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Advances In Lipid And Metal Nanoparticles For Antimicrobial Peptide Delivery

Marcin Makowski, Ítala C Silva, Constança Pais do Amaral, S. Gonçalves, N. Santos
Published 2019 · Chemistry, Medicine

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Antimicrobial peptides (AMPs) have been described as excellent candidates to overcome antibiotic resistance. Frequently, AMPs exhibit a wide therapeutic window, with low cytotoxicity and broad-spectrum antimicrobial activity against a variety of pathogens. In addition, some AMPs are also able to modulate the immune response, decreasing potential harmful effects such as sepsis. Despite these benefits, only a few formulations have successfully reached clinics. A common flaw in the druggability of AMPs is their poor pharmacokinetics, common to several peptide drugs, as they may be degraded by a myriad of proteases inside the organism. The combination of AMPs with carrier nanoparticles to improve delivery may enhance their half-life, decreasing the dosage and thus, reducing production costs and eventual toxicity. Here, we present the most recent advances in lipid and metal nanodevices for AMP delivery, with a special focus on metal nanoparticles and liposome formulations.
This paper references
10.3109/1040841X.2015.1018131
Strategic role of selected noble metal nanoparticles in medicine
M. Rai (2016)
10.3389/fphar.2014.00275
Antimicrobial peptides: a new class of antimalarial drugs?
N. Vale (2014)
10.2147/IJN.S596
Drug delivery and nanoparticles: Applications and hazards
W. D. de Jong (2008)
10.1016/j.bbagen.2012.02.015
Characterization of dual effects induced by antimicrobial peptides: regulated cell death or membrane disruption.
E. J. Paredes-Gamero (2012)
10.1039/c2an35170f
Label-free Raman spectroscopy for accessing intracellular anticancer drug release on gold nanoparticles.
Kwang-Su Ock (2012)
10.1016/j.cis.2015.01.007
Understanding nanoparticle cellular entry: A physicochemical perspective.
C. Beddoes (2015)
10.3233/JAD-160355
Development of Nasal Lipid Nanocarriers Containing Curcumin for Brain Targeting.
Gustavo Richter Vaz (2017)
10.1039/c4nr01284d
LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control.
Mariana Vignoni (2014)
10.1166/ASEM.2017.2027
Synthesis and Applications of Noble Metal Nanoparticles: A Review
Vikram Pareek (2017)
10.1155/2019/2834941
Lipid Nano- and Microparticles: An Overview of Patent-Related Research
L. Battaglia (2019)
10.1016/j.ijpharm.2017.04.071
Interactions of the antimicrobial peptide nisin Z with conventional antibiotics and the use of nanostructured lipid carriers to enhance antimicrobial activity.
Angélique Lewies (2017)
10.3389/fchem.2018.00237
Application of Light Scattering Techniques to Nanoparticle Characterization and Development
P. Carvalho (2018)
10.2147/IJN.S72923
Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control
Paramesh Ramulu Lambadi (2015)
10.1021/JF0348368
Size, stability, and entrapment efficiency of phospholipid nanocapsules containing polypeptide antimicrobials.
L. Were (2003)
10.4172/2161-0525.1000384
Gold and Silver Nanoparticles: Synthesis Methods, Characterization Routes and Applications towards Drugs
Khalid Alaqad (2016)
10.2147/IDR.S164262
Efficiency of gold nanoparticles coated with the antimicrobial peptide indolicidin against biofilm formation and development of Candida spp. clinical isolates
E. de Alteriis (2018)
10.1038/srep19800
Dual-functionalized liposomal delivery system for solid tumors based on RGD and a pH-responsive antimicrobial peptide
Q. Zhang (2016)
10.1021/LA062851B
Hexosome and hexagonal phases mediated by hydration and polymeric stabilizer.
Idit Amar-Yuli (2007)
10.3390/molecules22101581
Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials
Sandra García-Gallego (2017)
10.1111/exd.12929
Antimicrobial peptides and wound healing: biological and therapeutic considerations
M. Mangoni (2016)
10.1016/j.bbamem.2015.11.012
The protein corona of circulating PEGylated liposomes.
S. Palchetti (2016)
10.1016/J.FOODCONT.2015.11.037
Inhibition of Listeria monocytogenes in vitro and in goat milk by liposomal nanovesicles containing bacteriocins produced by Lactobacillus sakei subsp sakei 2a
P. S. Malheiros (2016)
10.1016/j.smim.2017.09.011
Effects of engineered nanoparticles on the innate immune system.
Yuanchang Liu (2017)
10.1021/acs.jpca.7b02186
Role of Capping Agent in Wet Synthesis of Nanoparticles.
C. Phan (2017)
10.3390/ma10030232
Advances in the Fabrication of Antimicrobial Hydrogels for Biomedical Applications
C. González-Henríquez (2017)
10.1016/S0006-3495(82)84681-X
Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue.
W. DeGrado (1982)
10.1021/nn3057005
Gold nanoparticles as a vaccine platform: influence of size and shape on immunological responses in vitro and in vivo.
K. Niikura (2013)
10.1016/j.biotechadv.2008.09.002
Silver nanoparticles as a new generation of antimicrobials.
M. Rai (2009)
10.1039/c2ib20117h
Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory.
Rachael M. Crist (2013)
10.1007/s12035-017-0728-7
Intranasal Administration of TAT-Conjugated Lipid Nanocarriers Loading GDNF for Parkinson’s Disease
S. Hernando (2017)
10.1086/511642
Mutant selection window hypothesis updated.
K. Drlica (2007)
10.1039/c1pp05100h
Antimicrobial peptide-modified liposomes for bacteria targeted delivery of temoporfin in photodynamic antimicrobial chemotherapy.
K. Yang (2011)
10.1093/femsyr/foz013
Antifungal activity of analogues of antimicrobial peptides isolated from bee venoms against vulvovaginal Candida spp
Jitka Kočendová (2019)
10.1039/C6NR07976H
Sprayable peptide-modified silver nanoparticles as a barrier against bacterial colonization.
S. Mclaughlin (2016)
10.3322/caac.20114
Photodynamic therapy of cancer: An update
P. Agostinis (2011)
10.2147/IJN.S41695
Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic, for topical skin therapy
C. Li (2013)
10.1016/j.actbio.2016.01.035
High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells.
Akhilesh Rai (2016)
10.3389/fchem.2017.00040
D-BMAP18 Antimicrobial Peptide Is Active In vitro, Resists to Pulmonary Proteases but Loses Its Activity in a Murine Model of Pseudomonas aeruginosa Lung Infection
Mario Mardirossian (2017)
10.1002/wnan.1325
Advances in the synthesis and application of nanoparticles for drug delivery.
W. Park (2015)
10.18632/oncotarget.16743
Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
B. Deslouches (2017)
10.1016/j.ab.2011.12.024
Signal-enhanced electrochemiluminescence immunosensor based on synergistic catalysis of nicotinamide adenine dinucleotide hydride and silver nanoparticles.
G. Wang (2012)
10.1080/1040841X.2017.1313813
Factors pivotal for designing of nanoantimicrobials: an exposition
B. Jamil (2018)
10.1186/s12866-018-1227-3
Gold nanoparticles attenuates bacterial sepsis in cecal ligation and puncture mouse model through the induction of M2 macrophage polarization
Sujittra Taratummarat (2018)
10.1517/14712598.1.6.923
Developments in liposomal drug delivery systems
N. Maurer (2001)
10.1016/j.jconrel.2017.07.007
Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential.
Michela Comune (2017)
10.1016/j.micpath.2017.12.034
Determining the effects of green chemistry synthesized Ag-nisin nanoparticle on macrophage cells.
M. Moein (2018)
10.1016/j.nano.2017.01.013
Smuggling gold nanoparticles across cell types - A new role for exosomes in gene silencing.
C. Roma-Rodrigues (2017)
10.1016/j.colsurfb.2015.12.033
Solid lipid nanoparticles for encapsulation of hydrophilic drugs by an organic solvent free double emulsion technique.
Luana Becker Peres (2016)
10.1039/c2cc34653b
Retention of nisin activity at elevated pH in an organic acid complex and gold nanoparticle composite.
Manab Deb Adhikari (2012)
10.1039/c8bm00807h
Antimicrobial peptide modification enhances the gene delivery and bactericidal efficiency of gold nanoparticles for accelerating diabetic wound healing.
S. Wang (2018)
10.1093/JAC/DKM053
Antimycobacterial activity of bacteriocins and their complexes with liposomes.
Vasily Sosunov (2007)
10.1155/2017/5831959
Antibacterial Efficacy of Gold and Silver Nanoparticles Functionalized with the Ubiquicidin (29–41) Antimicrobial Peptide
E. Morales-Avila (2017)
10.3389/fphar.2015.00286
Advances and Challenges of Liposome Assisted Drug Delivery
Lisa Sercombe (2015)
10.3390/ijms19124031
Applications of Noble Metal-Based Nanoparticles in Medicine
B. Klębowski (2018)
10.1016/j.biomaterials.2013.09.045
Bioconjugated nanoparticles for attachment and penetration into pathogenic bacteria.
L. Mei (2013)
10.1016/j.nano.2015.09.004
Nanostructured lipid carriers: Promising drug delivery systems for future clinics.
A. Beloqui (2016)
10.3389/fcimb.2016.00194
Antimicrobial Peptides: An Emerging Category of Therapeutic Agents
M. Mahlapuu (2016)
10.1002/smll.200900126
Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes.
Hung-Jen Yen (2009)
10.2147/IJN.S165125
Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
Yun’an Qing (2018)
10.1016/j.ijpharm.2019.03.041
Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy.
M. Dul (2019)
10.1007/s11095-016-1958-5
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date
Daniel Bobo (2016)
10.1124/pr.115.012070
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come
Phatsapong Yingchoncharoen (2016)
10.4103/0975-7406.72127
Introduction to metallic nanoparticles
V. Mody (2010)
10.3109/10837450.2010.542163
The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients
K. W. Kasongo (2012)
10.3109/13880209.2012.717227
Sustainable inhibition efficacy of liposome-encapsulated nisin on insoluble glucan-biofilm synthesis by Streptococcus mutans
K. Yamakami (2013)
10.1016/j.immuni.2014.10.015
The macrophage paradox.
J. Price (2014)
10.1371/journal.pone.0143077
Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification
S. Sarkar (2015)
10.1016/j.carbpol.2017.09.053
Development of chitosan-sodium phytate nanoparticles as a potent antibacterial agent.
J. Yang (2017)
10.1016/j.carbpol.2018.07.077
Topical delivery of chitosan-capped silver nanoparticles speeds up healing in burn wounds: A preclinical study.
A. Oryan (2018)
10.2147/IJN.S117618
Cationic PEGylated liposomes incorporating an antimicrobial peptide tilapia hepcidin 2–3: an adjuvant of epirubicin to overcome multidrug resistance in cervical cancer cells
V. Juang (2016)
10.1186/s13045-017-0442-y
A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety
Jie Mao (2017)
10.1016/j.nano.2011.06.014
Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles.
F. Martinez-Gutierrez (2012)
10.3109/08982109209039901
Size Homogeneity of a Liposome Preparation is Crucial for Liposome Biodistribution in Vivo
Dexi Liu (1992)
10.4103/0250-474X.57282
Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System
S. Mukherjee (2009)
10.1016/j.ijpharm.2017.10.046
Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications.
M. Šala (2018)
10.1080/10717544.2018.1501119
The challenges of oral drug delivery via nanocarriers
Jonas Reinholz (2018)
10.3390/pharmaceutics9020012
Liposomal Formulations in Clinical Use: An Updated Review
Upendra Bulbake (2017)
10.1038/nbt1267
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
R. Hancock (2006)
10.1016/j.bmc.2017.10.038
Exploiting the human peptidome for novel antimicrobial and anticancer agents.
M. Bosso (2018)
10.26717/BJSTR.2018.04.0001011
Metallic Nanoparticle: A Review
K. Harishkumar (2018)
10.1039/c3nr34254a
The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for gram-positive bacteria over erythrocytes.
L. Liu (2013)
10.1016/J.AJPS.2014.09.004
A review on phospholipids and their main applications in drug delivery systems
Jing Li (2015)
10.1038/nrmicro.2017.99
Targeting microbial biofilms: current and prospective therapeutic strategies
H. Koo (2017)
10.1016/j.toxlet.2008.04.009
Cellular responses induced by silver nanoparticles: In vitro studies.
S. Arora (2008)
10.1093/toxsci/kfw011
Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent.
A. Mishra (2016)
10.1111/j.1468-3083.2009.03100.x
Liposomes in dermatology today
J. de Leeuw (2009)
10.1007/s12275-015-4686-3
Antibacterial potential of a small peptide from Bacillus sp. RPT-0001 and its capping for green synthesis of silver nanoparticles
S. Patil (2015)
10.1007/s00253-015-6622-1
Bacteriagenic silver nanoparticles: synthesis, mechanism, and applications
R. Singh (2015)
10.1039/c7bm00069c
Antibiotic gold: tethering of antimicrobial peptides to gold nanoparticles maintains conformational flexibility of peptides and improves trypsin susceptibility.
P. Wadhwani (2017)
10.1371/journal.pone.0123905
Immune Activation Efficacy of Indolicidin Is Enhanced upon Conjugation with Carbon Nanotubes and Gold Nanoparticles
A. Sur (2015)
10.1021/acsnano.7b00497
Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles.
L. Talamini (2017)
10.1016/J.INTIMP.2007.08.025
The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells.
Seung-Heon Shin (2007)
10.1039/C6MD00124F
Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance
Shariq Qayyum (2016)
10.1042/BCJ20161039
Scolopendin, an antimicrobial peptide from centipede, attenuates mitochondrial functions and triggers apoptosis in Candida albicans.
H. Lee (2017)
10.1111/j.1365-2672.2012.05253.x
Silver nanoparticles: the powerful nanoweapon against multidrug‐resistant bacteria
M. Rai (2012)
10.1016/j.taap.2015.12.022
Current understanding of interactions between nanoparticles and the immune system.
M. Dobrovolskaia (2016)
10.1016/j.drudis.2019.05.004
Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems.
Thiagarajan Madheswaran (2019)
10.1166/JBN.2017.2355
A Fresh Shine onCystic Fibrosis Inhalation Therapy: Antimicrobial Synergy of Polymyxin B in Combination with Silver Nanoparticles.
Raad Jasim (2017)
10.1039/c7bm00929a
pH-Triggered nanostructural transformations in antimicrobial peptide/oleic acid self-assemblies.
M. Gontsarik (2018)
10.1016/j.colsurfb.2017.07.009
Stabilized cationic dipeptide capped gold/silver nanohybrids: Towards enhanced antibacterial and antifungal efficacy.
M. Bajaj (2017)
10.1039/C7RA12008G
Factors affecting the structure of lyotropic liquid crystals and the correlation between structure and drug diffusion
Yiming Huang (2018)
10.1007/s00284-015-0813-y
Co-spinning of Silver Nanoparticles with Nisin Increases the Antimicrobial Spectrum of PDLLA: PEO Nanofibers
J. J. Ahire (2015)
10.1146/annurev-med-040210-162544
Nanoparticle delivery of cancer drugs.
A. Wang (2012)
10.1166/JNN.2014.9526
Recent advances in gold and silver nanoparticles: synthesis and applications.
Amin F. Majdalawieh (2014)
10.3389/fmicb.2014.00241
Antibacterial activities of bacteriocins: application in foods and pharmaceuticals
S. Yang (2014)
10.1128/AAC.02475-12
Cationic Antimicrobial Peptides and Biogenic Silver Nanoparticles Kill Mycobacteria without Eliciting DNA Damage and Cytotoxicity in Mouse Macrophages
Soumitra Mohanty (2013)
10.4049/jimmunol.169.7.3883
The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses1
M. G. Scott (2002)
10.1016/j.biomaterials.2016.07.009
Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellular Salmonella enterica serovar Typhimurium.
Ji-Hyun Yeom (2016)
10.1007/s00249-016-1160-z
Findings on the interaction of the antimicrobial peptide cecropin-melittin with a gold surface from molecular dynamics studies
A. F. Ferreira (2016)
10.1128/AAC.02319-16
Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B?
A. Zavascki (2016)
10.3389/fimmu.2017.00416
Nanoparticle Interactions with the Immune System: Clinical Implications for Liposome-Based Cancer Chemotherapy
N. M. La-Beck (2017)
10.1186/s12951-017-0308-z
Metal nanoparticles: understanding the mechanisms behind antibacterial activity
Yael N. Slavin (2017)
10.1016/j.cbi.2015.08.023
Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells.
Yu-Li Lo (2015)
10.1038/PHYSCI241020A0
Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions
G. Frens (1973)
10.1039/c7nr04062h
Multivalent gold nanoparticle-peptide conjugates for targeting intracellular bacterial infections.
Rimi Chowdhury (2017)
10.3109/10611869308996088
Liposomal (MLV) polymyxin B: physicochemical characterization and effect of surface charge and drug association.
S. M. Lawrence (1993)
10.1088/0957-4484/22/18/185101
Antimicrobial activity and cellular toxicity of nanoparticle-polymyxin B conjugates.
Soonhyang Park (2011)
10.1172/JCI17545
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.
R. Koczulla (2003)
10.1016/J.AJPS.2013.07.011
Liposomes as sterile preparations and limitations of sterilisation techniques in liposomal manufacturing
Ming-Ren Toh (2013)
10.1016/j.actbio.2016.09.041
Gold-nanoparticles coated with the antimicrobial peptide esculentin-1a(1-21)NH2 as a reliable strategy for antipseudomonal drugs.
B. Casciaro (2017)
10.1136/bmj.4.5734.525
Effects of Large Doses of Colistin Sulphomethate Sodium on Renal Function
D. Price (1970)
10.1093/JAC/43.2.203
Antimicrobial properties of liposomal polymyxin B.
S. McAllister (1999)
10.1021/acs.jpclett.6b01622
Antimicrobial Peptide-Driven Colloidal Transformations in Liquid-Crystalline Nanocarriers.
M. Gontsarik (2016)
10.1038/s41598-019-41005-7
A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria
I. Pal (2019)
10.1186/s12951-018-0334-5
A review on biosynthesis of silver nanoparticles and their biocidal properties
K. S. Siddiqi (2018)
10.1080/21691401.2017.1282496
Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications
Y. Panahi (2017)
10.1016/j.molimm.2014.06.038
Complement activation-related pseudoallergy: a stress reaction in blood triggered by nanomedicines and biologicals.
J. Szebeni (2014)
10.1186/s40580-018-0170-1
Peptide–nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?
Woojin Jeong (2018)
10.3390/molecules21010037
Peptide KSL-W-Loaded Mucoadhesive Liquid Crystalline Vehicle as an Alternative Treatment for Multispecies Oral Biofilm
J. Bernegossi (2015)
10.1038/s41598-019-44256-6
Exploiting chitosan and gold nanoparticles for antimycobacterial activity of in silico identified antimicrobial motif of human neutrophil peptide-1
R. Sharma (2019)
10.3390/ijms12095971
The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation
S. Park (2011)
10.1517/14656566.2015.983077
Clinical, economic and societal impact of antibiotic resistance
S. Barriere (2015)
10.1016/j.peptides.2014.04.015
Cell penetrating peptides: Efficient vectors for delivery of nanoparticles, nanocarriers, therapeutic and diagnostic molecules
Samad Mussa Farkhani (2014)
10.1016/j.jconrel.2012.03.020
Doxil®--the first FDA-approved nano-drug: lessons learned.
Y. Barenholz (2012)
10.1002/anie.201403036
Engineered nanoparticles for drug delivery in cancer therapy.
T. Sun (2014)
10.1016/j.ijantimicag.2013.07.009
Pharmacokinetics and efficacy of liposomal polymyxin B in a murine pneumonia model.
J. He (2013)
10.3762/bjoc.10.136
Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs
F. Chiodo (2014)
10.1128/microbiolspec.MCHD-0012-2015
Strategies Used by Bacteria to Grow in Macrophages.
G. Mitchell (2016)
10.1016/S0378-5173(03)00376-4
Shifting paradigms: biopharmaceuticals versus low molecular weight drugs.
D. J. Crommelin (2003)
10.1021/la2004535
Nano meets biology: structure and function at the nanoparticle interface.
Daniel F. Moyano (2011)
10.1111/1462-2920.12534
A single exposure to a sublethal pediocin concentration initiates a resistance-associated temporal cell envelope and general stress response in Listeria monocytogenes.
M. Laursen (2015)
10.1007/s40204-019-0106-9
Effect of peptide-conjugated nanoparticles on cell lines
K. Banerjee (2019)
10.1002/psc.1007
What can light scattering spectroscopy do for membrane‐active peptide studies?
M. Domingues (2008)
10.1074/JBC.M006770200
Specific Binding of Nisin to the Peptidoglycan Precursor Lipid II Combines Pore Formation and Inhibition of Cell Wall Biosynthesis for Potent Antibiotic Activity*
I. Wiedemann (2001)
10.3109/10717544.2014.880756
Liposomal co-delivery of daptomycin and clarithromycin at an optimized ratio for treatment of methicillin-resistant Staphylococcus aureus infection
Y. Li (2015)
10.3389/fcimb.2019.00128
Application of Antimicrobial Peptides of the Innate Immune System in Combination With Conventional Antibiotics—A Novel Way to Combat Antibiotic Resistance?
M. Zharkova (2019)
10.1038/415389a
Antimicrobial peptides of multicellular organisms
M. Zasloff (2002)
10.1016/j.biomaterials.2016.06.057
Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity.
L. Peng (2016)
10.1021/acs.langmuir.6b00338
Lipid-Based Liquid Crystals As Carriers for Antimicrobial Peptides: Phase Behavior and Antimicrobial Effect.
Lukas Boge (2016)
10.1038/s41598-018-29870-0
Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells
P. Pedrosa (2018)
10.2147/IJN.S107107
Novel antimicrobial peptide–modified azithromycin-loaded liposomes against methicillin-resistant Staphylococcus aureus
X. Liu (2016)
10.1056/NEJM197609302951406
The carrier potential of liposomes in biology and medicine (second of two parts).
G. Gregoriadis (1976)
10.1016/j.ijpharm.2007.11.035
Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains.
M. Alipour (2008)
10.7150/thno.19780
Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy
Huaxin Tan (2017)
10.1021/CM500316K
Synthesis of Highly Monodisperse Citrate-Stabilized Silver Nanoparticles of up to 200 nm: Kinetic Control and Catalytic Properties
Neus G Bastús (2014)
10.1021/acs.chemrev.5b00046
New Developments in Liposomal Drug Delivery.
Bhushan S. Pattni (2015)
10.1099/jmm.0.000032
Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control.
S. L. Percival (2015)
10.4315/0362-028X-67.5.922
Encapsulation of nisin and lysozyme in liposomes enhances efficacy against Listeria monocytogenes.
L. Were (2004)
10.3201/eid0809.020063
Biofilms: Microbial Life on Surfaces
R. Donlan (2002)
10.1128/AAC.01106-08
Synergistic Interaction between Silver Nanoparticles and Membrane-Permeabilizing Antimicrobial Peptides
Serge Ruden (2009)
10.1016/j.jcis.2019.03.052
Conjugating gold nanoclusters and antimicrobial peptides: From aggregation-induced emission to antibacterial synergy.
Youkun Zheng (2019)
10.1155/2015/143720
Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications
Yueh-Hsia Luo (2015)
10.1039/c3cs60218d
Nanosilver-based antibacterial drugs and devices: mechanisms, methodological drawbacks, and guidelines.
L. Rizzello (2014)
10.1016/j.bpj.2015.07.033
PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties
N. B. Leite (2015)
10.1016/J.IFSET.2016.07.017
Antimicrobial activity of nanoliposomes co-encapsulating nisin and garlic extract against Gram-positive and Gram-negative bacteria in milk
Cristian Mauricio Barreto Pinilla (2016)
10.2147/IJN.S146315
Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors
Fakhar ud Din (2017)
10.1021/ACS.BIOCONJCHEM.6B00437
Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer?
Y. Nakamura (2016)
10.3389/fchem.2017.00005
Peptides with Dual Antimicrobial and Anticancer Activities
Mário R. Felício (2017)
10.1038/nrd2591
Strategies in the design of nanoparticles for therapeutic applications
Robby A. Petros (2010)
10.1016/j.trecan.2015.11.003
Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine
K. Lipiński (2016)
10.1080/02652048.2016.1242665
Stability study of sodium colistimethate-loaded lipid nanoparticles
M. Moreno-Sastre (2016)
10.1021/AR960016N
Some interesting properties of metals confined in time and nanometer space of different shapes.
M. El-Sayed (2001)
10.1371/journal.pone.0005724
Activity and Interactions of Liposomal Antibiotics in Presence of Polyanions and Sputum of Patients with Cystic Fibrosis
M. Alipour (2009)
10.1155/2010/735349
Nonviral Gene Delivery to Mesenchymal Stem Cells Using Cationic Liposomes for Gene and Cell Therapy
C. Madeira (2010)
10.1007/s12013-015-0529-4
Gold Nanoparticles: Recent Advances in the Biomedical Applications
X. Zhang (2015)
10.1016/j.jcf.2015.12.005
Killing effect of nanoencapsulated colistin sulfate on Pseudomonas aeruginosa from cystic fibrosis patients.
E. Sans-Serramitjana (2016)
10.2174/1874285801711010053
Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents
S. Singh (2017)
10.1016/J.BEJ.2017.04.013
A simple nanostructured biosensor based on clavanin A antimicrobial peptide for gram-negative bacteria detection
Juliana Miranda (2017)
10.1007/s10096-008-0553-z
Human antimicrobial peptides’ antifungal activity against Aspergillus fumigatus
A. Lupetti (2008)
10.1128/AAC.24.5.742
Enhanced activity of streptomycin and chloramphenicol against intracellular Escherichia coli in the J774 macrophage cell line mediated by liposome delivery.
M. Stevenson (1983)
10.1016/j.jconrel.2014.05.034
Biodegradable nanoparticles for intracellular delivery of antimicrobial agents.
Shuyu Xie (2014)
10.3389/fimmu.2018.00722
Cathelicidin-Derived Antimicrobial Peptides Inhibit Zika Virus Through Direct Inactivation and Interferon Pathway
Miao He (2018)
10.4238/2015.April.17.15
Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-α production via MAPK pathway in leukemic cell lines.
C. Parnsamut (2015)
Long-circulating and target-specific nanoparticles: theory to practice.
S. Moghimi (2001)
10.1073/PNAS.81.6.1715
pH-sensitive liposomes: acid-induced liposome fusion.
J. Connor (1984)
10.1038/s41598-017-14127-z
Antimicrobial peptide-loaded gold nanoparticle-DNA aptamer conjugates as highly effective antibacterial therapeutics against Vibrio vulnificus
Boeun Lee (2017)
10.1016/j.freeradbiomed.2016.11.016
Interfacial assembly at silver nanoparticle enhances the antibacterial efficacy of nisin.
Manoranjan Arakha (2016)
10.2147/IJN.S150897
Human β-defensin 3-combined gold nanoparticles for enhancement of osteogenic differentiation of human periodontal ligament cells in inflammatory microenvironments
J. Zhou (2018)
10.1038/nrd1632
Recent advances with liposomes as pharmaceutical carriers
V. Torchilin (2005)
10.1016/j.fct.2017.11.051
Stable PEG-coated silver nanoparticles - A comprehensive toxicological profile.
I. Pinzaru (2018)
10.1007/s13346-015-0220-8
Influence of cholesterol on liposome stability and on in vitro drug release
Maria-Lucia Briuglia (2015)
10.1021/acsami.6b15200
TAT-Modified Gold Nanoparticle Carrier with Enhanced Anticancer Activity and Size Effect on Overcoming Multidrug Resistance.
Rui-hui Wang (2017)
10.1016/j.drudis.2014.10.003
Peptide therapeutics: current status and future directions.
K. Fosgerau (2015)
10.1016/j.smim.2017.08.013
Nanoparticles and innate immunity: new perspectives on host defence.
D. Boraschi (2017)
10.1038/srep31030
Tuning the anticancer activity of a novel pro-apoptotic peptide using gold nanoparticle platforms
M. Akrami (2016)
10.1038/s41598-017-04229-z
The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles
X. Xie (2017)
10.1016/j.jcis.2016.08.043
Enhanced stability and activity of an antimicrobial peptide in conjugation with silver nanoparticle.
I. Pal (2016)
10.1016/j.nano.2016.08.016
Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections.
Tejabhiram Yadavalli (2017)
10.3390/ijms15058216
Efficient pH Dependent Drug Delivery to Target Cancer Cells by Gold Nanoparticles Capped with Carboxymethyl Chitosan
A. Madhusudhan (2014)
10.2174/187221050902150819151721
Recent Progress in Liposome Production, Relevance to Drug Delivery and Nanomedicine.
R. Koynova (2015)
10.1038/nrmicro1098
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
K. Brogden (2005)
10.1021/acsami.6b03355
High Antimicrobial Activity and Low Human Cell Cytotoxicity of Core-Shell Magnetic Nanoparticles Functionalized with an Antimicrobial Peptide.
Hajar Maleki (2016)
10.1517/17425247.2014.891582
Gold nanoparticle conjugates: recent advances toward clinical applications
Roberto Cao-Milán (2014)
10.1007/s00253-018-9476-5
Prospects for the use of spherical gold nanoparticles in immunization
S. Staroverov (2018)
10.1021/acs.bioconjchem.8b00706
Small Synthetic Peptides Bioconjugated to Hybrid Gold Nanoparticles Destroy Potentially Deadly Bacteria at Submicromolar Concentrations.
Gianna Palmieri (2018)
10.1039/DF9511100055
A study of the nucleation and growth processes in the synthesis of colloidal gold
J. Turkevich (1951)
10.1038/nbt.3330
Principles of nanoparticle design for overcoming biological barriers to drug delivery
E. Blanco (2015)
10.1021/acs.bioconjchem.7b00368
Recent Developments in Antimicrobial-Peptide-Conjugated Gold Nanoparticles.
Urawadee Rajchakit (2017)
10.4155/fmc-2014-0032
Ask the experts: how to curb antibiotic resistance and plug the antibiotics gap?
L. Piddock (2016)
10.1155/2011/202187
Gold nanoparticles: promising nanomaterials for the diagnosis of cancer and HIV/AIDS
Anil Kumar (2011)
10.1128/AEM.68.8.3683-3690.2002
Inhibition of Listeria innocua in Cheddar Cheese by Addition of Nisin Z in Liposomes or by In Situ Production in Mixed Culture
R. Benech (2002)
10.1021/acs.jpcb.8b05717
Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle By Well-Tempered Metadynamics.
A. F. Ferreira (2018)
10.1007/s11095-008-9562-y
Role of Particle Size in Phagocytosis of Polymeric Microspheres
J. Champion (2008)
10.1016/j.biomaterials.2016.01.051
One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model.
Akhilesh Rai (2016)
10.1016/j.bpj.2018.03.007
Multivalent Binding of a Ligand-Coated Particle: Role of Shape, Size, and Ligand Heterogeneity.
Matt Mckenzie (2018)
10.1016/j.nano.2016.06.002
Antimicrobial molecular nanocarrier-drug conjugates.
Andrzej S Skwarecki (2016)
10.26717/BJSTR.2018.07.001536
The Antimicrobial Peptides: Ready for Clinical Trials?
Michael A. B. Naafs (2018)
10.1016/0168-1605(93)90217-5
Antilisterial activity of pediocin AcH in model food systems in the presence of an emulsifier or encapsulated within liposomes.
A. J. Degnan (1993)
10.2147/IJN.S133832
Physicochemical characterization of drug nanocarriers
Eloísa Berbel Manaia (2017)
10.1186/s12951-015-0109-1
One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care
B. Veigas (2015)
10.2174/1386207053764558
Design of host defence peptides for antimicrobial and immunity enhancing activities.
J. B. McPhee (2005)
10.1002/btm2.10003
Nanoparticles in the clinic
Aaron C. Anselmo (2016)
10.3390/nano7100305
Lyotropic Liquid Crystal Phases from Anisotropic Nanomaterials
I. Dierking (2017)
10.3390/v7102883
Perspective of Use of Antiviral Peptides against Influenza Virus
S. Skalickova (2015)



This paper is referenced by
10.3390/nano10010140
Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation
F. Carrouel (2020)
10.3390/molecules25122850
Antimicrobial Peptides as Anticancer Agents: Functional Properties and Biological Activities
Anna Lucia Tornesello (2020)
10.1002/wnan.1636
Nanomaterials with active targeting as advanced antimicrobials.
Kristyna Smerkova (2020)
10.3390/molecules25133048
Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance
Matthew Drayton (2020)
10.1007/s11274-020-02907-1
Antimicrobial peptide polymers: no escape to ESKAPE pathogens—a review
Songhita Mukhopadhyay (2020)
10.1016/j.surfcoat.2020.125696
Polyelectrolyte multilayer coatings for short/long-term release of antibacterial agents
X. Liu (2020)
10.3389/fimmu.2020.02177
Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
D. Mercer (2020)
10.1016/j.drudis.2019.05.004
Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems.
Thiagarajan Madheswaran (2019)
10.2147/IJN.S150897
Human β-defensin 3-combined gold nanoparticles for enhancement of osteogenic differentiation of human periodontal ligament cells in inflammatory microenvironments
J. Zhou (2018)
10.3389/fchem.2020.00286
Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances
Yuan-Chieh Yeh (2020)
10.1007/978-3-030-43855-5
Preclinical Evaluation of Antimicrobial Nanodrugs
J. Bueno (2020)
10.31031/rdms.2020.12.000793
Metal Nanoparticles in Immunotherapy: Applications, Limitations and Pespectives
M Dukhinova (2020)
10.1038/s41598-018-29870-0
Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells
P. Pedrosa (2018)
10.3390/ph13100299
The Principles, Mechanisms, and Benefits of Unconventional Agents in the Treatment of Biofilm Infection
Jasminka Talapko (2020)
10.1007/978-3-030-43855-5_2
Antimicrobial Activity of Nanomaterials: From Selection to Application
Juan Bueno (2020)
10.1007/978-3-030-43855-5_6
Antimicrobial Nanotechnology in Preventing the Transmission of Infectious Disease
Juan Bueno (2020)
10.3390/challe11020015
Nanotechnology as an Alternative to Reduce the Spread of COVID-19
Roberto Vazquez-Munoz (2020)
10.1016/j.jddst.2020.102016
Advances in delivery systems for the therapeutic application of LL37
Xiaoxuan Lin (2020)
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