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Proton Pump Inhibitors Interfere With Zinc Absorption And Zinc Body Stores

Christopher P. Farrell, Melissa Morgan, David S. Rudolph, Austin Hwang, Nicole E. Albert, Mary Carmen Valenzano, Xuexuan Wang, Giancarlo Mercogliano, James M Mullin
Published 2011 · Medicine
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Background Proton pump inhibitors (PPIs) cause a sharp elevation of gastro-duodenal luminal pH which in turn has resulted in reports of reduced absorption of magnesium and certain other nutrients. Methods Gastroesophageal reflux disease (GERD) patients on long-term PPI therapy (> 6 months) or healthy test subjects (not on any acid preventive or neutralizing medication) were administered oral doses of zinc gluconate (26.2 mg zinc, twice daily) for 14 days followed by 5 cc venous blood samples. Plasma was analyzed for total zinc content by atomic absorption spectrophotometry. Baseline plasma and red blood cell zinc levels were also measured in these two groups when not taking any zinc supplementation. Results Plasma zinc levels of healthy controls increased by 126% during the period of zinc supplementation compared to only a 37% increase for individuals on long-term PPI therapy. On their normal diet (with no zinc supplementation), PPI-users had a 28% lower plasma zinc level than healthy controls (P < 0.005). Conclusions PPI use dramatically reduces supplemental zinc uptake and can result in decreased zinc body stores. Certain individuals on long-term PPI therapy, such as infants being treated for colic, may be at risk for decreased systemic levels of trace metals needed for developmental, regenerative and immunological requirements.
This paper references
Long-term safety concerns with proton pump inhibitors.
Tauseef Ali (2009)
Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis.
Louise Y. Y. Fong (2011)
Denture Cream Zinc Poisoning Consequence of Lax Chemical Regulations
MA Broeren (2010)
Vader HL, van den Wall Bake AW. Hypomagnesemia induced by several protonpump inhibitors
M A Broeren (2009)
Trace Elements in Human and Animal Nutrition
Eric J. Underwood (1971)
The role of zinc in life: a review.
S. Frassinetti (2006)
Exchangeable zinc pool masses and turnover are maintained in healthy men with low zinc intakes.
Kathryn Pinna (2001)
Does poor zinc nutriture retard skeletal growth and mineralization in adolescents?
Janet C King (1996)
Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition.
S. Rerksuppaphol (2002)
Proton pump inhibitor side effects and drug interactions: Much ado about nothing?
Ryan D. Madanick (2011)
Dietary zinc deficiency enhances esophageal cell proliferation and N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumor incidence in C57BL/6 mouse.
Louise Y. Y. Fong (1999)
Esomeprazole for the treatment of erosive esophagitis in children: an international, multicenter, randomized, parallel-group, double-blind (for dose) study
Vasundhara Tolia (2010)
Hypomagnesemia induced by several proton-pump inhibitors.
Maarten A. C. Broeren (2009)
Systematic Review of the Risk of Enteric Infection in Patients Taking Acid Suppression
J. Leonard (2007)
IMS Health Reports U.S. Prescription Sales Grew 5.1 Percent in 2009, to $300.3 Billion
G. Gatyas (2010)
Prescription Sales Grew 5.1 Percent in 2009, to $300.3 Billion
G Gatyas (2010)
Effect of Proton Pump Inhibitors on Vitamins and Iron
Kenneth E. L. McColl (2009)
Assessment of zinc status.
R P Thompson (1991)
Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial.
M. B. O'Connell (2005)
Oral zinc therapy in patients with supposed mild zinc deficiency--a critical review.
Michael Hocke (2001)
Zinc.In. Trace elements in human and animal nutrition
CC HambidgeKM (1986)
Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Women's Health Initiative.
S. Gray (2010)
Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs.
R. Laheij (2004)
Zinc absorption and achlorhydria.
Brittmarie Sandström (1989)
Zinc requirements and zinc intakes of breast-fed infants.
Nancy F. Krebs (1986)
Long-term proton pump inhibitor therapy and risk of hip fracture.
Yu-Xiao Yang (2006)
Trace Elements in Human and Animal Nutrition
Arthur H. Bryan (1957)
The Essential Toxin: Impact of Zinc on Human Health
Laura Marie Plum (2010)
Proton pump inhibitors in pediatrics: evaluation of efficacy in GERD therapy.
Claudio Romano (2011)
Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis
C. Hutchinson (2007)

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Lactobacillus reuteri DSM 17938 Protects against Gastric Damage Induced by Ethanol Administration in Mice: Role of TRPV1/Substance P Axis
Ana P Oliveira (2019)
Zinc and gastrointestinal disease.
Sonja M. Skrovanek (2014)
Supporting the intoxicated patient: toxicants affecting the haematological and renal systems
Karen Humm (2020)
Drug interactions produced by proton pump inhibitors: not simply a pH effect.
James M Mullin (2013)
Effect of chronic proton pump inhibitor therapy on complete blood count parameters and selected trace elements - pilot study.
Olga Kaczmarczyk (2019)
Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update
Emily S Mohn (2018)
Drug delivery of zinc to Barrett's metaplasia by oral administration to Barrett's esophagus patients.
Mary Carmen Valenzano (2014)
Dietary and Nutritional Aspects of Zinc in Critically Ill Adult Patients
Beth Y. Besecker (2014)
Zinc Deficiency in Men Over 50 and Its Implications in Prostate Disorders
Ann Katrin Sauer (2020)
Response to "Physiologically based pharmacokinetic modeling at the extremes of age".
O. Della Casa Alberighi (2013)
Micromotors for drug delivery in vivo: The road ahead
S. Srivastava (2019)
Oral Zinc Supplementation Reduces the Erythropoietin Responsiveness Index in Patients on Hemodialysis
Hiroki Kobayashi (2015)
Zinc Nutritional Status in Patients with Cystic Fibrosis
Marlene Fabiola Escobedo Monge (2019)
Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells
Florentina Sophie Ferstl (2016)
Unexpected hypozincaemia in a patient with discharging empyema that proved resistant to replacement therapy
Lynn Rowbottom (2013)
Dietary Zinc Deficiency Exaggerates Ethanol-Induced Liver Injury in Mice: Involvement of Intrahepatic and Extrahepatic Factors
W. Zhong (2013)
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