Online citations, reference lists, and bibliographies.
← Back to Search

Nanomedicine For Uterine Leiomyoma Therapy.

Hazem Ali, G. Kilic, Kathleen Vincent, M. Motamedi, E. Rytting
Published 2013 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
BACKGROUND The purpose of this work was to engineer polymeric nanoparticles to encapsulate and deliver 2-methoxyestradiol, a potential antitumor drug for treatment of uterine leiomyoma (fibroids), the most common hormone-dependent pathology affecting women of reproductive age. METHODS/RESULTS Encapsulation efficiency and drug release from the nanoparticles were monitored by HPLC. Cell morphology and in vitro cytotoxicity experiments were carried out in a human leiomyoma cell line. The nanoparticles displayed high encapsulation efficiency (>86%), which was verified by differential scanning calorimetry and x-ray diffraction. Excellent long-term stability of the nanoparticles and gradual drug release without burst were also observed. Cellular uptake of fluorescent nanoparticles was confirmed by confocal imaging. The drug-loaded poly(lactic acid) and poly(lactic-co-glycolic acid) nanoparticles induced cytotoxicity in human leiomyoma cells to a significantly greater extent than the free drug at 0.35 µM. CONCLUSION This novel approach represents a potential fertility-preserving alternative to hysterectomy.
This paper references
10.1016/J.ADDR.2007.04.008
Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles.
H. L. Wong (2007)
10.1016/j.ijpharm.2009.12.040
Understanding the quality of protein loaded PLGA nanoparticles variability by Plackett-Burman design.
Z. Rahman (2010)
10.1016/j.jsgi.2005.10.007
Catechol-O-Methyltransferase Polymorphism Is Associated With Increased Uterine Leiomyoma Risk in Different Ethnic Groups
A. Al-Hendy (2006)
10.1038/nmat2456
Drug delivery: Old polymer learns new tracts.
Michael J. Campolongo (2009)
10.1016/j.nurt.2009.01.018
Nanotechnology for delivery of drugs to the brain for epilepsy
Margaret F Bennewitz (2011)
10.1016/J.IJPHARM.2007.08.034
PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: systematic study of particle size and drug entrapment efficiency.
Xiangrong Song (2008)
10.1016/j.fertnstert.2009.08.065
Antiproliferative and proapoptotic effects of epigallocatechin gallate on human leiomyoma cells.
D. Zhang (2010)
10.1016/S0015-0282(16)45789-4
Uterine leiomyomata: etiology, symptomatology, and management.
V. Buttram (1981)
10.1016/J.OGC.2005.12.004
Epidemiology of myomas.
M. Payson (2006)
10.1016/J.ADDR.2007.04.013
Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering.
H. Bunjes (2007)
10.1210/JCEM.79.3.8077380
Relative overexpression of collagen type I and collagen type III messenger ribonucleic acids by uterine leiomyomas during the proliferative phase of the menstrual cycle.
E. Stewart (1994)
10.1097/01.LAB.0000017499.51216.3E
Immortalization of Human Uterine Leiomyoma and Myometrial Cell Lines After Induction of Telomerase Activity: Molecular and Phenotypic Characteristics
Sara A. Carney (2002)
10.1016/S0168-3659(97)00106-5
Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method.
M. Zambaux (1998)
10.1111/j.1365-2818.1983.tb04163.x
Electron microscopy of frozen biological suspensions
J. Lepault (1983)
10.1016/j.ejps.2010.09.008
PLGA:poloxamer blend micro- and nanoparticles as controlled release systems for synthetic proangiogenic factors.
Yolanda Parajó (2010)
10.1016/j.bpobgyn.2008.01.014
Molecular genetics and racial disparities of uterine leiomyomas.
E. R. Othman (2008)
10.1016/J.JCONREL.2004.02.018
Poly(ether-anhydride) dry powder aerosols for sustained drug delivery in the lungs.
J. Fiegel (2004)
10.1016/S1535-6108(03)00077-1
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
N. Mabjeesh (2003)
10.1158/1078-0432.CCR-04-1393
2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor 1α, Tumor Growth, and Angiogenesis and Augments Paclitaxel Efficacy in Head and Neck Squamous Cell Carcinoma
J. Ricker (2004)
10.1016/S0378-5173(02)00180-1
Nanostructured lipid matrices for improved microencapsulation of drugs.
R. Mueller (2002)
10.1023/A:1025065418309
Physicochemical Investigations on Solid Lipid Nanoparticles and on Oil-Loaded Solid Lipid Nanoparticles: A Nuclear Magnetic Resonance and Electron Spin Resonance Study
K. Jores (2004)
10.1055/S-2004-828615
Apoptosis in human uterine leiomyomas.
Kristina M Martel (2004)
10.1016/S0142-9612(00)00115-0
The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.
R. Jain (2000)
PLGA - lecithinPEG coreshell nanoparticles for controlled drug delivery
JM Chan (2009)
10.1073/pnas.0905998106
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
Benjamin C Tang (2009)
10.1007/978-1-60761-609-2_11
Polymeric nanoparticles for drug delivery.
J. M. Chan (2010)
10.1007/BF03188928
Drug targeting with nanoparticles
J. Kreuter (2010)
10.3310/HTA8260
EVALUATE hysterectomy trial: a multicentre randomised trial comparing abdominal, vaginal and laparoscopic methods of hysterectomy.
R. Garry (2004)
10.1159/000055275
Molecular Bases for the Actions of Ovarian Sex Steroids in the Regulation of Proliferation and Apoptosis of Human Uterine Leiomyoma
H. Matsuo (1999)
10.1159/000095627
Gene Therapy of Uterine Leiomyoma: Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Treatment Inhibits Growth of Human and Rat Leiomyoma Cells in vitro and in a Nude Mouse Model
S.A. Salama (2006)
10.1016/j.jsgi.2006.09.003
Estrogen Metabolite 2-Methoxyestradiol Induces Apoptosis and Inhibits Cell Proliferation and Collagen Production in Rat and Human Leiomyoma Cells: A Potential Medicinal Treatment for Uterine Fibroids
S. Salama (2006)
10.1021/MA049853S
Synthesis and characterization of PEG-based ether-anhydride terpolymers: Novel polymers for controlled drug delivery
J. Fu (2004)
10.1128/JVI.00876-10
Structure of the Recombinant Alphavirus Western Equine Encephalitis Virus Revealed by Cryoelectron Microscopy
M. Sherman (2010)
10.1016/j.biomaterials.2008.12.013
PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery.
J. M. Chan (2009)
10.1016/j.ejpb.2008.11.012
Development of new lipid-based paclitaxel nanoparticles using sequential simplex optimization.
X. Dong (2009)
10.1016/j.ijpharm.2008.11.016
Studies on bioadhesive PLGA nanoparticles: A promising gene delivery system for efficient gene therapy to lung cancer.
W. Zou (2009)
10.4161/cbt.5.1.2349
Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors
W. Dahut (2006)
10.1016/J.YMTHE.2006.08.642
Gene therapy of uterine leiomyoma: adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir treatment inhibits growth of human and rat leiomyoma cells in vitro and in a nude mouse model.
S. Salama (2006)
10.1016/S0142-9612(02)00182-5
New polymeric carriers for controlled drug delivery following inhalation or injection.
Jie Fu (2002)
10.1161/01.RES.0000233318.85181.2e
2-Methoxyestradiol, an Estradiol Metabolite, Inhibits Neointima Formation and Smooth Muscle Cell Growth via Double Blockade of the Cell Cycle
F. Barchiesi (2006)
10.1016/S0168-3659(00)00339-4
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
10.1093/AJCP/94.4.435
The frequency of uterine leiomyomas.
S. Cramer (1990)
10.1371/journal.pone.0007356
Catechol-O-Methyltransferase Expression and 2-Methoxyestradiol Affect Microtubule Dynamics and Modify Steroid Receptor Signaling in Leiomyoma Cells
S. Salama (2009)



This paper is referenced by
10.17116/ROSAKUSH20181805136
Biological role and therapeutic potential of phytoflavonoids and vitamin D in the treatment of patients with uterine myoma, as well as other promising pharmacological directions
S. N. Buyanova (2018)
10.22358/JAFS/65623/2015
Nanobiotechnology in reproduction – pros and cons. A review
M. Zielińska-Górska (2015)
10.1201/9781315374581-30
Applications of nanotechnology in reproductive medicine
Céline Jones (2017)
10.3109/17435390.2014.984251
Microvascular and mitochondrial dysfunction in the female F1 generation after gestational TiO2 nanoparticle exposure
P. Stapleton (2015)
10.1016/j.ajog.2016.06.036
Statin use and uterine fibroid risk in hyperlipidemia patients: a nested case-control study.
M. Borahay (2016)
10.1016/j.nano.2014.01.001
Nanotechnology in reproductive medicine: emerging applications of nanomaterials.
N. Barkalina (2014)
10.1007/s43032-020-00248-w
Liposomal 2-Methoxyestradiol Nanoparticles for Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model
M. Borahay (2020)
10.1055/s-0037-1606303
New and Emerging Therapies for Uterine Fibroids
K. Fritton (2017)
10.2147/IJN.S97572
Nanomedicine applications in women’s health: state of the art
Oliver Lloyd-Parry (2018)
10.1007/s13346-017-0423-2
Drug delivery for the treatment of endometriosis and uterine fibroids
D. Friend (2017)
10.1016/j.biochi.2019.05.001
Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington's disease (HD) and spinocerebellar ataxia (SCAs).
Eshan Khan (2019)
The Peep of Nanotechnology in Reproductive Medicine: A Mini-review
M. Razi (2015)
10.4155/tde.15.79
Transport of digoxin-loaded polymeric nanoparticles across BeWo cells, an in vitro model of human placental trophoblast.
N. Albekairi (2015)
Semantic Scholar Logo Some data provided by SemanticScholar