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Development Of Gallic Acid-Modified Hydrogels Using Interpenetrating Chitosan Network And Evaluation Of Their Antioxidant Activity
Byungman Kang, Temmy Pegarro Vales, Byoung-Ki Cho, J. Kim, H. Kim
Published 2017 · Chemistry, Medicine
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In this work, antioxidant hydrogels were prepared by the construction of an interpenetrating chitosan network and functionalization with gallic acid. The poly(2-hydroxyethyl methacrylate) p(HEMA)-based hydrogels were first synthesized and subsequently surface-modified with an interpenetrating polymer network (IPN) structure prepared with methacrylamide chitosan via free radical polymerization. The resulting chitosan-IPN hydrogels were surface-functionalized with gallic acid through an amide coupling reaction, which afforded the antioxidant hydrogels. Notably, gallic-acid-modified hydrogels based on a longer chitosan backbone exhibited superior antioxidant activity than their counterpart with a shorter chitosan moiety; this correlated to the amount of gallic acid attached to the chitosan backbone. Moreover, the surface contact angles of the chitosan-modified hydrogels decreased, indicating that surface functionalization of the hydrogels with chitosan-IPN increased the wettability because of the presence of the hydrophilic chitosan network chain. Our study indicates that chitosan-IPN hydrogels may facilitate the development of applications in biomedical devices and ophthalmic materials.
This paper references
A drug delivery hydrogel system based on activin B for Parkinson's disease.
J. Li (2016)
Effect of silk fibroin interpenetrating networks on swelling/deswelling kinetics and rheological properties of poly(N-isopropylacrylamide) hydrogels.
E. S. Gil (2007)
Structure-antioxidant activity relationships of o-hydroxyl, o-methoxy, and alkyl ester derivatives of p-hydroxybenzoic acid.
R. Farhoosh (2016)
Influence of Pb(II) on the radical properties of humic substances and model compounds.
E. Giannakopoulos (2005)
Snapshot of phase transition in thermoresponsive hydrogel PNIPAM: Role in drug delivery and tissue engineering
S. Ashraf (2016)
The hydrophilic and lipophilic contribution to total antioxidant activity
M. Arnao (2001)
Poly(2-hydroxyethyl methacrylate) film as a drug delivery system for pilocarpine.
G. H. Hsiue (2001)
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution
Crystal and molecular structure of piceatannol; scavenging features of resveratrol and piceatannol on hydroxyl and peroxyl radicals and docking with transthyretin.
M. Rossi (2008)
A validated 1H NMR method for the determination of the degree of deacetylation of chitosan.
M. Lavertu (2003)
Fabrication of photochromic hydrogels using an interpenetrating chitosan network
C. W. Lee (2017)
Quantitative analysis of TEGDMA and HEMA eluted into saliva from two dental composites by use of GC/MS and tailor-made internal standards.
V. B. Michelsen (2008)
Chemical cross-linking gelatin with natural phenolic compounds as studied by high-resolution NMR spectroscopy.
X. Zhang (2010)
Preparation and characterization of caffeic acid grafted chitosan/CPTMS hybrid scaffolds
Jia Ching Shiu (2010)
Inhibition of radical-induced oxidative DNA damage by antioxidants loaded in electrospun polylactide nanofibers
E. Llorens (2014)
Biomimetic fabrication of information-rich phenolic-chitosan films
Kelsey M. Gray (2011)
Interpenetrating Polymer Networks polysaccharide hydrogels for drug delivery and tissue engineering.
P. Matricardi (2013)
Natural polypeptide-based supramolecular nanogels for stable noncovalent encapsulation.
Keunsuk Kim (2013)
Synthesis and swelling behavior of pH-sensitive semi-interpenetrating polymer network composite hydrogels based on native and modified potatoes starch as potential sorbent for cationic dyes
E. Dragan (2011)
A unique polymeric gel by thiol–alkyne click chemistry
Mutyala Naidu Ganivada (2015)
Sustained drug release from an ultrathin hydrogel film
W. Zhu (2015)
Peptide surface modification of methacrylamide chitosan for neural tissue engineering applications.
L. Yu (2007)
Glucomannan-poly(N-vinyl pyrrolidinone) bicomponent hydrogels for wound healing.
M. Shahbuddin (2014)
Oxidative dimers produced from protocatechuic and gallic esters in the DPPH radical scavenging reaction.
J. Kawabata (2002)
Hyaluronic acid containing hydrogels for the reduction of protein adsorption.
Mark van Beek (2008)
Wetting of biopolymer coatings: contact angle kinetics and image analysis investigation.
S. Farris (2011)
Design and applications of interpenetrating polymer network hydrogels. A review
E. Dragan (2014)
Water-solubility of partially N-acetylated chitosans as a function of pH: effect of chemical composition and depolymerisation
K. M. Vårum (1994)
Hydrogels for tissue engineering.
K. Lee (2001)
Antioxidant–polysaccharide conjugates for food application by eco-friendly grafting procedure
U. G. Spizzirri (2010)
Hydrogels for Therapeutic Delivery: Current Developments and Future Directions.
Sytze J Buwalda (2017)
Molecular Biology of Axon Guidance
M. Nieto (1996)
Design and applications of interpenetrating polymer network hydrogels
E. S. Dragan (2014)
Development of pH sensitive polyacrylamide grafted pectin hydrogel for controlled drug delivery system
P. Sutar (2008)
Superoxide radical scavenging activity of the major polyphenols in fresh plums.
O. K. Chun (2003)
Photo-stabilisation mechanism under natural weathering and accelerated photo-oxidative conditions of LDPE films for agricultural applications
M. Scoponi (2000)
Self-healing hydrogels containing reversible oxime crosslinks.
Soma Mukherjee (2015)
Hydrogels for tissue
K. Y. Lee (2001)
Hydrogels cross-linked by native chemical ligation.
Bi-Huang Hu (2009)
Thermoresponsive Injectable Hydrogels Cross-Linked by Native Chemical Ligation
Kristel W. M. Boere (2014)
Versatile Pectin Grafted Poly (N-isopropylacrylamide); Modulated Targeted Drug Release
S. Assaf (2011)
A silver complex of hyaluronan-lipoate (SHLS12): Synthesis, characterization and biological properties.
Pasquale Sacco (2016)
Use of a Free Radical Method to Evaluate Antioxidant Activity
W. Brand-Williams (1995)
Drug release behaviors of a pH sensitive semi-interpenetrating polymer network hydrogel composed of poly(vinyl alcohol) and star poly[2-(dimethylamino)ethyl methacrylate].
W. Wu (2011)
Chitin Chemistry, 1st ed.; Macmillan
G.A.F. Roberts (1992)
Exploring the Science and Technology of Contact Lens Comfort
H. A. Ketelson (2011)
G A Roberts (1992)
Synthesis of polyHEMA hydrogels for using as biomaterials. Bulk and solution radical-initiated polymerization techniques
J. M. Seidel (2000)
Preparation and characterization of radical and pH-responsive chitosan–gallic acid conjugate drug carriers
S. Yu (2011)
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M. Alfieri (2020)
Papain Immobilization on NiFe2O4 Magnetic Nanoparticles Functionalized with Gallic Acid and Microwave Assisted Digestion of Bovine Serum Albumin
Nuray Güy (2018)
Daylight-Mediated, Passive, and Sustained Release of the Glaucoma Drug Timolol from a Contact Lens
Changhua Mu (2018)
Gallic Acid-Laminarin Conjugate Is a Better Antioxidant than Sulfated or Carboxylated Laminarin
Marília Medeiros Fernandes-Negreiros (2020)
Chitosan-based hydrogels: From preparation to biomedical applications.
M. G. Pellá (2018)
Recent Developments in the Reduction of Oxidative Stress through Antioxidant Polymeric Formulations
M. Zafar (2019)
Epidermal growth factor receptor conjugated fucoidan/alginates loaded hydrogel for activating EGFR/AKT signaling pathways in colon cancer cells during targeted photodynamic therapy.
K. Shanmugapriya (2020)
Polydopamine Antioxidant Hydrogels for Wound Healing Applications
Naphtali A O'Connor (2020)
Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering
Pasquale Marrazzo (2020)