Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Utilizing The Folate Receptor For Active Targeting Of Cancer Nanotherapeutics

Grant L. Zwicke, G. Mansoori, C. Jeffery
Published 2012 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The development of specialized nanoparticles for use in the detection and treatment of cancer is increasing. Methods are being proposed and tested that could target treatments more directly to cancer cells, which could lead to higher efficacy and reduced toxicity, possibly even eliminating the adverse effects of damage to the immune system and the loss of quick replicating cells. In this mini-review we focus on recent studies that employ folate nanoconjugates to target the folate receptor. Folate receptors are highly overexpressed on the surface of many tumor types. This expression can be exploited to target imaging molecules and therapeutic compounds directly to cancerous tissues.
This paper references
10.1016/j.addr.2008.08.005
Active targeting schemes for nanoparticle systems in cancer therapeutics.
J. D. Byrne (2008)
10.1158/1535-7163.MCT-06-0141
Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery
Rajni Sinha (2006)
10.1002/SMLL.201090081
Mesoporous materials: Why PMO? Towards Functionality and Utility of Periodic Mesoporous Organosilicas (Small 23/2010)
W. Wang (2010)
10.3109/10611869808997890
Superparamagnetic agents in magnetic resonance imaging: physicochemical characteristics and clinical applications. A review.
B. Bonnemain (1998)
10.1158/0008-5472.CAN-11-3883
"OA02" peptide facilitates the precise targeting of paclitaxel-loaded micellar nanoparticles to ovarian cancer in vivo.
K. Xiao (2012)
10.1002/ijc.21712
The role of folate receptor α in cancer development, progression and treatment: Cause, consequence or innocent bystander?
L. Kelemen (2006)
10.1158/0008-5472.CAN-10-3069
Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles.
X. Wang (2011)
10.1021/mp900143a
A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: preparation, characterization and in vivo application.
S. Liu (2009)
Shape tunable plasmonic nanoparticles
IH El-Sayed (2009)
10.1002/smll.201000538
Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals.
J. Lu (2010)
Targeted drug delivery via the transferrin receptro-mediated endocytotic pathway
ZM Qian (2002)
10.1016/S0009-9260(66)80052-1
Microcirculation of tumors. II. The supervascularized state of irradiated regressing tumors.
P. Rubin (1966)
Superparamagnetic iron oxide nanoparticleaptamer bioconjugates for combined prostate cancer imaging and therapy
AZ Wang (2008)
Photochemical release of methotrexate from folate receptor- Grant L. Zwicke et al. targeting PAMAM dendrimer nanoconjugate
Sk Choi (2012)
Bioscan from Mouse to Man
10.1002/ANIE.200604775
Development of a T1 contrast agent for magnetic resonance imaging using MnO nanoparticles.
Hyon Bin Na (2007)
10.1021/mp300188f
Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier.
Hidetoshi Arima (2012)
10.1007/s003300100908
Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
Y. Wang (2014)
10.1021/mp3002232
Polyvalent dendrimer-methotrexate as a folate receptor-targeted cancer therapeutic.
T. Thomas (2012)
10.1002/NBM.1084
Evaluating SPIO‐labelled cell MR efficiency by three‐dimensional quantitative T  2* MRI
P. Mowat (2007)
10.1016/J.AB.2004.12.026
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay.
N. Parker (2005)
10.1586/14737159.6.2.231
Multicolor quantum dots for molecular diagnostics of cancer
A. Smith (2006)
10.3390/cancers2041911
A Comparative Study of Two Folate-Conjugated Gold Nanoparticles for Cancer Nanotechnology Applications
G. Mansoori (2010)
J Control Release
(2004)
10.1021/ac8004555
Assessment of cytotoxicity of quantum dots and gold nanoparticles using cell-based impedance spectroscopy.
K. Male (2008)
10.2174/187221010792483726
Nanoparticles for improved therapeutics and imaging in cancer therapy.
D. Chithrani (2010)
10.1158/0008-5472.CAN-04-3921
Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer.
J. Kukowska-Latallo (2005)
A novel type of dualmodality molecular probe for MR and nuclear imaging of tumor preparation , characterization and in v i v o application
MY Gao (2009)
Jeffery Department of Biological Sciences University of Illinois at Chicago MC567 900 S
Constance
10.1088/0953-8984/24/16/164206
Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique.
C. Lamprecht (2012)
[Medical application of liposomes].
T. Yasuda (1991)
10.1002/smll.201102695
Improved photodynamic cancer treatment by folate-conjugated polymeric micelles in a KB xenografted animal model.
Wei-Jhe Syu (2012)
10.1038/nbt929
Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction
D. Lidke (2004)
10.1021/JA057254A
Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods.
X. Huang (2006)
10.1007/s10439-005-9002-7
Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging
D. Thorek (2005)
10.1007/978-1-60761-901-7
Molecular Imaging
K. Luker (2011)
USA Email: mansoori@uic.edu Folate directed cancer nanotherapies Citation
Il Chicago (2012)
10.1016/j.biomaterials.2012.01.036
Theranostic liposomes of TPGS coating for targeted co-delivery of docetaxel and quantum dots.
M. Muthu (2012)
Trophoblast and ovarian cancer antigen LK26. Sensitivity and specificity in immunopathology and molecular identification as a folate-binding protein.
P. Garinchesa (1993)
10.1016/j.bcp.2011.01.023
In search of the Holy Grail: Folate-targeted nanoparticles for cancer therapy.
Alfonso E. Garcia-Bennett (2011)
Folate intake, postÁfolic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Bm Oaks (2010)
10.2217/17435889.2.1.125
Hyperthermic effects of gold nanorods on tumor cells.
T. Huff (2007)
Shape tunable plasmonic nanoparticles. US Patent
I H El-Sayed (2009)
10.3945/ajcn.2009.28433
Folate intake, post-folic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Brietta M Oaks (2010)
10.1016/J.JCONREL.2004.08.017
Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate.
H. Yoo (2004)
10.1016/j.ijpharm.2012.04.009
Folate-targeting magnetic core-shell nanocarriers for selective drug release and imaging.
H. Wang (2012)
Folate directed cancer nanotherapies Citation
(2012)
10.2147/IJN.S27823
Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan–folic acid micelles
Feihu Wang (2012)
10.2147/IJN.S32620
Antitumor activity of folate-targeted, paclitaxelloaded polymeric micelles on a human esophageal EC9706 cancer cell line
W. Wu (2012)
10.1016/j.urolonc.2007.03.015
Nanoparticles for drug delivery in cancer treatment.
B. Haley (2008)
10.1038/nbt764
Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots
X. Wu (2003)
10.1016/0009-8981(87)90097-0
Medical application of liposomes: Kunio Yagi (editor) Japan Scientific Societies Press, Tokyo/Japan 1986 Karger, London, UK, 201 pp., £56.10
J. Hobbs (1987)
10.1002/cmdc.200800091
Superparamagnetic Iron Oxide Nanoparticle–Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy
A. Wang (2008)
10.1002/NBM.924
Iron oxide MR contrast agents for molecular and cellular imaging
J. Bulte (2004)
10.1016/J.ADDR.2005.09.014
Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex.
A. Patri (2005)
10.1039/b901729a
Ultra-small water-dispersible fluorescent chitosan nanoparticles: synthesis, characterization and specific targeting.
Padmavathy Tallury (2009)
10.1351/pac200476071321
Polymeric micelles for oral drug delivery: Why and how
M. F. Francis (2004)
Waterdispersible multiwalled carbon nanotube/iron oxide hybrids as contrast agents for cellular magnetic resonance imaging
M Yin (2012)
10.1007/s10555-008-9155-6
Tumor detection using folate receptor-targeted imaging agents
Emanuela I. Sega (2008)
Superparamagnetic iron oxide agents: physicochemical characteristics and applications in MR imaging
YXJ Wang (2001)
10.1158/1078-0432.CCR-07-1441
Therapeutic Nanoparticles for Drug Delivery in Cancer
Kwangjae Cho (2008)
10.1073/pnas.0914140107
Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles
C. Choi (2009)
10.1016/J.CARBON.2011.01.003
Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells
R. Li (2011)
10.1016/J.CANLET.2005.07.035
Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles.
I. El-Sayed (2006)
Stolzenberg-Solomon RZ. Folate intake, postÁfolic acid grain fortification, and pancreatic cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
B M Oaks (2010)
10.1038/nrclinonc.2010.97
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
D. L. Wheeler (2010)
10.1080/10611860903013248
Folate receptor–targeted quantum dot liposomes as fluorescence probes
C. Yang (2009)
10.3390/cancers3032888
Nanotechnology-Based Detection and Targeted Therapy in Cancer: Nano-Bio Paradigms and Applications
S. Mousa (2011)
10.2967/jnumed.107.049478
Exploratory Study of 99mTc-EC20 Imaging for Identifying Patients with Folate Receptor–Positive Solid Tumors
R. Fisher (2008)
10.2967/jnumed.110.076018
Folic Acid Conjugates for Nuclear Imaging of Folate Receptor–Positive Cancer
C. Müller (2011)
10.1007/s003300050535
Hepatic MRI with SPIO: detection and characterization of focal liver lesions
P. Reimer (1998)
10.1002/SMLL.200400093
Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity.
E. E. Connor (2005)
10.1016/J.ADDR.2004.01.004
Folate-receptor-targeted radionuclide imaging agents.
Chun-Yen Ke (2004)
10.1038/nature07043
Imaging stem-cell-driven regeneration in mammals
T. Schroeder (2008)
Ali Mansoori Department of Bioengineering, Chemical Engineering and Physics University of Illinois at Chicago MC063 851 S
10.1016/J.CARBON.2012.01.026
Water-dispersible multiwalled carbon nanotube/iron oxide hybrids as contrast agents for cellular magnetic resonance imaging
M. Yin (2012)
10.1016/j.addr.2008.03.018
Magnetic nanoparticles in MR imaging and drug delivery.
C. Sun (2008)
10.1038/NMAT1390
Quantum dot bioconjugates for imaging, labelling and sensing
Igor L. Medintz (2005)
10.1038/nnano.2007.387
Nanocarriers as an emerging platform for cancer therapy.
D. Peer (2007)
10.1016/j.colsurfb.2012.04.018
Functionalized mesoporous silicon for targeted-drug-delivery.
Ozra Tabasi (2012)
10.1039/c2pp05355a
Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate.
Seok Ki Choi (2012)



This paper is referenced by
10.1080/1061186X.2017.1339194
Therapeutic efficacy of folate receptor-targeted amphiphilic cyclodextrin nanoparticles as a novel vehicle for paclitaxel delivery in breast cancer
N. Erdoğar (2018)
10.5772/INTECHOPEN.68160
Liposomal Nanoformulations as Current Tumor-Targeting Approach to Cancer Therapy
A. Porfire (2017)
10.1021/acs.bioconjchem.7b00659
Clickable Cubosomes for Antibody-Free Drug Targeting and Imaging Applications.
N. Alcaraz (2018)
10.1016/j.gep.2017.08.002
Expression and characterization of the zebrafish orthologue of the human FOLR1 gene during embryogenesis.
Rojenia Jones (2017)
10.2217/nnm-2017-0120
Carbon nanotubes functionalized with folic acid attached via biomimetic peptide linker.
Justyna Frączyk (2017)
10.1016/j.colsurfb.2017.06.025
Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers.
Duy Luong (2017)
10.1186/s12951-016-0183-z
Delivery of disulfiram into breast cancer cells using folate-receptor-targeted PLGA-PEG nanoparticles: in vitro and in vivo investigations
Hamidreza Fasehee (2016)
10.1039/C5RA08154H
Targeting vitamin E TPGS–cantharidin conjugate nanoparticles for colorectal cancer therapy
S. Sheng (2015)
Caracterización de micelas de gangliósidos modificadas con moléculas de reconocimiento celular como estrategia de direccionamiento de fármacos
Ga Garro (2017)
10.1021/acsami.7b17756
Mechanistic Investigation into the Selective Anticancer Cytotoxicity and Immune System Response of Surface-Functionalized, Dichloroacetate-Loaded, UiO-66 Nanoparticles.
Isabel Abánades Lázaro (2018)
One-Pot Syntheses and Characterizations of “Click-able” Polyester Polymers for Potential Biomedical Applications
Beach (2017)
Chapter 9 Liposomal Nanoformulations as Current Tumor-Targeting Approach to Cancer Therapy
A. Porfire (2019)
10.1002/ddr.21530
Efficacy of targeted liposomes and nanocochleates containing imatinib plus dexketoprofen against fibrosarcoma
Ö. Çoban (2019)
Chemical surface modification of porous silicon nanoparticles for cancer therapy
Chang-Fang Wang (2015)
10.1016/B978-0-323-38945-7.00006-7
Chapter 6 – Applications and perspectives of boron nitride nanotubes in cancer therapy
T. H. Ferreira (2016)
10.1038/s41417-019-0156-0
Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications
S. L. Hulin-Curtis (2020)
10.1021/acsnano.6b05630
Magnetic and Folate Functionalization Enables Rapid Isolation and Enhanced Tumor-Targeting of Cell-Derived Microvesicles.
W. Zhang (2017)
Development of nanoparticle platform for therapeutic siRNA and drug delivery to breast cancer
Worapol Ngamcherdtrakul (2015)
10.2147/IJN.S165210
Application of active targeting nanoparticle delivery system for chemotherapeutic drugs and traditional/herbal medicines in cancer therapy: a systematic review
N. Muhamad (2018)
10.1021/am506094c
Target specific delivery of anticancer drug in silk fibroin based 3D distribution model of bone-breast cancer cells.
B. Subia (2015)
10.2174/1389200220666191003161114
Recognition Sites for Cancer-Targeting Durg Delivery Systems.
Siyu Guan (2019)
10.1021/acsami.8b21609
Combinational Effects of Active Targeting, Shape, and Enhanced Permeability and Retention for Cancer Theranostic Nanocarriers.
Armin Tahmasbi Rad (2019)
10.1007/s12192-019-00999-9
Quantitative bioimage analytics enables measurement of targeted cellular stress response induced by celastrol-loaded nanoparticles
E. Niemelä (2019)
10.1016/j.bmc.2019.04.013
Development of 99mTc-labeled trivalent isonitrile radiotracer for folate receptor imaging.
N. A. Lodhi (2019)
10.1016/j.ijpharm.2016.05.040
Design and optimization of novel paclitaxel-loaded folate-conjugated amphiphilic cyclodextrin nanoparticles.
N. Erdoğar (2016)
10.1021/acs.chemrev.8b00195
Cooperativity Principles in Self-Assembled Nanomedicine.
Y. Li (2018)
10.4172/2157-7439.1000481
Utility of Nanomedicine for Cancer Treatment
O. U. Akakuru (2018)
10.1016/j.canlet.2018.04.017
Reversal of drug resistance by planetary ball milled (PBM) nanoparticle loaded with resveratrol and docetaxel in prostate cancer.
S. Singh (2018)
10.1016/j.actbio.2015.01.021
Dual-drug delivery by porous silicon nanoparticles for improved cellular uptake, sustained release, and combination therapy.
Chang-Fang Wang (2015)
10.1088/2043-6254/AA5982
Enhanced anticancer efficacy and tumor targeting through folate-PEG modified nanoliposome loaded with 5-fluorouracil
V. M. Le (2017)
10.1038/s41598-017-06014-4
Dual functionality nanobioconjugates targeting intracellular bacteria in cancer cells with enhanced antimicrobial activity
R. Singh (2017)
10.1016/j.jconrel.2016.05.062
Nanotechnology in hyperthermia cancer therapy: From fundamental principles to advanced applications.
J. Beik (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar