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PLGA Biodegradable Nanoparticles Containing Perphenazine Or Chlorpromazine Hydrochloride: Effect Of Formulation And Release

Mohammed Halayqa, U. Domańska
Published 2014 · Chemistry, Medicine

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In our study, poly(dl-lactide-co-glycolide) (PLGA) nanoparticles loaded with perphenazine (PPH) and chlorpromazine hydrochloride (CPZ-HCl) were formulated by emulsion solvent evaporation technique. The effect of various processing variables, including PLGA concentration, theoretical drug loading, poly(vinyl alcohol) (PVA) concentration and the power of sonication were assessed systematically to obtain higher encapsulation efficiency and to minimize the nanoparticles size. By the optimization formulation process, the nanoparticles were obtained in submicron size from 325.5 ± 32.4 to 374.3 ± 10.1 nm for nanoparticles loaded with PPH and CPZ-HCl, respectively. Nanoparticles observed by scanning electron microscopy (SEM) presented smooth surface and spherical shape. The encapsulation efficiency of nanoparticles loaded with PPH and CPZ-HCl were 83.9% and 71.0%, respectively. The drug loading were 51.1% and 39.4% for PPH and CPZ-HCl, respectively. Lyophilized nanoparticles with different PLGA concentration 0.8%, 1.3% and 1.6% (w/v) in formulation process were evaluated for in vitro release in phosphate buffered saline (pH = 7.4) by using dialysis bags. The release profile for both drugs have shown that the rate of PPH and CPZ-HCl release were dependent on a size and amount of drugs in the nanoparticles.
This paper references
Integrated PLGA–Ag nanocomposite systems to control the degradation rate and antibacterial properties
S. Rinaldi (2013)
Physicochemical Parameters Associated with Nanoparticle Formation in the Salting-Out, Emulsification-Diffusion, and Nanoprecipitation Methods
S. Galindo-Rodriguez (2004)
New high throughput screening method for drug release measurements.
A. Pelczarska (2013)
Preparation of PLGA nanoparticles containing estrogen by emulsification–diffusion method
Hye young Kwon (2001)
Integrated PLGA-Agnanocomposite systems to control the degradation rate and antibacterial properties
S Rinaldi
PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution.
R. Mainardes (2005)
Detection of PLGA-based nanoparticles at a single-cell level by synchrotron radiation FTIR spectromicroscopy and correlation with X-ray fluorescence microscopy
L. Pascolo (2014)
Preparation and characterization of poly-?-caprolactone nanoparticles containing griseofulvin
Z. Zhang (2005)
Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation.
F. Danhier (2009)
Influence of stabilizing agents and preparative variables on the formation of poly(d,l-lactic acid) nanoparticles by an emulsification-diffusion technique
D. Quintanar-Guerrero (1996)
Chlorpromazine versus every other antipsychotic for schizophrenia: A systematic review and meta-analysis challenging the dogma of equal efficacy of antipsychotic drugs
M. Samara (2014)
Promazine Hydrochloride/PLGA Biodegradable Nanoparticles Formulation and Release
U. Domańska (2014)
Biodegradable polymeric nanoparticles based drug delivery systems.
A. Kumari (2010)
Coalescence in Surfactant-Stabilized Emulsions Subjected to Shear Flow
A. Nandi (2001)
Paclitaxelloaded PEGylated PLGA-based nanoparticles: In vitro and in vivo evaluation
F Danhier (2009)
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license
Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient.
Andreas Fritze (2006)
Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content.
A. Budhian (2007)
J. Appl. Polym. Sci
PLGA nanopartcles containing praziquantel: Effect of formulation variable on size distribution
R M Mainardes (2005)
The role of serotonin receptors in the action of atypical antipsychotic drugs.
H. Meltzer (2011)
Monodispersed Polymeric Nanoparticles Fabrication by Electrospray Atomization
A. Zarrabi (2012)
Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method.
H. Murakami (1999)
Solubility and pKa determination of six structurally related phenothiazines.
U. Domańska (2011)
Fluphenazine release from biodegradable microparticles: Characterization and modelling of release
M. Dunne (2009)
Optimization, in vitro-in vivo evaluation, and short-term tolerability of novel levofloxacin-loaded PLGA nanoparticle formulation.
G. Kumar (2012)
Synthesis of high loading and encapsulation efficient paclitaxel-loaded poly(n-butyl cyanoacrylate) nanoparticles via miniemulsion.
C. Huang (2007)
PLGA-Agnanocomposite systems to control the degradation rate and antibacterial properties
S Rinaldi (2013)
Self-Assembled, Chitosan Grafted PLGA Nanoparticles for Intranasal Delivery: Design, Development and Ex Vivo Characterization
S. Chalikwar (2013)
Uptake of phenothiazines by the harvested chylomicrons ex vivo model: influence of self-nanoemulsifying formulation design.
G. Shahnaz (2011)
Design and Optimization of PLGA-Based Diclofenac Loaded Nanoparticles
D. L. Cooper (2014)
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons
Available online: drugdb/029. html (accessed on
Pieno (2014)
Preparation and pharmacodynamics of stearic acid and poly (lactic-co-glycolic acid) grafted chitosan oligosaccharide micelles for 10-hydroxycamptothecin.
Yue-Yu Zhou (2010)
Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery
Cunxian Song (1997)
PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: systematic study of particle size and drug entrapment efficiency.
Xiangrong Song (2008)
Influence of increasing viscosity of the aqueous phase on the short-term stability of protein stabilized emulsions
S. Tesch (2002)
Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
M. R. Aji Alex (2011)
Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells.
R. Das (2010)
Microencapsulation of nanoparticles with enhanced drug loading for pH‐sensitive oral drug delivery for the treatment of colon cancer
Yichao Wang (2013)

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Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation
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R. Ismail (2019)
Formulation and Optimization of Avanafil Biodegradable Polymeric Nanoparticles: A Single-Dose Clinical Pharmacokinetic Evaluation
Hibah M Aldawsari (2020)
Extended-release of chlorpromazine intercalated into montmorillonite clays
M. A. Djebbi (2018)
Thesis submitted for the degree Master in Nanoscience The production and characterization of drug-loaded liposomal and PLGA nanocarriers for targeted treatment of acute myeloid leukemia
Edvin Tang (2016)
Challenges with conventional methods of manufacturing PLGA nanoparticles
A comparison of models for the analysis of the kinetics of drug release from PLGA-based nanoparticles
Leila Pourtalebi Jahromi (2020)
Delivery of Antipsychotics with Nanoparticles
Y. Sun (2016)
Studying of drug solubility in water and alcohols using drug‐ammonium ionic liquid‐compounds
Mohammad Halayqa (2018)
Targeting Cancer by Natural Polymeric Nanoparticles
S. Sagar (2018)
Development and characterisation of disulfiram‐loaded PLGA nanoparticles for the treatment of non‐small cell lung cancer
M. Najlah (2017)
Polymer – Ionic liquid – Pharmaceutical conjugates as drug delivery systems
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Alaa A A Aljabali (2020)
Interaction of Solid Lipid Nanoparticles and Specific Proteins of the Corona Studied by Surface Plasmon Resonance
Mauricio E. Di Ianni (2017)
PLGA nanoparticles embedding molybdenum cluster salts: influence of chemical composition on physico-chemical properties, encapsulation efficiencies, colloidal stabilities and in vitro release.
G. Dollo (2020)
Self-assembled supermolecular hydrogel based on hydroxyethyl cellulose: Formation, in vitro release and bacteriostasis application.
N. Sun (2017)
Microfluidics-A ssisted S ize T uning and B iological E valuation of PLGA P articles
M. C. Operti (2019)
Design of triphasic poly(lactic-co-glycolic acid) nanoparticles containing a perfluorocarbon phase for biomedical applications
E. Swider (2018)
Formulation and evaluation of osteotropic drug delivery system of methotrexate with a potential for passive bone targeting
V. Raichur (2016)
Formulation & Evaluation of PLGA Nanoparticles of Ropinirole HCl for Targeting Brain
A. Balla (2020)
Biodegradable self-assembled nanoparticles of PEG-PLGA amphiphilic diblock copolymer as a promising stealth system for augmented vinpocetine brain delivery.
Osama A. A. Ahmed (2020)
Improving Encapsulation of Hydrophilic Chloroquine Diphosphate into Biodegradable Nanoparticles: A Promising Approach against Herpes Virus Simplex-1 Infection
T. Lima (2018)
Microfluidics-Assisted Size Tuning and Biological Evaluation of PLGA Particles
M. C. Operti (2019)
Caffeic acid phenethyl ester loaded PLGA nanoparticles: effect of various process parameters on reaction yield, encapsulation efficiency, and particle size
S. Derman (2015)
Research and Reviews: Journal of Botanical Sciences Nanoparticles- The current Research
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Karol Yesenia Hernández-Giottonini (2020)
Amorphous nanoparticle complex of perphenazine and dextran sulfate as a new solubility enhancement strategy of antipsychotic perphenazine
B. Dong (2017)
Chitosan coated PLGA nanoparticles amplify the ocular hypotensive effect of forskolin: Statistical design, characterization and in vivo studies.
N. Khan (2018)
Preparation and evaluation of PLGA nanoparticle-loaded biodegradable light-responsive injectable implants as a promising platform for intravitreal drug delivery
R. Bisht (2017)
Enhanced and Extended Anti-Hypertensive Effect of VP5 Nanoparticles
T. Yu (2016)
Novel approaches to cancer therapy with ibuprofen-loaded Eudragit® RS 100 and/or octadecylamine-modified PLGA nanoparticles by assessment of their effects on apoptosis
Gülsel Yurtdaş-Kırımlıoğlu (2020)
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