Prospective Applications Of MicroRNAs In Oral Cancer
Chuan Fang, Yunqiao Li
Published 2019 · Medicine
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MicroRNAs (miRNAs) are non-coding RNA molecules that are generally encoded by endogenous genes and exert suppressive effects on post-transcriptional regulation of their target genes by translation repression or degradation of mRNA. This subsequently mediates activation or blocking of downstream signaling pathways associated with oral malignancies. Aberrant levels of certain miRNAs have been identified in cell experiments, clinical carcinomatous specimens, saliva, serum or plasma samples of patients with oral malignancies. miRNAs are associated with multiple aspects of oral cancer, including tumor growth, cellular proliferation, apoptosis, migration, invasion, metastasis, glycometabolism, radiosensitivity and chemosensitivity. miRNAs have the potential to be used in clinical applications as minimally invasive or non-invasive tools for early diagnosis and prognosis by the detection of serum, plasma and saliva levels, and may provide a new ancillary or additional reference index of traditional pathological grading and clinical staging. Furthermore, miRNAs may be used as prognostic biomarkers or targets for novel therapies for oral cancer.
This paper references
Association of Decreased Expression of Serum miR-9 with Poor Prognosis of Oral Squamous Cell Carcinoma Patients
Legang Sun (2016)
microRNA-451a regulates colorectal cancer proliferation in response to radiation
Rebecca Ruhl (2018)
MiR-497 enhances metastasis of oral squamous cell carcinoma through SMAD7 suppression.
J. Hu (2016)
MicroRNA-203 Induces Apoptosis by Targeting Bmi-1 in YD-38 Oral Cancer Cells
Jae-Sung Kim (2018)
MicroRNA-24 induces cisplatin resistance by targeting PTEN in human tongue squamous cell carcinoma.
Xiangqian Zheng (2015)
miR‐200c‐3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment
Tomoyo Kawakubo-Yasukochi (2018)
Oral squamous cell carcinoma cells are resistant to doxorubicin through upregulation of miR-221
Liangzhi Du (2017)
Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer.
Ya-Ching Lu (2015)
MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1
Ruijie Gong (2018)
miRNA expression profile of mucoepidermoid carcinoma.
N. Binmadi (2018)
miR-203 inhibits cell proliferation and promotes cisplatin induced cell death in tongue squamous cancer.
J. Lin (2016)
Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer.
Qin Xu (2013)
MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study
S. Andreasen (2018)
Decrease of miR-146a is associated with the aggressiveness of human oral squamous cell carcinoma.
Zonggao Shi (2015)
Epstein−Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas
Eleni Anastasiadou (2018)
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery (2009)
miR-21 modulates chemosensitivity of tongue squamous cell carcinoma cells to cisplatin by targeting PDCD4
Wenhao Ren (2014)
Alterations in miRNA expression patterns in whole blood of OSCC patients.
J. Ries (2014)
miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/β-Catenin Pathway in Tongue Squamous Cell Carcinoma
Junquan Weng (2017)
MicroRNA-27b inhibits cell proliferation in oral squamous cell carcinoma by targeting FZD7 and Wnt signaling pathway.
Bingyao Liu (2017)
Loss of PTEN Expression Is Associated With High MicroRNA 24 Level and Poor Prognosis in Patients With Tongue Squamous Cell Carcinoma.
Jingzhu Zhao (2017)
Oral Potentially Malignant Disorders: An Overview of More than 20 Entities
Hamed Mortazavi (2014)
Prognostic significance of altered miRNA expression in whole blood of OSCC patients.
J. Ries (2017)
Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma.
Chung-Ji Liu (2012)
MYCN-mediated miR-21 overexpression enhances chemo-resistance via targeting CADM1 in tongue cancer
Guopei Zheng (2016)
The role of long non-coding RNA ANRIL in the carcinogenesis of oral cancer by targeting miR-125a.
Luyi Chai (2018)
MicroRNA-375 as a biomarker for malignant transformation in oral lesions.
Amani M. Harrandah (2016)
Tumor‐suppressive roles of ΔNp63β‐miR‐205 axis in epithelial–mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2
Yuma Hashiguchi (2018)
miR-204-5p regulates cell proliferation and metastasis through inhibiting CXCR4 expression in OSCC.
Xinjuan Wang (2016)
miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling.
Meng Lu (2018)
Preoperative chemotherapy in advanced resectable OCSCC: long-term results of a randomized phase III trial.
Paolo Bossi (2014)
Relationship between microRNA expression levels and histopathological features of dysplasia in oral leukoplakia.
João Artur Ricieri Brito (2014)
Downregulation of miR-218-5p promotes invasion of oral squamous cell carcinoma cells via activation of CD44-ROCK signaling.
Xiaojie Li (2018)
Suppression of Oral Carcinoma Oncogenic Activity by microRNA-203 via Down-regulation of SEMA6A.
Hyoung-Sup Lim (2017)
Low expression of miR-30a-5p induced the proliferation and invasion of oral cancer via promoting the expression of FAP
Peng Ruan (2018)
MiR‐124 down‐regulation is critical for cancer associated fibroblasts‐enhanced tumor growth of oral carcinoma
Xia Li (2017)
Cancer of the oral cavity.
Pablo H Montero (2015)
Recurrence patterns and management of oral cavity premalignant lesions.
Demetri Arnaoutakis (2013)
MicroRNA-375 Inhibits Growth and Enhances Radiosensitivity in Oral Squamous Cell Carcinoma by Targeting Insulin Like Growth Factor 1 Receptor
Bin Zhang (2017)
MicroRNA-27a-3p regulates epithelial to mesenchymal transition via targeting YAP1 in oral squamous cell carcinoma cells.
Guang Zeng (2016)
The MYB/miR-130a/NDRG2 axis modulates tumor proliferation and metastatic potential in salivary adenoid cystic carcinoma
Yu Wang (2018)
MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity.
Yi-Fen Chen (2016)
MicroRNA-137 suppresses tongue squamous carcinoma cell proliferation, migration and invasion.
Lanying Sun (2016)
Downregulation of miR-377 Promotes Oral Squamous Cell Carcinoma Growth and Migration by Targeting HDAC9
Bhawna Rastogi (2017)
Up - regulation of miR - 187 modulates the advances of oral carcinoma by targeting BARX 2 tumor suppressor
SC Lin (2016)
miR182 activates the Ras–MEK–ERK pathway in human oral cavity squamous cell carcinoma by suppressing RASA1 and SPRED1
Jinhui Wang (2017)
Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing
Kyu-Hyeon Yeom (2006)
miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14
Tong Wang (2017)
MicroRNA‐802 plays a tumour suppressive role in tongue squamous cell carcinoma through directly targeting MAP2K4
Xiaozhen Wu (2017)
High expression of microRNA‑127 is involved in cell cycle arrest in MC‑3 mucoepidermoid carcinoma cells.
Ji-Ae Shin (2013)
MicroRNA - 542 - 3 p inhibits oral squamous cell carcinoma progression by inhibiting ILK / TGF - β 1 / Smad 2 / 3 signaling
B Qiao (2017)
Deregulation of the miR-222-ABCG2 regulatory module in tongue squamous cell carcinoma contributes to chemoresistance and enhanced migratory/invasive potential
Luo-dan Zhao (2015)
miR-27b-regulated TCTP as a novel plasma biomarker for oral cancer: from quantitative proteomics to post-transcriptional study.
Wan-Yu Lo (2012)
MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A.
Zhenghao Cao (2017)
Dysregulation of AKT1, a miR‐138 target gene, is involved in the migration and invasion of tongue squamous cell carcinoma
Muyuan Ji (2017)
miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients
Gordana Supic (2017)
Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection
Noh Jin Park (2009)
microRNA-188 is downregulated in oral squamous cell carcinoma and inhibits proliferation and invasion by targeting SIX1
Li Wang (2015)
Changes in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus.
Elisabet Nylander (2012)
Genetic variants in microRNA-146a (C>G) and microRNA-1269b (G>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer.
H. Chen (2016)
MicroRNA-27a-3p Modulates the Wnt/β-Catenin Signaling Pathway to Promote Epithelial-Mesenchymal Transition in Oral Squamous Carcinoma Stem Cells by Targeting SFRP1
Bin Qiao (2017)
Prognostic value of quantitative p63 immunostaining in adenoid cystic carcinoma of salivary gland assessed by computerized image analysis.
Naomi Ramer (2009)
MTSS1 gene regulated by miR-96 inhibits cell proliferation and metastasis in tongue squamous cellular carcinoma Tca8113 cell line.
Yan Guo (2015)
MiR‐375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion
Yadong Wu (2017)
MiR‐139‐5p inhibits the tumorigenesis and progression of oral squamous carcinoma cells by targeting HOXA9
Kai Wang (2017)
miR-182-5p Promotes Growth in Oral Squamous Cell Carcinoma by Inhibiting CAMK2N1
Nan Li (2018)
miR-381-3p suppresses the proliferation of oral squamous cell carcinoma cells by directly targeting FGFR2.
Xiao Yang (2017)
miR-15b inhibits cancer-initiating cell phenotypes and chemoresistance of cisplatin by targeting TRIM14 in oral tongue squamous cell cancer.
Xijun Wang (2017)
miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7.
Jingzhu Zhao (2016)
miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression.
Shih-Yuan Peng (2018)
Neoadjuvant Chemotherapy for Locally Advanced Squamous Carcinoma of Oral Cavity: a Pilot Study.
Sanambar Sadighi (2015)
MicroRNA-340 Mediates Metabolic Shift in Oral Squamous Cell Carcinoma by Targeting Glucose Transporter-1.
P. Xu (2016)
Downregulation of Microrna-148a in Cancer-Associated Fibroblasts from Oral Cancer Promotes Cancer Cell Migration and Invasion by Targeting Wnt10b.
Anjie Min (2016)
MicroRNA-221 induces autophagy through suppressing HDAC6 expression and promoting apoptosis in pancreatic cancer.
Yifan Yang (2018)
MicroRNA-200c suppresses tumor metastasis in oral squamous carcinoma by inhibiting epithelial-mesenchymal transition.
N-N Xie (2018)
miR-200c inhibits the arecoline-associated myofibroblastic transdifferentiation in buccal mucosal fibroblasts.
Ming-Yi Lu (2018)
miR-494-3p Induces Cellular Senescence and Enhances Radiosensitivity in Human Oral Squamous Carcinoma Cells
Jui-Hung Weng (2016)
Regulation of microRNA biogenesis
Minju Ha (2014)
Impact of Oral Cancer on Quality of Life.
Jesus Amadeo Valdez (2018)
miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo
Li-Yin Yeh (2015)
Oncogenic Function and Early Detection Potential of miRNA-10b in Oral Cancer as Identified by microRNA Profiling
Y. Lu (2012)
MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc
Zuojun Wang (2018)
Plasma miR-187* is a potential biomarker for oral carcinoma
Chung-Ji Liu (2016)
Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5
Wen Shi (2015)
MicroRNA‑655 suppresses cell proliferation and invasion in oral squamous cell carcinoma by directly targeting metadherin and regulating the PTEN/AKT pathway.
Qiang Wang (2018)
The increase of oncogenic miRNA expression in tongue carcinogenesis of a mouse model.
Yu-Yu Kao (2015)
MiR-376c-3p regulates the proliferation, invasion, migration, cell cycle and apoptosis of human oral squamous cancer cells by suppressing HOXB7.
Kai Wang (2017)
miR-639 regulates transforming growth factor beta-induced epithelial–mesenchymal transition in human tongue cancer cells by targeting FOXC1
Zhaoyu Lin (2014)
miR-26b is downregulated in human tongue squamous cell carcinoma and regulates cell proliferation and metastasis through a COX-2-dependent mechanism.
Jing Cao (2015)
Salivary microRNAs in oral cancer.
Fatheya Zahran (2015)
MiR-222 Targeted PUMA to Improve Sensitization of UM1 Cells to Cisplatin
Fangfang Jiang (2014)
MicroRNA-31 upregulation predicts increased risk of progression of oral potentially malignant disorder.
Kai-Feng Hung (2016)
Non-coding RNA networks in cancer
Eleni Anastasiadou (2018)
Serum, plasma and saliva biomarkers for head and neck cancer
L. M. R. B. Arantes (2018)
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
T. Chendrimada (2005)
MicroRNA-205-5p suppresses the invasiveness of oral squamous cell carcinoma by inhibiting TIMP‑2 expression.
H. Nagai (2018)
miRNA-10a promotes cancer cell proliferation in oral squamous cell carcinoma by upregulating GLUT1 and promoting glucose metabolism
Yuan-Hua Chen (2019)
hsa-miR-485-5p reverses epithelial to mesenchymal transition and promotes cisplatin-induced cell death by targeting PAK1 in oral tongue squamous cell carcinoma
Xiu-juan Lin (2017)
miR-196a Overexpression and miR-196a2 Gene Polymorphism Are Prognostic Predictors of Oral Carcinomas
Chung-Ji Liu (2012)
miR-22 regulates cell invasion, migration and proliferation in vitro through inhibiting CD147 expression in tongue squamous cell carcinoma.
Kaifeng Qiu (2016)
Identification of microRNA profiles in salivary adenoid cystic carcinoma cells during metastatic progression
Wei Chen (2014)
Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma
S. .. Sakha (2016)
MicroRNA-29a upregulates MMP2 in oral squamous cell carcinoma to promote cancer invasion and anti-apoptosis.
Le N. Lu (2014)
miR-138 suppresses the proliferation of oral squamous cell carcinoma cells by targeting Yes-associated protein 1.
R. Xu (2015)
miR-24 up-regulation in oral carcinoma: positive association from clinical and in vitro analysis.
Shu-Chun Lin (2010)
Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor
Shu-Chun Lin (2016)
Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Chao-min Cheng (2016)
MiR-1275 promotes cell migration, invasion and proliferation in squamous cell carcinoma of head and neck via up-regulating IGF-1R and CCR7.
Min-Da Liu (2018)
Cancer statistics, 2018.
Rebecca L Siegel (2018)
Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma.
Chao Wang (2018)
Evaluating the accuracy of microRNA27b and microRNA137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients
Sana Maher Aghbari (2018)
miR-98 suppresses tumor cell growth and metastasis by targeting IGF1R in oral squamous cell carcinoma.
Yu Du (2015)
The nuclear RNase III Drosha initiates microRNA processing
Yoontae Lee (2003)
Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
Thian-Sze Wong (2008)
Characterization of RNA in Saliva
N. J. Park (2006)
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray (2018)
Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics.
Talal El-Hefnawy (2004)
The Nefarious Nexus of Noncoding RNAs in Cancer
Eleni Anastasiadou (2018)
Transcription Regulation of E-Cadherin by Zinc Finger E-Box Binding Homeobox Proteins in Solid Tumors
Thian-Sze Wong (2014)
MicroRNAs-208b-3p, 204-5p, 129-2-3p and 3065-5p as predictive markers of oral leukoplakia that progress to cancer.
Elizabeth M. Philipone (2016)
miR - 1825 p promotes growth in oral squamous cell carcinoma by inhibiting CAMK 2 N 1
N Li (2018)
Stability of endogenous and added RNA in blood specimens, serum, and plasma.
N. Tsui (2002)
Micro-ribonucleic acid 143 (MiR-143) inhibits oral squamous cell carcinoma (OSCC) cell migration and invasion by downregulation of phospho-c-Met through targeting CD44 v3.
P. Xu (2015)
MiR-155 regulates oral squamous cell carcinoma Tca8113 cell proliferation, cycle, and apoptosis via regulating p27Kip1.
S. Fu (2017)
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
R. Rupaimoole (2017)
MicroRNA-542-3p inhibits oral squamous cell carcinoma progression by inhibiting ILK/TGF-β1/Smad2/3 signaling
Bin Qiao (2017)
Downregulation of miR-221/222 by a microRNA sponge promotes apoptosis in oral squamous cell carcinoma cells through upregulation of PTEN
Lijie Zhou (2016)
Serum miR-483-5p: a novel diagnostic and prognostic biomarker for patients with oral squamous cell carcinoma
Huanxi Xu (2015)
MicroRNA-218 promotes cisplatin resistance in oral cancer via the PPP2R5A/Wnt signaling pathway
Zehang Zhuang (2017)
miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma.
Cheng-Chieh Yang (2011)
miR-9 induces cell arrest and apoptosis of oral squamous cell carcinoma via CDK 4/6 pathway
Anquan Shang (2018)
Reversal of cisplatin resistance by microRNA-139-5p-independent RNF2 downregulation and MAPK inhibition in ovarian cancer.
Ying Chen (2018)
MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis.
O. Baba (2016)
Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma.
L. Zhong (2013)
MicroRNA-92b promotes tumor growth and activation of NF-κB signaling via regulation of NLK in oral squamous cell carcinoma.
Zhiming Liu (2015)
This paper is referenced by
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Non-Invasive Approaches for Oral Potential Malignant Disorders Surveillance: A Review
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