Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Papillary Craniopharyngioma: A Clinicopathological Study Of 48 Cases.

T. Crotty, B. Scheithauer, W. Young, D. Davis, E. Shaw, G. M. Miller, P. Burger
Published 1995 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Two distinct clinicopathological variants of craniopharyngioma exist: the classic adamantinomatous type and a recently described papillary form that predominates in adults and reportedly behaves in a less aggressive manner. The present study describes the clinicopathological features of 48 patients with papillary craniopharyngioma treated at the Mayo Clinic between 1910 and 1994. An additional four tumors were found to have histological features of both adamantinomatous and papillary craniopharyngioma. Whereas adamantinomatous tumors typically occur in adolescent patients, the mean age of the 48 patients (23 males and 25 females) with papillary craniopharyngioma was 44.7 years (range 10 to 74 years). Presenting clinical features included visual impairment (84%), headache (68%), and pituitary insufficiency (anterior 42%; posterior 27%). Preoperative computerized tomography (CT) and magnetic resonance (MR) imaging in 17 patients typically revealed a noncalcified, partially cystic mass that enhanced peripherally and contained mural nodules (67%). Many (41%) of the lesions involved or extended into the third ventricle on imaging. At first surgery, gross total tumor removal was achieved in 17 patients (36%) and subtotal resection in 30 patients (64%) in whom tumor resection was attempted. Tumor recurrence was noted in two patients who underwent gross total removal. Tumor-free survival rates of 100% and 78% were obtained in patients who underwent gross total and subtotal resection at initial surgery, respectively. Postoperative radiation therapy was beneficial to patients having undergone a subtotal resection, with an increase in tumor-free survival from 26% to 86%. Aside from well-documented morphological distinctions, papillary craniopharyngiomas differ from adamantinomatous tumors in several important respects. These include the almost exclusive occurrence of papillary tumors in adulthood and their more uniform appearance on both CT and MR imaging. However, a preliminary analysis of our data suggests there are no significant differences between the two lesions with respect to resectability, efficacy of radiation therapy, and overall survival.
This paper references
10.1002/1097-0142(197604)37:4<1944::AID-CNCR2820370446>3.0.CO;2
Craniopharyngiomas: a clinical and pathological review.
C. Petito (1976)
10.1016/0090-3019(85)90075-8
Ciliated craniopharyngioma.
J. Goodrich (1985)
10.1016/S0161-6420(89)32914-9
Visual outcome after surgical removal of craniopharyngiomas.
M. Repka (1989)
10.1016/0167-8140(93)90019-5
Craniopharyngioma--a long-term results following limited surgery and radiotherapy.
B. Rajan (1993)
10.3171/JNS.1990.73.1.0003
Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients.
M. Yașargil (1990)
Forty-five years experience with the craniopharyngiomas.
Kahn Ea (1973)
10.3171/JNS.1986.65.1.0022
Surgical management of craniopharyngiomas. A review of 74 cases.
D. Baskin (1986)
10.1016/0090-3019(92)90045-O
Intraventricular craniopharyngioma: report of two cases and review of the literature.
K. Iwasaki (1992)
Forty-five years experience with the craniopharyngiomas.
E. A. Kahn (1973)
10.1007/BF01400850
Status of vision following surgical treatment of craniopharyngiomas
J. C. Cabezudo Artero (1984)
10.3171/JNS.1990.73.1.0012
Correlation of clinical and pathological features in surgically treated craniopharyngiomas.
T. E. Adamson (1990)
10.1093/AJCP/75.5.734
A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies.
S. Hsu (1981)
10.3109/02688699208995036
Microsurgical management of craniopharyngiomas.
D. Wen (1992)
10.1016/0360-3016(89)90005-9
A comparison of the roles of surgery and radiation therapy in the management of craniopharyngiomas.
B. Wen (1989)
10.3171/JNS.1981.55.3.0371
Craniopharyngiomas: a critical approach to treatment.
J. Cabezudo (1981)
10.1002/1097-0142(19810301)47:5<847::AID-CNCR2820470505>3.0.CO;2-W
Treatment results of craniopharyngiomas
D. I. Sung (1981)
10.3109/02688699209002926
Paediatric craniopharyngiomas: a regional review.
P. Graham (1992)
10.1097/00006123-199210000-00032
Surgical Pathology of the Nervous System and Its Coverings
B. H. Choi (1992)
Craniopharyngioma in adults.
M. Banna (1973)
10.1016/0360-3016(84)90235-9
Surgery and radiation therapy in the management of craniopharyngiomas.
J. Hoogenhout (1984)
10.1097/00004728-198507010-00004
Computed Tomography of the Head, Neck and Spine
R. Latchaw (1985)



This paper is referenced by
10.1016/j.jocn.2010.10.004
Management of recurrent craniopharyngioma
S. Liubinas (2011)
10.1007/s003810100458
Radical excision of pediatric craniopharyngioma: recurrence pattern and prognostic factors
S. Kim (2001)
10.36593/rev.chil.neurocir.v43i2.73
Matices del abordaje endonasal endoscópico extendido en la exéresis de los craneofaringiomas
Marlon Ortíz Machin (2019)
10.3171/JNS.1999.90.2.0237
Surgical treatment of craniopharyngiomas: experience with 168 patients.
R. Fahlbusch (1999)
10.2176/NMC.40.324
Repeated hemorrhage in ciliated craniopharyngioma--case report.
H. Nishioka (2000)
10.18632/oncotarget.10501
TREM-1 expression in craniopharyngioma and Rathke's cleft cyst: its possible implication for controversial pathology
Y. Liu (2016)
10.1016/j.clineuro.2006.01.007
Clinico-pathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomas
M. Tena-Suck (2006)
Craniopharyngioma: prognostic importance of histologic features.
C. Petito (1996)
10.1111/j.1365-2559.2003.01751.x
Cathepsin B, D and K expression in adamantinomatous craniopharyngiomas relates to their levels of differentiation as determined by the patterns of retinoic acid receptor expression
A. Lubansu (2003)
10.3171/JNS.2003.98.1.0145
Characterization of the levels of expression of retinoic acid receptors, galectin-3, macrophage migration inhibiting factor, and p53 in 51 adamantinomatous craniopharyngiomas.
F. Lefranc (2003)
10.1007/s00381-018-3925-4
Papillary craniopharyngioma in a 4-year-old girl with BRAF V600E mutation: a case report and review of the literature
R. Borrill (2018)
10.1080/01913120500408018
Morphological and Ultrastructural Findings of Prognostic Impact in Craniopharyngiomas
L. Agozzino (2006)
10.1007/s11060-009-0053-8
Involvement of osteopontin as a core protein in craniopharyngioma calcification formation
Q. Song-tao (2009)
10.1097/01.pas.0000213328.64121.12
Nuclear β-Catenin Accumulation as Reliable Marker for the Differentiation Between Cystic Craniopharyngiomas and Rathke Cleft Cysts: A Clinico-Pathologic Approach
B. Hofmann (2006)
10.3892/ol.2014.2690
Craniopharyngioma: Survivin expression and ultrastructure
J. Zhu (2015)
10.4103/neuroindia.NI_552_16
Papillary craniopharyngioma: A clinicopathologic study of a rare entity from a major tertiary care center in Pakistan
M. Tariq (2017)
10.1007/s003810050108
Long-term results of treatment for craniopharyngioma in children
G. Tomei (1997)
10.1007/s11102-018-0909-z
BRAF V600E mutant papillary craniopharyngiomas: a single-institutional case series
Emanuele La Corte (2018)
10.1016/j.wneu.2020.03.088
Pituitary Adenoma and Papillary Craniopharyngioma: A rare case of collision tumor and review of the literature.
Fred Bteich (2020)
10.1186/s40478-016-0287-6
Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles
A. Hoelsken (2016)
10.1007/s10143-012-0439-5
Hypothalamus-referenced classification for craniopharyngiomas: evidence provided by the endoscopic endonasal approach
José M Pascual (2012)
ADAMANTINOMATOUS CRANIOPHARYNGIOMAS: THEIR ABILITY
Christine Decaestecker (2005)
10.1210/JCEM.84.11.6114
Cystic lesions of the pituitary: clinicopathological features distinguishing craniopharyngioma, Rathke's cleft cyst, and arachnoid cyst.
J. L. Shin (1999)
10.1016/B978-0-443-06967-3.00003-X
3 – Classification and pathogenesis of brain tumors
M. Gonzales (2012)
10.1016/B978-0-323-05355-6.00013-6
Pathology of the Central Skull Base
H. Curtin (2011)
10.3340/jkns.2016.59.5.466
Craniopharyngiomas : Radiological Differentiation of Two Types
I. H. Lee (2016)
10.1016/B978-0-12-416706-3.00004-0
Craniopharyngioma: Embryology, Pathology, and Molecular Aspects
A. Yachnis (2015)
10.1385/EP:15:4:339
Craniopharyngioma: A clinicopathological study of 141 cases
S. M. Tavangar (2004)
10.1007/978-1-59259-037-7_27
Benign Epithelial Lesions—Craniopharyngiomas and Cysts
R. Prayson (2000)
10.1016/S0360-3016(99)00030-9
The role of radiation therapy in the management of craniopharyngioma: a 25-year experience and review of the literature.
J. Habrand (1999)
10.1016/j.critrevonc.2013.07.013
Surgical strategies and modern therapeutic options in the treatment of craniopharyngiomas.
P. Mortini (2013)
10.1007/s11060-010-0407-2
Malignant transformation of craniopharyngioma: case report and review of the literature
Shuzi Gao (2010)
See more
Semantic Scholar Logo Some data provided by SemanticScholar