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CD28 Costimulation And Parasite Dose Combine To Influence The Susceptibility Of BALB/c Mice To Infection With Leishmania Major1
H. Compton, J. Farrell
Published 2002 · Biology, Medicine
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Infection with Leishmania major in BALB/c mice is accompanied by the development of a nonprotective Th2-type response. It has previously been shown that disease progression, and the activation of a Th2-type response, can occur in the absence of CD28 costimulation following the inoculation of high numbers of L. major promastigotes. In this study, we show that in the absence of CD28-B7 interactions, BALB/c mice can spontaneously resolve their infections following the inoculation of low numbers of parasites. BALB/c CD28+/+ and CD28−/− mice were inoculated with 250, 500, and 750 metacyclic parasites. The CD28−/− mice controlled their lesions, whereas the wild-type (WT) mice developed progressive nonhealing infections. Resistance to infection was associated with reduced numbers of parasites in the CD28−/− mice compared with the WT mice. Infection of the CD28−/− mice resulted in the activation of a Th1-type response as evidenced by increased levels of mRNA for IFN-γ and reduced levels of message for IL-4 and IL-10 in draining lymph nodes compared with those in WT mice. Healing of infected CD28−/− mice could also be ablated with anti-CD4 Ab treatment or treatment with anti-IFN-γ Ab. In addition, healed CD28−/− mice were resistant to a challenge infection with L. major. These results suggest that CD28 costimulation influences the in vivo activation of a Th2-type response in a manner that is dependent on the size of the parasite inoculum.
This paper references
Immunoregulation of genetically controlled acquired responses to Leishmania donovani infection in mice: the effects of parasite dose, cyclophosphamide and sublethal irradiation
ORYSIA M. ULCZAK (1983)
Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.
R. Titus (1985)
Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.
D. Sacks (1985)
Distinctive cellular immunity in genetically susceptible BALB/c mice recovered from Leishmania major infection or after subcutaneous immunization with killed parasites.
F. Liew (1987)
T-cell subpopulations, expression of interleukin-2 receptor, and production of interleukin-2 and gamma interferon in human American cutaneous leishmaniasis
M. Castés (1988)
A role for Lyt-2+ T cells in resistance to cutaneous leishmaniasis in immunized mice.
J. Farrell (1989)
Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes.
C. June (1989)
Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism
Michael D. Sadick (1990)
Determinants of the immune response in visceral leishmaniasis: evidence for predominance of endogenous interleukin 4 over interferon-gamma production.
K. Zwingenberger (1990)
Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.
F. Heinzel (1991)
IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.
P. Scott (1991)
Transforming growth factor-beta in leishmanial infection: a parasite escape mechanism.
M. Barral-Netto (1992)
IL-4 induces a Th2 response in Leishmania major-infected mice.
R. Chatelain (1992)
Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major.
P. Bretscher (1992)
Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response
J. Sypek (1993)
IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts.
F. Heinzel (1993)
Recombinant interleukin 12 cures mice infected with Leishmania major
F. Heinzel (1993)
Gamma interferon response in secondary Leishmania major infection: role of CD8+ T cells
I. Müller (1993)
Interleukin 10 production correlates with pathology in human Leishmania donovani infections.
H. Ghalib (1993)
Potential role for interleukin-10 in the immunosuppression associated with kala azar.
B. Holaday (1993)
Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis
L. C. Afonso (1993)
Differential T cell costimulatory requirements in CD28-deficient mice.
A. Shahinian (1993)
interferon response in secondary Leishmania major infection: role of CD8 T cells
I. Muller (1993)
␥ interferon response in secondary Leishmania major infection: role of CD8 ϩ T cells
I Muller (1993)
Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis
A. M. Da-Cruz (1994)
The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.
L. C. Afonso (1994)
Expansion of gamma interferon-producing CD8+ T cells following secondary infection of mice immune to Leishmania major
I. Müller (1994)
Dichotomy of the human T cell response to Leishmania antigens. I. Th1‐like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis
M. Kemp (1994)
Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.
D. Corry (1994)
Leishmania major infection in mice primes for specific major histocompatibility complex class I‐restricted CD8+ cytotoxic T cell responses
Fátima da Conceição‐Silva (1994)
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells
S. Constant (1995)
Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.
F. Heinzel (1995)
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.
L. Boise (1995)
In susceptible mice, Leishmania major induce very rapid interleukin‐4 production by CD4+ T cells which are NK1.1−
Pascal Launois (1995)
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model
N. Hosken (1995)
The effect of antigen dose on CD4 T helper cell phenotype development in a T cell receptor- -transgenic model
N. A. Hosken (1995)
The effect of antigen dose on CD4 ϩ T helper cell phenotype development in a T cell receptor-␣␤-transgenic model
N A Hosken (1995)
Duration of TCR stimulation determines costimulatory requirement of T cells.
T. Kündig (1996)
CD28‐deficient mice generate an impaired Th2 response to Schistosoma mansoni infection
C. King (1996)
Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response.
J. Brown (1996)
CD28/B7 system of T cell costimulation.
D. Lenschow (1996)
Limited role of CD28-mediated signals in T helper subset differentiation
D. Brown (1996)
Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge
J. Menon (1996)
Leishmania major: effect of infectious dose on T cell subset development in BALB/c mice.
T. M. Doherty (1996)
Leishmania major:Effect of Infectious Dose on T Cell Subset Development in BALB/c Mice
Doherty Tm (1996)
CD28 costimulation promotes the production of Th2 cytokines.
I. Rulifson (1997)
Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells
Y. Itoh (1997)
Leishmania major-infected C3H mice treated with anti-IL-12 mAb develop but do not maintain a Th2 response.
B. Hondowicz (1997)
Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.
X. Tao (1997)
B7-CD28/CTLA-4 costimulatory pathways are required for the development of T helper cell 2-mediated allergic airway responses to inhaled antigens.
A. Keane-Myers (1997)
Blockade of CD28/B7 co‐stimulation by mCTLA4‐Hγ1 inhibits antigen‐induced lung eosinophilia but not Th2 cell development or recruitment in the lung
N. Harris (1997)
Leishmania aethiopica derived from diffuse leishmaniasis patients preferentially induce mRNA for interleukin-10 while those from localized leishmaniasis patients induce interferon-gamma.
H. Akuffo (1997)
Parasite dose determines the Th1/Th2 nature of the response to Leishmania major independently of infection route and strain of host or parasite
J. Menon (1998)
CTLA4 (CD152) modulates the Th subset response and alters the course of experimental Leishmania major infection
B. Saha (1998)
Expression and contribution of B7-1 (CD80) and B7-2 (CD86) in the early immune response to Leishmania major infection.
M. Elloso (1999)
Critical role of CD28 in protective immunity against Salmonella typhimurium.
H. Mittrücker (1999)
Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii.
E. N. Villegas (1999)
Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: amplification of the lytic potential by B7.
M. Krummel (1999)
Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes
A. M. Dahl (2000)
Stat6 activation and Th2 cell proliferation driven by CD28 signals
S. Oki (2000)
In BALB/c Mice, IL-4 Production During the Initial Phase of Infection with Leishmania major Is Necessary and Sufficient to Instruct Th2 Cell Development Resulting in Progressive Disease1
H. Himmelrich (2000)
The Roles of CD28 and CD40 Ligand in T Cell Activation and Tolerance1
Kimberly C. Howland (2000)
A Natural Model of Leishmania major Infection Reveals a Prolonged “Silent” Phase of Parasite Amplification in the Skin Before the Onset of Lesion Formation and Immunity
Y. Belkaid (2000)
A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade1
A. M. Girvin (2000)
Role of CD40 Ligand and CD28 in Induction and Maintenance of Antiviral CD8+ Effector T Cell Responses1
S. Andreasen (2000)
CD28, Ox-40, LFA-1, and CD4 Modulation of Th1/Th2 Differentiation Is Directly Dependent on the Dose of Antigen1
P. Rogers (2000)
Costimulation Light: Activation of CD4+ T Cells with CD80 or CD86 Rather Than Anti-CD28 Leads to a Th2 Cytokine Profile1
C. Broeren (2000)
IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease
H Himmelrich (2000)
Stat 6 activation and Th 2 cell proliferation driven by CD 28 signals
C. H. June (2000)
Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen
P R Rogers (2000)
This paper is referenced by
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M. Rostamian (2018)
Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection
M. M. Opata (2013)
PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors
N. Isakov (2012)
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Suzanne J. Furlong (2012)
Role of Co-stimulation in Leishmaniasis
Rashmi Tuladhar (2011)
Distinct Roles of CD28- and CD40 Ligand-Mediated Costimulation in the Development of Protective Immunity and Pathology during Chlamydia muridarum Urogenital Infection in Mice
Lili Chen (2009)
Emergence of chronic Lyme arthritis: Putting the breaks on CD28 costimulation
B. Iliopoulou (2009)
4-1BBL costimulation retrieves CD28 expression in activated T cells.
M. Habibagahi (2009)
Trypanosoma cruzi infection from the view of CD8+ T cell immunity--an infection model for developing T cell vaccine.
Yasushi Miyahira (2008)
Immunity Against Chlamydia trachomatis
E. Marks (2008)
Leishmania infantum: mixed T-helper-1/T-helper-2 immune response in experimentally infected BALB/c mice.
N. Rolão (2007)
Differential CD28 and Inducible Costimulatory Molecule Signaling Requirements for Protective CD4+ T-Cell-Mediated Immunity against Genital Tract Chlamydia trachomatis Infection
E. Marks (2007)
Leishmania tropica infection, in comparison to Leishmania major, induces lower delayed type hypersensitivity in BALB/c mice.
H. Mahmoudzadeh-Niknam (2007)
CD28 Deficiency Exacerbates Joint Inflammation upon Borrelia burgdorferi Infection, Resulting in the Development of Chronic Lyme Arthritis1
B. P. Iliopoulou (2007)
Differential CD 28 and Inducible Costimulatory Molecule Signaling Requirements for Protective CD 4 T-Cell-Mediated Immunity against Genital Tract Chlamydia trachomatis Infection
E. Marks (2007)
Role for the CD28 Molecule in the Control of Coxiella burnetii Infection
A. Honstettre (2006)
Molecular regulation of cytoskeletal rearrangements during T cell signalling.
Theresia E. B. Stradal (2006)
Interferon Gamma Unresponsiveness Due to Down-Regulation of IFN-R Expression in Experimental Cutaneous Leishmaniasis
A. Kariminia (2006)
CD4+ T Cell Responses: A Complex Network of Activating and Tolerizing Signals as Revealed by Gene Expression Analysis: A Dissertation
D. Brown (2005)
CD28 is required for T cell activation and IFN-gamma production by CD4+ and CD8+ T cells in response to Trypanosoma cruzi infection.
G. Martins (2004)
Low Dose Leishmania major Promotes a Transient T Helper Cell Type 2 Response That Is Down-regulated by Interferon γ–producing CD8+ T Cells
J. Uzonna (2004)
Attenuation of Immunological Symptoms of Allergic Asthma in Mice Lacking the Tyrosine Kinase ITK1
Cynthia Mueller (2003)
CD 40-CD 40 Ligand Costimulation Is Not Required for Initiation and Maintenance of a Th 1-Type Response to Leishmania major Infection
U. Padigel (2003)
CD28-mediated co-stimulation: a quantitative support for TCR signalling
O. Acuto (2003)
CD40-CD40 Ligand Costimulation Is Not Required for Initiation and Maintenance of a Th1-Type Response to Leishmania major Infection
U. Padigel (2003)
Parasites and immune responses: memory illusion?
D. Brake (2003)
B7/CD28-Dependent CD4+CD25+ Regulatory T Cells Are Essential Components of the Memory-Protective Immunity to Candida albicans1
C. Montagnoli (2002)
Candida Memory-Protective Immunity to T Cells Are Essential Components of the Regulatory + CD 25 + B 7 / CD 28-Dependent CD 4
C. Montagnoli (2002)
The Immunology of Cutaneous Leishmaniasis: Experimental Infections and Human Disease
J. P. Farrell (2002)
Pkc-theta-mediated Signal Delivery from Thetcr/cd28 Surface Receptors Isakov and Altman Tcr/cd28-linked Pkcθ-mediated Signaling Isakov and Altman Tcr/cd28-linked Pkcθ-mediated Signaling Isakov and Altman Tcr/cd28-linked Pkcθ-mediated Signaling Isakov and Altman Tcr/cd28-linked Pkcθ-mediated Signalin
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