Online citations, reference lists, and bibliographies.
← Back to Search

Headache At The Onset Of Stroke: Frequencies, Background Characteristics And Correlation With Mortality

K. Shigematsu, H. Nakano, Y. Watanabe, Tatsuyuki Sekimoto, Kouichiro Shimizu, Akihiko Nishizawa, Atsushi Okumura, M. Makino, T. Seki, K. Bando, Y. Kitagawa
Published 2013 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Background: Headache is a common symptom and sometimes makes patients worry about stroke. Some stroke patients actually have headache. However, the frequency of headache at the onset of stroke and the relationship between headache and outcomes are not fully clarified. Objective: The aim of the study is to clarify frequency of headache, and to compare patients with headache with patients without headache in their characteristics, risk factors and early mortalities. Methods: We confirmed the presence or absence of onset headache in 1671 patients in the Kyoto Stroke Registry. We studied frequencies of headache, age, sex, blood pressure, arrhythmia, diabetes mellitus, hyperlipemia, tobacco and alcohol use and mortality of stroke patients. Results: Headache was observed in 21.4% of stroke patients; 12.0% in cerebral infarction (CI), 29.8% in cerebral hemorrhage (CH), and 93.9% in subarachnoid hemorrhage (SAH). Blood pressure at the first medical examination after stroke was higher in patients with headache. Factors associated with headache were age, diastolic blood pressure, hypertension and hyperlipemia histories, alcohol use, and paresis in CI, age, alcohol and tobacco use and paresis in CH and systolic blood pressure in SAH. The mortality rate 30 days after the stroke event was higher by 6.8% in CI and by 11.4% in CH in patients with headache than that in patients without headache. The hazard ratios for death between patients with headache and patients without headache were 4.94 (1.73 - 14.08, p = 0.003) in CI, and 3.20 (1.10 - 9.36, p = 0.033) in CH. Conclusions: Headache is common in stroke and predicts outcome. Headache is associated with younger age and alcohol use in CI and CH. Patients who could express presence of headache at the onset of CI or CH have higher mortality than patients who could express absence of headache. Headache is important both as an identifier of stroke and as a poor prognostic indicator in stroke.
This paper references
10.1007/s11606-012-2226-y
Prediction of Recovery, Dependence or Death in Elders Who Become Disabled During Hospitalization
D. Barnes (2012)
10.1016/S0140-6736(05)66779-7
Incidence, 30-day case-fatality rate, and prognosis of stroke in Iquique, Chile: a 2-year community-based prospective study (PISCIS project)
P. Lavados (2005)
10.1111/j.1526-4610.1994.hed3409531.x
Plasma Monoamines in Tension‐Type Headache
J. Castillo (1994)
10.1016/S1474-4422(10)70313-6
Neurological complications of acute ischaemic stroke
J. Balami (2011)
10.1016/j.jstrokecerebrovasdis.2008.04.009
Clinical characteristics of subarachnoid hemorrhage with or without headache.
M. Naganuma (2008)
10.5811/westjem.2011.2.1765
Cardiac Complications in Acute Ischemic Stroke
C. Wira (2011)
10.1016/0140-6736(91)90005-A
Migraine pain associated with middle cerebral artery dilatation: reversal by sumatriptan
L. Friberg (1991)
Headache in stroke : The Copenhagen Stroke Study
D. E. Barnes (1994)
10.1177/0333102409352911
Hypnic headache secondary to haemangioblastoma of the cerebellum
William J Mullally (2010)
10.1136/emermed-2012-201586
Vomiting should be a prompt predictor of stroke outcome
K. Shigematsu (2012)
10.1046/j.1468-2982.1994.1401037.x
Headache in Acute Cerebrovascular Disease: A Prospective Clinical Study in 240 Patients
A. Arboix (1994)
10.1136/emermed-2011-200088
Atraumatic headache in US emergency departments: recent trends in CT/MRI utilisation and factors associated with severe intracranial pathology
J. W. Gilbert (2011)
10.1038/nrneurol.2011.47
Stroke: Predicting outcome after ischemic stroke—hard but achievable
J. Baron (2011)
10.4236/HEALTH.2010.22017
Socio-demographic determinants of health status of elderly with self-reported diagnosed chronic medical conditions in Jamaica
P. A. Bourne (2010)
10.1177/0333102410392068
Multimodal neuroimaging in a child with sporadic hemiplegic migraine: A contribution to understanding pathogenesis
I. Toldo (2011)
10.1161/01.STR.24.11.1621
Headache in Stroke
K. Vestergaard (1993)
10.4236/HEALTH.2011.35052
The efficacy of ma-huang-tang (maoto) against influenza
M. Saita (2011)
10.1001/ARCHNEUR.1996.00550040037012
'Malignant' middle cerebral artery territory infarction: clinical course and prognostic signs.
W. Hacke (1996)
10.1136/jnnp.58.4.490
Headache at stroke onset: the Lausanne Stroke Registry.
E. Kumral (1995)
10.1001/ARCHNEUR.62.3.393
Neurologic worsening during the acute phase of ischemic stroke.
C. Weimar (2005)
10.1093/BJA/57.1.18
Brain oedema following brain ischaemia and the influence of therapy.
I. Klatzo (1985)
10.1161/01.STR.0000157662.09551.e5
Sex Differences in Stroke Care and Outcomes: Results From the Registry of the Canadian Stroke Network
M. Kapral (2005)
Experience from a multicentre stroke register: a preliminary report.
S. Hatano (1976)
10.1136/emermed-2011-200760
Modified early warning score with rapid lactate level in critically ill medical patients: the ViEWS-L score
Sion Jo (2012)
10.1001/JAMA.1980.03310080028019
Pitfalls in the recognition of subarachnoid hemorrhage.
H. Adams (1980)
10.1111/j.1468-2982.2005.01012.x
Factors Determining Headache at Onset of Acute Ischemic Stroke
P. Mitsias (2006)
10.1212/WNL.44.10.1793
Headache in stroke
H. Jørgensen (1994)
10.1136/emj.2010.109090
The value of the Mortality in Emergency Department Sepsis (MEDS) score, C reactive protein and lactate in predicting 28-day mortality of sepsis in a Dutch emergency department
M. Hermans (2011)
10.1136/emj.2009.079186
Intracranial hypotension: an unusual cause of headache in the emergency department
Y. Weng (2010)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar