Online citations, reference lists, and bibliographies.
← Back to Search

Immunohistochemistry And Molecular Diagnostics Of Pleural Malignant Mesothelioma.

P. Betta, C. Magnani, T. Bensi, N. Trincheri, S. Orecchia
Published 2012 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
CONTEXT The pathologic approach to pleural-based lesions is stepwise and uses morphologic assessment, correlated with clinical and imaging data supplemented by immunohistochemistry (IHC), and more recently, molecular tests, as an aid for 2 main diagnostic problems: malignant mesothelioma (MM) versus other malignant tumors and malignant versus reactive mesothelial proliferations. OBJECTIVE To present the current knowledge regarding IHC and molecular tests with respect to MM diagnosis, and in particular, the differentiation of the epithelioid type of MM from carcinoma metastatic to the pleural cavity. DATA SOURCES A review of immunohistochemical features of 286 consecutive MMs from 459 cases of pleural pathology, diagnosed during routine practice from 2003 to 2009. A survey of biomedical journal literature from MedLine/PubMed (US National Library of Medicine) focused on MM and associated tissue-based diagnostic IHC markers and molecular tests. CONCLUSIONS The search for a single diagnostic marker of MM has so far been discouraging, given the biologic and phenotypic tumor heterogeneity of MM. The use of antibody panels has gained unanimous acceptance especially in the differential diagnosis between MM and metastatic carcinoma, whereas the usefulness of IHC is more limited when dealing with spindle cell malignancies or distinguishing malignant from reactive mesothelium. A great degree of interlaboratory variability in antibody combinations and clone selection within diagnostic panels still exists. Current investigations aim at selecting the most suitable and cost-effective combination of antibodies by using novel statistical approaches for assessing diagnostic performance beyond the traditional measures of sensitivity and specificity.
This paper references
[Malignant mesothelioma].
J. Espinosa Arranz (1994)
Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group.
A. Husain (2009)
Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity
H. Yaziji (2006)
Sarcomatoid mesothelioma: a clinical–pathologic correlation of 326 cases
S. Klebe (2010)
MicroRNA expression profiles classify human cancers
J. Lu (2005)
Sensitivity and specificity of immunohistochemical markers used in the diagnosis of epithelioid mesothelioma: a detailed systematic analysis using published data
J. King (2006)
Immunohistochemistry of pulmonary and pleural neoplasia.
M. Beasley (2008)
Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles.
B. Christensen (2009)
Distinguishing benign mesothelial hyperplasia from neoplasia: a practical approach.
R. Kradin (2006)
Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review
S. Klebe (2008)
The diagnostic value of Ki-67 and repp86 in distinguishing between benign and malignant mesothelial proliferations.
Z. Taheri (2008)
Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.
Y. Goto (2009)
Genomic events associated with progression of pleural malignant mesothelioma
S. V. Ivanov (2009)
Emerging methods for analysis of the cancer methylome.
J. W. Chang (2008)
Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas
S. Chiosea (2008)
Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma
Y. Kato (2007)
Expression of Cytokeratin 5/6 in Epithelial Neoplasms: An Immunohistochemical Study of 509 Cases
P. Chu (2002)
Immunohistochemical detection of XIAP in mesothelium and mesothelial lesions.
M. Wu (2007)
Immunohistochemical marker panels for distinguishing between epithelioid mesothelioma and lung adenocarcinoma
K. Kushitani (2007)
Anti‐mesothelial markers in sarcomatoid mesothelioma and other spindle cell neoplasms
R. Attanoos (2000)
Malignant mesothelioma of the pleura. The reproducibility of the immunohistological diagnosis.
P. Betta (1997)
PAX8 Reliably Distinguishes Ovarian Serous Tumors From Malignant Mesothelioma
Anna R. Laury (2010)
Malignant epithelioid mesothelioma: anti‐mesothelial marker expression correlates with histological pattern
R. Attanoos (2001)
[Differential diagnosis of preneoplastic lesions of the pleura and of early mesothelioma: immunohistochemical and morphological findings].
M. Krismann (2006)
Diagnostic importance of 9 p 21 homozygous deletion in malignant mesothelio
S Chiosea (2008)
9p21 deletion in the diagnosis of malignant mesothelioma, using fluorescence in situ hybridization analysis
M. Takeda (2010)
Malignant epithelioid mesothelioma: anti-mesothelial marker expression correlates with histologic pattern. Histopathology
RL Attanoos (2001)
D. Hawes (2006)
Calretinin expression in human normal and neoplastic tissues: a tissue microarray analysis on 5233 tissue samples.
A. Lugli (2003)
Cell proliferation rate and telomerase activity in the differential diagnosis between benign and malignant mesothelial proliferations
Çağlar Çakır (2006)
Tumors of the serosal membranes
H. Battifora (1995)
D2-40 and calretinin—a tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation
Marc Hinterberger (2007)
Sensitivity and specificity of immunohistochemical markers used in the diagnosis of epithelioid mesothelioma: a detailed systematic analysis using published data. Histopathology
JE King (2006)
Calretinin and Other Mesothelioma Markers in Synovial Sarcoma: Analysis of Antigenic Similarities and Differences With Malignant Mesothelioma
M. Miettinen (2001)
Tenascin-X is a Novel Diagnostic Marker of Malignant Mesothelioma
Y. Yuan (2009)
Genome-Wide Profile of Pleural Mesothelioma versus Parietal and Visceral Pleura: The Emerging Gene Portrait of the Mesothelioma Phenotype
O. D. Røe (2009)
Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma
G. V. Gee (2010)
Spindle cell tumors of the pleura: differential diagnosis.
M. Rdzanek (2006)
The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium. A novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet‐derived growth factor‐receptor, P‐glycoprotein and Bcl‐2
R. Attanoos (2003)
Molecular deletion of 9p sequences in non‐small cell lung cancer and malignant mesothelioma
R. Center (1993)
Immunodiagnosis of mesothelioma. Use of antimesothelial cell serum in an indirect immunofluorescence assay
G. Singh (1979)
Podoplanin is a Better Immunohistochemical Marker for Sarcomatoid Mesothelioma Than Calretinin
Diana M Padgett (2008)
Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma.
J. Bishop (2010)
Diagnosis of epithelial mesothelioma using tree‐based regression analysis and a minimal panel of antibodies
S. Klebe (2009)
Sarcomatoid mesothelioma and its histological mimics: a comparative immunohistochemical study
D. Lucas (2003)
Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma
Y. Takeshima (2009)
Recurrent deletions of specific chromosomal sites in 1p, 3p, 6q, and 9p in human malignant mesothelioma.
T. Taguchi (1993)
Evidence-based Guidelines for the Utilization of Immunostains in Diagnostic Pathology: Pulmonary Adenocarcinoma Versus Mesothelioma
A. Marchevsky (2007)
Recent Mortality from Pleural Mesothelioma, Historical Patterns of Asbestos Use, and Adoption of Bans: A Global Assessment
K. Nishikawa (2008)
9p21 Deletion in the diagnosis of malignant mesothelioma in serous effusions additional to immunocytochemistry, DNA‐ICM, and AgNOR analysis
F. Onofre (2008)
Expression of Calretinin, Thrombomodulin, Keratin 5, and Mesothelin in Lung Carcinomas of Different Types: An Immunohistochemical Analysis of 596 Tumors in Comparison With Epithelioid Mesotheliomas of the Pleura
M. Miettinen (2003)
Spindle cell tumours of the pleura: a clinical, histological and comparative genomic hybridization analysis of 14 cases
A. Knuuttila (2005)
CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma—A miRNA microarray analysis
Mohamed Guled (2009)
Molecular processes of chromosome 9p21 deletions causing inactivation of the p16 tumor suppressor gene in human cancer: deduction from structural analysis of breakpoints for deletions.
T. Kohno (2006)
Pulmonary sarcomatous tumors.
L. Litzky (2008)
Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways.
N. H. Heintz (2010)
Differential microRNA expression in pleural mesothelioma: Implications for early detection and prognostication
H. Pass (2008)
Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma
A. Scherpereel (2009)
Caveolin‐1 is a novel immunohistochemical marker to differentiate epithelioid mesothelioma from lung adenocarcinoma
V. Amatya (2009)
Classification and histologic features of epithelioid mesotheliomas
F Galateau-Salle (2006)

This paper is referenced by
Diagnostic value of immunopathology in malignant pleural tumors
Taghreed S. Farag (2018)
Sarcomatoid Mesothelioma: Future Advances in Diagnosis, Biomolecular Assessment, and Therapeutic Options in a Poor-Outcome Disease
Domenico Galetta (2016)
Molecular Classification of Malignant Pleural Mesothelioma: Identification of a Poor Prognosis Subgroup Linked to the Epithelial-to-Mesenchymal Transition
A. de Reyniès (2014)
Tumors of the lung and mediastinum
P. Chu (2014)
Diagnostic tools and staging of malignant pleural mesothelioma
Amy C. Powers (2015)
Malignant Mesothelioma Diagnosis.
Qudsia Arif (2015)
Establishing a panel of chemo-resistant mesothelioma models for investigating chemo-resistance and identifying new treatments for mesothelioma
A. Hudson (2014)
Title Molecular classification of malignant pleural mesothelioma : Identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition
Aurélien de Reyniès (2013)
Malignant pleural mesothelioma : novel biomarkers and related pathways
Filip Mundt (2013)
On the diagnosis of malignant pleural mesothelioma: A necropsy-based study of 171 cases (1997–2016)
P. Barbieri (2018)
The diagnosis of thoracic malignant mesothelioma: practical considerations and recent developments.
M. Smith (2014)
A rare cause of heart failure with preserved ejection fraction: primary pericardial mesothelioma masquerading as pericardial constriction
R. Fernandes (2014)
Mesothelioma-Hiding Behind the ‘‘Community Border’’: Case Report and Literature Review
Ricardo Villasmil (2018)
Immunohistochemical Differentiation between Reactive and Malignant Mesothelial Proliferations in Pleural Effusion
Mohebat H. Gouda (2019)
Pleural fluid biomarkers: beyond the Light criteria.
J. M. Porcel (2013)
Hepatic Mesotheliomas and Related Neoplasms
A. Zimmermann (2016)
III Italian Consensus Conference on Malignant Mesothelioma of the Pleura. Epidemiology, Public Health and Occupational Medicine related issues.
C. Magnani (2015)
Thoracic Neoplasia–Mesothelioma
Didier Jean (2014)
Pegylated liposomal doxorubicin in malignant pleural mesothelioma: a possible guardian for long-term survival
Paul Zarogoulidis (2012)
Establishment of anti-mesothelioma monoclonal antibodies
Natsuko Mizutani (2016)
DNA copy number gains in malignant pleural mesothelioma.
Masashi Furukawa (2015)
Chirurgische Aspekte des malignen Pleuramesothelioms
Annette Fisseler-Eckhoff (2012)
CD24: a potential new marker in differentiating malignant mesothelioma from pulmonary adenocarcinoma
D. Pinato (2012)
Chirurgische Aspekte des malignen Pleuramesothelioms
Aus Sicht der Pathologie (2013)
Pathological Diagnosis of Mesothelioma
Gabriella Fontanini (2019)
Prognostic factors in malignant pleural mesothelioma.
B. Davidson (2015)
Monoclonal Caveolin 1 Expression in the Differential Diagnosis of Malignant Pleural Mesothelioma and Pulmonary Adenocarcinoma: Is it Useful?
Zehra Bozdağ (2019)
D2-40, combined with calretinin, WT-1, CEA, and TTF-1, an immunohistochemical panel for differentiating malignant pleural mesothelioma from lung adenocarcinoma
Ghada E. Esheba (2013)
Mesothelioma: Update on Diagnostic Strategies
Carmen M. Rosario (2012)
The Third Italian Consensus Conference for Malignant Pleural Mesothelioma: State of the art and recommendations.
S. Novello (2016)
Hétérogénéité moléculaire des mésothéliomes pleuraux malins
Robin Tranchant (2017)
BIBLIOGRAPHIC REVIEW July 2016 Third Consensus Conference on Malignant Pleural Mesothelioma: State-of-the-art and recommendations
See more
Semantic Scholar Logo Some data provided by SemanticScholar