Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Targeted Phototherapy For Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin

Y. Nishinaga, Kazuhide Sato, Hirotoshi Yasui, S. Taki, K. Takahashi, M. Shimizu, Rena Endo, Chiaki Koike, Noriko Kuramoto, S. Nakamura, T. Fukui, H. Yukawa, Yoshinobu Baba, Mika K. Kaneko, T. Chen-Yoshikawa, Hisataka Kobayashi, Y. Kato, Y. Hasegawa
Published 2020 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Malignant pleural mesothelioma (MPM) has extremely limited treatment despite a poor prognosis. Moreover, molecular targeted therapy for MPM has not yet been implemented; thus, a new targeted therapy is highly desirable. Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed cancer therapy that combines the specificity of antibodies for targeting tumors with toxicity induced by the photoabsorber after exposure to NIR-light. In this study, we developed a new phototherapy targeting podoplanin (PDPN) for MPM with the use of both NIR-PIT and an anti-PDPN antibody, NZ-1. An antibody–photosensitizer conjugate consisting of NZ-1 and phthalocyanine dye was synthesized. In vitro NIR-PIT-induced cytotoxicity was measured with both dead cell staining and luciferase activity on various MPM cell lines. In vivo NIR-PIT was examined in both the flank tumor and orthotopic mouse model with in vivo real-time imaging. In vitro NIR-PIT-induced cytotoxicity was NIR-light dose dependent. In vivo NIR-PIT led to significant reduction in both tumor volume and luciferase activity in a flank model (p < 0.05, NIR-PIT group versus NZ-1-IR700 group). The PDPN-targeted NIR-PIT resulted in a significant antitumor effect in an MPM orthotopic mouse model (p < 0.05, NIR-PIT group versus NZ-1-IR700 group). This study suggests that PDPN-targeted NIR-PIT could be a new promising treatment for MPM.
This paper references
Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain.
Y. Kato (2006)
Podoplanin - a small glycoprotein with many faces.
M. Ugorski (2016)
Near infrared photoimmunotherapy for lung metastases.
Kazuhide Sato (2015)
Armed antibodies for cancer treatment: a promising tool in a changing era
R. Danielli (2014)
Near Infrared Photoimmunotherapy in the Treatment of Disseminated Peritoneal Ovarian Cancer
Kazuhide Sato (2014)
Management and Survival of Pleural Mesothelioma: A Record Linkage Study
G. Carioli (2018)
Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment
A. Bibby (2016)
Near-Infrared Photochemoimmunotherapy by Photoactivatable Bifunctional Antibody-Drug Conjugates Targeting Human Epidermal Growth Factor Receptor 2 Positive Cancer.
K. Ito (2017)
Value of D24-0 in the differential diagnosis of pleural neoplasms with emphasis on its positivity in solitary fibrous tumor
Y. Hu (2010)
Value of D2-40 in the Differential Diagnosis of Pleural Neoplasms With Emphasis on Its Positivity in Solitary Fibrous Tumor
Y. Hu (2010)
Near infrared photoimmunotherapy with an anti-mesothelin antibody
Tadanobu Nagaya (2016)
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
Antibody derivatives as new therapeutics for hematologic. Immunotoxins for leukemia
A. S. Wayne (2015)
Role of Fluorophore Charge on the In Vivo Optical Imaging Properties of Near-Infrared Cyanine Dye/Monoclonal Antibody Conjugates.
Kazuhide Sato (2016)
Checkpoint Blockade in Lung Cancer and Mesothelioma
L. Lievense (2017)
Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy
Kazuhide Sato (2016)
Near infrared photoimmunotherapy prevents lung cancer metastases in a murine model
Kazuhide Sato (2015)
Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer
Y. Isobe (2020)
Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline.
H. Kindler (2018)
Impact of C4'-O-Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates.
Kazuhide Sato (2015)
Near Infrared Photoimmunotherapy for Cancer
Hisataka Kobayashi (2019)
Podoplanin is a Better Immunohistochemical Marker for Sarcomatoid Mesothelioma Than Calretinin
Diana M Padgett (2008)
Near Infrared Photoimmunotherapy in the Treatment of Pleural Disseminated NSCLC: Preclinical Experience
Kazuhide Sato (2015)
Podoplanin in Inflammation and Cancer
M. Quintanilla (2019)
Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy
Kazuhide Sato (2018)
Psallidas, I. Malignant pleural mesothelioma: An update on investigation, diagnosis and treatment
A C Bibby (2016)
A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin
Y. Kato (2014)
D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma.
N. Ordóñez (2005)
Numb controls E-cadherin endocytosis through p120 catenin with aPKC
Kazuhide Sato (2011)
A Novel Targeting Therapy of Malignant Mesothelioma Using Anti-Podoplanin Antibody
S. Abe (2013)
Clinical efficacy and safety of nivolumab: Results of a multicenter, open-label, single-arm, Japanese phase II study in malignant pleural mesothelioma
M. Okada (2019)
Occupational and environmental exposures and cancers in developing countries.
D. Hashim (2014)
Antibody drug conjugates in thoracic malignancies.
J. Pacheco (2018)
Photoimmunotherapy of Gastric Cancer Peritoneal Carcinomatosis in a Mouse Model
Kazuhide Sato (2014)
Current treatment strategies in malignant pleural mesothelioma with a treatment
M. Sayan (2019)
The global spread of asbestos.
Arthur L. Frank (2014)
Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique.
Kazuhide Sato (2016)
Therapeutic efficacy evaluation of radioimmunotherapy with 90Y‐labeled anti‐podoplanin antibody NZ‐12 for mesothelioma
H. Sudo (2019)
Immunotoxins for leukemia.
A. Wayne (2014)
Effect of charge localization on the in vivo optical imaging properties of near-infrared cyanine dye/monoclonal antibody conjugates.
Kazuhide Sato (2016)
Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.
K. Kawaguchi (2009)
Clinical Efficacy and Safety of Nivolumab: Results of a Multicenter, Open-label, Single-arm, Japanese Phase II study in Malignant Pleural Mesothelioma (MERIT)
M. Okada (2019)
Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients.
N. Usami (2006)
Cancer Cell-Selective In Vivo Near Infrared Photoimmunotherapy Targeting Specific Membrane Molecules
M. Mitsunaga (2011)
Malignant Pleural Mesothelioma: State-of-the-Art on Current Therapies and Promises for the Future
Fabio Nicolini (2019)
Significance of podoplanin expression in cancer-associated fibroblasts: a comprehensive review.
B. Puła (2013)
PD-1 and PD-L1 antibodies in cancer: current status and future directions
A. Balar (2017)
Podoplanin expression in cancerous stroma induces lymphangiogenesis and predicts lymphatic spread and patient survival.
H. Kitano (2010)
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial
G. Zalcman (2016)
[Malignant mesothelioma].
J. Espinosa Arranz (1994)
Current treatment strategies in malignant pleural mesothelioma with a treatment algorithm.
M. Sayan (2019)
Increasing incidence of malignant mesothelioma after exposure to asbestos during home maintenance and renovation
N. Olsen (2011)
Molecular analysis of the pathophysiological binding of the platelet aggregation‐inducing factor podoplanin to the C‐type lectin‐like receptor CLEC‐2
Y. Kato (2008)
Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine.
Kazuhide Sato (2015)
Photoimmunotherapy: Comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor
Kazuhide Sato (2014)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar