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Chitosan Based Polyelectrolyte Complexes As Potential Carrier Materials In Drug Delivery Systems

J. Hamman
Published 2010 · Biology, Medicine

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Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysaccharide in modified release dosage forms for oral administration is its fast dissolution rate in the stomach. Since chitosan is positively charged at low pH values (below its pKa value), it spontaneously associates with negatively charged polyions in solution to form polyelectrolyte complexes. These chitosan based polyelectrolyte complexes exhibit favourable physicochemical properties with preservation of chitosan’s biocompatible characteristics. These complexes are therefore good candidate excipient materials for the design of different types of dosage forms. It is the aim of this review to describe complexation of chitosan with selected natural and synthetic polyanions and to indicate some of the factors that influence the formation and stability of these polyelectrolyte complexes. Furthermore, recent investigations into the use of these complexes as excipients in drug delivery systems such as nano- and microparticles, beads, fibers, sponges and matrix type tablets are briefly described.
This paper references
10.1179/174328408X341744
Chitosan composites for biomedical applications: status, challenges and perspectives
S. Hein (2008)
10.1016/S1773-2247(10)50006-6
Progress in chitosan-based vaccine delivery systems
Farid Esmaeili (2010)
10.1016/S0142-9612(98)00036-2
Chitosan-chondroitin sulfate and chitosan-hyaluronate polyelectrolyte complexes: biological properties.
A. Denuzière (1998)
10.1016/J.MSEC.2008.08.032
Chitosan/“angico” gum nanoparticles: Synthesis and characterization
Marília A. Oliveira (2009)
Polyelectrolyte complexes of EudragitL30D-55 and gelatine: Antinociceptive activity of entrapped piroxicam. Drug Deliv
A A Attama (2007)
10.1063/1.2387173
Stoichiometric polyelectrolyte complexes of ionic block copolymers and oppositely charged polyions.
E. Y. Kramarenko (2006)
Polyionic hydrogels obtained by complexation: Their properties as support for enzyme immobilization
S. Dumitriu (1994)
10.1007/S10853-005-3929-9
A preliminary study on chitosan/gelatin polyelectrolyte complex formation
Yuji Yin (2005)
Eur. J. Pharm. Biopharm
(2005)
10.1179/174327807X238945
Properties and degradation of selected polysaccharides: hyaluronan and chitosan
M. Rinaudo (2007)
10.1016/J.REACTFUNCTPOLYM.2009.09.009
Encapsulation of glucose oxidase (GOD) in polyelectrolyte complexes of chitosan-carrageenan
A. Briones (2010)
10.1016/J.MEMSCI.2009.02.001
Synthesis and characterization of soluble chitosan/sodium carboxymethyl cellulose polyelectrolyte complexes and the pervaporation dehydration of their homogeneous membranes
Q. Zhao (2009)
Handbook of Pharmaceutical Excipients; Pharmaceutical Press: Washington
A. H. Kibbe (2000)
10.1023/A:1015985229667
Chitosan–Carrageenan Gels
E. V. Shumilina (2002)
10.1002/APP.29763
Ionic self‐assembly and characterization of a polysaccharide‐based polyelectrolyte complex of maleic starch half‐ester acid with chitosan
Congming Xiao (2009)
10.1007/S11167-005-0324-X
Polyelectrolyte Complexes of Fibroin with Chitosan
E. Sashina (2005)
10.1111/J.1469-8137.2004.00980.X
Primary cell wall metabolism: tracking the careers of wall polymers in living plant cells
S. Fry (2004)
10.1007/S00289-005-0439-5
Swelling behavior of chitosan/pectin polyelectrolyte complex membranes. Effect of thermal cross-linking
P. Bernabé (2005)
10.1016/j.ejpb.2008.04.008
Comparative evaluation of interpolyelectrolyte complexes of chitosan with Eudragit L100 and Eudragit L100-55 as potential carriers for oral controlled drug delivery.
R. I. Moustafine (2008)
10.1080/10717540601036864
Polyelectrolyte Complexes of Eudragit L30 D-55 and Gelatin: Antinociceptive Activity of Entrapped Piroxicam
A. Attama (2007)
Morphological, physic-chemical and structural characterisation of gum kondagogu (Cochlospermum gossypium): A tree gum from India. Food Hydrocol
V T P Vinod (2008)
10.1016/j.addr.2009.07.019
Chitosan-based hydrogels for controlled, localized drug delivery.
N. Bhattarai (2010)
10.1016/J.BIOMATERIALS.2005.02.012
Preparation of γ-PGA/chitosan composite tissue engineering matrices
Chien-Yang Hsieh (2005)
10.1016/J.FOODCHEM.2009.03.009
Solution and conformational properties of gum kondagogu (Cochlospermum gossypium) ― A natural product with immense potential as a food additive
V. Vinod (2009)
10.1080/10717540801905009
Matrix polymeric excipients: comparing a novel interpolyelectrolyte complex with hydroxypropylmethylcellulose.
Zhilei Lu (2008)
10.1016/S0144-8617(02)00044-9
Formation and properties of polyelectrolyte complexes of chitosan hydrochloride and sodium dextransulfate
A. I. Gamzazade (2002)
10.1007/s12272-001-1249-7
Preparation of Carbopol/chitosan interpolymer complex as a controlled release tablet matrix; effect of complex formation medium on drug release characteristics
Myung-hak Lee (2008)
10.1016/J.EJPB.2006.12.014
Swelling and erosion of pectin matrix tablets and their impact on drug release behavior.
P. Sriamornsak (2007)
10.1016/J.BBAGEN.2004.10.011
Glycosaminoglycan destabilization of DNA-chitosan polyplexes for gene delivery depends on chitosan chain length and GAG properties.
S. Danielsen (2005)
10.1016/J.MEMSCI.2008.04.011
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization
C. L. Silva (2008)
10.2174/156720107782151232
Chitosan-polycarbophil complexes in swellable matrix systems for controlled drug release.
Z. Lu (2007)
10.1016/J.FOODHYD.2007.05.006
Morphological, physico-chemical and structural characterization of gum kondagogu (Cochlospermum gossypium) : A tree gum from India
V. Vinod (2008)
10.1016/S0939-6411(03)00160-7
Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications.
J. Berger (2004)
10.1016/S0939-6411(03)00153-X
Comparative studies on polyelectrolyte complexes and mixtures of chitosan-alginate and chitosan-carrageenan as prolonged diltiazem clorhydrate release systems.
Cristián Tapia (2004)
10.1016/J.JCONREL.2005.02.013
Controlled release from fibers of polyelectrolyte complexes.
I. Liao (2005)
10.1016/J.IJPHARM.2007.06.024
Preparation of an extended-release matrix tablet using chitosan/Carbopol interpolymer complex.
Sung-hyun Park (2008)
Synthesis and characterization of soluble chitosan/sodium carboxymethyl cellulose polyelectrolyte complexes and the pervaporation dehydration of their homogenous membranes
Q. Zhao (2009)
10.1007/S00396-007-1785-7
Nanoparticles prepared by self-assembly of Chitosan and poly-γ-glutamic acid
I. Hajdú (2007)
10.1016/S0168-3659(97)00203-4
Design of microencapsulated chitosan microspheres for colonic drug delivery.
M. L. Lorenzo-Lamosa (1998)
10.1016/J.CARBPOL.2008.11.010
Polyelectrolyte complexes of gum kondagogu and chitosan, as diclofenac carriers
V. Naidu (2009)
Kwon, I.C. Targeted delivery of low molecular drugs using chitosan and its derivatives
J H Park (2010)
10.3390/molecules14072602
Polymeric Plant-derived Excipients in Drug Delivery
Carien E. Beneke (2009)
10.1016/J.CARBPOL.2003.11.013
Physicochemical and structural characterization of a polyionic matrix of interest in biotechnology, in the pharmaceutical and biomedical fields
D. Magnin (2004)
10.1016/J.EURPOLYMJ.2005.05.009
Chitosan/carboxymethyl cashew gum polyelectrolyte complex: synthesis and thermal stability
J. S. Maciel (2005)
10.1016/j.ejps.2008.09.004
Chitosan/pectin polyelectrolyte complexes: selection of suitable preparative conditions for colon-specific delivery of vancomycin.
F. Bigucci (2008)
10.1016/J.EJPB.2006.07.014
Reversed chitosan-alginate polyelectrolyte complex for stability improvement of alpha-amylase: optimization and physicochemical characterization.
M. Sankalia (2007)
10.1016/J.CARBPOL.2006.09.007
Evaluation of acrylamide-grafted-xanthan gum copolymer matrix tablets for oral controlled delivery of antihypertensive drugs ☆
R. C. Mundargi (2007)
10.1016/j.ijpharm.2009.04.009
Chitosan-hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma.
F. Oyarzun-Ampuero (2009)
10.1070/RC2008V077N09ABEH003750
Polyelectrolyte complexes of chitosan: formation, properties and applications
M. Krayukhina (2008)
10.1016/0928-0987(94)90011-6
Liposome-associated retinoids: production, characterization and antiproliferative activity on neoplastic cells
R. Cortesi (1994)
10.1016/J.JCONREL.2004.11.031
Characteristics of interpolyelectrolyte complexes of Eudragit E100 with Eudragit L100.
R. I. Moustafine (2005)
10.1016/J.POLYMDEGRADSTAB.2008.10.017
Characterization and biodegradation of chitosan-alginate polyelectrolyte complexes
X. Li (2009)
10.1016/J.EJPB.2007.08.012
Temperature-sensitive hydrogels composed of chitosan and hyaluronic acid as injectable carriers for drug delivery.
Jia-You Fang (2008)
Physicochemical and structural characterisation of a polyionic matrix of interest in biotechnology, in the pharmaceutical and biomedical fields. Carbohydr. Polym
D. Magnin (2004)
Handbook of Pharmaceutical Excipients
Pharmaceutical Press (2012)
10.1080/10837450701702636
Chitosan-polycarbophil interpolyelectrolyte complex as an excipient for bioadhesive matrix systems to control macromolecular drug delivery.
Zhilei Lu (2008)
10.1016/j.biomaterials.2008.12.066
In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery.
K. Sonaje (2009)
10.1016/0378-5173(95)04098-6
Interactions between bioadhesive poly(acrylic acid) and calciumions
B. Kriwet (1996)
10.4103/0250-474X.58165
Polyelectrolyte Complexes: A Review of their Applicability in Drug Delivery Technology
S. Lankalapalli (2009)
10.1016/J.EJPS.2005.03.005
Polyelectrolyte complex formation and stability when mixing polyanions and polycations in salted media: a model study related to the case of body fluids.
T. Etrych (2005)
10.1016/j.addr.2009.10.003
Targeted delivery of low molecular drugs using chitosan and its derivatives.
J. H. Park (2010)
10.1016/J.CARBPOL.2007.11.017
On the gelling behaviour of ‘nopal’ (Opuntia ficus indica) low methoxyl pectin
A. Cárdenas (2008)
10.1007/s10438-005-0002-z
Chitosan-based polyelectrolyte complexes: A review
A. Il’ina (2005)
10.1016/J.CARBPOL.2008.04.048
Polyelectrolyte complex formation using alginate and chitosan
Heidi Vogt Sæther (2008)
10.1016/J.ADDR.2007.03.012
Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications.
P. B. Malafaya (2007)
10.1016/J.FOODHYD.2007.12.011
Effect of complexation conditions on xanthan-chitosan polyelectrolyte complex gels
Sanem Argin-Soysal (2009)
10.1016/J.EJPB.2004.08.002
pH- and temperature-sensitive release behaviors from polyelectrolyte complex films composed of chitosan and PAOMA copolymer.
T. Yoshizawa (2005)
10.1016/J.EURPOLYMJ.2004.11.017
Polyelectrolyte capsules made of two biocompatible natural polymers
S. Vasiliu (2005)
10.1016/J.EJPB.2006.10.024
Two galactomannans and scleroglucan as matrices for drug delivery: preparation and release studies.
T. Coviello (2007)
10.1007/S00396-009-2022-3
Self-assembling chitosan/poly-γ-glutamic acid nanoparticles for targeted drug delivery
Z. Keresztessy (2009)
10.1080/10717540801905009
Matrix Polymeric Excipients: Comparing a Novel Interpolyelectrolyte Complex with Hydroxypropylmethylcellulose
Z. Lu (2008)
This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license
10.1177/088391159400900205
Polyionic Hydrogels Obtained by Complexation between Xanthan and Chitosan: Their Properties as Supports for Enzyme Immobilization
S. Dumitriu (1994)
10.1016/S0939-6411(03)00161-9
Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications.
J. Berger (2004)
10.1080/03639040600975188
Implantable Biodegradable Sponges: Effect of Interpolymer Complex Formation of Chitosan With Gelatin on the Release Behavior of Tramadol Hydrochloride
N. Foda (2007)
10.1016/j.biomaterials.2010.01.042
Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery.
K. Sonaje (2010)
10.1016/S1773-2247(10)50001-7
Chitosan and its derivatives as drug penetration enhancers
C. Caramella (2010)
10.1016/0168-3659(93)90080-O
Controlled release of indomethacin by chitosan-polyelectrolyte complex: optimization and in vivo/in vitro evaluation
S. Shiraishi (1993)
10.1016/S0032-3861(99)00396-1
Conductimetric study of the interpolyelectrolyte reaction between chitosan and polygalacturonic acid
W. Argüelles-Monal (2000)
10.1007/BF00159410
Polyionic hydrogels as support for immobilization of lipase
S. Dumitriu (1995)
10.1081/MA-120022272
Thermal Characteristics of Polyelectrolyte Complexes Composed of Chitosan and Hyaluronic Acid
S. J. Kim (2003)



This paper is referenced by
10.1016/j.colsurfb.2015.03.018
Improved stability and skin permeability of sodium hyaluronate-chitosan multilayered liposomes by Layer-by-Layer electrostatic deposition for quercetin delivery.
Soha Jeon (2015)
10.1007/s10856-011-4494-1
Design and synthesis of dual-ligand modified chitosan as a liver targeting vector
Houxiang Chen (2011)
DAPTOMYCIN DELIVERY INTO THE EYE BY ENCAPSULATION INTO CHITOSAN COATED ALGINATE NANOPARTICLES
Joana R Costa (2013)
10.1016/J.EURPOLYMJ.2013.07.003
Soluble–insoluble polyelectrolyte complex of quaternized chitosan with DIVEMA (pyran copolymer)
Vladimir A. Izumrudov (2013)
10.1002/jps.24213
In vitro liberation of indomethacin from chitosan gels containing microemulsion in different dissolution mediums.
Lenka Starýchová (2014)
10.1081/e-ebpp-120049954
Gelatin and Gelatin–Polyelectrolyte Complexes: Drug Delivery
Nirmala Devi (2015)
10.1002/POLA.26017
Tetramethylguanidinium‐polyallylamine (Tmg‐PA): A new class of nonviral vector for efficient gene transfection
Manohar Mahato (2012)
10.5937/arhfarm2004173q
Biocompatible non-covalent complexes of chitosan and different polymers: characteristics and application in drug delivery
Ana Ćirić (2020)
10.1039/c1cs15239d
Polysaccharides as building blocks for nanotherapeutics.
Shoshy Mizrahy (2012)
10.1016/J.MSEC.2011.10.020
Chitosan-based polyelectrolyte complex scaffolds with antibacterial properties for treating dental bone defects
Hong Da Wu (2012)
10.1016/j.ijbiomac.2017.05.081
Studies of chitosan/pectin complexes exposed to UV radiation.
J. Kowalonek (2017)
10.1002/MASY.201600205
Preparation and Characterization of HAp Coated Chitosan‐Alginate PEC Porous Scaffold for Bone Tissue Engineering
Trupti Patil (2017)
10.1016/j.carbpol.2017.10.050
Pervaporation multilayer membranes based on a polyelectrolyte complex of λ-carrageenan and chitosan.
S. Kononova (2018)
10.2298/APT1748221M
Interfacial properties of chitosan/sodium dodecyl sulfate complexes
Jelena Milinkovic (2017)
10.1016/J.CARBPOL.2011.08.024
Mucoadhesive chitosan/gelatin films for buccal delivery of propranolol hydrochloride
A. Abruzzo (2012)
10.1016/j.ejpb.2016.11.005
Polyelectrolyte complexes as prospective carriers for the oral delivery of protein therapeutics
V. Bourganis (2017)
10.1016/j.bioorg.2018.11.036
Encapsulation of ciprofloxacin within modified xanthan gum- chitosan based hydrogel for drug delivery.
Demiana H. Hanna (2019)
10.1080/00914037.2015.1038816
A Review: Overview of Novel Polyelectrolyte Complexes as Prospective Drug Bioavailability Enhancers
M. Siyawamwaya (2015)
10.1007/s11882-012-0302-3
Immune Response to Nanomaterials: Implications for Medicine and Literature Review
S. Syed (2012)
10.1016/j.addr.2015.11.015
Polysaccharide-based nanoparticles for theranostic nanomedicine.
M. Swierczewska (2016)
10.1016/J.CEJ.2011.08.079
Self-assembled nanoparticles from thermo-sensitive polyion complex micelles for controlled drug release
Guiying Li (2011)
10.1590/S1516-14392012005000013
Cytotoxicity Tests for Nanostructured Chitosan/PEO Membranes Using the Agar Diffusion Method
Valcinir Aloisio Scalla Vulcani (2012)
10.21608/bfsa.2014.65794
REVIEW ARTICLE CHITOSAN MICROSPHERES AS POTENTIAL CARRIERS FOR COLON TARGETING
Hytham H Gadalla (2014)
10.3390/molecules20034337
Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles
F. Yang (2015)
10.17863/CAM.13854
Production and Characterisation of Self-Crosslinked Chitosan-Carrageenan Polyelectrolyte Complexes
Nawar Al-Zebari (2017)
10.22270/jddt.v9i4-s.3325
Antitumor efficacy of Folic Acid conjugated Polymeric Nanoparticles of SN-38 after oral delivery
Prasad Shilpi (2019)
10.3390/md9122572
Marine Polysaccharides in Microencapsulation and Application to Aquaculture: “From Sea to Sea”
M. Borgogna (2011)
10.1016/J.MSEC.2011.08.005
Characterization of surface charge and mechanical properties of chitosan/alginate based biomaterials
Devendra Verma (2011)
10.2147/IJN.S55255
Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics
Mingrong Cheng (2014)
Development of food polymer-based colloidal delivery systems for nutraceuticals
Yangchao Luo (2012)
10.1039/C5TB00663E
Evaluation of enzymatically crosslinked injectable glycol chitosan hydrogel.
Shalini V. Gohil (2015)
Structure et mécanisme d’élaboration de biomatériaux par complexation contrôlée de polysaccharides
M. Costalat (2014)
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