Online citations, reference lists, and bibliographies.
← Back to Search

Phytochemicals In Ocular Health: Therapeutic Potential And Delivery Challenges

Goutham R. Adelli, R. Srirangam, S. Majumdar
Published 2013 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
This paper references
10.1016/J.EJPHAR.2004.07.046
Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas.
S. Ayalasomayajula (2004)
10.1136/BJO.85.3.366
The absence of diabetic retinopathy in patients with retinitis pigmentosa: implications for pathophysiology and possible treatment
Arden Gb (2001)
10.1016/S0092-8674(00)81318-5
NF-κB: Ten Years After
P. Baeuerle (1996)
10.1076/ceyr.27.6.345.18187
Effect of P-glycoprotein on the ocular disposition of a model substrate, quinidine
Sridhar Duvvuri (2003)
10.1167/iovs.08-2666
Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation.
S. Kubota (2009)
10.1016/0039-6257(79)90158-9
The blood-ocular barriers.
J. Cunha-Vaz (1979)
10.2174/1381612043383142
Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide.
J. Wilkinson-Berka (2004)
10.1167/IOVS.06-0464
alpha-lipoic acid corrects late-phase supernormal retinal oxygenation response in experimental diabetic retinopathy.
R. Roberts (2006)
10.1007/s00125-006-0174-y
Effect of R-(+)-α-lipoic acid on experimental diabetic retinopathy
J. Lin (2006)
10.1016/S0024-3205(00)00809-2
Effects of baicalein and wogonin on drug-metabolizing enzymes in C57BL/6J mice.
Y. Ueng (2000)
10.1167/IOVS.05-0945
Concentrations of betaxolol in ocular tissues of patients with glaucoma and normal monkeys after 1 month of topical ocular administration.
G. Holló (2006)
Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats.
X. Li (2009)
10.1016/0891-5849(94)00240-K
Flavonoids as antioxidant agents: importance of their interaction with biomembranes.
A. Saija (1995)
10.3109/00498251003663724
Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives
N. Srinivas (2010)
10.1172/JCI118962
Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.
M. Kuroki (1996)
10.1007/s00417-007-0728-9
Quercetin inhibits choroidal and retinal angiogenesis in vitro
Y. Chen (2007)
Meeting ReviewNF-κB: Ten Years After
Patrick A. Baeuerle (1996)
10.1093/JN/133.9.2802
The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors.
R. Cermak (2003)
10.1186/1743-7075-4-8
Effects of curcumin on retinal oxidative stress and inflammation in diabetes
R. Kowluru (2007)
10.1016/S1470-2045(03)01220-8
Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents?
G. Gasparini (2003)
10.1016/0306-4522(93)90473-S
The role of müller cells in the formation of the blood-retinal barrier
S. Tout (1993)
10.1089/jop.2007.0073
Quercetin attenuates UV- and H(2)O(2)-induced decrease of collagen type I in cultured human lens epithelial cells.
Q. Jiang (2008)
10.1167/IOVS.02-0346
Topical nepafenac inhibits ocular neovascularization.
K. Takahashi (2003)
10.1136/BMJ.326.7395.924
ABC of diabetes: Retinopathy
P. Watkins (2003)
10.1002/j.1460-2075.1989.tb08557.x
Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT‐20 cells.
J. Plouët (1989)
Effect of curcumin on galactose-induced cataractogenesis in rats.
P. Suryanarayana (2003)
10.1002/dmrr.562
Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy
S. Yatoh (2006)
10.3109/02713683.2010.506970
Inhibitory Effect of Epigallocatechin Gallate (EGCG), Resveratrol, and Curcumin on Proliferation of Human Retinal Pigment Epithelial Cells In Vitro
A. Alex (2010)
The regional distribution of vitamins E and C in mature and premature human retinas.
J. Nielsen (1988)
10.1016/S0014-4835(03)00023-X
Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration.
Fong-Qi Liang (2003)
10.1167/IOVS.02-0655
Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia.
W. Lukiw (2003)
10.1167/iovs.08-2642
Baicalein reduces inflammatory process in a rodent model of diabetic retinopathy.
L. Yang (2009)
10.1124/JPET.103.052167
A Selective and Oral Small Molecule Inhibitor of Vascular Epithelial Growth Factor Receptor (VEGFR)-2 and VEGFR-1 Inhibits Neovascularization and Vascular Permeability
N. Patel (2003)
10.1194/JLR.M200292-JLR200
Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress Published, JLR Papers in Press, November 4, 2002. DOI 10.1194/jlr.M200292-JLR200
M. Balestrieri (2003)
10.1677/JME.1.02008
Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy.
S. Zhang (2006)
10.1016/J.MRFMMM.2005.03.025
Pharmacological consequences of oxidative stress in ocular tissues.
S. Ohia (2005)
[Swimming pool granuloma].
F. Nürnberger (1968)
10.1007/s00011-007-7005-6
Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma
A. P. Rogerio (2007)
10.3109/10408449309104073
Free radicals as mediators of tissue injury and disease.
J. Kehrer (1993)
10.1089/jop.2010.0123
Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms.
S. K. Gupta (2011)
10.1161/01.RES.83.3.295
Hypoxia induces high-mobility-group protein I(Y) and transcription of the cyclooxygenase-2 gene in human vascular endothelium.
Y. Ji (1998)
10.1258/ebm.2011.010395
Baicalein potently suppresses angiogenesis induced by vascular endothelial growth factor through the p53/Rb signaling pathway leading to G1/S cell cycle arrest
Y. Ling (2011)
10.1167/IOVS.04-0925
Functional characterization and comparison of the outer blood-retina barrier and the blood-brain barrier.
Heiko Steuer (2005)
10.1155/2007/43603
Oxidative Stress and Diabetic Retinopathy
R. Kowluru (2007)
10.1167/IOVS.02-1068
Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles.
Jean-Louis Bourges (2003)
10.1006/ABBI.1995.1493
DNA Damage and Oxidation of Thiols Peroxynitrite Causes in Rat Thymocytes
M. G. Salgo (1995)
10.1016/S0014-2999(02)02848-0
Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential.
W. Tan (2003)
10.1515/znc-2003-7-823
Propolis and Some of its Constituents Down-Regulate DNA Synthesis and Inflammatory Cytokine Production but Induce TGF-β1 Production of Human Immune Cells
S. Ansorge (2003)
10.3341/kjo.2007.21.4.232
Protective Effects of Epigallocatechin Gallate after UV Irradiation in Cultured Human Retinal Pigment Epithelial Cells
Seongwon Yang (2007)
10.1016/S1470-2045(01)00488-0
Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer.
A. Dannenberg (2001)
10.1211/jpp.59.5.0002
Cyclodextrin microparticles for drug delivery to the posterior segment of the eye: aqueous dexamethasone eye drops
T. Loftsson (2007)
10.1006/BBRC.1996.0568
Vascular endothelial growth factor is induced by long-term high glucose concentration and up-regulated by acute glucose deprivation in cultured bovine retinal pigmented epithelial cells.
H. Sone (1996)
Biological effects of hesperidin, a citrus flavonoid. (Note I): antiinflammatory and analgesic activity.
E. M. Galati (1994)
10.1016/j.preteyeres.2008.10.001
Molecular pathology of age-related macular degeneration
X. Ding (2009)
Sustained stress response after oxidative stress in trabecular meshwork cells
Guorong Li (2007)
10.1016/S0014-4835(95)80063-8
Development of the blood-retinal barrier in vitro: formation of tight junctions as revealed by occludin and ZO-1 correlates with the barrier function of chick retinal pigment epithelial cells.
K. Konari (1995)
10.1089/15209150050502023
New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets.
T. Gardner (2000)
10.2133/DMPK.DMPK-10-RG-044
Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.
L. Quintieri (2010)
10.1136/BMJ.285.6339.425
Diabetic complications: retinopathy.
P. Watkins (1982)
10.1126/SCIENCE.6823562
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
D. Senger (1983)
Antioxidant-dependent amelioration of brain injury: role of CuZn-superoxide dismutase.
P. Chan (1992)
Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy
R. Mancino (2011)
10.1016/j.brainres.2007.05.029
Epigallocatechin gallate, an active ingredient from green tea, attenuates damaging influences to the retina caused by ischemia/reperfusion
B. Zhang (2007)
10.1016/J.TOX.2006.06.018
Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity.
G. Kaur (2006)
10.1159/000054070
Adhesion Molecule Expression in Postischemic Microvascular Dysfunction: Activity of a Micronized Purified Flavonoid Fraction
R. Korthuis (1999)
10.3892/OR_00000411
Curcumin induces apoptosis through FAS and FADD, in caspase-3-dependent and -independent pathways in the N18 mouse-rat hybrid retina ganglion cells.
H. Lu (2009)
10.1016/j.biomaterials.2009.08.025
Subconjunctivally implantable hydrogels with degradable and thermoresponsive properties for sustained release of insulin to the retina.
G. P. Misra (2009)
10.1054/bjoc.2000.1691
EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells
Y. Jung (2001)
10.1007/s592-001-8076-6
Diabetes-induced elevations in retinal oxidative stress, protein kinase C and nitric oxide are interrelated
R. Kowluru (2001)
Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase, SOD-1, and HO-1 expression
Y. Zheng (2010)
10.1172/JCI114322
Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.
D. Connolly (1989)
10.1016/J.BBRC.2007.07.059
Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina.
T. Mrudula (2007)
10.1371/journal.pone.0023194
Curcumin Inhibits Neuronal and Vascular Degeneration in Retina after Ischemia and Reperfusion Injury
L. Wang (2011)
10.1016/S0378-4274(00)00191-0
Dietary curcumin prevents ocular toxicity of naphthalene in rats.
U. Pandya (2000)
10.1167/IOVS.04-1369
Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death.
A. Hanneken (2006)
10.1093/JNCI/69.2.475
Role of prostaglandin E1 and copper in angiogenesis.
M. Ziche (1982)
10.1016/j.jpba.2010.01.015
Development and validation of a fast and sensitive bioanalytical method for the quantitative determination of glucocorticoids--quantitative measurement of dexamethasone in rabbit ocular matrices by liquid chromatography tandem mass spectrometry.
R. Earla (2010)
10.1038/nrd2060
Therapeutic potential of resveratrol: the in vivo evidence
J. Baur (2006)
10.1016/J.EJPHAR.2007.01.048
Effect of magnolol on TGF-beta1 and fibronectin expression in human retinal pigment epithelial cells under diabetic conditions.
Y. Kim (2007)
10.2174/156720106776359186
Review of ocular drug delivery.
Y. Sultana (2006)
10.1016/S0304-3835(03)00386-0
Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line.
K. Sakata (2003)
10.1016/J.BBRC.2006.06.153
Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.
Susan E Pollard (2006)
10.1074/JBC.275.14.10405
Curcuminoids Inhibit the Angiogenic Response Stimulated by Fibroblast Growth Factor-2, Including Expression of Matrix Metalloproteinase Gelatinase B*
R. Mohan (2000)
Nutritional Supplements for Age-Related Macular Degeneration: A Systematic Review
D. Kansagara (2012)
10.1076/CEYR.17.9.875.5134
Modulation of VEGF production by pH and glucose in retinal Müller cells.
S. Brooks (1998)
10.1074/jbc.M203201200
Cyclooxygenase-2 and Presenilin-1 Gene Expression Induced by Interleukin-1β and Amyloid β42 Peptide Is Potentiated by Hypoxia in Primary Human Neural Cells*
N. Bazan (2002)
Polarity and the development of the outer blood-retinal barrier.
L. Rizzolo (1997)
10.1074/jbc.M800268200
Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells
A. Fernandes (2008)
10.1016/S0197-0186(00)00112-1
Retinal glutamate in diabetes and effect of antioxidants
R. Kowluru (2001)
10.1016/S0278-6915(01)00125-9
In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids.
V. Breinholt (2002)
10.1161/01.CIR.0000051367.92927.07
High Glucose Causes Upregulation of Cyclooxygenase-2 and Alters Prostanoid Profile in Human Endothelial Cells: Role of Protein Kinase C and Reactive Oxygen Species
F. Cosentino (2003)
10.1007/s10456-007-9067-z
Vascular permeability in ocular disease and the role of tight junctions
K. Erickson (2007)
10.1046/J.1365-2168.1998.00787.X
Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischaemia–reperfusion injury: an experimental study
I. Huk (1998)
10.1167/iovs.09-3510
Enhanced diabetes-induced cataract in copper-zinc superoxide dismutase-null mice.
Eva M Olofsson (2009)
Kinetics of radical-scavenging activity of hesperetin and hesperidin and their inhibitory activity on COX-2 expression.
A. Hirata (2005)
10.1016/j.pneurobio.2011.05.011
Age related macular degeneration and drusen: Neuroinflammation in the retina
Elisa Buschini (2011)
10.1016/S0014-4835(77)80043-2
Prostaglandin and non-prostaglandin mediated breeakdown of the blood-aqueous barrier.
K. Eakins (1977)
10.1016/S0891-5849(02)00843-2
Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract.
Kelly M Cornish (2002)
Protective effect of quercetin on ischemia/reperfusion-induced gastric mucosal injury in rats.
J. Mojžiš (2001)
10.1097/00005344-199308000-00009
Inhibitory Effect of the Ruscus Extract and of the Flavonoid Hesperidine Methylchalcone on Increased Microvascular Permeability Induced by Various Agents in the Hamster Cheek Pouch
E. Bouskela (1993)
[Effects of oxidative stress on the expression of endothelial-leukocyte adhesion molecule-1 in porcine trabecular meshwork cells].
Qi Zhou (2007)
10.1016/S0008-6363(00)00084-5
Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy.
P. Hardy (2000)
10.1517/14712598.3.1.45
Drug delivery to the retina: challenges and opportunities
Sridhar Duvvuri (2003)
10.1016/S0161-6420(87)33400-1
Retinopathy of prematurity. A randomized, prospective trial of transcutaneous oxygen monitoring.
J. Flynn (1987)
10.1016/j.visres.2009.08.018
Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration
M. Cano (2010)
10.1167/IOVS.05-0397
Flavonoids protect retinal ganglion cells from oxidative stress-induced death.
P. Maher (2005)
10.1089/jop.2010.0144
Antioxidant effect of trans-resveratrol in cultured human retinal pigment epithelial cells.
A. Pintea (2011)
10.1089/108076804773710777
Effects of some natural flavonoids on retinal function recovery after ischemic insult in the rat.
G. Chiou (2004)
10.2337/DIABETES.51.5.1565
Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells.
T. Sato (2002)
10.1038/nm950
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
J. Ambati (2003)
10.1167/IOVS.04-0633
Role of interleukin-1beta in the development of retinopathy in rats: effect of antioxidants.
R. Kowluru (2004)
10.1016/j.exer.2009.12.004
Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways.
M. Chen (2010)
10.1177/1358863X9600100403
Vascular Permeability/Vascular Endothelial Growth Factors: A Potential Role in the Pathogenesis and Treatment of Vascular Diseases
B. Williams (1996)
10.1111/j.1349-7006.2009.01241.x
(–)‐Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor–vascular endothelial growth factor receptor axis
Yohei Shirakami (2009)
10.1002/CM.970180304
Microvascular endothelial-derived autacoids regulate pericyte contractility.
A. B. Dodge (1991)
Local injection of receptor tyrosine kinase inhibitor MAE 87 reduces retinal neovascularization in mice.
Anke S. Unsoeld (2004)
10.1167/IOVS.06-1304
Responses of human lens epithelial cells to quercetin and DMSO.
Xiao-guang Cao (2007)
10.1079/BJN20041397
Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids.
Y. Jeong (2005)
10.1161/01.CIR.97.1.99
Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin.
T. Murohara (1998)
10.1158/1535-7163.MCT-05-0490
Green tea extract and (−)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1α protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells
Q. Zhang (2006)
10.1186/1756-9966-28-80
Preventive effect of the flavonoid, quercetin, on hepatic cancer in rats via oxidant/antioxidant activity: molecular and histological evidences
A. Seufi (2009)
10.1167/IOVS.02-0473
Apical and basal regulation of the permeability of the retinal pigment epithelium.
S. Peng (2003)
10.1371/journal.pone.0021193
Rescue of Photoreceptor Degeneration by Curcumin in Transgenic Rats with P23H Rhodopsin Mutation
V. Vasireddy (2011)
10.1111/j.1439-0264.2006.00736.x
Fine Structure of the Retinal Pigment Epithelium, Bruch's Membrane and Choriocapillaris in the Camel
H. Altunay (2000)
10.1007/BF00146764
The blood-retinal barriers
J. Cunha-vaz (2004)
10.1016/j.cbi.2009.05.011
Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: An in vitro study using isolated lens.
R. Manikandan (2009)
10.1016/J.CBI.2004.11.003
Resveratrol reduces oxidation and proliferation of human retinal pigment epithelial cells via extracellular signal-regulated kinase inhibition.
R. E. King (2005)
10.1096/fj.03-1476fje
A central role for inflammation in the pathogenesis of diabetic retinopathy
A. Joussen (2004)
10.1089/jop.2010.0063
Baicalein significantly protects human retinal pigment epithelium cells against H₂O₂-induced oxidative stress by scavenging reactive oxygen species and downregulating the expression of matrix metalloproteinase-9 and vascular endothelial growth factor.
J. Liu (2010)
Epigallocatechin gallate protects against oxidative stress-induced mitochondria-dependent apoptosis in human lens epithelial cells
K. Yao (2008)
10.1016/0006-2952(90)90120-A
Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages.
C. V. de Whalley (1990)
10.3109/02713689308999484
The prevention of cataract caused by oxidative stress in cultured rat lenses. I. H2O2 and photochemically induced cataract.
A. Spector (1993)
10.1017/S146239941000164X
Oxidation and age-related macular degeneration: insights from molecular biology.
S. Khandhadia (2010)
10.1006/EXER.1993.1139
Digital image analysis of cultured rat lens during oxidative stress-induced cataractogenesis.
A. Bhatnagar (1993)
10.1126/SCIENCE.2479986
Vascular endothelial growth factor is a secreted angiogenic mitogen.
D. W. Leung (1989)
10.1179/joc.2005.17.1.86
Inhibition of P-Glycoprotein Function and Expression by Kaempferol and Quercetin
P. Limtrakul (2005)
10.1039/c2fo10224b
Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites.
Hiroko Takumi (2012)
10.1021/JM040099A
Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.
G. Kuo (2005)
10.1093/JN/136.5.1178
Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells.
Steven J T Jackson (2006)
10.1167/iovs.09-5144
Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin (STZ) model of diabetic retinopathy (DR).
V. R. Rao (2010)
10.1016/J.EXER.2006.05.015
Nutritional antioxidants and age-related cataract and maculopathy.
Chung-Jung Chiu (2007)
10.1111/J.1600-0420.2007.00885.X
Topical and systemic absorption in delivery of dexamethasone to the anterior and posterior segments of the eye.
H. Sigurdsson (2007)
10.1002/dmrr.1005
Baicalin reduces mitochondrial damage in streptozotocin‐induced diabetic Wistar rats
V. Waisundara (2009)
10.1167/iovs.07-0477
The protective effect of quercetin against oxidative stress in the human RPE in vitro.
D. Kook (2008)
10.1007/BF00968993
Liposome-entrapped superoxide dismutase reduces ischemia/reperfusion ‘oxidative stress’ in gerbil brain
D. Stanimirovic (2004)
10.1017/S0007114508966083
A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells.
I. Crespo (2008)
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
H. Dvorak (1995)
10.1038/eye.1990.41
Permeability of ocular vessels and transport across the blood-retinal-barrier
P. Törnquist (1990)
10.1007/s12272-001-2110-5
Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells
Hyo-Hyun Park (2008)
[Curcumin inhibits the proliferation of cultured human fetal retinal pigment epithelium cells].
L. Gong (2004)
10.1016/S0024-3205(00)00999-1
Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1.
G. Raso (2001)
10.1152/AJPCELL.1993.264.4.C866
Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia.
C. Michiels (1993)
10.1006/BBRC.1995.2578
Peroxynitrite causes apoptosis in rat thymocytes.
M. G. Salgo (1995)
10.1016/J.ABB.2005.09.021
Elevated expression of αA- and αB-crystallins in streptozotocin-induced diabetic rat
P. A. Kumar (2005)
Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor.
F. Kinose (2005)
10.1089/jmf.2011.0135
Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment.
A. S. Yar (2012)
10.1007/s002280000197
Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
I. Erlund (2000)
10.1079/BJN20061753
Divergent effects of quercetin conjugates on angiogenesis.
S. Donnini (2006)
10.1016/J.EXER.2007.11.009
Flavonoids protect retinal ganglion cells from ischemia in vitro.
P. Maher (2008)
10.1002/jcp.10246
VEGF‐TRAPR1R2 suppresses choroidal neovascularization and VEGF‐induced breakdown of the blood–retinal barrier
Yoshitsugu Saishin (2003)
10.1096/fj.01-0707fje
Nonsteroidal anti‐inflammatory drugs prevent early diabetic retinopathy via TNF‐α suppression
Antonia M. Joussen (2002)
10.1016/j.lfs.2011.05.003
Flavonoids: potential Wnt/beta-catenin signaling modulators in cancer.
Nathália G. Amado (2011)
10.1093/AJCN/64.5.761
Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses.
S. Awasthi (1996)
10.1016/S0304-3835(01)00443-8
Resveratrol and quercetin inhibit angiogenesis in vitro.
K. Igura (2001)
10.1167/IOVS.03-0351
Oxidative stress affects the junctional integrity of retinal pigment epithelial cells.
T. A. Bailey (2004)
10.1093/JN/135.6.1359
Quercetin Attenuates Nuclear Factor-κB Activation and Nitric Oxide Production in Interleukin-1β–Activated Rat Hepatocytes
S. Martínez-Flórez (2005)
10.1517/14728214.10.2.441
Current and future pharmacological intervention for diabetic retinopathy
G. Comer (2005)
10.1152/AJPCELL.2000.279.2.C341
Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells.
S. Zhuang (2000)
10.1016/S0891-5849(98)00262-7
Quercetin inhibits hydrogen peroxide-induced oxidation of the rat lens.
J. Sanderson (1999)
10.1007/s0023200100082
Effects of Hyperglycemia and Protein Kinase C on Connexin43 Expression in Cultured Rat Retinal Pigment Epithelial Cells
M. Malfait (2001)
10.1007/BF02569055
The blood-ocular barriers: past, present, and future
J. Cunha-Vaz (2007)
10.1172/JCI119392
Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor.
R. Tilton (1997)
10.1038/aps.2009.150
Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet
Hong-xia Guo (2009)
10.1076/CEYR.19.3.234.5320
Intraocular pressure-lowering activity of phenolic antioxidants in normotensive rabbits.
L. Hodges (1999)
10.1167/IOVS.05-0132
Drug intervention can correct subnormal retinal oxygenation response in experimental diabetic retinopathy.
B. Berkowitz (2005)
10.1007/s00210-004-0964-z
Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels
V. Calderone (2004)
10.1016/S0014-2999(02)02793-0
Celecoxib, a selective cyclooxygenase-2 inhibitor, inhibits retinal vascular endothelial growth factor expression and vascular leakage in a streptozotocin-induced diabetic rat model.
S. Ayalasomayajula (2003)
10.3181/00379727-172-41548
PGE2 and Angiogenesis 1
D. Form (1983)
10.1046/j.1440-1789.2002.00439.x
Degeneration of retinal neuronal processes and pigment epithelium in the early stage of the streptozotocin‐diabetic rats
Yoshinori Aizu (2002)
10.1016/S0049-3848(98)00216-3
Effect of a micronized purified flavonoid fraction on in vivo platelet functions in the rat.
L. McGregor (1999)
10.1016/j.fct.2008.10.029
Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells.
C. Luna (2009)
Effects of Mirtogenol® on ocular blood flow and intraocular hypertension in asymptomatic subjects
R. Steigerwalt (2008)
10.2174/187152810793358741
The role of quercetin, flavonols and flavones in modulating inflammatory cell function.
S. Chirumbolo (2010)
10.1007/BF02482607
Oxygen-induced retinopathy in the rat: Possible contribution of peroxidation reactions
J. Penn (2006)
10.3109/02713688408997188
Molecular mechanism of cataractogenesis: III. Toxic metabolites of oxygen as initiators of lipid peroxidation and cataract.
K. Bhuyan (1984)
10.1167/iovs.07-0419
Delayed disruption of barrier function in cultured human corneal epithelial cells induced by tumor necrosis factor-alpha in a manner dependent on NF-kappaB.
K. Kimura (2008)
10.1016/j.neuint.2008.09.004
The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes
S. H. Jung (2008)
10.1152/ajpheart.1997.273.5.H2224
Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells.
R. Natarajan (1997)
10.1016/S0014-5793(97)00469-9
What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?
B. Halliwell (1997)
10.1007/s00210-004-0994-6
Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin
F. Orallo (2004)
10.1016/J.FCT.2005.08.025
Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation.
Tatiana L Cirico (2006)
10.1039/b802662a
Dietary phenolics: chemistry, bioavailability and effects on health.
A. Crozier (2009)
10.1016/j.phrs.2009.10.005
Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice.
A. P. Rogerio (2010)
10.1016/S0014-4835(03)00116-7
Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line.
N. Nakamura (2003)
10.1074/jbc.M602110200
Pigment Epithelium-derived Factor Inhibits Advanced Glycation End Product-induced Retinal Vascular Hyperpermeability by Blocking Reactive Oxygen Species-mediated Vascular Endothelial Growth Factor Expression*
S. Yamagishi (2006)
10.1016/S0014-827X(01)01111-9
Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.
T. Guardia (2001)
10.1016/S0014-4835(05)80063-6
A brief photochemically induced oxidative insult causes irreversible lens damage and cataract. II. Mechanism of action.
A. Spector (1995)
10.1046/j.1442-9071.2000.00222.x
Retinal neurodegeneration: early pathology in diabetes
E. Lieth (2000)
10.1074/JBC.272.1.601
Hypoxia Induces Cyclooxygenase-2 via the NF-κB p65 Transcription Factor in Human Vascular Endothelial Cells*
J. F. Schmedtje (1997)
10.1006/EXER.1993.1174
The prevention of cataract caused by oxidative stress in cultured rat lenses. II. Early effects of photochemical stress and recovery.
A. Spector (1993)
10.1016/J.EXER.2005.10.029
P-Glycoprotein expression in human retinal pigment epithelium cell lines.
P. Constable (2006)
10.2217/17435889.2.1.11
Ocular drug delivery: nanomedicine applications.
J. Vandervoort (2007)
10.1016/J.BCP.2005.03.014
Down-regulatory effect of quercitrin gallate on nuclear factor-kappa B-dependent inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7.
B. H. Kim (2005)
10.1080/10715760310001604189
Diabetes-induced Activation of Nuclear Transcriptional Factor in the Retina, and its Inhibition by Antioxidants
R. Kowluru (2003)
Flavonoids and nitric oxide synthase.
R. Olszanecki (2002)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar