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Vitamin D And Immune Response: Implications For Prostate Cancer In African Americans

Ken Batai, A. Murphy, L. Nonn, R. Kittles
Published 2016 · Medicine

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Prostate cancer (PCa) is the most common cancer among men in the U.S. African American (AA) men have a higher incidence and mortality rate compared to European American (EA) men, but the cause of PCa disparities is still unclear. Epidemiologic studies have shown that vitamin D deficiency is associated with advanced stage and higher tumor grade and mortality, while its association with overall PCa risk is inconsistent. Vitamin D deficiency is also more common in AAs than EAs, and the difference in serum vitamin D levels may help explain the PCa disparities. However, the role of vitamin D in aggressive PCa in AAs is not well explored. Studies demonstrated that the active form of vitamin D, 1,25-dihydroxyvitamin D, has anti-inflammatory effects by mediating immune-related gene expression in prostate tissue. Inflammation also plays an important role in PCa pathogenesis and progression, and expression of immune-related genes in PCa tissues differs significantly between AAs and EAs. Unfortunately, the evidence linking vitamin D and immune response in relation to PCa is still scarce. This relationship should be further explored at a genomic level in AA populations that are at high risk for vitamin D deficiency and fatal PCa.
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10.1172/jci.insight.91054
Prostatic compensation of the vitamin D axis in African American men.
Zachary Richards (2017)
Biochemical profiling of antifungal activity of Betel leaf ( Piper betle L . ) extract and its significance in traditional medicine
Thomas Smith (2018)
SOCIOECONOMIC AND BEHAVIORAL FACTORS CONTRIBUTING TO RACIAL DISPARITIES IN PROSTATE CANCER
A. Bhardwaj (2016)
The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
Leanne W. Burnham (2018)
10.1038/s41598-018-33150-2
Glucocorticoids Induce Stress Oncoproteins Associated with Therapy-Resistance in African American and European American Prostate Cancer Cells
Leanne Woods-Burnham (2018)
10.2217/imt-2017-0131
Vitamin D aggravates breast cancer by inducing immunosuppression in the tumor bearing mouse.
Yu Cao (2018)
10.1016/j.clinthera.2017.03.012
Immune Modulation by Vitamin D: Special Emphasis on Its Role in Prevention and Treatment of Cancer.
F. Pandolfi (2017)
10.1158/0008-5472.CAN-17-3810
Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men.
Marc Gillard (2018)
10.1038/ni.3754
Nutrition, inflammation and cancer
L. Zitvogel (2017)
10.2174/1573395513666171031162100
Immunomodulatory effects of Vitamin D in influenza infection
Ramazan Rezaei (2018)
Disparate Vitamin D Activity in the Prostate of Men with African Ancestry
L. Nonn (2015)
10.1007/978-3-319-64550-6_21
Nutrigenomics, Epigenetics and Pain in Cancer
S. Pirouzpanah (2017)
Prostate Specific Antigen Level in Exposure to Sulfur Mustard
Y. Panahi (2017)
10.1080/0284186X.2020.1837391
Vitamin D levels and the risk of prostate cancer and prostate cancer mortality
H. V. Stroomberg (2020)
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