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Vitamin D And Immune Response: Implications For Prostate Cancer In African Americans
Ken Batai, A. Murphy, L. Nonn, R. Kittles
Published 2016 · Medicine
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Prostate cancer (PCa) is the most common cancer among men in the U.S. African American (AA) men have a higher incidence and mortality rate compared to European American (EA) men, but the cause of PCa disparities is still unclear. Epidemiologic studies have shown that vitamin D deficiency is associated with advanced stage and higher tumor grade and mortality, while its association with overall PCa risk is inconsistent. Vitamin D deficiency is also more common in AAs than EAs, and the difference in serum vitamin D levels may help explain the PCa disparities. However, the role of vitamin D in aggressive PCa in AAs is not well explored. Studies demonstrated that the active form of vitamin D, 1,25-dihydroxyvitamin D, has anti-inflammatory effects by mediating immune-related gene expression in prostate tissue. Inflammation also plays an important role in PCa pathogenesis and progression, and expression of immune-related genes in PCa tissues differs significantly between AAs and EAs. Unfortunately, the evidence linking vitamin D and immune response in relation to PCa is still scarce. This relationship should be further explored at a genomic level in AA populations that are at high risk for vitamin D deficiency and fatal PCa.
This paper references
Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3.
G. Schwartz (1998)
Baseline prostate inflammation is associated with a reduced risk of prostate cancer in men undergoing repeat prostate biopsy: Results from the REDUCE study
D. Moreira (2014)
Chemokine Ligand 5 (CCL5) and chemokine receptor (CCR5) genetic variants and prostate cancer risk among men of African Descent: a case-control study
L. Kidd (2012)
Expression of cyclooxygenase-1 and cyclooxygenase-2 in the human prostate.
A. Kirschenbaum (2000)
Relationship between vitamin D and inflammatory markers in older individuals
F. Vita (2014)
Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis
D. Peehl (2004)
Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults
T. Barker (2012)
Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes
S. Shab-Bidar (2012)
Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects
A. Bellia (2011)
A prospective study of plasma 25-hydroxyvitamin D concentration and prostate cancer risk
M. Deschasaux (2015)
Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004.
A. Looker (2008)
Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial
A. Hossein-Nezhad (2013)
Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
A. V. Van Dyke (2009)
Vitamin D: Considerations in the Continued Development as an Agent for Cancer Prevention and Therapy
D. Trump (2010)
Disparities at presentation, diagnosis, treatment, and survival in African American men, affected by prostate cancer
G. Chornokur (2011)
Genes Associated with Prostate Cancer Are Differentially Expressed in African American and European American Men
I. Powell (2013)
Treatment of early recurrent prostate cancer with 1,25-dihydroxyvitamin D3 (calcitriol)
C. Gross (1998)
Age differences in suprathreshold sensory function
M. Heft (2013)
Vitamin D deficiency.
T. Oppé (1979)
Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages.
M. Di Rosa (2012)
Association between serum 25(OH)D and death from prostate cancer
S. Tretli (2009)
African American Men : The Challenge of Racism
Kenneth Clatterbaugh (2018)
A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.
S. Ramagopalan (2010)
Association of CD14 variant with prostate cancer in African American men
Tshela E. Mason (2010)
The reactive stroma microenvironment and prostate cancer progression.
D. Barron (2012)
Cancer statistics, 2014
R. Siegel (2014)
Fine-Mapping of IL16 Gene and Prostate Cancer Risk in African Americans
Ken Batai (2012)
Determinants of serum 25 hydroxyvitamin D levels in a nationwide cohort of blacks and non-Hispanic whites
J. Chan (2009)
Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells
W. Wang (2011)
PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3).
L. Dossus (2010)
Vitamin D Intake Is Negatively Associated with Promoter Methylation of the Wnt Antagonist Gene DKK1 in a Large Group of Colorectal Cancer Patients
J. B. Rawson (2012)
Chronic Inflammation in Benign Prostate Tissue Is Associated with High-Grade Prostate Cancer in the Placebo Arm of the Prostate Cancer Prevention Trial
B. Gurel (2014)
Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways.
A. Schetter (2010)
Effects of Supplemental Vitamin D and Calcium on Biomarkers of Inflammation in Colorectal Adenoma Patients: A Randomized, Controlled Clinical Trial
M. Hopkins (2011)
High‐dose weekly oral calcitriol in patients with a rising PSA after prostatectomy or radiation for prostate carcinoma
T. Beer (2003)
Inflammation and Race and Gender Differences in Computerized Tomography‐measured Adipose Depots
Lydia E Beasley (2009)
Over‐expression of cyclooxygenase‐2 in human prostate adenocarcinoma
S. Gupta (2000)
Associations of circulating 25‐hydroxyvitamin D with prostate cancer diagnosis, stage and grade
R. Gilbert (2012)
A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer
H. Li (2007)
No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects.
R. Jorde (2010)
Vitamin D insufficiency among African Americans in the southeastern United States: Implications for cancer disparities.
K. Egan (2007)
The Effects of Calcium and Vitamin D Supplementation on Blood Glucose and Markers of Inflammation in Nondiabetic Adults
S. Tournis (2007)
Molecular Mechanism(s) Involved in 25-Hydroxyvitamin D's Antiproliferative Effects in CYP27B1-transfected LNCaP Cells.
M. Banks (2015)
Increased incidence of pathologically nonorgan confined prostate cancer in African-American men eligible for active surveillance.
Yun-Sok Ha (2013)
Socioeconomic status, healthcare density, and risk of prostate cancer among African American and Caucasian men in a large prospective study
Jacqueline M. Major (2012)
Plasma levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and the risk of prostate cancer
E. Jacobs (2004)
Vitamin D and the RNA transcriptome: more than mRNA regulation
M. J. Campbell (2014)
Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within the European Prospective Investigation into Cancer and Nutrition (EPIC)
R. Travis (2009)
Serum cytokine profiles in patients with prostate carcinoma.
Eri Tazaki (2011)
Vitamin D3 potentiates the growth inhibitory effects of metformin in DU145 human prostate cancer cells mediated by AMPK/mTOR signalling pathway
H. Li (2015)
25-Hydroxyvitamin D3, the prohormone of 1,25-dihydroxyvitamin D3, inhibits the proliferation of primary prostatic epithelial cells.
A. M. Barreto (2000)
Clinical characteristics and biopsy specimen features in African-American and white men without prostate cancer.
J. Eastham (1998)
Relation between serum 25-hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey
M Amer (2001)
Serum vitamin D concentration and prostate cancer risk: a nested case-control study.
J. Ahn (2008)
Impact of Vitamin D Supplementation on Inflammatory Markers in African Americans: Results of a Four-Arm, Randomized, Placebo-Controlled Trial
P. Chandler (2013)
Role of genetic variants in ADIPOQ in human eating behavior
K. Rohde (2014)
Serum 25-Hydroxy Vitamin D and Prostate Cancer Risk in a Large Nested Case–Control Study
D. Albanes (2011)
PTGS 2 and IL 6 genetic variation and risk of breast and prostate cancer : results from the Breast and Prostate Cancer Cohort Consortium ( BPC 3 )
L. Dossus (2010)
Characterizing genetic risk at known prostate cancer susceptibility loci in February 2016 | Volume 7 | Article
CA Haiman (2011)
Vitamin D Deficiency Predicts Prostate Biopsy Outcomes
A. Murphy (2014)
Plasma 25-hydroxyvitamin D and prostate cancer risk: the multiethnic cohort.
S. Park (2010)
Characterizing Genetic Risk at Known Prostate Cancer Susceptibility Loci in African Americans
C. Haiman (2011)
Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.
L. Nonn (2006)
Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study.
I. Shui (2012)
VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression.
Mark B Meyer (2012)
Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects.
J. Beilfuss (2012)
Evidence supports a faster growth rate and/or earlier transformation to clinically significant prostate cancer in black than in white American men, and influences racial progression and mortality disparity.
I. Powell (2010)
The role of vitamin D in cancer prevention.
Rachel A. Ness (2015)
Vitamin D insufficiency in southern Arizona.
E. Jacobs (2008)
Interleukin-6 polymorphism is associated with more aggressive prostate cancer.
D. Tan (2005)
Vitamin D receptor gene polymorphisms are associated with obesity and inflammasome activity
NM Al-Daghri (2014)
Differences in clinicopathologic features of prostate cancer between black and white patients treated in the 1990s and 2000s.
A. D. Berger (2006)
Toll-Like Receptor (TLR)-Associated Sequence Variants and Prostate Cancer Risk among Men of African Descent
E. N. Rogers (2013)
Aspirin, NSAIDs, and Risk of Prostate Cancer: Results from the REDUCE Study
A. Vidal (2014)
Vitamin D insufficiency among African-Americans in the southeastern United States: implications for cancer disparities (United States)
K. Egan (2008)
Genome-wide (over)view on the actions of vitamin D
C. Carlberg (2014)
Vitamin D, Inflammation, and Prostate Cancer Frontiers in Immunology | www.frontiersin.org African Americans
Serum levels of IL-6 and TNF-α correlate with clinicopathological features and patient survival in patients with prostate cancer
V. Michalaki (2004)
MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation
Yongxi Song (2010)
Differential distribution of allelic variants in cytokine genes among African Americans and White Americans.
R. Ness (2004)
The role of vitamin D in reducing cancer risk and progression
D. Feldman (2014)
Relationship between vitamin D and inflammatory markers in older individuals. Age
F De Vita (2014)
The African Americans
D. Cohen (1993)
A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer
S. Bigler (2011)
Plasma 1,25-Dihydroxy- and 25-Hydroxyvitamin D and Subsequent Risk of Prostate Cancer
E. Platz (2004)
Vitamin D deficiency is associated with inflammation in older Irish adults.
E. Laird (2014)
Results from a prostate cancer admixture mapping study in African-American men
C. Bock (2009)
Interleukin-6 gene −174G>C and −636G>C promoter polymorphisms and prostate cancer risk
J. F. Magalhaes (2012)
Predictors of Serum Vitamin D Levels in African American and European American Men in Chicago
A. Murphy (2012)
Serum levels of IL-6 and TNF-alpha correlate with clinicopathological features and patient survival in patients with prostate cancer
V Michalaki (2004)
Inflammation in prostate carcinogenesis
A. D. Marzo (2007)
Plasma Vitamin D and Prostate Cancer Risk: Results from the Selenium and Vitamin E Cancer Prevention Trial
A. Kristal (2014)
Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment.
A. Krishnan (2010)
Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation
M. Wacker (2013)
Vitamin D and Serum Cytokines in a Randomized Clinical Trial
E. Yusupov (2010)
Circulating vitamin D metabolites in relation to subsequent development of prostate cancer.
P. Gann (1996)
Vitamin D Receptor Gene Polymorphisms Are Associated with Obesity and Inflammosome Activity
N. Aldaghri (2014)
The impact of genetic variants in inflammatory-related genes on prostate cancer risk among men of African Descent: a case control study
Dominique Z Jones (2013)
Vitamin D3 supplementation at 4000 international units per day for one year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance.
D. Marshall (2012)
Differential expression and regulation of vitamin D hydroxylases and inflammatory genes in prostate stroma and epithelium by 1,25-dihydroxyvitamin D in men with prostate cancer and an in vitro model
A. A. Giangreco (2015)
Correlates and Prevalence of Insufficient 25‐Hydroxyvitamin D Status in Black and White Older Adults: The Health, Aging and Body Composition Study
M. Shea (2011)
Prostate cancer and inflammation: the evidence
K. Sfanos (2012)
Expression patterns of vitamin D receptor in human prostate
D. Krill (2001)
The vitamin D receptor gene FokI polymorphism: Functional impact on the immune system
E. van Etten (2007)
Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women
C. Peterson (2007)
Null Association between Vitamin D and PSA Levels among Black Men in a Vitamin D Supplementation Trial
P. Chandler (2014)
Maintenance of wintertime vitamin D status with cholecalciferol supplementation is not associated with alterations in serum cytokine concentrations among apparently healthy younger or older adults.
M. S. Barnes (2011)
Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells.
Jacqueline Moreno (2005)
Vitamin D and the Immune System
N. Maruotti (2010)
Generalizability of established prostate cancer risk variants in men of African ancestry
Y. Han (2015)
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
C. Haiman (2011)
Analysis of vitamin D‐regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays
A. Krishnan (2004)
Vitamin d deficiency and seasonal variation in an adult South Florida population.
S. Levis (2005)
Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial.
S. S. Schleithoff (2006)
Relation between serum 25-hydroxyvitamin D and C-reactive protein in asymptomatic adults (from the continuous National Health and Nutrition Examination Survey 2001 to 2006).
M. Amer (2012)
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
Kristin K. Deeb (2007)
Vitamin D3 supplementation, low-risk prostate cancer, and health disparities
B. Hollis (2013)
Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1
Y. Zhang (2012)
T. Guthrie (1987)
The Stroma—A Key Regulator in Prostate Function and Malignancy
Christina Hägglöf (2012)
Prostate specific antigen and pathological features of prostate cancer in black and white patients: a comparative study based on radical prostatectomy specimens.
C. Pettaway (1998)
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
M. Freedman (2006)
Prevalence and correlates of vitamin D status in African American men
M. Tseng (2009)
Regulatory Role of Promoter and 3′ UTR Variants of Vitamin D Receptor Gene on Cytokine Response in Pulmonary Tuberculosis
P. Selvaraj (2007)
Immune Infiltration and Prostate Cancer
A. Strasner (2015)
Biological determinants of health disparities in prostate cancer
D. Martin (2013)
Cancer Incidence and Mortality and Vitamin D in Black and White Male Health Professionals
E. Giovannucci (2006)
Integrative network-based analysis of mRNA and microRNA expression in 1,25-dihydroxyvitamin D3-treated cancer cells
Martina Kutmon (2015)
1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis.
B. Bao (2006)
Genetic Polymorphisms in Inflammation Pathway Genes and Prostate Cancer Risk
E. Kwon (2011)
Vitamin D receptor protein expression in tumor tissue and prostate cancer progression.
Whitney K. Hendrickson (2011)
The epidemiology of vitamin D and cancer incidence and mortality: A review (United States)
E. Giovannucci (2004)
Association between Serum 25-Hydroxyvitamin D and Inflammatory Cytokines in Healthy Adults
X. Sun (2014)
Effect of Vitamin D Supplementation on the Level of Circulating High-Sensitivity C-Reactive Protein: A Meta-Analysis of Randomized Controlled Trials
Neng Chen (2014)
Vitamin D and the epigenome
I. S. Fetahu (2014)
Randomized clinical trial of vitamin D3 doses on prostatic vitamin D metabolite levels and ki67 labeling in prostate cancer patients.
D. Wagner (2013)
Possible Role of Serum 25-Hydroxyvitamin D in Black-White Health Disparities in the United States
M. Ilić (2011)
1,25-dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes
D. Gao (2013)
1 α , 25dihydroxyvitamin D 3 suppresses interleukin8mediated
Bao B-Y (2006)
Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma.
H. Adler (1999)
Genetic and Molecular Differences in Prostate Carcinogenesis between African American and Caucasian American Men
J. Farrell (2013)
The Vitamin D Receptor and T Cell Function
M. Kongsbak (2013)
Vitamin D in inflammatory diseases
Thea K. Wöbke (2014)
Expression differences between African American and Caucasian prostate cancer tissue reveals that stroma is the site of aggressive changes
Matthew A. Kinseth (2014)
Pretreatment PSA velocity and risk of death from prostate cancer following external beam radiation therapy.
A. D'Amico (2005)
Common vitamin D pathway gene variants reveal contrasting effects on serum vitamin D levels in African Americans and European Americans
Ken Batai (2014)
African American men with very low-risk prostate cancer exhibit adverse oncologic outcomes after radical prostatectomy: should active surveillance still be an option for them?
D. Sundi (2013)
Nuclear hormone 1α,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy
S. Heikkinen (2011)
Tumor Suppressor microRNAs, miR-100 and -125b, Are Regulated by 1,25-dihydroxyvitamin D in Primary Prostate Cells and in Patient Tissue
A. A. Giangreco (2013)
Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study
R. Reams (2009)
VDR regulation of microRNA differs across prostate cell models suggesting extremely flexible control of transcription
P. Singh (2015)
Primary Vitamin D Target Genes Allow a Categorization of Possible Benefits of Vitamin D3 Supplementation
C. Carlberg (2013)
Prediagnostic Plasma Vitamin D Metabolites and Mortality among Patients with Prostate Cancer
F. Fang (2011)
The sum of many small changes: microRNAs are specifically and potentially globally altered by vitamin D3 metabolites
A. A. Giangreco (2013)
Population differences in proinflammatory biology: Japanese have healthier profiles than Americans
C. Coe (2011)
Interactions of cytokine gene polymorphisms in prostate cancer risk.
J. Zabaleta (2008)
Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns.
Craig L. Doig (2013)
Tumor immunobiological differences in prostate cancer between African-American and European-American men.
Tiffany A. Wallace (2008)
Racial/Ethnic Patterns in Prostate Cancer Outcomes in an Active Surveillance Cohort
J. Cullen (2011)
This paper is referenced by
High Prevalence of Vitamin D Deficiency and Correlation of Serum Vitamin D with Cardiovascular Risk in Patients with Metabolic Syndrome.
M. Alkhatatbeh (2017)
Genetic and epigenetic cancer chemoprevention on molecular targets during multistage carcinogenesis
Hyung Sik Kim (2016)
Can vitamin D supplementation reduce prostate cancer disparities?
Ken Batai (2016)
Effects of High-Dose Vitamin D Supplementation on Phase Angle and Physical Function in Patients with Prostate Cancer on ADT.
Julia E Inglis (2020)
Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges.
A. Mondul (2017)
Circulating vitamin D concentration and risk of prostate cancer: a dose–response meta-analysis of prospective studies
Jialin Gao (2018)
The 22Rv1 prostate cancer cell line carries mixed genetic ancestry: Implications for prostate cancer health disparities research using pre‐clinical models
Leanne Woods-Burnham (2017)
The Use of 1α,25-Dihydroxyvitamin D3 as an Anticancer Agent
E. Marcinkowska (2016)
Association between Dietary Inflammatory Index and the Risk of Prostate Cancer: A Meta-Analysis
R. Mohseni (2019)
Prostate cancer risk factors in black and white men in the NIH-AARP Diet and Health Study
T. Layne (2018)
Prostatic compensation of the vitamin D axis in African American men.
Zachary Richards (2017)
Biochemical profiling of antifungal activity of Betel leaf ( Piper betle L . ) extract and its significance in traditional medicine
Thomas Smith (2018)
SOCIOECONOMIC AND BEHAVIORAL FACTORS CONTRIBUTING TO RACIAL DISPARITIES IN PROSTATE CANCER
A. Bhardwaj (2016)
The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
Leanne W. Burnham (2018)
Glucocorticoids Induce Stress Oncoproteins Associated with Therapy-Resistance in African American and European American Prostate Cancer Cells
Leanne Woods-Burnham (2018)
Vitamin D aggravates breast cancer by inducing immunosuppression in the tumor bearing mouse.
Yu Cao (2018)
Immune Modulation by Vitamin D: Special Emphasis on Its Role in Prevention and Treatment of Cancer.
F. Pandolfi (2017)
Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men.
Marc Gillard (2018)
Nutrition, inflammation and cancer
L. Zitvogel (2017)
Immunomodulatory effects of Vitamin D in influenza infection
Ramazan Rezaei (2018)
Disparate Vitamin D Activity in the Prostate of Men with African Ancestry
L. Nonn (2015)
Nutrigenomics, Epigenetics and Pain in Cancer
S. Pirouzpanah (2017)
Prostate Specific Antigen Level in Exposure to Sulfur Mustard
Y. Panahi (2017)
Vitamin D levels and the risk of prostate cancer and prostate cancer mortality
H. V. Stroomberg (2020)