Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Novel Topical Drug Carriers As A Tool For Treatment Of Psoriasis: Progress And Advances

P. Suresh, P. Singh, S. Saraf
Published 2013 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Psoriasis is a chronic inflammatory skin disease portrayed by erythematous, papulosquamous lesions. It is characterized by excessive growth and aberrant differentiation of keratatinocytes. The conventional topical treatments that have been used in the past, such as coal tar and dithranol, have low efficacy, poor aesthetic and cosmetic appeal, leading to poor patient compliance while systemic therapies such as methotrexate, cyclosporine and acitretin  produce significant side effects. In recent years, several novel carriers like liposomes, nanostructured lipid carriers (NLC), etc. have been used in psoriasis, with promising results. Small and relatively narrow size distribution with novel carriers permits site specific delivery to the skin, with improved drug solubilization of hydrophobic drugs and bioavailability. This review highlights the recent advancements in the field of novel carriers for topical applications of antipsoriatic active moieties and bioactives.   Key words: Novel carriers, topical, antipsoriatic drugs, psoriasis, skin.
This paper references
10.3109/02652049309104381
Current progress and future prospects of liposomes in dermal drug delivery.
S. Moghimi (1993)
Percutaneous absorption and delivery systems.
P. Morganti (2001)
10.1016/S0378-5173(02)00632-4
Microemulsions for topical delivery of estradiol.
S. Peltola (2003)
10.1590/S1984-82502011000300008
Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design
M. S. Gambhire (2011)
10.1080/09546630601028729
A randomized, double‐blind, vehicle‐controlled study of a novel liposomal dithranol formulation in psoriasis
A. Saraswat (2007)
Tagetting psoriasis with new therapies
A Prohić (2007)
Vesicular carriers for topical delivery
V Meidan (1998)
10.1067/MJD.2003.103
Tazarotene cream in the treatment of psoriasis: Two multicenter, double-blind, randomized, vehicle-controlled studies of the safety and efficacy of tazarotene creams 0.05% and 0.1% applied once daily for 12 weeks.
G. Weinstein (2003)
Development and validation of a fast RP HPLC method for the determination of clobetasol propionate in topical nanocapsule suspensions . J . Chromatogr . Sci
MC Fontana (2010)
10.1016/S0738-081X(01)00183-3
Percutaneous absorption and delivery systems3
P. Morganti (2001)
Topical therapies for psoriasis: evidence-based review.
T. Afifi (2005)
10.1159/000086444
Cost-Effectiveness of Once-Daily Treatment with Calcipotriol/Betamethasone Dipropionate Followed by Calcipotriol Alone Compared with Tacalcitol in the Treatment of Psoriasis vulgaris
P. Peeters (2005)
Herbs : A potential source for the development of new pytomedicinals . Pharma . Rev
V Kumar (2003)
Preparation and quality evaluation of methotrexate microemulsion . China Pharm
XH Zhi (2011)
10.1358/mf.2008.30.4.1185802
Antipsoriatic microemulsion gel formulations for topical drug delivery of babchi oil (Psoralea corylifolia).
J. Ali (2008)
pathophysiology and management
B Bonnekoh (1991)
10.1016/J.IJPHARM.2005.12.019
Transdermal drug delivery using microemulsion and aqueous systems: influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems.
A. Sintov (2006)
10.1016/j.ijpharm.2010.09.007
Development, evaluation and clinical studies of Acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis.
Y. Agrawal (2010)
10.1016/j.ijpharm.2012.01.045
Physico-chemical characteristics of methotrexate-entrapped oleic acid-containing deformable liposomes for in vitro transepidermal delivery targeting psoriasis treatment.
Pathomthat Srisuk (2012)
10.1016/S0140-6736(05)64447-9
Circulating vascular permeability factor/vascular endothelial growth factor in erythroderma
D. Creamer (1996)
Liposome and proliposome based drug
B Dermatol. 25510-518. Nanjwade (2011)
10.1016/S0168-3659(00)00309-6
Microemulsions for topical delivery of 8-methoxsalen.
B. Baroli (2000)
10.1111/j.2042-7158.1997.tb06769.x
Absorption of Ciprofloxacin and Norfloxacin when Administered as Niosome‐encapsulated Inclusion Complexes
S. A. D'Souza (1997)
10.1016/j.ejpb.2009.07.011
Topical delivery of 5-aminolevulinic acid-encapsulated ethosomes in a hyperproliferative skin animal model using the CLSM technique to evaluate the penetration behavior.
Yi-Ping Fang (2009)
Liposome and proliposome based drug delivery : Paclitaxel loaded proliposome
B Nanjwade (2011)
10.4103/0378-6323.32709
Niosomal methotrexate gel in the treatment of localized psoriasis: phase I and phase II studies.
P. K. Lakshmi (2007)
10.1111/j.1365-2613.2009.00669.x
Angiogenesis drives psoriasis pathogenesis
R. Heidenreich (2009)
Tamoxifen in topical liposomes: development, characterization and in-vitro evaluation.
A. Bhatia (2004)
10.1016/j.jconrel.2012.09.018
Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models.
C. Marianecci (2012)
Liposomal methotrexate hydrogel for treatment of localized psoriasis: preparation, characterization and laser targeting.
M. F. Ali (2008)
10.1016/J.DET.2004.03.010
Current concepts in the immunopathogenesis of psoriasis.
M. A. Lowes (2004)
10.2174/157341311796196835
Enhanced Topical Delivery of Cyclosporin-A Using PLGA Nanoparticles as Carrier
S. Jain (2011)
10.1016/J.IJPHARM.2006.12.045
Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application.
W. Weyenberg (2007)
10.1046/j.1365-2133.2003.05437.x
Topical PTH (1–34) is a novel, safe and effective treatment for psoriasis: a randomized self‐controlled trial and an open trial
M. Holick (2003)
10.1056/NEJMOA021359
Methotrexate versus cyclosporine in moderate-to-severe chronic plaque psoriasis.
V. M. Heydendael (2003)
10.1517/17425247.5.1.119
Microemulsions as novel drug carriers: the formation, stability, applications and toxicity
H. Karasulu (2008)
liposomes in dermal drug delivery
P Morganti (2001)
Control Release 164:17-25
J. models (2012)
10.1001/ARCHDERM.135.9.1104
The immunologic and genetic basis of psoriasis.
B. Nickoloff (1999)
10.1046/j.1365-2133.1997.01845.x
Localization of endothelial proliferation and microvascular expansion in active plaque psoriasis
D. Creamer (1997)
10.1208/s12248-008-9078-8
Elastic Liposomal Formulation for Sustained Delivery of Colchicine: In Vitro Characterization and In Vivo Evaluation of Anti-gout Activity
H. Singh (2008)
10.1016/j.colsurfb.2009.09.033
Formulating fluticasone propionate in novel PEG-containing nanostructured lipid carriers (PEG-NLC).
S. Doktorovová (2010)
Microemulsion Based Transdermal Drug Delivery of Tea Tree Oil
K. Sonia (2011)
10.3109/08982104.2010.492476
Efficacy study of vesicular gel containing methotrexate and menthol combination on parakeratotic rat skin model
Amrita Nagle (2011)
10.1111/j.1365-2133.1978.tb01965.x
Suppression of epidermal proliferation by ultraviolet light, coal tar and anthralin
J. Walter (1978)
10.1016/J.CLINDERMATOL.2007.08.003
The clinical spectrum of psoriasis.
L. Naldi (2007)
10.1177/247553031117a00102
Psoriasis Treatments: A Review of the Current Research Pipeline
Alexandra K. Golant (2011)
Novasome-A Breakthrough in Pharmaceutical Technology
Anupama Singh (2013)
Vesicular carriers for topical
V Meidan (1998)
Niosomes As Drug Carriers
A. Namdeo (1996)
10.1517/14712598.2.7.723
Drug delivery across the skin
E. Touitou (2002)
Elastic liposomal
HP Singh (2009)
Suppression of epidermal DNA synthesis , suppression by ultraviolet light , coal tar and anthralin . Br . J . Dermatol
JF Walter (1978)
The antipsoriatic compound anthralin influence bioenergic parameters and redox properties of energy transducing membranes . J . Investig . Dermatol
J Fuchs (1990)
10.1016/j.colsurfb.2008.12.030
Development of different temoporfin-loaded invasomes-novel nanocarriers of temoporfin: characterization, stability and in vitro skin penetration studies.
Nina Dragicevic-Curic (2009)
10.1111/j.1365-4632.2007.03136.x
Optimal time for therapeutic drug monitoring of cyclosporine microemulsion in patients with psoriasis
Y. Umezawa (2007)
10.1016/J.IJPHARM.2003.10.006
Deformable liposomes for dermal administration of methotrexate.
M. Trotta (2004)
10.5012/BKCS.2011.32.3.956
Investigation of Tacrolimus Loaded Nanostructured Lipid Carriers for Topical Drug Delivery
S. Nam (2011)
10.1016/j.jphotobiol.2008.03.008
Characterisation of liposomes containing aminolevulinic acid and derived esters.
G. Di Venosa (2008)
10.1016/J.ADDR.2007.04.007
Solid lipid nanoparticles as a drug delivery system for peptides and proteins.
A. Almeida (2007)
10.1007/BF00371789
Stability of anthralin in liposomal phospholipids
G. Mahrle (2004)
Anti-inflammatory activity of novel ammonium
M Carafa (2012)
Nano - emulsions . Curr . Opin . Coll . Interf . Sci
C Solans (2005)
10.1016/S0378-5173(98)00169-0
Non-ionic surfactant based vesicles (niosomes) in drug delivery
I. Uchegbu (1998)
10.3109/10717540903581679
Nanoemulsions as vehicles for topical administration of glycyrrhetic acid: Characterization and in vitro and in vivo evaluation
C. Puglia (2010)
therapies. Medicinski Glasnik
C Puglia (2010)
10.1186/1757-1626-2-210
Acitretin-associated erectile dysfunction: a case report
M. Rossi (2009)
10.1002/jgm.1459
Gene therapy for psoriasis in the K14‐VEGF transgenic mouse model by topical transdermal delivery of interleukin‐4 using ultradeformable cationic liposome
J. Li (2010)
10.1016/j.colsurfb.2009.07.005
Development of liposomes containing ethanol for skin delivery of temoporfin: characterization and in vitro penetration studies.
Nina Dragicevic-Curic (2009)
10.1136/ard.2004.030791
Psoriasis treatment: traditional therapy
M. Lebwohl (2005)
10.1016/j.ejpb.2011.02.016
Development and evaluation of colloidal modified nanolipid carrier: application to topical delivery of tacrolimus.
Pallavi V Pople (2011)
10.1016/S0169-409X(01)00105-3
Solid lipid nanoparticles: production, characterization and applications.
W. Mehnert (2001)
The effect of combined ultraviolet A irradiation and oral psoralens (PUVA) on skin arachidonic acid and prostaglandin concentrations in psoriasis [proceedings].
M. Greaves (1978)
10.2147/IJN.S17524
Oil components modulate the skin delivery of 5-aminolevulinic acid and its ester prodrug from oil-in-water and water-in-oil nanoemulsions
Li-wen Zhang (2011)
10.1002/JPS.20995
Microemulsions--modern colloidal carrier for dermal and transdermal drug delivery.
Sandra Heuschkel (2008)
10.2174/092986706776360888
Aminolevulinic acid derivatives and liposome delivery as strategies for improving 5-aminolevulinic acid-mediated photodynamic therapy.
A. Casas (2006)
Drug delivery across the skin . Exp . Opin . Biol . Ther
E Touitou (2002)
10.1001/ARCHDERM.138.6.791
Mediation of systemic vascular hyperpermeability in severe psoriasis by circulating vascular endothelial growth factor.
D. Creamer (2002)
Herbs: A potential source for the development of new pytomedicinals
V Kumar (2003)
liposome drugs for skin disease
A Singh (2011)
10.3109/02652048.2010.546435
Novel dithranol phospholipid microemulsion for topical application: development, characterization and percutaneous absorption studies
K. Raza (2011)
The use of topical tacrolimus and pimecrolimus to treat psoriasis: a review.
N. Scheinfeld (2004)
10.1136/pgmj.2007.061473
Psoriasis: advances in pathophysiology and management
A. Macdonald (2007)
10.1016/J.ADDR.2007.04.012
Nanostructured lipid carriers (NLC) in cosmetic dermal products.
R. Mueller (2007)
10.2147/IJN.S17242
The preparation of 3,5-dihydroxy-4-isopropylstilbene nanoemulsion and in vitro release
Yue Zhang (2011)
10.1080/09546630701537678
Washability and fabric‐staining properties of a novel phospholipid‐structured coal tar formulation
A. Bhatia (2008)
parakeratotic rat skin model
SH Nam (2011)
10.1517/14656566.8.5.617
An attempt to formulate an evidence-based strategy in the management of moderate-to-severe psoriasis: a review of the efficacy and safety of biologics and prebiologic options
A. Leon (2007)
10.1186/1477-3155-9-44
Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments
D. S. Bernardi (2011)
10.1016/0169-409X(95)00019-4
Therapeutic progress with topical liposome drugs for skin disease
M. Schmid (1996)
Acitretin-associated erectile dysfunction
M Pellegrino (2009)
10.1046/j.1365-2133.2001.04280.x
Immunohistochemical evaluation of psoriatic plaques following selective photothermolysis of the superficial capillaries
S. Hern (2001)
10.1038/nature05663
Pathogenesis and therapy of psoriasis
M. A. Lowes (2007)
10.3329/JSR.V2I3.3258
Development and Evaluation of Liposomes for Topical Delivery of Tacrolimus (Fk-506)
S. S. Patel (2010)
10.1002/9780470571224.PSE360
Transdermal Drug Delivery
C. Asbill (2010)
10.1093/CHROMSCI/48.8.637
Development and validation of a fast RP-HPLC method for the determination of clobetasol propionate in topical nanocapsule suspensions.
M. Fontana (2010)
10.4103/0378-6323.72451
Novel drug delivery systems in topical treatment of psoriasis: rigors and vigors.
O. Katare (2010)
10.1016/j.ejpb.2012.04.005
Calcipotriol delivery into the skin with PEGylated liposomes.
N. Knudsen (2012)
10.1016/S0923-1811(02)00136-6
Similarly potent action of 1,25-dihydroxyvitamin D3 and its analogues, tacalcitol, calcipotriol, and maxacalcitol on normal human keratinocyte proliferation and differentiation.
H. Takahashi (2003)
Preparation and Quality Evaluation of Methotrexate Microemulsion
Jin Li-li (2011)
Angiogenesis drives psoriasis pathogenesis : Int . J . Exp . Pathol
R Heidenreich (2009)
Novel drug delivery systems in topical treatment of psoriasis : Rigors and vigors . Indian J . Dermatol . Venereol . Leprol
OP Katare (2010)
10.1046/j.0007-0963.2001.04689.x
Topical 5‐aminolaevulinic acid photodynamic therapy for the treatment of skin conditions other than non‐melanoma skin cancer
S. Ibbotson (2002)
10.1615/CRITREVTHERDRUGCARRIERSYST.V13.I3-4.30
Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery.
G. Cevc (1996)
[Therapy of psoriasis].
E. Christophers (1983)
Development and evaluation of colloidal
PV 25499–107.Pople (2011)
10.1016/S0378-5173(00)00674-8
Transdermal delivery of methotrexate: iontophoretic delivery from hydrogels and passive delivery from microemulsions.
M. J. Alvarez-Figueroa (2001)
10.1042/BST0250625
Immune deviation towards Th2 inhibits Th-1-mediated autoimmune diabetes.
L. Adorini (1997)
10.1016/S0378-5173(01)00810-9
Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol.
R. Agarwal (2001)
10.1016/j.ejps.2009.03.009
Development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: Physicochemical characterization and stability study.
Rohit Mulik (2009)
10.2147/IJN.S12125
Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method
Z. Urbán-Morlán (2010)
10.1016/0001-8686(95)00242-I
Non-ionic surfactant vesicles (niosomes): Physical and pharmaceutical chemistry
I. Uchegbu (1995)
10.1517/17425240902832827
Retinoids: new use by innovative drug-delivery systems
E. Trapasso (2009)
10.1016/S0169-409X(02)00116-3
Influence of microemulsions on cutaneous drug delivery.
M. Kreilgaard (2002)
10.1182/BLOOD-2002-12-3793
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis.
Y. Xia (2003)
10.4065/76.9.943
Topical therapies for localized psoriasis.
P. Witman (2001)
The clinical spectrum of psoriasis . Clin . Dermatol
L Naldi (2007)
Solid lipid nanoparticles as a drug delivery system for peptides and proteins . Adv . Drug Del . Rev
AJ Almeida (2007)
Enhanced topical delivery of cyclosporine - A using PLGA nanoparticle as carrier . Curr . Nanosci
S Jain (2011)
10.3109/02652048.2012.717115
Improved therapeutic performance of dithranol against psoriasis employing systematically optimized nanoemulsomes
K. Raza (2013)
10.1111/1523-1747.EP12873369
The antipsoriatic compound anthralin influences bioenergetic parameters and redox properties of energy transducing membranes.
J. Fuchs (1990)
10.2147/IJN.S9155
Combination of calcipotriol and methotrexate in nanostructured lipid carriers for topical delivery
Y. Lin (2010)
10.1038/SJ.JID.5700485
Nanoemulsions as versatile formulations for paclitaxel delivery: peroral and dermal delivery studies in rats.
S. Khandavilli (2007)



This paper is referenced by
10.1055/S-0042-115177
Topically Used Herbal Products for the Treatment of Psoriasis - Mechanism of Action, Drug Delivery, Clinical Studies.
A. Herman (2016)
10.1007/s00289-019-02984-9
Targeting keratinocyte hyperproliferation, inflammation, oxidative species and microbial infection by biological macromolecule-based chitosan nanoparticle-mediated gallic acid–rutin combination for the treatment of psoriasis
Amarjeet Shandil (2019)
Passive Enhancement of Transdermal Drug Delivery : Lipid-Based Nano-carriers as Emerging Technology Platform
L. Moradi (2019)
TOPICAL AND SYSTEMIC DERMAL CARRIERS FOR PSORIASIS Review Article
R. Abdelgawad (2016)
10.1002/jbm.b.34338
Self-assembling water-soluble polymethacrylate-MTX conjugates: The significance of macromolecules architecture on drug conjugation efficiency, the final shape of particles, and drug release.
Katarzyna Bernaczek (2019)
10.22159/IJPPS.2017V9I8.18571
BETAMETHASONE DIPROPIONATE GEL FOR TREATMENT OF LOCALIZED PLAQUE PSORIASIS
Sanaa El Gizaway (2017)
Psoriasis: History, Present and Future Prospects
Ajay N Singh (2013)
10.3109/10837450.2015.1026605
A novel nanogel formulation of methotrexate for topical treatment of psoriasis: optimization, in vitro and in vivo evaluation
Vivek Avasatthi (2016)
RECENT ADVANCES IN TOPICAL DRUG DELIVERY SYSTEM
Jotinder Kaur (2016)
Development, characterization and evaluation of in-vitro anti-inflammatory activity of ginger extract based micro emulsion.
Ayesha Akram (2019)
10.1016/j.colsurfb.2018.01.053
Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties.
Thais P. Pivetta (2018)
10.5897/AJPAC2017.0717
Comparative evaluation of the antipsoriatic activity of Acalypha wilkesiana, Culcasia scandens with Kigelia africana using the mouse tail model
F. O. Oyedeji (2017)
10.1080/03639045.2020.1793998
Systematic development and characterization of curcumin-loaded nanogel for topical application
Payal Kesharwani (2020)
10.1080/17425247.2020.1772750
Analytical tools and evaluation strategies for nanostructured lipid carrier-based topical delivery systems
Sheefali Mahant (2020)
10.1016/j.ejps.2016.09.007
Comparative anti‐psoriatic efficacy studies of clobetasol loaded chitin nanogel and marketed cream
Rajitha Panonnummal (2017)
10.21276/irjps.2017.4.3.6
ANTIPSORIATIC THERAPY: DISCOVERING NEW HORIZONS
P. Gupta (2017)
Antipsoriatic activity of Cassia auriculata L. flowers in Freund’s adjuvantformaldehyde induced animal model
Vijaya lakshmi (2020)
10.1080/02652048.2019.1612475
Enhanced anti-psoriatic efficacy and regulation of oxidative stress of a novel topical babchi oil (Psoralea corylifolia) cyclodextrin-based nanogel in a mouse tail model
S. Kumar (2019)
Niosomes : A Non-Ionic Surfactant Based Vesicles as a Carriers for Drug Delivery
Shaumika S Rane (2018)
An Overview On Niosome As Carrier In Dermal Drug Delivery
A. Jothy (2015)
NANOEMULSION: An Effective Drug Carrier for the Management of Psoriasis
Rimmi Singh (2015)
Primjena suvremenih topikalnih pripravaka u liječenju psorijaze
I. Petric (2017)
10.5530/ijper.54.3.115
Commiphora mukul and Quercetin Loaded Liposphere Gel: Potential Treatment for Psoriasis
Madhura Mestry (2020)
10.1016/J.JDDST.2018.12.020
Chaulmoogra oil based methotrexate loaded topical nanoemulsion for the treatment of psoriasis
P. Rajitha (2019)
SYSTEMIC DERMAL CARRIERS FOR PSORIASIS Review Article
Rana Abdelgawad (2016)
10.2217/nnm-2020-0274
In vivo drug delivery applications of nanogels: a review.
Filippo Pinelli (2020)
10.2147/IJN.S156412
Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: ex vivo–in vivo evaluation study
I. I. Abu Hashim (2018)
10.3109/10717544.2015.1041578
Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients
S. A. Rahman (2016)
Semantic Scholar Logo Some data provided by SemanticScholar