of articular cartilage injury and repair
Jun-Kyo Francis Suh (1995)
DOI: 10.3109/07388551.2014.889079 Polysaccharide hydrogels for cartilage regeneration 15
Lateral compartment
N Adachi (2006)
10.1097/01.tp.0000239518.23354.64
Differentiation of Encapsulated Embryonic Stem Cells After Transplantation
Sophia K. Dean (2006)
10.1016/j.copbio.2004.08.010
Current strategies for cell delivery in cartilage and bone regeneration.
Michael Sittinger (2004)
10.1016/j.biomaterials.2008.09.030
Cryopreservation of alginate-fibrin beads involving bone marrow derived mesenchymal stromal cells by vitrification.
Gajadhar Bhakta (2008)
10.1177/0363546508323256
Arthroscopic Second-Generation Autologous Chondrocyte Implantation Compared with Microfracture for Chondral Lesions of the Knee
Elizaveta Kon (2009)
10.1089/ten.TEA.2009.0581
Passaged adult chondrocytes can form engineered cartilage with functional mechanical properties: a canine model.
K. W. H. Ng (2010)
10.1038/nprot.2009.63
Investigating conversion of mechanical force into biochemical signaling in three-dimensional chondrocyte cultures
Carole Bougault (2009)
10.1016/j.joca.2004.04.001
Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads.
Tatiana Gründer (2004)
10.1016/j.biomaterials.2007.01.010
Hydrogel effects on bone marrow stromal cell response to chondrogenic growth factors.
Rhima M. Coleman (2007)
10.1016/S0929-6646(09)60039-5
Repair of articular cartilage defects: review and perspectives.
Hongsen Chiang (2009)
10.1016/j.biomaterials.2011.07.008
Cryopreservation of tissue-engineered epithelial sheets in trehalose.
Fanfan Chen (2011)
Three step derivation
HY Bai (2010)
10.1007/s10811-012-9875-4
A practical perspective on ulvan extracted from green algae
Anabela Alves (2012)
10.1177/096368970901805-618
Cryopreservation in Situ of Cell Monolayers on Collagen Vitrigel Membrane Culture Substrata: Ready-to-Use Preparation of Primary Hepatocytes and ES Cells
Yoshitaka Miyamoto (2009)
10.1016/j.bbrc.2008.09.154
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
Sam D. Thorpe (2008)
10.1002/jbm.a.30816
Low-intensity ultrasound stimulates the viability and matrix gene expression of human articular chondrocytes in alginate bead culture.
Byung Hyune Choi (2006)
Synthesis and swelling behavior of temperature responsive k-carrageenan nanogels
Daniel-Da Silva (2011)
10.5185/AMLETT.2011.1211
Cartilage tissue engineering: current scenario and challenges
Chhavi Sharma (2011)
10.1007/S12257-008-0269-Z
Antitumor and immunomodulating activity of polysaccharides from Enteromorpha intestinalis
Lili Jiao (2010)
10.1002/1097-4644(20010501)81:2<368::AID-JCB1051>3.0.CO;2-J
Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro.
Marcel Jakob (2001)
10.1016/j.biomaterials.2003.10.045
Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds.
Hani A Awad (2004)
10.1302/0301-620X.87B5.15905
Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study.
William Bartlett (2005)
Processing ulvan into 2D
A Alves (2012)
10.1016/j.arthro.2008.10.009
New technique for cell-seeded collagen-matrix-supported autologous chondrocyte transplantation.
Matthias Dr. Steinwachs (2009)
10.1039/9781849732765-00227
Chapter 9:Alginates as biomaterials in tissue engineering
Therese Andersen (2011)
10.1089/tea.2007.0272
Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional alginate gels.
Jinping Xu (2008)
10.1016/S0301-4622(02)00341-1
Thermoreversible gelation of kappa-carrageenan: relation between conformational transition and aggregation.
Maria Rosalia Mangione (2003)
10.1016/j.biomaterials.2006.10.006
Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels.
John T Connelly (2007)
Arthroscopic second
E Kon (2009)
10.1002/term.411
Gene expression of alginate-embedded chondrocyte subpopulations and their response to exogenous IGF-1 delivery.
Emily E. Coates (2012)
10.1177/03635465980260022701
Articular cartilage repair.
A. P. Newman (1998)
The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-Î 2 3. Osteoarthritis Cartilage
E G Lima (2007)
10.1089/ten.teb.2008.0423
Adipose tissue-derived stem cells and their application in bone and cartilage tissue engineering.
Tommaso Rada (2009)
10.1002/jbm.a.32466
Development of new chitosan/carrageenan nanoparticles for drug delivery applications.
Ana Grenha (2010)
10.1016/j.ijpharm.2012.01.021
Processing ulvan into 2D structures: cross-linked ulvan membranes as new biomaterials for drug delivery applications.
Anabela Alves (2012)
10.1016/B978-1-4557-2834-3.00016-1
Natural Polymers in Tissue Engineering Applications
Manuela E Gomes (2013)
10.1089/scd.2008.0030
Cyclic compression maintains viability and induces chondrogenesis of human mesenchymal stem cells in fibrin gel scaffolds.
Daniel Valerio Peláez (2009)
10.1016/j.injury.2005.10.007
Advances in articular cartilage repair.
Alexandros E. Beris (2005)
10.1016/S0142-9612(99)00241-0
Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate.
E. Fragonas (2000)
10.1067/j.cpsurg.2010.11.002
Regenerative medicine.
Jason P Glotzbach (2011)
Advances in articular cartilage repair. Injury
F Berthiaume (2011)
10.1089/ten.2007.0044
Short-term retention of labeled chondrocyte subpopulations in stratified tissue-engineered cartilaginous constructs implanted in vivo in mini-pigs.
Kanika Chawla (2007)
10.1016/j.biomaterials.2012.01.007
Alginate derivatization: a review of chemistry, properties and applications.
Siddhesh N. Pawar (2012)
10.3109/03008207.2012.712583
Agarose Gel as Biomaterial or Scaffold for Implantation Surgery: Characterization, Histological and Histomorphometric Study on Soft Tissue Response
Elena Maria Varoni (2012)
Cartilage tissue engineering with silk scaffolds and human articular
Y Wang (2006)
Production, properties and uses of carrageenan Production and utilization of products from commercial seaweeds. FAO Fisheries Technical Paper 288
N Stanley (1987)
Critical Reviews in Biotechnology Downloaded from informahealthcare.com by Mrs Claire
Low-intensity ultrasound stimulates the viability and matrix gene expression of human articular DOI: 10
Bh Choi (2006)
Spatial and temporal
T-AN Kelly (2006)
10.1016/j.cell.2006.06.044
Matrix Elasticity Directs Stem Cell Lineage Specification
Adam J Engler (2006)
10.1016/S0142-9612(01)00281-2
Alginate as a chondrocyte-delivery substance in combination with a non-woven scaffold for cartilage tissue engineering.
Willem J.C.M. Marijnissen (2002)
Bone morphogenetic
C Kaps (2002)
10.1007/s001670050063
Osteonecrosis of the knee
E. Store Eriksson (1998)
Evaluation of adult
JD Kisiday (2008)
Autologous chondrocyte implantation: a comparison between an open periosteal-covered and an arthroscopic matrix-guided technique.
Massimiliano Manfredini (2007)
10.1016/j.aanat.2008.07.007
Mesenchymal stem cells as a potential pool for cartilage tissue engineering.
Constanze Csaki (2008)
Articular cartilage: tissue design and chondrocyte-matrix interactions.
Joseph A. Buckwalter (1998)
10.1038/ncprheum0816
Technology Insight: adult mesenchymal stem cells for osteoarthritis therapy
Ulrich Noeth (2008)
10.1093/bmb/ldn025
Articular cartilage: structure, injuries and review of management.
Abhijit M. Bhosale (2008)
10.1002/jbm.a.34403
Processing of degradable ulvan 3D porous structures for biomedical applications.
Anabela Alves (2013)
10.1016/j.jbiomech.2009.11.005
Functional properties of cartilaginous tissues engineered from infrapatellar fat pad-derived mesenchymal stem cells.
Conor Timothy Buckley (2010)
10.1089/scd.2006.0026
Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells.
Maikel J Oedayrajsingh Varma (2007)
10.1302/0301-620X.94B4.27117
Autologous chondrocyte implantation for osteochondral lesions in the knee using a bilayer collagen membrane and bone graft: a two- to eight-year follow-up study.
Sridhar Vijayan (2012)
10.1053/joca.1997.0092
Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits.
B. Rahfoth (1998)
[Treatment of osteochondritis dissecans of the knee: one-step procedure with bone grafting and matrix-supported autologous chondrocyte transplantation].
Bjoern Gunnar Ochs (2007)
10.2106/00004623-198870030-00027
Osteonecrosis of the knee.
Paul A. Lotke (1985)
10.1002/jbm.a.33226
Chondrocyte redifferentiation in 3D: the effect of adhesion site density and substrate elasticity.
Elena Schuh (2012)
10.3390/molecules13092069
Marine Derived Polysaccharides for Biomedical Applications: Chemical Modification Approaches
Giovanna Gomez d’Ayala (2008)
10.1016/J.SUPFLU.2012.02.023
PDLLA enriched with ulvan particles as a novel 3D porous scaffold targeted for bone engineering
Anabela Alves (2012)
10.1021/bm8014973
Carrageenan-based hydrogels for the controlled delivery of PDGF-BB in bone tissue engineering applications.
Vítor E Santo (2009)
10.1016/j.joca.2003.08.006
The role of cell seeding density and nutrient supply for articular cartilage tissue engineering with deformational loading.
Robert L Mauck (2003)
10.1089/ten.tea.2008.0099
Differential maturation and structure-function relationships in mesenchymal stem cell- and chondrocyte-seeded hydrogels.
Isaac E. Erickson (2009)
Chondrocytes culture in threedimensional porous alginate scaffolds enhanced cell proliferation, matrix synthesis and gene expression
Y-J Lin (2009)
10.1006/bbrc.2001.6270
Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo.
Geoffrey R. Erickson (2002)
10.5897/JMPR10.019
In vitro antioxidant activity of acetylated derivatives of polysaccharide extracted from Ulva pertusa (Cholorophta)
Huimin Qi (2010)
10.1089/ten.2005.11.953
In vivo response of polylactic acid-alginate scaffolds and bone marrow-derived cells for cartilage tissue engineering.
Jennifer S. Wayne (2005)
10.3390/md9122514
Seaweed Polysaccharides and Derived Oligosaccharides Stimulate Defense Responses and Protection Against Pathogens in Plants
Jeannette Vera (2011)
10.1016/j.biomaterials.2003.07.002
A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering.
Molly M Stevens (2004)
10.1002/jbm.a.10370
Chondrogenesis of human mesenchymal stem cells encapsulated in alginate beads.
Hsiao-Li Ma (2003)
Specific growth factors
M Jakob (2001)
10.1146/annurev-chembioeng-061010-114257
Tissue engineering and regenerative medicine: history, progress, and challenges.
François Berthiaume (2011)
10.1080/14653240310004539
Yield of human adipose-derived adult stem cells from liposuction aspirates.
Louise B Aust (2004)
10.1016/j.cryobiol.2011.01.012
Cytotoxicity effects of cryoprotectants as single-component and cocktail vitrification solutions.
Alison Lawson (2011)
10.1016/j.carbpol.2009.01.020
Carrageenans: biological properties, chemical modifications and structural analysis - a review.
Vanessa Leiria Campo (2009)
genesis in hydrogel cultures
G Klöck (1997)
Alginates as biomaterials
101A (2012)
10.1002/bip.21429
Biological activity of laminin peptide-conjugated alginate and chitosan matrices.
Yuji Yamada (2010)
10.1016/j.biomaterials.2007.02.035
Integration of layered chondrocyte-seeded alginate hydrogel scaffolds.
Christopher S. D. Lee (2007)
10.22203/ECM.V020A30
In vivo comparison of the effects of rhBMP-2 and rhBMP-4 in osteochondral tissue regeneration.
Yaiza Lópiz-Morales (2010)
10.1002/jbm.a.32732
Three step derivation of cartilage like tissue from human embryonic stem cells by 2D-3D sequential culture in vitro and further implantation in vivo on alginate/PLGA scaffolds.
Hai Yan Bai (2010)
10.1002/MACP.200900562
Ulvan as a New Type of Biomaterial from Renewable Resources: Functionalization and Hydrogel Preparation
Andrea Morelli (2010)
10.1002/term.335
Polysaccharide-based materials for cartilage tissue engineering applications.
João Tiago Correia Oliveira (2011)
10.1016/j.arthro.2005.10.019
Lateral compartment osteoarthritis of the knee after meniscectomy treated by the transplantation of tissue-engineered cartilage and osteochondral plug.
Nobuo Adachi (2006)
10.1002/art.21779
Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6.
Bradley T. Estes (2006)
10.1007/s10522-007-9088-4
Methodological models for in vitro amplification and maintenance of human articular chondrocytes from elderly patients
A Carossino (2007)
10.1021/bm061185q
Structure and functional properties of ulvan, a polysaccharide from green seaweeds.
Marc Lahaye (2007)
10.3390/md9020196
Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae
Guangling Jiao (2011)
Production and utilization of products from commercial seaweeds. FAO Fisheries Technical Paper
N Stanley (1987)
10.1016/S0001-4001(99)80005-1
Implantation de chondrocytes autologues pour lésions cartilagineuses du sujet jeune. Etude de 24 cas.
J. Bahuaud (1998)
10.1038/424870a
Cell culture: Biology's new dimension
Alison Abbott (2003)
10.1016/j.intimp.2007.02.007
Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh.
José Manuel Leiro (2007)
10.1007/s10856-011-4396-2
A hydrophobically-modified alginate gel system: utility in the repair of articular cartilage defects
Mohammad Kazem Ghahramanpoor (2011)
10.1016/J.FOODHYD.2010.05.003
Rheology and microstructure of κ-carrageenan under different conformations induced by several concentrations of potassium ion
María del Carmen Núñez-Santiago (2011)
10.1016/j.csm.2008.10.007
Osteochondral allografts: state of the art.
Christian Lattermann (2009)
10.1002/jor.20508
Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures.
John D. Kisiday (2008)
10.1002/bit.20828
Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: influence of collagen type II extracellular matrix on MSC chondrogenesis.
Darko Bosnakovski (2006)
10.1016/S0142-9612(03)00498-8
Animal models for cartilage reconstruction.
Gregory G. Reinholz (2004)
10.1002/(SICI)1097-0290(19960520)50:4<374::AID-BIT4>3.0.CO;2-I
Stability of hydrogels used in cell encapsulation: An in vitro comparison of alginate and agarose.
Molly S. Shoichet (1996)
10.1177/0363546511398646
Matrix-Associated Implantation of Predifferentiated Mesenchymal Stem Cells Versus Articular Chondrocytes
Bastian Marquaß (2011)
Critical Reviews in Biotechnology Downloaded from informahealthcare.com by Mrs Claire Summerfield on 04/08/14 For personal use only. microfracture for chondral lesions of the knee
10.1177/230949900301100104
Autologous Chondrocyte Implantation Using a Bilayer Collagen Membrane: A Preliminary Report
P. Cherubino (2003)
10.1038/267531a0
Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture
Klaus von der Mark (1977)
10.1002/bdrc.20167
Regulation of the chondrogenic phenotype in culture.
Brent E. Bobick (2009)
10.1038/nmat2022
Microfluidic scaffolds for tissue engineering.
Nak Won Choi (2007)
Ulvan, a sulfated
V Jaulneau (2010)
10.2174/157488809789649205
Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapy.
Claire Vinatier (2009)
10.5772/24901
Ulvan: A Versatile Platform of Biomaterials from Renewable Resources
Federica Chiellini (2011)
10.22203/eCM.v014a02
Boundary mode frictional properties of engineered cartilaginous tissues.
Jason P. Gleghorn (2007)
10.1089/ten.TEA.2009.0198
Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner.
Alice H. Huang (2009)
10.1016/j.biomaterials.2006.02.048
Biocompatibility of alginate-poly-L-lysine microcapsules for cell therapy.
Gorka Orive (2006)
10.1002/bab.1007
Chondrogenic phenotype of different cells encapsulated in κ-carrageenan hydrogels for cartilage regeneration strategies.
Elena Geta Popa (2012)
10.1016/j.jamcollsurg.2005.01.006
Characterization of human nasal septal chondrocytes cultured in alginate.
Stanley Chia (2005)
10.1243/09544119JEIM288
Tissue engineering of the synovial joint: The role of cell density
Alexander J. Troken (2007)
Potential biological properties of sulphated polysaccharides extracted from the macroalgae Ulva lactuca L
HHA El-Baky (2009)
Production, properties and uses of carrageenan
N Stanley (1987)
A practical perspective on ulvan
A Alves (2013)
Arthroscopic secondgeneration autologous chondrocyte implantation compared with 12
E Kon (2009)
10.1039/9781849730747-00407
A Comparative Study of Iota Carrageenan, Kappa Carrageenan and Alginate as Tissue Engineering Scaffolds
Nazia Mehrban (2009)
10.1016/j.biomaterials.2006.03.050
Cartilage tissue engineering with silk scaffolds and human articular chondrocytes.
Yongzhong Wang (2006)
10.1089/scd.2009.0173
Evaluation of methylcellulose and dimethyl sulfoxide as the cryoprotectants in a serum-free freezing media for cryopreservation of adipose-derived adult stem cells.
Sreedhar Thirumala (2010)
10.1016/j.actbio.2012.06.028
Variations in chondrogenesis of human bone marrow-derived mesenchymal stem cells in fibrin/alginate blended hydrogels.
Kun Ma (2012)
10.1016/0092-8674(82)90027-7
Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
Paul D. Benya (1982)
Effect of seeding density on stability of the differentiated phenotype of pig articular chondrocytes in culture.
Fiona M. Watt (1988)
10.1002/term.1683
Chondrogenic potential of injectable κ-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications.
Elena Geta Popa (2015)
10.1002/term.145
Novel injectable gel (system) as a vehicle for human articular chondrocytes in cartilage tissue regeneration.
Rui Cruz Pereira (2009)
10.1016/j.joca.2007.03.008
The beneficial effect of delayed compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3.
Eric G. Lima (2007)
10.1002/cm.20041
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.
T. S. Yeung (2005)
10.1186/ar561
Tissue engineering: chondrocytes and cartilage
Tim E. Hardingham (2002)
10.1002/1529-0131(200201)46:1<149::AID-ART10058>3.0.CO;2-W
Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction.
Christian Kaps (2002)
10.1002/1097-4636(20010615)55:4<503::AID-JBM1043>3.0.CO;2-S
Injection molding of chondrocyte/alginate constructs in the shape of facial implants.
Sophia Chia-Ning Chang (2001)
10.1055/s-2007-989353
[Clinical results after three years use of matrix-associated ACT for the treatment of osteochondral defects of the knee].
U. Maus (2008)
10.4414/smw.2009.12742
Do we really need cartilage tissue engineering?
Karoliina Pelttari (2009)
10.1016/j.actbio.2012.03.016
Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure.
Andrew J. Steward (2012)
10.1007/s10529-010-0221-0
Cell encapsulation using biopolymer gels for regenerative medicine
Nicola Claire Hunt (2010)
10.1089/ten.TEA.2011.0544
A comparison of the functionality and in vivo phenotypic stability of cartilaginous tissues engineered from different stem cell sources.
Tatiana Vinardell (2012)
10.1016/J.PROGPOLYMSCI.2011.11.004
Polymers used to influence cell fate in 3D geometry: New trends
Yukie Aizawa (2012)
[Implantation of autologous chondrocytes for cartilagenous lesions in young patients. A study of 24 cases].
J. Bahuaud (1998)
10.1016/j.biomaterials.2010.01.085
Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma.
Philipp Niemeyer (2010)
10.1016/S0169-409X(98)00017-9
Culture of organized cell communities.
Vunjak-Novakovic (1998)
10.1016/j.addr.2006.01.012
Cartilage tissue engineering for degenerative joint disease.
Dobrila Nesic (2006)
10.1186/ar2638
Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results
Peter Cornelius Kreuz (2009)
10.1201/9781420027563.ch3
Polysaccharide Scaffolds for Tissue Engineering
T Ehrenfreund-Kleinman (2005)
Crit Rev Biotechnol
10.1002/jor.1100100602
Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix.
Michael D. Buschmann (1992)
10.1055/s-2007-989353
Klinische Drei-Jahres-Ergebnisse der matrixgekoppelten ACT zur Behandlung osteochondraler Defekte am Kniegelenk
Uwe Maus (2008)
Development of new
A Grenha (2009)
Autologous chondrocyte implantation in a novel alginate-agarose hydrogel
T. Ait Si Selmi (2008)
10.1016/j.molcatb.2004.08.004
Entrapment of lipase into K-carrageenan beads and its use in hydrolysis of olive oil in biphasic system
P. D. Desai (2004)
10.1016/j.biomaterials.2006.11.047
Vitrification as a prospect for cryopreservation of tissue-engineered constructs.
Lilia L. Kuleshova (2007)
10.1056/NEJM199410063311401
Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.
Mats Brittberg (1994)
10.1016/j.joca.2006.08.008
Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells.
Ryosuke Kuroda (2007)
10.4161/biom.22947
Marine algae sulfated polysaccharides for tissue engineering and drug delivery approaches
Tiago H Silva (2012)
10.1016/S0142-9612(03)00340-5
Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L Drury (2003)
10.1016/j.addr.2007.03.012
Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications.
Patrícia B. Malafaya (2007)
10.1016/j.copbio.2005.08.004
Advancing cartilage tissue engineering: the application of stem cell technology.
Joanne Raghunath (2005)
10.1016/j.injury.2008.01.036
Smart biomaterials for tissue engineering of cartilage.
Reinout Stoop (2008)
10.1016/j.joca.2005.09.002
Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture.
Robert L Mauck (2006)
10.1021/bm200965x
Cell delivery systems using alginate--carrageenan hydrogel beads and fibers for regenerative medicine applications.
Elena Geta Popa (2011)
10.1186/1758-2555-3-10
MACI - a new era?
Matthias Jacobi (2011)
10.1016/j.jcis.2010.12.071
Synthesis and swelling behavior of temperature responsive κ-carrageenan nanogels.
Ana Luísa Daniel-da-Silva (2011)
10.1016/j.biomaterials.2009.01.034
Photocrosslinked alginate hydrogels with tunable biodegradation rates and mechanical properties.
Oju Jeon (2009)
10.1155/2012/291431
Stem Cells for Augmenting Tendon Repair
Lawrence Vincent Gulotta (2012)
10.1016/j.biomaterials.2011.07.013
Injectable in situ crosslinkable RGD-modified alginate matrix for endothelial cells delivery.
Sílvia J. Bidarra (2011)
10.1177/03635465020300011601
Autologous Chondrocyte Transplantation
Lars Peterson (2002)
10.1089/107632702753503072
Differential effects of growth factors on tissue-engineered cartilage.
Torsten Blunk (2002)
10.1016/j.jbiomech.2005.03.031
Spatial and temporal development of chondrocyte-seeded agarose constructs in free-swelling and dynamically loaded cultures.
Terri-Ann N. Kelly (2006)
swelling and dynamically loaded cultures
M Kino-Oka (2005)
10.3390/md8092435
Marine Polysaccharides in Pharmaceutical Applications: An Overview
Paola Laurienzo (2010)
The Design of Scaffolds for Use in Tissue Engineering
Tabatabaei Qomi (2014)
10.1097/01.PRS.0000069711.31021.94
Tissue Engineering of Autologous Cartilage for Craniofacial Reconstruction by Injection Molding
Sophia Chia-Ning Chang (2003)
10.1097/01.blo.0000165845.21735.05
Long-Term Followup of the Use of Fresh Osteochondral Allografts for Posttraumatic Knee Defects
Allan E. Gross (2005)
Alginate as a chondrocyte-delivery substance in combination with a nonwoven scaffold for cartilage tissue
WJ Marijnissen (2002)
10.1053/j.oto.2009.10.004
Advances in Tissue Engineering Techniques for Articular Cartilage Repair.
Amgad M. Haleem (2010)
10.1007/s11626-007-9039-z
Serum-free solutions for cryopreservation of cells
Lia H. Campbell (2007)
10.1016/S0142-9612(96)00204-9
Biocompatibility of mannuronic acid-rich alginates.
Gerd Dr Kloeck (1997)
FGF-2 enhances TGF-beta1-induced periosteal chondrogenesis.
Molly M Stevens (2004)
10.1263/jbb.99.197
A kinetic modeling of chondrocyte culture for manufacture of tissue-engineered cartilage.
Masahiro Kino-oka (2005)
10.1007/s00339-007-4270-8
Hydrogel-based encapsulation of biological, functional tissue: fundamentals, technologies and applications
Heiko Zimmermann (2007)
Yield of human adipose
L Aust (2004)
10.1055/s-2007-965167
Einzeitige Rekonstruktion osteochondraler Defekte am Kniegelenk bei Osteochondrosis dissecans
Bjoern Gunnar Ochs (2007)
10.1038/489036a
Materials science: A hard concept in soft matter
Kenneth R Shull (2012)
10.1038/nature11409
Highly stretchable and tough hydrogels
Jeong-Yun Sun (2012)
10.1177/0883911511420700
Encapsulation of adipose-derived stem cells and transforming growth factor-β1 in carrageenan-based hydrogels for cartilage tissue engineering
Pedro Rocha (2011)
10.1089/ten.TEA.2009.0482
Dynamic mechanical loading enhances functional properties of tissue-engineered cartilage using mature canine chondrocytes.
Liming Bian (2010)
10.1115/1.429656
Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels.
Robert L Mauck (2000)
10.1302/0301-620X.91B8.21824
An overview of autologous chondrocyte implantation.
Panagiotis D Gikas (2009)
10.1053/jars.2000.4827
Marrow stromal cells embedded in alginate for repair of osteochondral defects.
David R. Diduch (2000)
mannuronic acid-rich alginates
Ko H-F (2010)
Transient exposure
AH Huang (2009)
10.1016/B978-0-12-370869-4.00006-9
Chapter 6 – Natural Polymers in tissue engineering applications
Manuela E Gomes (2008)
10.2106/JBJS.F.00983
Osteonecrosis of the knee treated with a tissue-engineered cartilage and bone implant. A case report.
Nobuo Adachi (2007)
Advances in tissue engineering techniques
AM Haleem (2012)
DOI: 10.3109/07388551.2014.889079 Polysaccharide hydrogels for cartilage regeneration 13
10.1089/ten.teb.2007.0332
Cell encapsulation in biodegradable hydrogels for tissue engineering applications.
Garret D. Nicodemus (2008)
Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee
W Bartlett (2005)
10.1046/j.1525-1594.2003.07073.x
Effects of cell density on proliferation and matrix synthesis of chondrocytes embedded in atelocollagen gel.
Junji Iwasa (2003)
10.22203/eCM.v017a01
Three-dimensional cultures of osteogenic and chondrogenic cells: a tissue engineering approach to mimic bone and cartilage in vitro.
Federico Tortelli (2009)
10.1016/S0378-5173(01)00814-6
Preparation and in vitro evaluation of verapamil HCl and ibuprofen containing carrageenan beads.
Oya Sipahigil (2001)
10.1007/s10853-007-1851-z
Synthesis and characterization of porous κ-carrageenan/calcium phosphate nanocomposite scaffolds
Ana L. Daniel-da-Silva (2007)
Processing of degradable ulvan
A Alves (2012)
10.1385/0-89603-516-6:195
Isolation and in vitro proliferation of chondrocytes, tenocytes, and ligament cells.
Sonya Shortkroff (1999)
10.1089/ten.2006.0290
Differential effects on messenger ribonucleic acid expression by bone marrow-derived human mesenchymal stem cells seeded in agarose constructs due to ramped and steady applications of cyclic hydrostatic pressure.
Allison R Finger (2007)
Rheology and microstructure of k-carrageenan under different conformations induced by several concentrations of potassium ion. Food Hydrocoll
10.1089/TEN.TEB.2012.0080
Leveraging "raw materials" as building blocks and bioactive signals in regenerative medicine.
Amanda N. Renth (2012)
10.1007/S11837-011-0062-X
Engineering cell attachments to scaffolds in cartilage tissue engineering
Andrew J. Steward (2011)
10.1155/2010/525291
Ulvan, a Sulfated Polysaccharide from Green Algae, Activates Plant Immunity through the Jasmonic Acid Signaling Pathway
Valérie Jaulneau (2010)
10.1038/nmat2441
Complexity in biomaterials for tissue engineering.
Elsie S. Place (2009)
10.2106/00004623-200309000-00015
Chondrocyte transplantation into articular cartilage defects with use of calcium alginate: the fate of the cells.
Cay M Mierisch (2003)
10.1039/C2SM26846A
Cryopreservation of cell laden natural origin hydrogels for cartilage regeneration strategies
Elena Geta Popa (2013)
10.1186/ar991
Current state of cartilage tissue engineering
Richard Tuli (2003)
10.1016/j.copbio.2011.04.006
Current strategies for osteochondral regeneration: from stem cells to pre-clinical approaches.
Márcia T. Rodrigues (2011)
10.1089/107632701753337645
The design of scaffolds for use in tissue engineering. Part I. Traditional factors.
Shoufeng Yang (2001)
10.1302/0301-620X.90B5.20360
Autologous chondrocyte implantation in a novel alginate-agarose hydrogel: outcome at two years.
T. Ait Si Selmi (2008)
Bone morphogenetic
T Gründer (2004)
10.1177/1947603511415839
Cell-Seeded Collagen Matrix–Supported Autologous Chondrocyte Transplantation (ACT-CS)
Matthias Dr. Steinwachs (2012)
10.1002/mabi.200600069
Alginate hydrogels as biomaterials.
Alexander Augst (2006)
10.1016/j.bbrc.2011.11.105
Oxygen tension regulates the osteogenic, chondrogenic and endochondral phenotype of bone marrow derived mesenchymal stem cells.
Eamon J. Sheehy (2012)
10.3390/POLYM4031590
Hydrogel-Based Platforms for the Regeneration of Osteochondral Tissue and Intervertebral Disc
Vincenzo Guarino (2012)
10.1089/ten.TEB.2009.0590
Strategies for articular cartilage lesion repair and functional restoration.
Tamer A. E. Ahmed (2010)



This paper is referenced by
10.3390/polym8020028
Magnetically-Responsive Hydrogels for Modulation of Chondrogenic Commitment of Human Adipose-Derived Stem Cells
Elena Geta Popa (2016)
10.1016/J.CARBPOL.2019.04.074
Ulvan, a bioactive marine sulphated polysaccharide as a key constituent of hybrid biomaterials: A review.
Leto-Aikaterini Tziveleka (2019)
10.1016/j.enzmictec.2016.06.009
Seaweeds: A resource for marine bionanotechnology.
Sri Ramkumar Vijayan (2016)
10.3390/md17060357
Ulva lactuca, A Source of Troubles and Potential Riches
Herminia Domínguez (2019)
10.1155/2017/8309256
In Vivo Articular Cartilage Regeneration Using Human Dental Pulp Stem Cells Cultured in an Alginate Scaffold: A Preliminary Study
Manuel Mata (2017)
10.1016/j.ijpharm.2015.11.008
Effective genetic modification and differentiation of hMSCs upon controlled release of rAAV vectors using alginate/poloxamer composite systems.
Pablo Díaz-Rodríguez (2015)
10.1016/j.biomaterials.2019.05.025
Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering.
Jeremy Nicolas Dinoro (2019)
10.1002/term.2663
Activated platelet-rich plasma improves cartilage regeneration using adipose stem cells encapsulated in a 3D alginate scaffold.
Mohammad-Hossein Beigi (2018)
10.1016/j.jmbbm.2019.06.014
Enhanced rheological behaviors of alginate hydrogels with carrageenan for extrusion-based bioprinting.
Myoung Hwan Kim (2019)
Biomedical potential of cyanobacteria and algae
Bettina Ughy (2015)
10.3390/md17100555
Biomaterials Based on Marine Resources for 3D Bioprinting Applications
Yu Zhang (2019)
10.1074/jbc.RA117.001642
Structure–function analyses of a PL24 family ulvan lyase reveal key features and suggest its catalytic mechanism
T. V. Ulaganathan (2018)
10.1007/978-3-319-61288-1_3
Seaweed Polysaccharides: Structure and Applications
Vanina A. Cosenza (2017)
Engineering articular cartilage using newly developed carrageenan basedhydrogels
Elena Geta Popa (2014)
10.1016/B978-0-12-809816-5.00016-5
Perspectives on Biomedical Applications of Ulvan
Andrea Morelli (2017)
10.2174/1381612825666190423155116
Macroalgal Polysacharrides in Biomimetic Nanodelivery Systems.
Nikola Geškovski (2019)
10.4324/9781315152271-6
Carbohydrate based Hydrogels for Controlled Release of Cancer Therapeutics
S. Eswaramma (2017)
10.1080/09506608.2020.1724705
Polymer-based porous microcarriers as cell delivery systems for applications in bone and cartilage tissue engineering
Zhi-hua Zhou (2020)
10.1080/09205063.2019.1620592
Nonwoven membranes for tissue engineering: an overview of cartilage, epithelium, and bone regeneration
Thalles Canton Trevisol (2019)
10.1074/jbc.RA118.003659
Structural and functional characterization of PL28 family ulvan lyase NLR48 from Nonlabens ulvanivorans
T. V. Ulaganathan (2018)
10.1007/s10856-018-6109-6
Fibro/chondrogenic differentiation of dental stem cells into chitosan/alginate scaffolds towards temporomandibular joint disc regeneration
Maria Bousnaki (2018)
10.1007/978-3-030-12919-4_16
Alginate: Pharmaceutical and Medical Applications
Patrícia Sofia Pinhanços Batista (2019)
Mise au point sur les algues vertes : risques environnementaux et valorisations en 2016
Simon Pillard (2016)
10.1007/s11517-015-1352-1
Effect of Longan polysaccharides on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro
Shuyu Zhu (2015)
10.1155/2016/5692852
Reviews on Mechanisms of In Vitro Antioxidant Activity of Polysaccharides
Junqiao Wang (2016)
10.1007/978-3-319-44785-8_5
Cartilage tissue engineering and regenerative strategies
Alain da Silva Morais (2017)
10.5897/AJPP2017.4869
Absorption, distribution, metabolism and elimination (ADME) and toxicity profile of marine sulfated polysaccharides used in bionanotechnology
Sutapa Biswas Majee (2018)
10.1016/B978-1-78242-086-6.00008-X
Drug delivery systems and cartilage tissue engineering scaffolding using marine-derived products
Tiago H Silva (2015)
Semantic Scholar Logo Some data provided by SemanticScholar