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Sodium Benzoate, A Food Additive And A Metabolite Of Cinnamon, Modifies T Cells At Multiple Steps And Inhibits Adoptive Transfer Of Experimental Allergic Encephalomyelitis1
S. Brahmachari, K. Pahan
Published 2007 · Medicine
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Experimental allergic encephalomyelitis (EAE) is the animal model for multiple sclerosis. This study explores a novel use of sodium benzoate (NaB), a commonly used food additive and a Food and Drug Administration-approved nontoxic drug for urea cycle disorders, in treating the disease process of relapsing-remitting EAE in female SJL/J mice. NaB, administered through drinking water at physiologically tolerable doses, ameliorated clinical symptoms and disease progression of EAE in recipient mice and suppressed the generation of encephalitogenic T cells in donor mice. Histological studies reveal that NaB effectively inhibited infiltration of mononuclear cells and demyelination in the spinal cord of EAE mice. Consequently, NaB also suppressed the expression of proinflammatory molecules and normalized myelin gene expression in the CNS of EAE mice. Furthermore, we observed that NaB switched the differentiation of myelin basic protein-primed T cells from Th1 to Th2 mode, enriched regulatory T cell population, and down-regulated the expression of various contact molecules in T cells. Taken together, our results suggest that NaB modifies encephalitogenic T cells at multiple steps and that NaB may have therapeutic importance in multiple sclerosis.
This paper references
Activation of nuclear factor- B in the spinal cord of experimental allergic encephalomyelitis
K. Pahan (2000)
Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels.
P. Vajkoczy (2001)
Final Report on the Safety Assessment of Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate
B. Nair (2001)
Efficient Recruitment of Lymphocytes in Inflamed Brain Venules Requires Expression of Cutaneous Lymphocyte Antigen and Fucosyltransferase-VII1
L. Piccio (2005)
CD4 CD25 regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
D. Xu (2003)
Inflammation and degeneration in multiple sclerosis
W. Brück (2003)
“Classic” myelin basic proteins are expressed in lymphoid tissue macrophages
Hong-biao Liu (2001)
Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
E. N. Benveniste (1997)
Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis1
A. Kohm (2002)
Forkhead-box transcription factors and their role in the immune system
P. Coffer (2004)
Immunopathogenesis of multiple sclerosis: the role of T cells.
G. Martino (1999)
Tregs and transplantation tolerance.
P. Walsh (2004)
Urea cycle disorders.
J. Leonard (2002)
CD4+CD25+ Regulatory T Cells Suppress Differentiation and Functions of Th1 and Th2 Cells, Leishmania major Infection, and Colitis in Mice1
D. Xu (2003)
The T lymphocyte in experimental allergic encephalomyelitis.
S. Zamvil (1990)
Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse.
B. Steffen (1994)
Administration of dehydroepiandrosteronesuppresses experimental allergic encephalomyelitis in SJL/J mice
C. Du (2001)
Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis
K. Pahan (2000)
Myelin basic protein-primed T cells induce nitric oxide synthase in microglial cells: implications for multiple sclerosis
S. Dasgupta (2002)
Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System
M. D. Lawrence Steinman (1996)
Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans
K. Kubota (2004)
Antineuroinflammatory Effect of NF-κB Essential Modifier-Binding Domain Peptides in the Adoptive Transfer Model of Experimental Allergic Encephalomyelitis1
S. Dasgupta (2004)
Up-regulation of Microglial CD11b Expression by Nitric Oxide*
Avik Roy (2006)
Lack of tumorigenicity of sodium benzoate in mice.
B. Tóth (1984)
The role of nitric oxide in multiple sclerosis
John F. Parkinson (1997)
Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyelitis in SJL/J Mice
C. Du (2001)
Final report on the safety assessment of Benzyl Alcohol, Benzoic Acid, and Sodium benzoate
F. Andersen (2001)
Sodium Phenylacetate Inhibits Adoptive Transfer of Experimental Allergic Encephalomyelitis in SJL/J Mice at Multiple Steps1
S. Dasgupta (2003)
IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage.
A. O’Garra (2004)
CD4 ϩ CD25 ϩ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
D Xu (2003)
Cinnamic acid is a precursor of benzoic acids in cell cultures of Hypericum androsaemum L. but not in cell cultures of Centaurium erythraea RAFN
A. A. El-Mawla (2001)
Immunological aspects of demyelinating diseases.
R. Martin (1992)
The fate of benzoic acid in various species.
J. Bridges (1970)
CD25+CD4+ Cells Contribute to Th2 Polarization during Helminth Infection by Suppressing Th1 Response Development1
Amy S McKee (2004)
T-cell function and migration. Two sides of the same coin.
U. V. von Andrian (2000)
Effect of alternative pathway therapy on branched chain amino acid metabolism in urea cycle disorder patients.
F. Scaglia (2004)
Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain
B. Becher (2006)
Tregs and transplantation
P. T. Walsh (2004)
Current and investigational therapies used to alter the course of disease in multiple sclerosis.
A. Miller (1997)
VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses.
M. Mittelbrunn (2004)
This paper is referenced by
Cinnamon and its Metabolite Protect the Nigrostriatum in a Mouse Model of Parkinson’s Disease Via Astrocytic GDNF
D. Patel (2019)
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Suresh B Rangasamy (2018)
Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Reduces Microglial and Astroglial Inflammatory Responses1
S. Brahmachari (2009)
Gender-Specific Expression of β1 Integrin of VLA-4 in Myelin Basic Protein-Primed T Cells: Implications for Gender Bias in Multiple Sclerosis
S. Brahmachari (2010)
Glyceryl Tribenzoate: A Flavoring Ingredient, Inhibits the Adoptive Transfer of Experimental Allergic Encephalomyelitis via TGF-β: Implications for Multiple Sclerosis Therapy
S. Mondal (2017)
Exploring the therapeutic potential of sodium benzoate in acetic acid-induced ulcerative colitis in rats
Deepali Walia (2019)
Special Issue: "Inflammation and Pathophysiology of COVID-19"
K. Kalantar (2020)
Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease
Saurabh Khasnavis (2014)
Uses of Complementary and Alternative Medicine in Multiple Sclerosis
F. Namjooyan (2014)
Intranasal Methylprednisolone Effectively Reduces Neuroinflammation in Mice With Experimental Autoimmune Encephalitis.
Dunia Rassy (2019)
Microfibrillar Polysaccharide-Derived Biochars as Sodium Benzoate Adsorbents
D. Liu (2017)
Improving the dietary management of orofacial granulomatosis
H. Campbell (2012)
Nebulization of RNS60, a Physically-Modified Saline, Attenuates the Adoptive Transfer of Experimental Allergic Encephalomyelitis in Mice: Implications for Multiple Sclerosis Therapy
S. Mondal (2017)
Urinary Urea, Uric Acid and Hippuric Acid as Potential Biomarkers in Multiple Sclerosis Patients
Hanaa B. Atya (2017)
Myelin Basic Protein Priming Reduces the Expression of Foxp3 in T Cells via Nitric Oxide
S. Brahmachari (2010)
Upregulation of tripeptidyl-peptidase 1 by 3-hydroxy-(2,2)-dimethyl butyrate, a brain endogenous ligand of PPARα: Implications for late-infantile Batten disease therapy
S. Chakrabarti (2019)
Profile of Circulatory Metabolites in a Relapsing-remitting Animal Model of Multiple Sclerosis using Global Metabolomics.
A. Mangalam (2013)
COMPLEMENTARY AND ALTERNATIVE MEDICINE USE IN MULTIPLE SCLEROSIS
Rahil Ghanavati (2014)
Food additives: Sodium benzoate, potassium sorbate, azorubine, and tartrazine modify the expression of NFκB, GADD45α, and MAPK8 genes.
B. Raposa (2016)
Reduction of Lewy Body Pathology by Oral Cinnamon.
Sumita Raha (2020)
Effect of potassium benzoate on BALB/c mice placenta: a histopathological study.
J. Khayatzadeh (2011)
iN TeTrAHymenA pyrIfOrmIs mAcroN ucleus After exposure to fooD preserv Atives soDium NitrA te AND soDium beNzoA te
Ariadni C. Loutsidou (2012)
Gemfibrozil and Fenofibrate, Food and Drug Administration-approved Lipid-lowering Drugs, Up-regulate Tripeptidyl-peptidase 1 in Brain Cells via Peroxisome Proliferator-activated Receptor α
Arunava Ghosh (2012)
DNA content alterations in Tetrahymena pyriformis macronucleus after exposure to food preservatives sodium nitrate and sodium benzoate.
Ariadni C. Loutsidou (2012)
Sodium benzoate, a food preservative, affects the functional and activation status of splenocytes at non cytotoxic dose.
Ashish Yadav (2016)
Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes
Khushbu K. Modi (2015)
Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by altering balance among CD4+ T-cell subsets.
J. Wang (2012)
Functional Blocking Monoclonal Antibodies against IL-12p40 Homodimer Inhibit Adoptive Transfer of Experimental Allergic Encephalomyelitis 1
S. Mondal (2009)
Multiple Sclerosis and Experimental Allergic Encephalomyelitis.
K. Pahan (2013)
Cinnamon Ameliorates Experimental Allergic Encephalomyelitis in Mice via Regulatory T Cells: Implications for Multiple Sclerosis Therapy
S. Mondal (2015)
Dietary naringenin supplementation attenuates experimental autoimmune encephalomyelitis by modulating autoimmune inflammatory responses in mice.
J. Wang (2018)
Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Neuroprotective Parkinson Disease Protein DJ-1 in Astrocytes and Neurons
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