Online citations, reference lists, and bibliographies.
← Back to Search

A Mathematical Model Of Fiber Carcinogenicity And Fibrosis In Inhalation And Intraperitoneal Experiments In Rats

Walter Eastes, J. Hadley
Published 1996 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
AbstractA hypothesis is presented that predicts the incidence of tumors and fibrosis in rats exposed to various types of rapidly dissolving fibers in an inhalation study or in an intraperitoneal (ip) injection experiment, for which the response to durable fibers has been determined. The model takes into account the fiber diameter and the dissolution rate of fibers longer than 20 μm in the lung, and it predicts the measured tumor and fibrosis incidence to within approximately the precision of the measurements. The basic concept of the model is that a rapidly dissolving long fiber has the same response in an animal bioassay as a much smaller dose of a durable fiber. Long, durable fibers are considered to have special significance since no effective mechanism is known by which these fibers may be removed. In particular, the hypothesis is that the effective dose of a dissolving long fiber scales as the residence time of that fiber in the extracellular fluid. For example, a certain dose of a fiber that dissolv...
This paper references
10.3109/08958379509029092
DISSOLUTION OF FIBERS INHALED BY RATS
Walter Eastes (1995)
10.1080/15298669291360067
Airborne glass fiber concentrations during installation of residential insulation
T. Jacob (1992)
10.3109/08958379509029093
Dissolution of Glass Fibers in the Rat Lung Following Intratracheal Instillation
Walter Eastes (1995)
10.3109/08958379509002566
Evaluation of the Biopersistence of Commercial and Experimental Fibers Following Inhalation
D. Bernstein (1995)
Untersuchung zur Beständigkeit chemisch unterschiedlicher Glasfasern in Rattenlungen
B. Bellmann (1990)
[The persistence of chemically different glass fibers in rat lungs].
B. Bellmann (1990)
10.1093/JNCI/48.3.797
Mechanisms of mesothelioma induction with asbestos and fibrous glass.
M. Stanton (1972)
10.1007/978-1-4684-1363-2_48
Tumours by the Intraperitoneal and Intrapleural Routes and their Significance for the Classification of Mineral Fibres
F. Pott (1991)
The Toxicologist 15:45
T. R. Gelzleichter (1995)
10.1289/EHP.94102S515
An experimental approach to the evaluation of the biopersistence of respirable synthetic fibers and minerals.
D. Bernstein (1994)
10.1093/ANNHYG/38.6.857
GLASS FIBRES IN SIMULATED LUNG FLUID: DISSOLUTION BEHAVIOUR AND ANALYTICAL REQUIREMENTS
S. M. Mattson (1994)
10.1080/15298669391354739
AIRBORNE GLASS FIBER CONCENTRATIONS DURING MANUFACTURING OPERATIONS INVOLVING GLASS WOOL INSULATION
T. Jacob (1993)
A comparative study of the fibrogenic and carcinogenic effects of UICC Canadian chrysotile B asbestos and glass microfibre (JM 100)
E. E. McConnell (1984)
10.1289/EHP.94102S5113
The role of clearance and dissolution in determining the durability or biopersistence of mineral fibers.
J. M. Davis (1994)
10.1289/EHP.94102S587
Glass fiber dissolution in simulated lung fluid and measures needed to improve consistency and correspondence to in vivo dissolution.
S. M. Mattson (1994)
Glass fiber dissolution in a physiological saline solution
R. Potter (1991)
The behaviour of glass fibres in the rat following intra-peritoneal injection
C. G. Collier (1994)
10.1080/15298669391354612
FIBER DIAMETER DISTRIBUTIONS IN TYPICAL MMVF WOOL INSULATION PRODUCTS
V. R. Christensen (1993)
Kanzerogenität von Glasfasern mit unterschiedlicher Beständigkeit
F. Pott (1990)
Beurteilung der Kanzerogenität von Fasern aufgrund von Tierversuchen
F. Pott (1991)
10.1289/EHP.94102S511
Biopersistence of respirable synthetic fibers and minerals: the point of view of the epidemiologist.
P. Boffetta (1994)
Inhaled dust and disease
P. Holt (1987)
10.1093/toxsci/20.4.464
Chronic inhalation toxicity of size-separated glass fibers in Fischer 344 rats.
T. W. Hesterberg (1993)
10.1007/978-1-4684-1363-2_17
Durability of Various Mineral Fibres in Rat Lungs
H. Muhle (1991)
Solubility of fibres in vitro and in vivo
J. P. Leineweber (1984)
Evaluating the biopersistence of man-made fibers
T. W. Hesterberg (1992)
10.3109/08958379409003042
Chronic Inhalation Study of Size-Separated Rock and Slag Wool Insulation Fibers in Fischer 344/N Rats
E. E. Mcconnell (1994)
10.1289/EHP.94102S9113
Assessment of carcinogenic hazard of chemical mixtures through analysis of binary chemical interaction data.
Y. T. Woo (1994)
10.1093/ANNHYG/31.4B.791
The effects of MMMF on animal systems: some reflections on their pathogenesis.
M. Kuschner (1987)
10.1093/ANNHYG/31.4B.731
Long-term health effects in hamsters and rats exposed chronically to man-made vitreous fibres.
D. Smith (1987)
10.3109/08958379509015209
Multiple-dose chronic inhalation toxicity study of size-separated kaolin refractory ceramic fiber in male Fischer 344 rats.
R. Mast (1995)
10.1289/EHP.94102S5145
Significance of durability of mineral fibers for their toxicity and carcinogenic potency in the abdominal cavity of rats in comparison with the low sensitivity of inhalation studies.
F. Pott (1994)
Role of fiber dissolution in biological activity in rats.
Walter Eastes (1994)
Animal experiments with MM(V)F -- Effects of inhalation and intrapleural inoculation in rats
J. C. Wagner (1984)
Aerodynamic considerations and other aspects of glass fiber
V. Timbrell (1976)
World health organization (WHO) consensus questionnaire on validity of methods for assessment of carcinogenicity of man-made fibers.
C. Rossiter (1994)
A comparison of human exposures to fiberglass with those used in a recent rat chronic inhalation study.
T. W. Hesterberg (1994)
Durability investigations on siliceous man-made mineral fibers: a critical review
H. Scholze (1988)
10.1016/0273-2300(92)90011-W
Approaches to evaluating the toxicity and carcinogenicity of man-made fibers: summary of a workshop held November 11-13, 1991, Durham, North Carolina.
R. Mcclellan (1992)
Asbestos in the occupational environment
D. Liddell (1991)



This paper is referenced by
10.1080/089583700196149
Estimating in vitro glass fiber dissolution rate from composition.
Walter Eastes (2000)
10.1093/ANNHYG/43.3.167
Influence of characteristics of inhaled fibres on development of tumours in the rat lung.
B. Miller (1999)
10.1006/RTPH.1997.1087
Quantitative risk assessment for a glass fiber insulation product.
W. Fayerweather (1997)
10.1080/08958370050198502
ESTIMATING ROCK AND SLAG WOOL FIBER DISSOLUTION RATE FROM COMPOSITION
Walter Eastes, Russell M. Potter, John G. Hadley (2000)
10.1080/08958370490505016
Extrapolation of the Carcinogenic Potency of Fibers from Rats to Humans
K. Rödelsperger (2004)
10.1080/089583700196149
ESTIMATING IN VITRO GLASS FIBER DISSOLUTION RATE FROM COMPOSITION
Walter Eastes, Russell M. Potter, John G. Hadley (2000)
10.1002/ijc.23609
Long‐term mortality from pleural and peritoneal cancer after exposure to asbestos: Possible role of asbestos clearance
F. Barone-Adesi (2008)
10.1016/J.YRTPH.2006.05.003
The role of fiber durability/biopersistence of silica-based synthetic vitreous fibers and their influence on toxicology.
L. Maxim (2006)
10.1002/047126363X.AGR358
Pathways and Measuring Exposure to Toxic Substances
Cih Morton Lippmann (2003)
10.1080/08958370050138012
Pathogenicity of a special-purpose glass microfiber (E glass) relative to another glass microfiber and amosite asbestos.
R. Cullen (2000)
10.1080/08958370591002030
A Review of the Toxicology and Epidemiology of Wollastonite
L. Maxim (2005)
10.1080/20014091111668
Synthetic Vitreous Fibers: A Review of Toxicology Research and Its Impact on Hazard Classification
T. W. Hesterberg (2001)
10.1093/ANNHYG/41.INHALED_PARTICLES_VIII.312
Biopersistence of Insulation Glass Fibres
M. Moore (1997)
10.1080/10408440802273156
A Meta-Analysis of Asbestos-Related Cancer Risk That Addresses Fiber Size and Mineral Type
D. Berman (2008)
10.1080/08958370050138012
PATHOGENICITY OF A SPECIAL-PURPOSE GLASS MICROFIBER (E GLASS) RELATIVE TO ANOTHER GLASS MICROFIBER AND AMOSITE ASBESTOS
R. T.Cullen, A. Searl, D. Buchanan, J. M. G. Davis (2000)
IN-VITRO ACELLULAR METHOD FOR DETERMINING FIBER DURABILITY IN SIMULATED LUNG FLUID
J. Bauer (2017)
10.1006/RTPH.2002.1552
Indices of fiber biopersistence and carcinogen classification for synthetic vitreous fibers (SVFs).
L. Maxim (2002)
10.1080/08958370050164644
Estimation of dissolution rate from in vivo studies of synthetic vitreous fibers.
Walter Eastes (2000)
10.1080/08958370290084494
QUANTITATIVE RISK ASSESSMENT OF DURABLE GLASS FIBERS
W. Fayerweather (2002)
10.1080/089583799197203
Models for mesothelioma incidence following exposure to fibers in terms of timing and duration of exposure and the biopersistence of the fibers.
G. Berry (1999)
10.1289/EHP.94102590
Priorities for Future IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
H. Vainio (1994)
10.1006/RTPH.2001.1509
Categorization and nomenclature of vitreous silicate wools.
M. A. Moore (2002)
10.3109/08958378.2013.857372
Wollastonite toxicity: an update
L. Maxim (2014)
Chromate Dissociation from Primer Paint in Simulated Lung Fluid
T. R. Morgan (2012)
10.1080/08958370050198502
Estimating rock and slag wool fiber dissolution rate from composition.
Walter Eastes (2000)
10.1006/RTPH.2000.1409
A science-based paradigm for the classification of synthetic vitreous fibers.
E. E. Mcconnell (2000)
10.1080/089583799196754
Studies on the inhalation toxicology of two fiberglasses and amosite asbestos in the Syrian golden hamster. Part II. Results of chronic exposure.
E. E. Mcconnell (1999)
10.1186/s12995-019-0235-z
Biosolubility of high temperature insulation wools in simulated lung fluids
A. Cannizzaro (2019)
10.1006/TAAP.1998.8472
Biopersistence of synthetic vitreous fibers and amosite asbestos in the rat lung following inhalation.
T. W. Hesterberg (1998)
10.1080/08958370601144530
Do Vitreous Fibers Break in the Lung?
Walter Eastes (2007)
10.1006/RTPH.2000.1444
Comment on "Long man-made fibers and lung cancer risk".
Walter Eastes (2001)
10.1007/S10853-009-4036-0
Evidence for a threshold in the biosolubility of aluminosilicate vitreous fibers
F. Devreux (2010)
See more
Semantic Scholar Logo Some data provided by SemanticScholar