Online citations, reference lists, and bibliographies.

Neisseria Meningitidis Endogenous Endophthalmitis With Meningitis In An Immunocompetent Child

Imran H. Yusuf, Z. Sipkova, Sejal Patel, L. Benjamin
Published 2014 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Abstract Neisseria meningitidis is a major cause of childhood morbidity and mortality worldwide. We describe an exceptional case of an immunocompetent 15-month-old child presenting with a unilateral anterior uveitis, hypopyon, and sepsis. Anterior chamber aspirate demonstrated gram-negative cocci before Neisseria meningitidis was identified in blood and cerebrospinal fluid. Meningococcal endophthalmitis presents variably with sepsis, meningitis, or isolated ocular symptoms. Diagnosis is a clinical challenge, requiring diagnostic sampling and treatment from both pediatricians and ophthalmologists. Delayed or incorrect treatment risks blindness, disability, or death. Simultaneous invasion of meningococcus across intact blood–brain and blood–ocular barriers in this child suggests antigenic correlates between meningeal and ocular endothelial interfaces. Meningococcus is an exclusively human pathogen; research is hampered by the lack of animal models. This clinical observation suggests the potential of a novel in vitro experimental approach of using ocular tissue from eye banks to further elucidate the meningococcal–endothelial interaction that underpins meningococcal disease.
This paper references
Endogenous endophthalmitis secondary to bacterial meningitis from Neisseria Meningitidis: a case report and review of the literature
Konstantinos Balaskas (2009)
Immunogenicity and tolerability of recombinant serogroup B meningococcal vaccine administered with or without routine infant vaccinations according to different immunization schedules: a randomized controlled trial.
Nicoletta Gossger (2012)
How do extracellular pathogens cross the blood-brain barrier?
X. Nassif (2002)
Neisseria meningitidis endogenous endophthalmitis presenting as anterior uveitis.
M. S. Chhabra (2007)
Polymerase chain reaction detection of Neisseria meningitidis in the intraocular fluid of a patient with endogenous endophthalmitis but without associated meningitis.
F. Kerkhoff (2003)
Retinal detachment following meningococcal endophthalmitis
P. Agrawal (2007)
A case of meningococcal endophthalmitis in a well patient
T. Sleep (1997)
Endogenous bacterial endophthalmitis: a 17-year prospective series and review of 267 reported cases.
T. Jackson (2003)
Bilateral endophthalmitis as an initial presentation in meningococcal meningitis.
T. Barnard (1997)
Meningococcal septicemia presenting as bilateral endophthalmitis.
E. Chacko (2005)
Evolving role of laminin receptors in microbial pathogenesis and therapeutics of CNS infection.
S. Huang (2009)
Bilateral panophthalmitis as the initial presentation of meningococcal meningitis in an infant.
S. Gartaganis (2001)
Role of the retinal vascular endothelial cell in ocular disease
Arpita Bharadwaj (2013)
Neisseria meningitidis endophthalmitis.
D. Zacks (2004)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar